The Nagata automorphism is wild.

abstract：:HetR is an essential regulator of heterocyst development in cyanobacteria. Many mutations in HetR render Anabaena incapable of nitrogen fixation. The protein binds to a DNA palindrome upstream of hetP and other genes. We have determined the crystal structures of HetR complexed with palindromic DNA targets, 21, 23, and...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kim Y,Ye Z,Joachimiak G,Videau P,Young J,Hurd K,Callahan SM,Gornicki P,Zhao J,Haselkorn R,Joachimiak A

更新日期：2013-05-07 00:00:00

abstract：:The molecular chaperone Hsp90 is a protein folding machine that is conserved from bacteria to man. Human, cytosolic Hsp90 is dedicated to folding of chiefly signal transduction components. The chaperoning mechanism of Hsp90 is controlled by ATP and various cochaperones, but is poorly understood and controversial. Here...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Karagöz GE,Duarte AM,Ippel H,Uetrecht C,Sinnige T,van Rosmalen M,Hausmann J,Heck AJ,Boelens R,Rüdiger SG

更新日期：2011-01-11 00:00:00

abstract：:We have investigated the differentiation potential of precursor cells within the developing spinal cord of mice and have shown that spinal cord cells from embryonic day 10 specifically give rise to neurons when plated onto an astrocytic monolayer, Ast-1. These neurons had the morphology of motor neurons and > 83% expr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Richards LJ,Murphy M,Dutton R,Kilpatrick TJ,Puche AC,Key B,Tan SS,Talman PS,Bartlett PF

更新日期：1995-10-24 00:00:00

abstract：:Unfolded RNase A is known to contain an equilibrium mixture of two forms, a slow-folding form (U(1)) and a fast-folding form (U(2)). If U(1) is produced after unfolding by the slow cis-trans isomerization of proline residues about X-Pro imide bonds, then the formation of U(1) should be catalyzed by strong acids. There...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schmid FX,Baldwin RL

更新日期：1978-10-01 00:00:00

abstract：:Old noninbred fly mortality decreases according to the inverse linear law and reduces to a single suborder-specific age. Relative child mortality (the mortality at a given age related to the mortality at 10 years) from 1 mo to 11 years is the same with 8% mean accuracy for all humans, independent of race, country, sex...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Azbel' MY

更新日期：1998-07-21 00:00:00

abstract：:Researchers have documented many cases in which individuals rationalize their regrettable actions. Four experiments examine situations in which people go beyond merely explaining away their misconduct to actively deceiving themselves. We find that those who exploit opportunities to cheat on tests are likely to engage ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chance Z,Norton MI,Gino F,Ariely D

更新日期：2011-09-13 00:00:00

abstract：:NRSF/REST is a protein that silences transcription of a number of genes that contain a DNA element called the neuron-restrictive silencer element (NRSE). During embryogenesis, REST is expressed ubiquitously in nonneural cells, but is down-regulated during differentiation of neural progenitors into neurons. REST is als...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Koenigsberger C,Chicca JJ 2nd,Amoureux MC,Edelman GM,Jones FS

更新日期：2000-02-29 00:00:00

abstract：:The VX2 carcinoma-bearing rabbit is an animal model for tumor-induced hypercalcemia, thought to be due to increased bone destruction effected by prostaglandin E2. The present experiments suggest that the pathophysiology of the hypercalcemia differs from that previously proposed. Tumor was transplanted intramuscularly ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Doppelt SH,Slovik DM,Neer RM,Nolan J,Zusman RM,Potts JT Jr

更新日期：1982-01-01 00:00:00

abstract：:Division of labor is fundamental to the success of all societies. The most striking examples are the physically polymorphic worker castes in social insects with clear morphological adaptations to different roles. These polymorphic worker castes have previously been thought to be a classic example of nongentically cont...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hughes WO,Sumner S,Van Borm S,Boomsma JJ

更新日期：2003-08-05 00:00:00

abstract：:Asian patients with chronic hepatitis C (CHC) are known to have better virological responses to pegylated (Peg) IFN-based therapy than Western patients. Although IL28B gene polymorphisms may contribute to this difference, whether favorable hepatitis C virus (HCV) kinetics during treatment plays a role remains unclear....

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hsu CS,Hsu SJ,Chen HC,Tseng TC,Liu CH,Niu WF,Jeng J,Liu CJ,Lai MY,Chen PJ,Kao JH,Chen DS

更新日期：2011-03-01 00:00:00

abstract：:Compressional waves that sample the lowermost mantle west of Central America show a rapid change in travel times of up to 4 s over a sampling distance of 300 km and a change in waveforms. The differential travel times of the PKP waves (which traverse Earth's core) correlate remarkably well with predictions for S-wave ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sun X,Song X,Zheng S,Helmberger DV

更新日期：2007-01-02 00:00:00

abstract：:X-linked dystonia-parkinsonism (XDP) is a neurodegenerative disease associated with an antisense insertion of a SINE-VNTR-Alu (SVA)-type retrotransposon within an intron of TAF1 This unique insertion coincides with six additional noncoding sequence changes in TAF1, the gene that encodes TATA-binding protein-associated...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bragg DC,Mangkalaphiban K,Vaine CA,Kulkarni NJ,Shin D,Yadav R,Dhakal J,Ton ML,Cheng A,Russo CT,Ang M,Acuña P,Go C,Franceour TN,Multhaupt-Buell T,Ito N,Müller U,Hendriks WT,Breakefield XO,Sharma N,Ozelius LJ

更新日期：2017-12-19 00:00:00

abstract：:Marriage in many traditional societies often concerns the institutionalized exchange of reproductive partners among groups of kin. Such exchanges most often involve cross-cousins-marriage with the child of a parent's opposite-sex sibling-but it is unclear who benefits from these exchanges. Here we analyze the fitness ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chagnon NA,Lynch RF,Shenk MK,Hames R,Flinn MV

更新日期：2017-03-28 00:00:00

abstract：:A critique is presented of the Lumsden-Wilson theory [Lumsden, C. J. & Wilson, E. O. (1980) Proc. Natl. Acad. Sci. USA 77, 4382-4386] of the transmission of cultural traits. An analysis of the underlying assumptions and the mathematical nature of the theory clarifies its essentially reductionist and determinist qualit...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Alper JS,Lange RV

更新日期：1981-06-01 00:00:00

abstract：:By the use of a rapid radioautographic screening procedure, two mutants of Bacillus brevis ATCC 8185 that have lost the ability to produce gramicidin have been isolated. These mutants produced normal levels of tyrocidine and sporulated at the same frequency as the parent strain. Their spores, however, were more heat-s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mukherjee PK,Paulus H

更新日期：1977-02-01 00:00:00

abstract：:Kinesin-73 cDNA was shown to encode a kinesin heavy chain protein that contains an N-terminal motor domain and a long central region that lacks extensive coiled-coils. The amino acid sequence of the motor domain of kinesin-73 protein is most closely related to the motor domains of Caenorhabditis elegans unc-104 and mo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li HP,Liu ZM,Nirenberg M

更新日期：1997-02-18 00:00:00

abstract：:The sequence of the cloned Bacillus amyloliquefaciens subtilisin gene suggested that this secreted serine protease is produced as a larger precursor, designated preprosubtilisin [Wells, J. A., Ferrari, E., Henner, D. J., Estell, D. A. & Chen, E. Y. (1983) Nucleic Acids Res. 11, 7911-7925]. Biochemical evidence present...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Power SD,Adams RM,Wells JA

更新日期：1986-05-01 00:00:00

abstract：:The principal axes of inertia are eigenvectors that can be calculated for any rigid body. We report studies of the position of the principal axes in crystallographically solved protein molecules. We find with high frequency that at least one principal axis penetrates the surface of the respective protein in a region u...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Foote J,Raman A

更新日期：2000-02-01 00:00:00

abstract：:Ultraviolet irradiation of the [3H]colchicine-tubulin complex leads to direct photolabeling of tubulin with low but practicable efficiency. The bulk (70% to greater than 90%) of the labeling occurs on beta-tubulin and appears early after irradiation, whereas alpha-tubulin is labeled later. The labeling ratio of beta-t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wolff J,Knipling L,Cahnmann HJ,Palumbo G

更新日期：1991-04-01 00:00:00

abstract：:We have recently characterized a transposable element, ISH1, which inactivates the bacterio-opsin (BO) gene in two purple membrane-deficient (Pum-) mutants of Halobacterium halobium. Examination of nine additional Pum- mutants now shows that in all of these the BO gene has been inactivated by insertion of one of two t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： DasSarma S,RajBhandary UL,Khorana HG

更新日期：1983-04-01 00:00:00

abstract：:Cyclonic atmospheric vortices of varying intensity, collectively known as low-pressure systems (LPS), travel northwest across central India and produce more than half of the precipitation received by that fertile region and its ∼600 million inhabitants. Yet, future changes in LPS activity are poorly understood, due in...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sandeep S,Ajayamohan RS,Boos WR,Sabin TP,Praveen V

更新日期：2018-03-13 00:00:00

abstract：:A "supermarket revolution" has occurred in developing countries in the past 2 decades. We focus on three specific issues that reflect the impact of this revolution, particularly in Asia: continuity in transformation, innovation in transformation, and unique development strategies. First, the record shows that the rapi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Reardon T,Timmer CP,Minten B

更新日期：2012-07-31 00:00:00

abstract：:The objective of this study was to determine whether the vascular smooth muscle contractile effect of NG-methyl-L-arginine (NMA) is endothelium dependent and attributed to a decline in smooth muscle levels of cyclic GMP. Vascular smooth muscle levels of cyclic GMP are severalfold greater in endothelium-intact than in ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gold ME,Wood KS,Byrns RE,Fukuto J,Ignarro LJ

更新日期：1990-06-01 00:00:00

abstract：:Influenza virus neuraminidase (NA; EC 3.2.1.18) possesses a signal-anchor hydrophobic domain at the amino terminus. To characterize the nature of this signal-anchor domain we have introduced single amino acid changes in this domain by oligonucleotide-directed mutagenesis. Three mutant NA proteins that were synthesized...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sivasubramanian N,Nayak DP

更新日期：1987-01-01 00:00:00

abstract：:In both human patients and murine models, the progression from insulitis to diabetes is neither immediate nor inevitable, as illustrated by the innocuous versus destructive infiltrates of BDC2.5 transgenic mice on the nonobese diabetic (NOD) versus C57BL/6.H-2g7 genetic backgrounds. Natural killer (NK)-cell-specific t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Poirot L,Benoist C,Mathis D

更新日期：2004-05-25 00:00:00

abstract：:ErbB2 interacting protein (Erbin) is a widely expressed protein and participates in inhibition of several intracellular signaling pathways. Its mRNA has been found to be present in relatively high levels in the heart. However, its physiological role in the heart has not been explored. In the present work, we elucidate...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rachmin I,Tshori S,Smith Y,Oppenheim A,Marchetto S,Kay G,Foo RS,Dagan N,Golomb E,Gilon D,Borg JP,Razin E

更新日期：2014-04-22 00:00:00

abstract：:Interphotoreceptor retinoid-binding protein (IRBP) has been hypothesized to function as an intercellular shuttle in the vertebrate eye, serving to transport retinoids between the retinal pigment epithelium (RPE) and photoreceptors in the process by which visual pigment is regenerated after photolysis. This hypothesis ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Okajima TI,Pepperberg DR,Ripps H,Wiggert B,Chader GJ

更新日期：1990-09-01 00:00:00

abstract：:In this model gravitation results from the emission and absorption of quanta (gravitons) that are scattered a few times in crossing a typical galaxy. Many features of the universe can be explained in terms of this model, although theoretical justification for the scattering of gravitons is lacking. Gravitons follow a ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Britten RJ

更新日期：1992-05-01 00:00:00

abstract：:beta-Adrenergic receptors on Friend erythroleukemic cells were identified by the use of 125I-labeled hydroxybenzylpindolol, a potent beta-adrenergic antagonist. Binding of this ligand was saturable and stereospecific. The relative orders of potency of isoproterenol, epinephrine, and norepinephrine to displace bound hy...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schmitt H,Guyaux M,Pochet R,Kram R

更新日期：1980-07-01 00:00:00

abstract：:Although gamma/delta T cells express numerous in vitro functions similar to alpha/beta T cells, little is known about their biological functioning in vivo. Furthermore, it is unclear whether alpha/beta T cells and gamma/delta T cells act independently or in a coordinated way. In the present study, gamma/delta T cells ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kaufmann SH,Blum C,Yamamoto S

更新日期：1993-10-15 00:00:00