Sequence analysis of carcinoembryonic antigen: identification of glycosylation sites and homology with the immunoglobulin supergene family.

abstract：:Relative cerebral glucose metabolism was examined with positron-emission tomography (PET) as a measure of neuronal activation during performance of the classically conditioned eyeblink response in 12 young adult subjects. Each subject received three sessions: (i) a control session with PET scan in which unpaired prese...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Logan CG,Grafton ST

更新日期：1995-08-01 00:00:00

abstract：:Ovarian cancer remains the most lethal gynecologic malignancy. We analyzed the mutational landscape of 64 primary, 41 metastatic, and 17 recurrent fresh-frozen tumors from 77 patients along with matched normal DNA, by whole-exome sequencing (WES). We also sequenced 13 pairs of synchronous bilateral ovarian cancer (SBO...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li C,Bonazzoli E,Bellone S,Choi J,Dong W,Menderes G,Altwerger G,Han C,Manzano A,Bianchi A,Pettinella F,Manara P,Lopez S,Yadav G,Riccio F,Zammataro L,Zeybek B,Yang-Hartwich Y,Buza N,Hui P,Wong S,Ravaggi A,Bigno

更新日期：2019-01-08 00:00:00

abstract：:Using both heterologous rabbit antisera and mouse monoclonal antibody to RNA.DNA hybrids, we have mapped the in situ hybridization locus of the 18/28S ribosomal RNA fraction to a single large band on polytene autosome 3 in Drosophila heteroneura and Drosophila silvestris. This portion of the chromosome is not physical...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Stuart WD,Bishop JG,Carson HL,Frank MB

更新日期：1981-06-01 00:00:00

abstract：:The plant hormones abscisic acid (ABA) and gibberellic acid (GA) are important regulators of the dormancy and germination of seeds. In cereals, GA enhances the synthesis and secretion of enzymes (principally alpha-amylases) in the aleurone cells of the endosperm, which then mobilize the storage reserves that fuel germ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ritchie S,Gilroy S

更新日期：1998-03-03 00:00:00

abstract：:We describe a new computer program, trilogy, for the automated discovery of sequence-structure patterns in proteins. trilogy implements a pattern discovery algorithm that begins with an exhaustive analysis of flexible three-residue patterns; a subset of these patterns are selected as seeds for an extension process in ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bradley P,Kim PS,Berger B

更新日期：2002-06-25 00:00:00

abstract：:Several polymorphisms of the transcription factor 4 (TCF4) have been shown to increase the risk for schizophrenia, particularly TCF4 rs9960767. This polymorphism is associated with impaired sensorimotor gating measured by prepulse inhibition--an established endophenotype of schizophrenia. We therefore investigated whe...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Quednow BB,Brinkmeyer J,Mobascher A,Nothnagel M,Musso F,Gründer G,Savary N,Petrovsky N,Frommann I,Lennertz L,Spreckelmeyer KN,Wienker TF,Dahmen N,Thuerauf N,Clepce M,Kiefer F,Majic T,Mössner R,Maier W,Gallinat J,D

更新日期：2012-04-17 00:00:00

abstract：:HsPKS1 from Huperzia serrata is a type III polyketide synthase (PKS) with remarkable substrate tolerance and catalytic potential. Here we present the synthesis of unnatural unique polyketide-alkaloid hybrid molecules by exploiting the enzyme reaction using precursor-directed and structure-based approaches. HsPKS1 prod...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Morita H,Yamashita M,Shi SP,Wakimoto T,Kondo S,Kato R,Sugio S,Kohno T,Abe I

更新日期：2011-08-16 00:00:00

abstract：:Export of LDL-derived cholesterol from lysosomes requires the cooperation of the integral membrane protein Niemann-Pick C1 (NPC1) and a soluble protein, Niemann-Pick C2 (NPC2). Mutations in the genes encoding these proteins lead to Niemann-Pick disease type C (NPC). NPC2 binds to NPC1's second (middle), lumenally orie...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li X,Saha P,Li J,Blobel G,Pfeffer SR

更新日期：2016-09-06 00:00:00

abstract：:Expression of T1ST2, the IL-33R, by Th2 cells requires GATA3. Resting Th2 cells express little GATA3, which is increased by IL-33 and a STAT5 activator, in turn increasing T1ST2 from its low-level expression on resting Th2 cells. Th2 cells that have upregulated T1ST2 produce IL-13, but not IL-4, in response to IL-33 p...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Guo L,Wei G,Zhu J,Liao W,Leonard WJ,Zhao K,Paul W

更新日期：2009-08-11 00:00:00

abstract：:Yeast RNA polymerase II initiation factor e was purified to homogeneity and identified by biochemical criteria as the counterpart of human transcription factor IIB. Factor e was essential for initiation of transcription from yeast and mammalian promoters in a reconstituted yeast transcription system. Activity resided ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tschochner H,Sayre MH,Flanagan PM,Feaver WJ,Kornberg RD

更新日期：1992-12-01 00:00:00

abstract：:The rewards of promiscuity for males are undisputed. But why should a female mate promiscuously, particularly when her partners offer no resources other than sperm and increase her chances of succumbing to predation or disease? This question has been hotly debated but at present remains largely unresolved [Jennions, M...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Evans JP,Magurran AE

更新日期：2000-08-29 00:00:00

abstract：:Radioimmunoassays specific for the N and C termini of human prothymosin alpha and the N terminus of human parathymosin alpha were employed for the measurement of the levels of alpha-thymosins in human thymus, spleen, and liver during normal growth and intestine and breast in malignant growth. A differential expression...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tsitsiloni OE,Stiakakis J,Koutselinis A,Gogas J,Markopoulos C,Yialouris P,Bekris S,Panoussopoulos D,Kiortsis V,Voelter W

更新日期：1993-10-15 00:00:00

abstract：:Progesterone is involved in the development and progression of breast cancers, and progesterone receptors (PR) are important markers of hormone dependence and disease prognosis. We have used a human PR cDNA probe, genomic DNA blotting of a series of Chinese hamster-human cell hybrids, and in situ hybridization to map ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Law ML,Kao FT,Wei Q,Hartz JA,Greene GL,Zarucki-Schulz T,Conneely OM,Jones C,Puck TT,O'Malley BW

更新日期：1987-05-01 00:00:00

abstract：:Agrobacterium tumefaciens can transfer part of its Ti plasmid, the T-DNA, to plant cells where it integrates into the nuclear genome via illegitimate recombination. Integration of the T-DNA results in small deletions of the plant target DNA, and may lead to truncation of the T-DNA borders and the production of filler ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bundock P,Hooykaas PJ

更新日期：1996-12-24 00:00:00

abstract：:A detailed model of the G(2) DNA damage checkpoint (G2DDC) system is presented that includes complex regulatory networks of the mitotic kinase Cdc2, phosphatase Cdc25, Wee1 kinase, and damage signal transduction pathways involving Chk1 and p53. Assumptions on the kinetic equations of the G2DDC are made, and computer s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Aguda BD

更新日期：1999-09-28 00:00:00

abstract：:Mutations in the potassium channel gene KCNQ4 underlie DFNA2, an autosomal dominant form of progressive hearing loss in humans. In the mouse cochlea, the transcript has been found exclusively in the outer hair cells. By using specific antibodies, we now show that KCNQ4 is situated at the basal membrane of these sensor...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kharkovets T,Hardelin JP,Safieddine S,Schweizer M,El-Amraoui A,Petit C,Jentsch TJ

更新日期：2000-04-11 00:00:00

abstract：:How likely is it that someone would approve of using a nuclear weapon to kill millions of enemy civilians in the hope of ending a ground war that threatens thousands of American troops? Ask them how they feel about prosecuting immigrants, banning abortion, supporting the death penalty, and protecting gun rights and yo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Slovic P,Mertz CK,Markowitz DM,Quist A,Västfjäll D

更新日期：2020-08-25 00:00:00

abstract：:Several overlapping chromosomal deletions spanning the albino locus in the mouse cause perinatal lethality when homozygous and a block in the transcriptional induction of various unlinked hepatocyte-specific genes. Studies of such lethal albino deletion homozygotes in perinatal stages revealed a deficiency in the tran...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zaret KS,Milos P,Lia M,Bali D,Gluecksohn-Waelsch S

更新日期：1992-07-15 00:00:00

abstract：:The preferential inactivation of the paternal X chromosome in extraembryonic cells during early mouse development is an example of parental imprinting, but it has not been studied at the transcriptional level because standard methods of measuring RNA levels do not allow detection of allele-specific RNAs in individual ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Singer-Sam J,Chapman V,LeBon JM,Riggs AD

更新日期：1992-11-01 00:00:00

abstract：:[3H]Thymidine-labeled progeny DNA was isolated after infection of Escherichia coli with two different bacteriophage T4 mutants. These strands were isolated shortly after the initiation of DNA replication and hybridized to 15 different (EcoRI) T4 restriction fragments cloned in plasmid vectors. Uniformly labeled T4 [32...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Halpern ME,Mattson T,Kozinski AW

更新日期：1979-12-01 00:00:00

abstract：:The best-studied cytoskeletal system is the inner surface of the erythrocyte membrane, which provides an erythrocyte with the structural support needed to be stable yet flexible as it passes through the circulation. Current structural models predict that the spectrin-actin-based cytoskeletal network is attached to the...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Stefanovic M,Markham NO,Parry EM,Garrett-Beal LJ,Cline AP,Gallagher PG,Low PS,Bodine DM

更新日期：2007-08-28 00:00:00

abstract：:Current theory indicates that mitochondria were obtained 1.5 billion years ago from an ancient prokaryote. The mitochondria provided the capacity for aerobic respiration, the creation of the eukaryotic cell, and eventually complex multicellular organisms. Recent reports have found that mitochondria play essential role...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Spees JL,Olson SD,Whitney MJ,Prockop DJ

更新日期：2006-01-31 00:00:00

abstract：:The polymerization of individual RecA-DNA filaments, containing either single-stranded or double-stranded DNA, was followed in real time, and their mechanical properties were characterized with force-measuring laser tweezers. It was found that the stretch modulus of a filament is dominated by its (central) DNA compone...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hegner M,Smith SB,Bustamante C

更新日期：1999-08-31 00:00:00

abstract：:Although inappropriate activation of the Wnt/beta-catenin pathway has been implicated in the development of hepatocellular carcinoma (HCC), the role of this signaling in liver carcinogenesis remains unclear. To investigate this issue, we constructed a mutant mouse strain, Apc(lox/lox), in which exon 14 of the tumor-su...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Colnot S,Decaens T,Niwa-Kawakita M,Godard C,Hamard G,Kahn A,Giovannini M,Perret C

更新日期：2004-12-07 00:00:00

abstract：:The appearance of jaws was a turning point in vertebrate evolution because it allowed primitive vertebrates to capture and process large, motile prey. The vertebrate jaw consists of separate dorsal and ventral skeletal elements connected by a joint. How this structure evolved from the unjointed gill bar of a jawless a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cerny R,Cattell M,Sauka-Spengler T,Bronner-Fraser M,Yu F,Medeiros DM

更新日期：2010-10-05 00:00:00

abstract：:Rat serine dehydratase cDNA clones were isolated from a lambda gt11 cDNA library on the basis of their reactivity with monospecific immunoglobulin to the purified enzyme. Using the cDNA insert from a clone that encoded the serine dehydratase subunit as a probe, additional clones were isolated from the same library by ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ogawa H,Miller DA,Dunn T,Su Y,Burcham JM,Peraino C,Fujioka M,Babcock K,Pitot HC

更新日期：1988-08-01 00:00:00

abstract：:Genetic variation in the serotonin transporter gene (SLC6A4) is associated with vulnerability to affective disorders and pharmacotherapy efficacy. We recently identified sequence polymorphisms in the common marmoset SLC6A4 repeat region (AC/C/G and CT/T/C) associated with individual differences in anxiety-like trait, ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Santangelo AM,Sawiak SJ,Fryer T,Hong Y,Shiba Y,Clarke HF,Riss PJ,Ferrari V,Tait R,Suckling J,Aigbirhio FI,Roberts AC

更新日期：2019-07-16 00:00:00

abstract：:Immunoreactive intact cholecystokinin and its COOH-terminal octapeptide are found in brain as well as in extracts of gut of the monkey, dog, and pig, by using an antiserum with equivalent sensitivities for detecting the octapeptide in free form or incorporated in the intact molecule. The failure to detect intact chole...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Straus E,Yalow RS

更新日期：1978-01-01 00:00:00

abstract：:An integral mitochondrial membrane protein (p32) of yeast has previously been molecularly cloned and sequenced and suggested to function as a mitochondrial import receptor. However, this protein has also been proposed to function as phosphate translocator [Guérin, B., Bukusoglu, C., Rakotomanana, F. & Wohlrab, H. (199...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Murakami H,Blobel G,Pain D

更新日期：1993-04-15 00:00:00

abstract：:Accumulating evidence suggests that α-synuclein (α-syn) occurs physiologically as a helically folded tetramer that resists aggregation. However, the mechanisms underlying the regulation of formation of α-syn tetramers are still mostly unknown. Cellular membrane lipids are thought to play an important role in the regul...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kim S,Yun SP,Lee S,Umanah GE,Bandaru VVR,Yin X,Rhee P,Karuppagounder SS,Kwon SH,Lee H,Mao X,Kim D,Pandey A,Lee G,Dawson VL,Dawson TM,Ko HS

更新日期：2018-01-23 00:00:00