Abstract:
:Expression of T1ST2, the IL-33R, by Th2 cells requires GATA3. Resting Th2 cells express little GATA3, which is increased by IL-33 and a STAT5 activator, in turn increasing T1ST2 from its low-level expression on resting Th2 cells. Th2 cells that have upregulated T1ST2 produce IL-13, but not IL-4, in response to IL-33 plus a STAT5 activator in an antigen-independent, NF-kappaB-dependent, cyclosporin A (CsA)-resistant manner. Similarly, Th17 cells produce IL-17A in response to IL-1beta and a STAT3 activator and Th1 cells produce IFNgamma in response to IL-18 and a STAT4 inducer. Thus, each effector Th cell produces cytokines without antigenic stimulation in response to an IL-1 family member and a specific STAT activator, implying an innate mechanism through which memory CD4 T cells are recruited by an induced cytokine environment.
journal_name
Proc Natl Acad Sci U S Aauthors
Guo L,Wei G,Zhu J,Liao W,Leonard WJ,Zhao K,Paul Wdoi
10.1073/pnas.0906988106subject
Has Abstractpub_date
2009-08-11 00:00:00pages
13463-8issue
32eissn
0027-8424issn
1091-6490pii
0906988106journal_volume
106pub_type
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