Gut-mediated hypercalcemia in rabbits bearing VX2 carcinoma: new mechanism for tumor-induced hypercalcemia.

abstract：:We examined the DNA and RNA of fresh leukemic cells (five patients) and long-term cultured T lymphocytes (four patients) from patients with adult T-cell leukemia for the presence of human T-cell leukemia virus (HTLV-I) sequences. In all cases HTLV-I provirus was found and several species of viral mRNAs were observed i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Franchini G,Wong-Staal F,Gallo RC

更新日期：1984-10-01 00:00:00

abstract：:The transporter associated with antigen processing (TAP) is essential for intracellular transport of protein fragments into the endoplasmic reticulum for loading of major histocompatibility complex (MHC) class I molecules. On the cell surface, these peptide-MHC complexes are monitored by cytotoxic T lymphocytes. To st...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gorbulev S,Abele R,Tampé R

更新日期：2001-03-27 00:00:00

abstract：:The 3' flanking region of the apolipoprotein B (apoB) gene contains a hypervariable region consisting of a variable number of tandemly repeated short A + T-rich DNA sequences (VNTRs). We present a general method that utilizes the polymerase chain reaction to rapidly and accurately type this and other VNTR loci. We use...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Boerwinkle E,Xiong WJ,Fourest E,Chan L

更新日期：1989-01-01 00:00:00

abstract：:Inflammation and vascular injury triggered by ischemia/reperfusion (I/R) represent a leading cause of morbidity and mortality in a number of clinical settings. Wnt and its homolog partners R-spondins, in addition to regulating embryonic development have recently been demonstrated to serve as wound-healing agents in in...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kannan L,Kis-Toth K,Yoshiya K,Thai TH,Sehrawat S,Mayadas TN,Dalle Lucca JJ,Tsokos GC

更新日期：2013-08-27 00:00:00

abstract：:The monomeric VDAC channel shows an accelerated pH titration of its transport properties with a Hill coefficient of about 2. This manifests itself as a sharp peak in conductance noise as well as a fast change in channel selectivity with pH. On the basis of the known structure of this channel, we propose that this coop...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rostovtseva TK,Liu TT,Colombini M,Parsegian VA,Bezrukov SM

更新日期：2000-07-05 00:00:00

abstract：:Mesencephalic dopamine neurons from the embryonic mouse brain were dissociated, aggregated in vitro in the presence of dissociated cells from appropriate or inappropriate target neuron areas, and visualized by the Falck-Hillarp histofluorescence technique after exposure to 1 microM exogenous dopamine. When aggregated ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hemmendinger LM,Garber BB,Hoffmann PC,Heller A

更新日期：1981-02-01 00:00:00

abstract：:The inositol 1,4,5-trisphosphate receptor (IP3R) associated with plasma membranes of lymphocytes differs in terminal sugar content and binding specificity from the cerebellar receptor, which is localized to endoplasmic reticulum. Lectin column chromatography reveals that 30% of IP3R in the thymus contains sialic acid,...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Khan AA,Steiner JP,Snyder SH

更新日期：1992-04-01 00:00:00

abstract：:A transformation-defective mutant of Abelson murine leukemia virus (A-MuLV), called A-MuLV-P92td, has been isolated. The mutant encodes a serologically identifiable A-MuLV protein of molecular weight 92,000 (P92) but it lacks the ability to transform either fibroblasts or bone marrow lymphoid cells. In contrast to the...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Witte ON,Goff S,Rosenberg N,Baltimore D

更新日期：1980-08-01 00:00:00

abstract：:Pyrrolysine (Pyl), the 22nd natural amino acid and genetically encoded by UAG, becomes attached to its cognate tRNA by pyrrolysyl-tRNA synthetase (PylRS). We have determined three crystal structures of the Methanosarcina mazei PylRS complexed with either AMP-PNP, Pyl-AMP plus pyrophosphate, or the Pyl analogue N-epsil...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kavran JM,Gundllapalli S,O'Donoghue P,Englert M,Söll D,Steitz TA

更新日期：2007-07-03 00:00:00

abstract：:Nucleotide excision repair proteins have been implicated in genetic recombination by experiments in Saccharomyces cerevisiae and Drosophila melanogaster, but their role, if any, in mammalian cells is undefined. To investigate the role of the nucleotide excision repair gene ERCC1, the hamster homologue to the S. cerevi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sargent RG,Rolig RL,Kilburn AE,Adair GM,Wilson JH,Nairn RS

更新日期：1997-11-25 00:00:00

abstract：:Proinflammatory signaling pathways are commonly up-regulated in breast cancer. In estrogen receptor-negative (ER-) and triple-negative breast cancer (TNBC), nitric oxide synthase-2 (NOS2) and cyclooxygenase-2 (COX2) have been described as independent predictors of disease outcome. We further explore these findings by ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Basudhar D,Glynn SA,Greer M,Somasundaram V,No JH,Scheiblin DA,Garrido P,Heinz WF,Ryan AE,Weiss JM,Cheng RYS,Ridnour LA,Lockett SJ,McVicar DW,Ambs S,Wink DA

更新日期：2017-12-05 00:00:00

abstract：:If, because of trade-offs or similar considerations, components of fitness are negatively correlated in equilibrium populations, they may then exhibit no correlation with total fitness. Lack of correlation with fitness is a fundamental characteristic of selective neutrality. Hence, selectively important traits become ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Reeve R,Smith E,Wallace B

更新日期：1990-03-01 00:00:00

abstract：:The complete soybean leghemoglobin lbc(3) gene was transferred into the legume Lotus corniculatus using an Agrobacterium rhizogenes vector system. Organ-specific expression of the soybean gene was observed in root nodules formed on regenerated transgenic plants after infection with Rhizobium loti. The primary transcri...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Stougaard J,Petersen TE,Marcker KA

更新日期：1987-08-01 00:00:00

abstract：:The human beta-globin locus is activated transcriptionally by a complex series of events that culminate in appropriate temporal and tissue-specific control over five separate genes during embryonic and early postnatal development. One cis-regulatory element in the locus, originally identified as an enhancer 3' to the ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liu Q,Tanimoto K,Bungert J,Engel JD

更新日期：1998-08-18 00:00:00

abstract：:Non-human primates (NHP) provide crucial research models. Their strong similarities to humans make them particularly valuable for understanding complex behavioral traits and brain structure and function. We report here the genetic mapping of an NHP nervous system biologic trait, the cerebrospinal fluid (CSF) concentra...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Freimer NB,Service SK,Ophoff RA,Jasinska AJ,McKee K,Villeneuve A,Belisle A,Bailey JN,Breidenthal SE,Jorgensen MJ,Mann JJ,Cantor RM,Dewar K,Fairbanks LA

更新日期：2007-10-02 00:00:00

abstract：:Cities are concentrated areas of CO2 emissions and have become the foci of policies for mitigation actions. However, atmospheric measurement networks suitable for evaluating urban emissions over time are scarce. Here we present a unique long-term (decadal) record of CO2 mole fractions from five sites across Utah's met...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mitchell LE,Lin JC,Bowling DR,Pataki DE,Strong C,Schauer AJ,Bares R,Bush SE,Stephens BB,Mendoza D,Mallia D,Holland L,Gurney KR,Ehleringer JR

更新日期：2018-03-20 00:00:00

abstract：:We describe a procedure for predicting the tertiary folds of alpha-helical proteins from their primary sequences. The central component of the procedure is a method for predicting interhelical contacts that is based on a helix-packing model. Instead of predicting the individual contacts, our method attempts to identif...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhang C,Hou J,Kim SH

更新日期：2002-03-19 00:00:00

abstract：:A direct method for the determination of N-linked glycosylation sites in highly glycosylated proteins is described. Carcinoembryonic antigen (CEA) and a nonspecific crossreacting antigen (NCA) were chemically deglycosylated, and peptide maps were prepared by reverse-phase HPLC. The peptides were sequenced on a gas-pha...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Paxton RJ,Mooser G,Pande H,Lee TD,Shively JE

更新日期：1987-02-01 00:00:00

abstract：:Alcohol exposure during development can cause brain malformations and neurobehavioral abnormalities. In view of the teratogenicity of ethanol, identification of molecules that could counteract the neurotoxic effects of alcohol deserves high priority. Here, we report that pituitary adenylate cyclase-activating polypept...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vaudry D,Rousselle C,Basille M,Falluel-Morel A,Pamantung TF,Fontaine M,Fournier A,Vaudry H,Gonzalez BJ

更新日期：2002-04-30 00:00:00

abstract：:Almost all theoretical and experimental studies of the mechanisms underlying learning and memory focus on synaptic efficacy and make the implicit assumption that changes in synaptic efficacy are both necessary and sufficient to account for learning and memory. However, network dynamics depends on the complex interacti...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Marder E,Abbott LF,Turrigiano GG,Liu Z,Golowasch J

更新日期：1996-11-26 00:00:00

abstract：:Eosinophils have been associated with fibrosis. To investigate their direct role in fibrosis, human peripheral blood eosinophil sonicate was added to human lung or dermal fibroblasts, and proliferation ([(3)H]thymidine) and collagen synthesis ([(3)H]proline) were evaluated. Proliferation was enhanced significantly in ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Levi-Schaffer F,Garbuzenko E,Rubin A,Reich R,Pickholz D,Gillery P,Emonard H,Nagler A,Maquart FA

更新日期：1999-08-17 00:00:00

abstract：:The study of the metabolome presents numerous challenges, first among them being the cataloging of its constituents. A step in this direction will be the development of tools to identify metabolites that share common structural features. The importance of sulfated molecules in cell-cell communication motivated us to d...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mougous JD,Leavell MD,Senaratne RH,Leigh CD,Williams SJ,Riley LW,Leary JA,Bertozzi CR

更新日期：2002-12-24 00:00:00

abstract：:The impact of projected global warming on crop yields has been evaluated by indirect methods using simulation models. Direct studies on the effects of observed climate change on crop growth and yield could provide more accurate information for assessing the impact of climate change on crop production. We analyzed weat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Peng S,Huang J,Sheehy JE,Laza RC,Visperas RM,Zhong X,Centeno GS,Khush GS,Cassman KG

更新日期：2004-07-06 00:00:00

abstract：:Hypermutation in immunoglobulin genes produces a high frequency of substitutions of all four bases, which are likely generated by low-fidelity DNA polymerases. Indeed, humans deficient for DNA polymerase (pol) eta have decreased substitutions of A.T base pairs in variable and switch regions. To study the role of pol e...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Martomo SA,Yang WW,Wersto RP,Ohkumo T,Kondo Y,Yokoi M,Masutani C,Hanaoka F,Gearhart PJ

更新日期：2005-06-14 00:00:00

abstract：:Xenopus laevis oocytes were injected with poly(A)+-mRNA isolated from chorionating follicular epithelium of the domesticated silk moth (Bombyx mori). On two-dimensional gel electrophoresis, the resultant translation products comigrated with authentic, secreted, chorion standards, demonstrating that the frog oocyte sys...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bock SC,Tiemeier DC,Mester K,Wu M,Goldsmith MR

更新日期：1982-02-01 00:00:00

abstract：:In response to insect attack, many plants exhibit dynamic biochemical changes, resulting in the induced production of direct and indirect defenses. Elicitors present in herbivore oral secretions are believed to positively regulate many inducible plant defenses; however, little is known about the specificity of elicito...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schmelz EA,Engelberth J,Alborn HT,Tumlinson JH 3rd,Teal PE

更新日期：2009-01-13 00:00:00

abstract：:Most humans in the United States have been infected with BK virus (BKV), a human papovavirus. Because BKV has oncogenic properties, we have investigated whether it may be a cause of human cancer. Basic principles of tumor virology imply that BKV-induced tumors should contain BKV DNA sequences. Therefore, we assayed (b...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wold WS,Mackey JK,Brackmann KH,Takemori N,Rigden P,Green M

更新日期：1978-01-01 00:00:00

abstract：:Higher plants process two distinct, nuclear gene-encoded glyceraldehyde-3-phosphate dehydrogenase (GAPDH) proteins, a Calvin-cycle enzyme active within chloroplasts and a glycolytic enzyme active within the cytosol. The gene for the chloroplast enzyme was previously suggested to be of endosymbiotic origin. Since the a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Martin W,Brinkmann H,Savonna C,Cerff R

更新日期：1993-09-15 00:00:00

abstract：:Scores of homeobox gene-encoded transcription factors are expressed in a definite spatiotemporal pattern during embryogenesis and regulate a series of as yet unidentified target genes to help coordinate the morphogenetic process. We have suggested that homeobox gene products modulate the expression of adhesion molecul...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jones FS,Holst BD,Minowa O,De Robertis EM,Edelman GM

更新日期：1993-07-15 00:00:00

abstract：:By affinity chromatography on heparin-Sepharose, two classes of lipoproteins were separated from high density lipoproteins (HDL) isolated from patients with primary or secondary lecithin:cholesterol acyltransferase (LCATase; EC 2.3.1.43) deficiency and from normal subjects. The unretained fraction, HDL(A), was charact...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Marcel YL,Vezina C,Emond D,Suzue G

更新日期：1980-05-01 00:00:00