Human and rat mast cell high-affinity immunoglobulin E receptors: characterization of putative alpha-chain gene products.

abstract：:The catalytic power of enzymes containing coenzyme B12 has been, in some respects, the "last bastion" for the strain hypothesis. Our previous study of this system established by a careful sampling that the major part of the catalytic effect is due to the electrostatic interaction between the ribose of the ado group an...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schopf P,Mills MJ,Warshel A

更新日期：2015-04-07 00:00:00

abstract：:Aspartate transcarbamoylase (EC 2.1.3.2) from Escherichia coli contains six zinc ions per molecule. Renaturation studies of this allosteric enzyme and its isolated subunits show that the metal binding site is in the regulatory polypeptide chain. Ultraviolet difference spectra of the cadmium and zinc derivatives have b...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rosenbusch JP,Weber K

更新日期：1971-05-01 00:00:00

abstract：:We have established a large panel of T-cell clones (TCCs) specific for Dermatophagoides pteronyssinus and Lolium perenne group I grass pollen allergens (total, 61) and for tetanus toxoid and protein purified derivative bacterial antigens (total, 38) from the peripheral blood of two atopic individuals and then analyzed...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Parronchi P,Macchia D,Piccinni MP,Biswas P,Simonelli C,Maggi E,Ricci M,Ansari AA,Romagnani S

更新日期：1991-05-15 00:00:00

abstract：:We used gene knockout mice to explore the role of Angiopoietin-like-4 (Angptl4) in lipid metabolism as well as to generate anti-Angptl4 mAbs with pharmacological activity. Angptl4 -/- mice had lower triglyceride (TG) levels resulting both from increased very low-density lipoprotein (VLDL) clearance and decreased VLDL ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Desai U,Lee EC,Chung K,Gao C,Gay J,Key B,Hansen G,Machajewski D,Platt KA,Sands AT,Schneider M,Van Sligtenhorst I,Suwanichkul A,Vogel P,Wilganowski N,Wingert J,Zambrowicz BP,Landes G,Powell DR

更新日期：2007-07-10 00:00:00

abstract：:Complex phenotypes can be modeled as networks of component traits connected by genetic, developmental, or functional interactions. Aposematism, which has evolved multiple times in poison frogs (Dendrobatidae), links a warning signal to a chemical defense against predators. Other traits are involved in this complex phe...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Santos JC,Cannatella DC

更新日期：2011-04-12 00:00:00

abstract：:The archaeological record shows that typically human cultural traits emerged at different times, in different parts of the world, and among different hominin taxa. This pattern suggests that their emergence is the outcome of complex and nonlinear evolutionary trajectories, influenced by environmental, demographic, and...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： d'Errico F,Banks WE,Warren DL,Sgubin G,van Niekerk K,Henshilwood C,Daniau AL,Sánchez Goñi MF

更新日期：2017-07-25 00:00:00

abstract：:Systemic amyloid A (AA) amyloidosis is a serious complication of chronic inflammation. Serum AA protein (SAA), an acute phase plasma protein, is deposited extracellularly as insoluble amyloid fibrils that damage tissue structure and function. Clinical AA amyloidosis is typically preceded by many years of active inflam...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Simons JP,Al-Shawi R,Ellmerich S,Speck I,Aslam S,Hutchinson WL,Mangione PP,Disterer P,Gilbertson JA,Hunt T,Millar DJ,Minogue S,Bodin K,Pepys MB,Hawkins PN

更新日期：2013-10-01 00:00:00

abstract：:Recent advances in understanding the role of neurotrophins on activity-dependent plasticity have provided insight into how behavior can affect specific aspects of neuronal biology. We present evidence that voluntary exercise can prime adult dorsal root ganglion neurons for increased axonal regeneration through a neuro...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Molteni R,Zheng JQ,Ying Z,Gómez-Pinilla F,Twiss JL

更新日期：2004-06-01 00:00:00

abstract：:Noniridescent coloration by the spongy keratin in parrot feather barbs has fascinated scientists. Nonetheless, its ultimate origin remains as yet unanswered, and a quantitative structural and optical description is still lacking. Here we report on structural and optical characterizations and numerical simulations of t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yin H,Dong B,Liu X,Zhan T,Shi L,Zi J,Yablonovitch E

更新日期：2012-07-03 00:00:00

abstract：:Chlorophyll d-producing cyanobacteria are a recently described group of phototrophic bacteria that is a major focus of photosynthesis research, previously known only from marine environments in symbiosis with eukaryotes. We have discovered a free-living member of this group from a eutrophic hypersaline lake. Phylogene...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Miller SR,Augustine S,Olson TL,Blankenship RE,Selker J,Wood AM

更新日期：2005-01-18 00:00:00

abstract：:Progressive myoclonus epilepsy of Univerricht-Lundborg type is a clinically defined entity among the progressive myoclonus epilepsies. It is an autosomal recessive disorder. The underlying biochemical defect is unknown. We used linkage analysis to localize the gene in 12 families with the aid of polymorphic DNA marker...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lehesjoki AE,Koskiniemi M,Sistonen P,Miao J,Hästbacka J,Norio R,de la Chapelle A

更新日期：1991-05-01 00:00:00

abstract：:Arguably the most foundational principle in perception research is that our experience of the world goes beyond the retinal image; we perceive the distal environment itself, not the proximal stimulation it causes. Shape may be the paradigm case of such "unconscious inference": When a coin is rotated in depth, we infer...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Morales J,Bax A,Firestone C

更新日期：2020-06-30 00:00:00

abstract：:For brain functions such as working memory and motor planning, neuronal circuits are able to sustain persistent activity after transient inputs. Theoretical studies have suggested that persistent activity can exist in recurrently connected networks as active reverberation. However, the actual cellular processes underl...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lau PM,Bi GQ

更新日期：2005-07-19 00:00:00

abstract：:We discuss the generic time behavior of reaction-diffusion processes capable of modeling various types of biological transport processes, such as ligand migration in proteins and gating fluctuations in ion channel proteins. The main observable in these two cases, the fraction of unbound ligands and the probability of ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nadler W,Stein DL

更新日期：1991-08-01 00:00:00

abstract：:The unfolded protein response (UPR) is an evolutionarily conserved mechanism by which all eukaryotic cells adapt to the accumulation of unfolded proteins in the endoplasmic reticulum (ER). Inositol-requiring kinase 1 (IRE1) and PKR-related ER kinase (PERK) are two type I transmembrane ER-localized protein kinase recep...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhou J,Liu CY,Back SH,Clark RL,Peisach D,Xu Z,Kaufman RJ

更新日期：2006-09-26 00:00:00

abstract：:We previously reported that short-term immobilization stress of rats causes increased colonic mucin release, goblet cell depletion, prostaglandin E2 secretion, and colonic mast cell activation, as well as increased colonic motility. The purpose of this study was to investigate whether neurotensin (NT), a peptide expre...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Castagliuolo I,Leeman SE,Bartolak-Suki E,Nikulasson S,Qiu B,Carraway RE,Pothoulakis C

更新日期：1996-10-29 00:00:00

abstract：:Twice each year, millions of night-migratory songbirds migrate thousands of kilometers. To find their way, they must process and integrate spatiotemporal information from a variety of cues including the Earth's magnetic field and the night-time starry sky. By using sensory-driven gene expression, we discovered that ni...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mouritsen H,Feenders G,Liedvogel M,Wada K,Jarvis ED

更新日期：2005-06-07 00:00:00

abstract：:Real-world studies show that the facial expressions produced during pain and orgasm-two different and intense affective experiences-are virtually indistinguishable. However, this finding is counterintuitive, because facial expressions are widely considered to be a powerful tool for social interaction. Consequently, de...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chen C,Crivelli C,Garrod OGB,Schyns PG,Fernández-Dols JM,Jack RE

更新日期：2018-10-23 00:00:00

abstract：:Cryopreservation is widely used to maintain backups of cells as it enables the semipermanent storage of cells. During the freezing process, ice crystals that are generated inside and outside the cells can lethally damage the cells. All conventional cryopreservation methods use at least one cryoprotective agent (CPA) t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Akiyama Y,Shinose M,Watanabe H,Yamada S,Kanda Y

更新日期：2019-04-16 00:00:00

abstract：:Reverse transcriptase (RNA-directed DNA polymerase, EC 2.7.7.49) of human immunodeficiency virus type 1 has been examined with respect to the steady-state kinetics of polymerization of dNTPs into product DNA. With dNTPs as variable substrate, the kinetics of polymerization deviated from standard Michaelis-Menten kinet...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： West AB,Roberts TM,Kolodner RD

更新日期：1992-10-15 00:00:00

abstract：:Specific low-affinity receptors for leukemia inhibitory factor (LIF), oncostatin M (OSM; gp130), and ciliary neurotrophic factor (CNTF; receptor alpha, CNTFR alpha) may be utilized in various combinations to generate high-affinity binding sites and signal transduction. We have tested the ability of combinations of the...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gearing DP,Ziegler SF,Comeau MR,Friend D,Thoma B,Cosman D,Park L,Mosley B

更新日期：1994-02-01 00:00:00

abstract：:Genes encoding thymidylate synthetase from Bacillus subtilis bacteriophages were cloned in Escherichia coli. Chimeric plasmids pCD1 and pCD3 were constructed from site-specific endonuclease digests of bacteriophage phi3T DNA cloned in pMB9 in E. coli. Similar cloning techniques with bacteriophage beta22 DNA yielded ch...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Duncan CH,Wilson GA,Young FE

更新日期：1978-08-01 00:00:00

abstract：:The lactate racemase enzyme (LarA) of Lactobacillus plantarum harbors a (SCS)Ni(II) pincer complex derived from nicotinic acid. Synthesis of the enzyme-bound cofactor requires LarB, LarC, and LarE, which are widely distributed in microorganisms. The functions of the accessory proteins are unknown, but the LarB C termi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Desguin B,Soumillion P,Hols P,Hausinger RP

更新日期：2016-05-17 00:00:00

abstract：:Activation-induced cytidine deaminase (AID) is essential to class-switch recombination (CSR) and somatic hypermutation (SHM) in both V region SHM and S region SHM (s-SHM). Uracil DNA glycosylase (UNG), a member of the base excision repair (BER) complex, is required for CSR. Strikingly, however, UNG deficiency causes a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yousif AS,Stanlie A,Mondal S,Honjo T,Begum NA

更新日期：2014-03-18 00:00:00

abstract：:The late Pleistocene witnessed the extinction of 35 genera of North American mammals. The last appearance dates of 16 of these genera securely fall between 12,000 and 10,000 radiocarbon years ago (approximately 13,800-11,400 calendar years B.P.), although whether the absence of fossil occurrences for the remaining 19 ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Faith JT,Surovell TA

更新日期：2009-12-08 00:00:00

abstract：:In flowering plants, the asymmetrical division of the zygote is the first hallmark of apical-basal polarity of the embryo and is controlled by a MAP kinase pathway that includes the MAPKKK YODA (YDA). In Arabidopsis, YDA is activated by the membrane-associated pseudokinase SHORT SUSPENSOR (SSP) through an unusual pare...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Neu A,Eilbert E,Asseck LY,Slane D,Henschen A,Wang K,Bürgel P,Hildebrandt M,Musielak TJ,Kolb M,Lukowitz W,Grefen C,Bayer M

更新日期：2019-03-19 00:00:00

abstract：:Glutamic acid decarboxylase (GAD) 65 is one of the major pancreatic antigens targeted by self-reactive T cells in type I diabetes mellitus. T cells specific for GAD65 are among the first to enter inflamed islets and may be important for the initiation of autoimmune diabetes. However, we previously reported that nonobe...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kim SK,Tarbell KV,Sanna M,Vadeboncoeur M,Warganich T,Lee M,Davis M,McDevitt HO

更新日期：2004-09-28 00:00:00

abstract：:Linear hierarchies, the classical pecking-order structures, are formed readily in both nature and the laboratory in a great range of species including humans. However, the probability of getting linear structures by chance alone is quite low. In this paper we investigate the two hypotheses that are proposed most often...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chase ID,Tovey C,Spangler-Martin D,Manfredonia M

更新日期：2002-04-16 00:00:00

abstract：:Cancers frequently arise as a result of an acquired genomic instability and the subsequent clonal evolution of neoplastic cells with variable patterns of genetic aberrations. Thus, the presence and behaviors of distinct clonal populations in each patient's tumor may underlie multiple clinical phenotypes in cancers. We...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ruiz C,Lenkiewicz E,Evers L,Holley T,Robeson A,Kiefer J,Demeure MJ,Hollingsworth MA,Shen M,Prunkard D,Rabinovitch PS,Zellweger T,Mousses S,Trent JM,Carpten JD,Bubendorf L,Von Hoff D,Barrett MT

更新日期：2011-07-19 00:00:00

abstract：:Although common in birds, social monogamy, or pair-living, is rare among mammals because internal gestation and lactation in mammals makes it advantageous for males to seek additional mating opportunities. A number of hypotheses have been proposed to explain the evolution of social monogamy among mammals: as a male ma...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Opie C,Atkinson QD,Dunbar RI,Shultz S

更新日期：2013-08-13 00:00:00