Autosomal dominant aniridia: probable linkage to acid phosphatase-1 locus on chromosome 2.

abstract：:Incubation of O6-[3H]ethylguanine-containing DNA with a rat liver chromatin fraction resulted in a decrease in the O6-ethylguanine content of the DNA. Analysis of the products of this reaction showed that the ethyl group had been transferred from the O6-ethylguanine to a protein acceptor. When the incubation mixture w...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mehta JR,Ludlum DB,Renard A,Verly WG

更新日期：1981-11-01 00:00:00

abstract：:Effects of the anti-T-cell monoclonal antibodies OKT3, OKT5, and OKT8 on T-cell surface properties and cell functions were evaluated. Incubation of mononuclear cells isolated from peripheral blood for 48 hr with each monoclonal antibody in the absence of complement resulted in modulation of their respective surface an...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Antel J,Oger JJ,Jackevicius S,Kuo HH,Arnason BG

更新日期：1982-05-01 00:00:00

abstract：:The incidence of pediatric adrenal cortical carcinoma (ACC) in southern Brazil is 10-15 times higher than that of pediatric ACC worldwide. Because childhood ACC is associated with Li-Fraumeni syndrome, we examined the cancer history and p53 status of 36 Brazilian patients and their families. Remarkably, 35 of 36 patie...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ribeiro RC,Sandrini F,Figueiredo B,Zambetti GP,Michalkiewicz E,Lafferty AR,DeLacerda L,Rabin M,Cadwell C,Sampaio G,Cat I,Stratakis CA,Sandrini R

更新日期：2001-07-31 00:00:00

abstract：:Although major research efforts have focused on how specific components of foodstuffs affect health, relatively little is known about a more fundamental aspect of diet, the frequency and circadian timing of meals, and potential benefits of intermittent periods with no or very low energy intakes. The most common eating...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mattson MP,Allison DB,Fontana L,Harvie M,Longo VD,Malaisse WJ,Mosley M,Notterpek L,Ravussin E,Scheer FA,Seyfried TN,Varady KA,Panda S

更新日期：2014-11-25 00:00:00

abstract：:Spontaneous liposome formation is predicted in binary mixtures of fluid phase phospholipids and poly(n)ethylene oxide (PEO)-bearing lipids by using single chain mean field theory. The range of stability of the spontaneous liposomes is determined as a function of percentage of PEO-conjugated lipids and polymer molecula...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Szleifer I,Gerasimov OV,Thompson DH

更新日期：1998-02-03 00:00:00

abstract：:The abelian sandpile is a cellular automaton which serves as the archetypical model to study self-organized criticality, a phenomenon occurring in various biological, physical, and social processes. Its recurrent configurations form an abelian group, whose identity is a fractal composed of self-similar patches. Here, ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lang M,Shkolnikov M

更新日期：2019-02-19 00:00:00

abstract：:Sympatric speciation (SS), i.e., speciation within a freely breeding population or in contiguous populations, was first proposed by Darwin [Darwin C (1859) On the Origins of Species by Means of Natural Selection] and is still controversial despite theoretical support [Gavrilets S (2004) Fitness Landscapes and the Orig...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li K,Hong W,Jiao H,Wang GD,Rodriguez KA,Buffenstein R,Zhao Y,Nevo E,Zhao H

更新日期：2015-09-22 00:00:00

abstract：:The enzymic activity of crystalline mitochondrial aspartate aminotransferase (L-aspartate:2-oxoglutarate aminotransferase, EC 2.6.1.1) was determined in suspensions of noncrosslinked microcrystals in 30% (wt/vol) polyethylene glycol. The crystals (average dimensions, 22 x 5 x 0.8 micron) were small enough to preclude ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kirsten H,Gehring H,Christen P

更新日期：1983-04-01 00:00:00

abstract：:The RNA world hypothesis presumes that RNA will be competent for varied essential cellular functions. One such indispensable cell function is regulation of membrane permeability. Though this was not a known RNA activity, selection-amplification yielded RNAs that bound phosphatidylcholine:cholesterol liposomes. At leas...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Khvorova A,Kwak YG,Tamkun M,Majerfeld I,Yarus M

更新日期：1999-09-14 00:00:00

abstract：:Glutaredoxins (Grxs) have been identified across taxa as important mediators in various physiological functions. A chloroplastic monothiol glutaredoxin, AtGRXS16 from Arabidopsis thaliana, comprises two distinct functional domains, an N-terminal domain (NTD) with GlyIleTyr-TyrIleGly (GIY-YIG) endonuclease motif and a ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liu X,Liu S,Feng Y,Liu JZ,Chen Y,Pham K,Deng H,Hirschi KD,Wang X,Cheng N

更新日期：2013-06-04 00:00:00

abstract：:A stable free-radical polymeric derivative of prostaglandin B1 (PGBx) has been synthesized that exhibits regenerative effects on oxidative phosphorylation in aged mitochondria. The molecular weights of the most active preparations fall between 2000 and 2600. PGBx is characterized by a single-line electron spin resonan...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Polis BD,Polis E,Kwong S

更新日期：1979-04-01 00:00:00

abstract：:The role of intraspecific and interspecific interactions in structuring biotic communities at fine spatial scales is well documented, but the signature of species interactions at coarser spatial scales is unclear. We present evidence that species interactions may be a significant factor in mediating the regional assem...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gotelli NJ,Graves GR,Rahbek C

更新日期：2010-03-16 00:00:00

abstract：:The Cu,Zn superoxide dismutase (SOD) was examined earlier and found to behave in a very unclock-like manner despite (accepted point mutation, or PAM) corrections for multiple replacements per site. Depending upon the time span involved, rates could differ 5-fold. We have sought to determine whether the data might be c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fitch WM,Ayala FJ

更新日期：1994-07-19 00:00:00

abstract：:Neural circuits are generated by precisely ordered synaptic connections among neurons, and this process is thought to rely on the ability of neurons to recognize specific partners. However, it is also known that neurons promiscuously form synapses with nonspecific partners, in particular when cultured in vitro, causin...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ito S,Takeichi M

更新日期：2009-08-04 00:00:00

abstract：:Rhesus monkeys were immunized by multiple inoculations with purified, disrupted, noninfectious simian immunodeficiency virus (SIV) in adjuvant. Immunized monkeys developed anti-SIV antibodies detectable by whole-virus ELISA and by immunoblot reactivity; these antibodies had weak neutralizing activity. One week after t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Desrosiers RC,Wyand MS,Kodama T,Ringler DJ,Arthur LO,Sehgal PK,Letvin NL,King NW,Daniel MD

更新日期：1989-08-01 00:00:00

abstract：:Explosions account for 79% of combat-related injuries, leading to multiorgan hemorrhage and uncontrolled bleeding. Uncontrolled bleeding is the leading cause of death in battlefield traumas as well as in civilian life. We need to stop the bleeding quickly to save lives, but, shockingly, there are no treatments to stop...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lashof-Sullivan MM,Shoffstall E,Atkins KT,Keane N,Bir C,VandeVord P,Lavik EB

更新日期：2014-07-15 00:00:00

abstract：:MinD is a widely conserved ATPase that has been demonstrated to play a pivotal role in selection of the division site in eubacteria and chloroplasts. It is a member of the large ParA superfamily of ATPases that are characterized by a deviant Walker-type ATP-binding motif. MinD localizes to the cytoplasmic face of the ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Szeto TH,Rowland SL,Rothfield LI,King GF

更新日期：2002-11-26 00:00:00

abstract：:Cellular DNA and RNA were simultaneously quantitated in individual cells of cycling and quiescent populations by flow cytometry. Based on differences in RNA content, two distinct subcompartments, G1A and G1B, were recognized in the G1 phase of exponentially growing cells. After mitosis, cells reside in the low-RNA, G1...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Darzynkiewicz Z,Sharpless T,Staiano-Coico L,Melamed MR

更新日期：1980-11-01 00:00:00

abstract：:In North America there are two generally recognized pathotypes (pathotypes 1 and 2) of the fungus Entomophaga grylli which show host-preferential infection of grasshopper subfamilies. Pathotype 3, discovered in Australia, has a broader grasshopper host range and was considered to be a good biocontrol agent. Between 19...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bidochka MJ,Walsh SR,Ramos ME,St Leger RJ,Silver JC,Roberts DW

更新日期：1996-01-23 00:00:00

abstract：:Apolipoprotein E (apoE) secreted by macrophages in the artery wall exerts an important protective effect against the development of atherosclerosis, presumably through its ability to promote lipid efflux. Previous studies have shown that increases in cellular free cholesterol levels stimulate apoE transcription in mac...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Laffitte BA,Repa JJ,Joseph SB,Wilpitz DC,Kast HR,Mangelsdorf DJ,Tontonoz P

更新日期：2001-01-16 00:00:00

abstract：:Extensive studies have detailed the molecular regulation of individual components of the hemostatic system, including platelets, coagulation factors, and regulatory proteins. Questions remain, however, about how these elements are integrated at the systems level within a rapidly changing physical environment. To answe...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tomaiuolo M,Matzko CN,Poventud-Fuentes I,Weisel JW,Brass LF,Stalker TJ

更新日期：2019-02-05 00:00:00

abstract：:The Xlim-1 gene is activated in the late blastula stage of Xenopus embryogenesis in the mesoderm, and its RNA product becomes concentrated in the Spemann organizer at early gastrula stage. A major regulator of early expression of Xlim-1 is activin or an activin-like signal. We report experiments aiming to identify the...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rebbert ML,Dawid IB

更新日期：1997-09-02 00:00:00

abstract：:Groundwater arsenic (As) is elevated in the shallow Holocene aquifers of Bangladesh. In the dry season, the shallow groundwater discharges to major rivers. This process may influence the chemistry of the river and the hyporheic zone sediment. To assess the fate of As during discharge, surface (0-5 cm) and subsurface (...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Datta S,Mailloux B,Jung HB,Hoque MA,Stute M,Ahmed KM,Zheng Y

更新日期：2009-10-06 00:00:00

abstract：:Within the scientific community, much attention has focused on improving communications between scientists, policy makers, and the public. To date, efforts have centered on improving the content, accessibility, and delivery of scientific communications. Here we argue that in the current political and media environment...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Iyengar S,Massey DS

更新日期：2019-04-16 00:00:00

abstract：:Lakes are considered the second largest natural source of atmospheric methane (CH4). However, current estimates are still uncertain and do not account for diel variability of CH4 emissions. In this study, we performed high-resolution measurements of CH4 flux from several lakes, using an automated and sensor-based flux...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sieczko AK,Duc NT,Schenk J,Pajala G,Rudberg D,Sawakuchi HO,Bastviken D

更新日期：2020-09-01 00:00:00

abstract：:Climate change affects organisms worldwide with profound ecological and evolutionary consequences, often increasing population extinction risk. Climatic factors can increase the strength, variability, or direction of natural selection on phenotypic traits, potentially driving adaptive evolution. Phenotypic plasticity ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Svensson EI,Gomez-Llano M,Waller JT

更新日期：2020-11-24 00:00:00

abstract：:To identify proteins that regulate the transcriptional activity of c-Jun, we have used the yeast two-hybrid screen to detect mammalian polypeptides that might interact functionally with the N-terminal segment of c-Jun, a known regulatory region. Among the proteins identified is a short form of Stat3 (designated Stat3 ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schaefer TS,Sanders LK,Nathans D

更新日期：1995-09-26 00:00:00

abstract：:In 1950, G. Ledyard Stebbins devoted two chapters of his book Variation and Evolution in Plants (Columbia Univ. Press, New York) to polyploidy, one on occurrence and nature and one on distribution and significance. Fifty years later, many of the questions Stebbins posed have not been answered, and many new questions h...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Soltis PS,Soltis DE

更新日期：2000-06-20 00:00:00

abstract：:The bifunctional Neurospora crassa mitochondrial tyrosyl-tRNA synthetase (CYT-18 protein) both aminoacylates mitochondrial tRNA(Tyr) and acts as a structure-stabilizing splicing cofactor for group I introns. Previous studies showed that CYT-18 has distinct tRNA(Tyr) and group I intron-binding sites, with the latter fo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Paukstelis PJ,Lambowitz AM

更新日期：2008-04-22 00:00:00

abstract：:Mitochondria are dynamic organelles that play a key role in energy conversion. Optimal mitochondrial function is ensured by a quality-control system tightly coupled to fusion and fission. In this connection, mitofusin 2 (Mfn2) participates in mitochondrial fusion and undergoes repression in muscle from obese or type 2...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sebastián D,Hernández-Alvarez MI,Segalés J,Sorianello E,Muñoz JP,Sala D,Waget A,Liesa M,Paz JC,Gopalacharyulu P,Orešič M,Pich S,Burcelin R,Palacín M,Zorzano A

更新日期：2012-04-03 00:00:00