Selective loss of a DNase I hypersensitive site upstream of the tyrosine aminotransferase gene in mice homozygous for lethal albino deletions.

abstract：:The "chlamydial anomaly," first coined by James Moulder, describes the inability of researchers to detect or purify peptidoglycan (PG) from pathogenic Chlamydiae despite genetic and biochemical evidence and antibiotic susceptibility data that suggest its existence. We recently detected PG in Chlamydia trachomatis by a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Packiam M,Weinrick B,Jacobs WR Jr,Maurelli AT

更新日期：2015-09-15 00:00:00

abstract：:The functional significance of the portal vascular link between the beta cells of the pancreatic islets and the liver has not been established. Previous studies indicated that insulin does not acutely regulate glucose metabolism by a direct hepatic effect. More recent observations suggest that the role of insulin in r...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Griffen SC,Russell SM,Katz LS,Nicoll CS

更新日期：1987-10-01 00:00:00

abstract：:The state-to-state transfer of rotational and vibrational energy has been studied for S1 glyoxal (CHOCHO) in collisions with D2, N2, CO and C2H4 using crossed molecular beams. A laser is used to pump glyoxal seeded in He to its S1 zero point level with zero angular momentum about its top axis (K' = 0). The inelastic s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Parmenter CS,Clegg SM,Krajnovich DJ,Lu S

更新日期：1997-08-05 00:00:00

abstract：:Aminoacyl-tRNA synthetases are multidomain proteins responsible for the attachment of specific amino acids to their tRNA substrates. Prolyl-tRNA synthetases (ProRSs) are notable due to their particularly diverse architectures through evolution. For example, Saccharomyces cerevisiae ProRS possesses an N-terminal extens...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： SternJohn J,Hati S,Siliciano PG,Musier-Forsyth K

更新日期：2007-02-13 00:00:00

abstract：:We have studied the kinetics of vitellogenin mRNA accumulation in rooster liver after a primary injection of 17beta-estradiol. The levels of vitellogenin mRNA have been determined both by hybridization of total cellular RNA to vitellogenin cDNA and by translation of vitellogenin mRNA in a wheat germ cell-free system. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Burns AT,Deeley RG,Gordon JI,Udell DS,Mullinix KP,Goldberger RF

更新日期：1978-04-01 00:00:00

abstract：:Unit electrical activity was recorded from single neurons in the isolated lumbo-sacral spinal cord of 14- to 19-day chick embryos, in situ. Spinal cord transection was combined with transection of all lumbo-sacral dorsal roots. The spontaneous discharge of cells is confined, for the most part, to the lower two thirds ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sharma SC,Provine RR,Hamburger V,Sandel TT

更新日期：1970-05-01 00:00:00

abstract：:We have examined the affinity of two recently synthesized flavin analogs for the isoalloxazine binding site of riboflavin-binding protein (RBP). The results showed that pyrimidopteridines could bind to RBP (Kd 160-250 microM). This suggested that, at the FMN or FAD level, these analogs might also bind to other apoflav...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wessiak A,Schopfer LM,Yuan LC,Bruice TC,Massey V

更新日期：1984-07-01 00:00:00

abstract：:To process plant-based renewable biofuels, pretreatment of plant feedstock with ionic liquids has significant advantages over current methods for deconstruction of lignocellulosic feedstocks. However, ionic liquids are often toxic to the microorganisms used subsequently for biomass saccharification and fermentation. W...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Khudyakov JI,D'haeseleer P,Borglin SE,Deangelis KM,Woo H,Lindquist EA,Hazen TC,Simmons BA,Thelen MP

更新日期：2012-08-07 00:00:00

abstract：:A genetic analysis is necessary to gain a greater understanding of the complex developmental processes in mammals. Toward this end, an insertional transgenic mouse mutant has been isolated that results in abnormal germ-cell development. This recessive mutation manifests as infertility in both males and females and is ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pellas TC,Ramachandran B,Duncan M,Pan SS,Marone M,Chada K

更新日期：1991-10-01 00:00:00

abstract：:Remarkable progress has come from whole-brain models linking anatomy and function. Paradoxically, it is not clear how a neuronal dynamical system running in the fixed human anatomical connectome can give rise to the rich changes in the functional repertoire associated with human brain function, which is impossible to ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kringelbach ML,Cruzat J,Cabral J,Knudsen GM,Carhart-Harris R,Whybrow PC,Logothetis NK,Deco G

更新日期：2020-04-28 00:00:00

abstract：:Hepatocyte growth factor (HGF) is an activating ligand of the Met receptor tyrosine kinase, whose activity is essential for normal tissue development and organ regeneration but abnormal activation of Met has been implicated in growth, invasion, and metastasis of many types of solid tumors. HGF has two natural splice v...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tolbert WD,Daugherty-Holtrop J,Gherardi E,Vande Woude G,Xu HE

更新日期：2010-07-27 00:00:00

abstract：:The Escherichia coli recQ gene, a member of the RecF recombination gene family, was set in an overexpression plasmid, and its product was purified to near-homogeneity. The purified RecQ protein exhibited a DNA-dependent ATPase and a helicase activity. Without DNA, no ATPase activity was detected. The capacity as ATPas...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Umezu K,Nakayama K,Nakayama H

更新日期：1990-07-01 00:00:00

abstract：:Glioblastoma is the most common primary malignant brain tumor of adults and one of the most lethal of all cancers. Patients with this disease have a median survival of 15 months from the time of diagnosis despite surgery, radiation, and chemotherapy. New treatment approaches are needed. Recent works suggest that gliob...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Horvath S,Zhang B,Carlson M,Lu KV,Zhu S,Felciano RM,Laurance MF,Zhao W,Qi S,Chen Z,Lee Y,Scheck AC,Liau LM,Wu H,Geschwind DH,Febbo PG,Kornblum HI,Cloughesy TF,Nelson SF,Mischel PS

更新日期：2006-11-14 00:00:00

abstract：:Chloroplast DNA of the protozoan flagellate, Euglena gracilis, exists as circular molecules, 40 mum in contour length, as shown by electron microscopy and buoyant density analyses. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Manning JE,Wolstenholme DR,Ryan RS,Hunter JA,Richards OC

更新日期：1971-06-01 00:00:00

abstract：:The flavin cofactor in photoenzyme photolyase and photoreceptor cryptochrome may exist in an oxidized state and should be converted into reduced state(s) for biological functions. Such redox changes can be efficiently achieved by photoinduced electron transfer (ET) through a series of aromatic residues in the enzyme. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liu Z,Tan C,Guo X,Li J,Wang L,Sancar A,Zhong D

更新日期：2013-08-06 00:00:00

abstract：:It has long been recognized that the renal proximal tubular epithelium of the hamster is a bona fide estrogen target tissue. The effect of estrogens on the growth of proximal tubule cell explants and dissociated single cells derived from these explant outgrowths has been studied in culture. Renal tubular cells were gr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Oberley TD,Lauchner LJ,Pugh TD,Gonzalez A,Goldfarb S,Li SA,Li JJ

更新日期：1989-03-01 00:00:00

abstract：:Mycobacterium marinum, a natural pathogen of fish and frogs and an occasional pathogen of humans, is capable of inducing actin tail formation within the cytoplasm of macrophages, leading to actin-based motility and intercellular spread. Actin tail formation by M. marinum is markedly reduced in macrophages deficient in...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Stamm LM,Pak MA,Morisaki JH,Snapper SB,Rottner K,Lommel S,Brown EJ

更新日期：2005-10-11 00:00:00

abstract：:Mesenteric fat is known to undergo inflammatory changes after 2,4,6,-trinitrobenzensulphonic acid (TNBS)-induced colitis. Neurotensin (NT) and neurotensin receptor 1 (NTR1) have been shown to play a major role in the pathogenesis of intestinal inflammation. This led us to explore whether NT and NTR1 are expressed in t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Koon HW,Kim YS,Xu H,Kumar A,Zhao D,Karagiannides I,Dobner PR,Pothoulakis C

更新日期：2009-05-26 00:00:00

abstract：:The genes encoding the histone acetyl-transferases (HATs) CREB binding protein (CREBBP) and EP300 are recurrently mutated in the activated B cell-like and germinal center (GC) B cell-like subtypes of diffuse large B cell lymphoma (DLBCL). Here, we introduced a patient mutation into a human DLBCL cell line using CRISPR...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hashwah H,Schmid CA,Kasser S,Bertram K,Stelling A,Manz MG,Müller A

更新日期：2017-09-05 00:00:00

abstract：:A principal goal of cancer nanomedicine is to deliver therapeutics effectively to cancer cells within solid tumors. However, there are a series of biological barriers that impede nanomedicine from reaching target cells. Here, we report a stimuli-responsive clustered nanoparticle to systematically overcome these multip...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li HJ,Du JZ,Du XJ,Xu CF,Sun CY,Wang HX,Cao ZT,Yang XZ,Zhu YH,Nie S,Wang J

更新日期：2016-04-12 00:00:00

abstract：:Metalloproteases (MPs) are a large and diverse class of enzymes implicated in numerous physiological and pathological processes, including tissue remodeling, peptide hormone processing, and cancer. MPs are tightly regulated by multiple posttranslational mechanisms in vivo, hindering their functional analysis by conven...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Saghatelian A,Jessani N,Joseph A,Humphrey M,Cravatt BF

更新日期：2004-07-06 00:00:00

abstract：:The molecular weight of the major glycoprotein from the human erythrocyte membrane is 29,000, of which 55% is carbohydrate and 45% is protein. The binding of sodium dodecyl sulfate to this glycoprotein is anomalous when compared to water soluble proteins and leads to migration rates in sodium dodecyl sulfate-polyacryl...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Grefrath SP,Reynolds JA

更新日期：1974-10-01 00:00:00

abstract：:The nit-2 major nitrogen regulatory gene of Neurospora crassa turns on the expression of various unlinked structural genes that specify nitrogen-catabolic enzymes under nitrogen-limitation conditions. The nit-2 gene encodes a protein of 1036 amino acid residues with a single zinc finger and a downstream basic region t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fu YH,Marzluf GA

更新日期：1990-07-01 00:00:00

abstract：:Development of spatial patterns in multicellular organisms depends on gradients in the concentration of signaling molecules that control gene expression. In the Drosophila embryo, Bicoid (Bcd) morphogen controls cell fate along 70% of the anteroposterior axis but is translated from mRNA localized at the anterior pole....

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gregor T,Bialek W,de Ruyter van Steveninck RR,Tank DW,Wieschaus EF

更新日期：2005-12-20 00:00:00

abstract：:Chronic inflammation is a major risk factor for colorectal cancer. The p38/MAPKAP Kinase 2 (MK2) kinase axis controls the synthesis of proinflammatory cytokines that mediate both chronic inflammation and tumor progression. Blockade of this pathway has been previously reported to suppress inflammation and to prevent co...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Suarez-Lopez L,Sriram G,Kong YW,Morandell S,Merrick KA,Hernandez Y,Haigis KM,Yaffe MB

更新日期：2018-05-01 00:00:00

abstract：:We show that an electric field can drive single-stranded RNA and DNA molecules through a 2.6-nm diameter ion channel in a lipid bilayer membrane. Because the channel diameter can accommodate only a single strand of RNA or DNA, each polymer traverses the membrane as an extended chain that partially blocks the channel. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kasianowicz JJ,Brandin E,Branton D,Deamer DW

更新日期：1996-11-26 00:00:00

abstract：:Methods for the construction of ordered nanoscale arrays have been implicated in fields ranging from separation technologies to microelectronics. Yet, despite the plethora of nanoscale structures assembled in nature that use a templating strategy, chemists have been unable to replicate this success. A technology is re...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Willis B,Eubanks LM,Wood MR,Janda KD,Dickerson TJ,Lerner RA

更新日期：2008-02-05 00:00:00

abstract：:Insig-1 and -2 are closely related proteins of the endoplasmic reticulum (ER) that block proteolytic activation of sterol regulatory element-binding proteins (SREBPs), transcription factors that activate the synthesis of cholesterol and fatty acids in liver and other organs. When cellular cholesterol levels are high, ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yabe D,Komuro R,Liang G,Goldstein JL,Brown MS

更新日期：2003-03-18 00:00:00

abstract：:The reported isolation of nanobacteria from human kidney stones raises the intriguing possibility that these microorganisms are etiological agents of pathological extraskeletal calcification [Kajander, E. O. & Ciftçioglu, N. (1998) Proc. Natl. Acad. Sci. USA 95, 8274-8279]. Nanobacteria were previously isolated from F...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cisar JO,Xu DQ,Thompson J,Swaim W,Hu L,Kopecko DJ

更新日期：2000-10-10 00:00:00

abstract：:We have cloned and determined the entire nucleotide sequence of cDNAs corresponding to the putative alpha subunits of the human and rat mast cell high-affinity IgE receptors. Both human and rat cDNAs encode an NH2-terminal signal peptide, two immunoglobulin-like extracellular domains (encoded by discrete exons), a hyd...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shimizu A,Tepler I,Benfey PN,Berenstein EH,Siraganian RP,Leder P

更新日期：1988-03-01 00:00:00