Antibodies and IL-3 support helminth-induced basophil expansion.

abstract：:With the increased popularity of zebrafish (Danio rerio) for mutagenesis studies, efficient methods for manipulation of its genome are needed. One approach is the use of a transposable element as a vector for gene transfer in this species. We report here the transformation of zebrafish and germ-line transmission of th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fadool JM,Hartl DL,Dowling JE

更新日期：1998-04-28 00:00:00

abstract：:Because of the rise in atmospheric oxygen 2.3 billion years ago (Gya) and the subsequent changes in oceanic redox state over the last 2.3-1 Gya, trace metal bioavailability in marine environments has changed dramatically. Although theorized to have influenced the biological usage of metals leaving discernable genomic ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dupont CL,Yang S,Palenik B,Bourne PE

更新日期：2006-11-21 00:00:00

abstract：:Cell cycle progression is tightly regulated by cyclin-dependent kinases (CDKs). The ankyrin-repeat protein p19INK4d functions as a key regulator of G1/S transition; however, its molecular mode of action is unknown. Here, we combine cell and structural biology methods to unravel the mechanism by which p19INK4d controls...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kumar A,Gopalswamy M,Wolf A,Brockwell DJ,Hatzfeld M,Balbach J

更新日期：2018-03-27 00:00:00

abstract：:We have cloned and characterized cDNAs coding for a receptor-class phosphotyrosine phosphatase gene from Drosophila melanogaster. The gene maps to the polytene chromosome bands 99A7-8. The cDNA clones code for a polypeptide of 1301 amino acids with a predicted molecular mass of 145 kDa. The extracellular domain includ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hariharan IK,Chuang PT,Rubin GM

更新日期：1991-12-15 00:00:00

abstract：:With continued debate over the functional significance of adult neurogenesis, identifying an in vivo correlate of neurogenesis has become an important goal. Here we rely on the coupling between neurogenesis and angiogenesis and test whether MRI measurements of cerebral blood volume (CBV) provide an imaging correlate o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pereira AC,Huddleston DE,Brickman AM,Sosunov AA,Hen R,McKhann GM,Sloan R,Gage FH,Brown TR,Small SA

更新日期：2007-03-27 00:00:00

abstract：:In Epstein-Barr virus (EBV)-positive Burkitt lymphoma (BL) the role of EBV in the translocation and deregulation of the MYC oncogene remains unknown. By utilizing an EBV-negative BL (BJAB) and several EBV-positive sublines derived from it by in vitro infection, it was possible to show that the presence of the virus wa...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lacy J,Summers WP,Watson M,Glazer PM,Summers WC

更新日期：1987-08-01 00:00:00

abstract：:Left-right (LR) asymmetry (handedness, chirality) is a well-conserved biological property of critical importance to normal development. Changes in orientation of the LR axis due to genetic or environmental factors can lead to malformations and disease. While the LR asymmetry of organs and whole organisms has been exte...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wan LQ,Ronaldson K,Park M,Taylor G,Zhang Y,Gimble JM,Vunjak-Novakovic G

更新日期：2011-07-26 00:00:00

abstract：:Salt and water secretion from intestinal epithelia requires enhancement of anion permeability across the apical membrane of Cl- secreting cells lining the crypt, the secretory gland of the intestine. Paneth cells located at the base of the small intestinal crypt release enteric defensins (cryptdins) apically into the ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lencer WI,Cheung G,Strohmeier GR,Currie MG,Ouellette AJ,Selsted ME,Madara JL

更新日期：1997-08-05 00:00:00

abstract：:Ischemia and reperfusion both contribute to tissue damage after myocardial infarction. Although many drugs have been shown to reduce infarct size when administered before ischemia, few have been shown to be effective when administered at reperfusion. Moreover, although it is generally accepted that a burst of reactive...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Granville DJ,Tashakkor B,Takeuchi C,Gustafsson AB,Huang C,Sayen MR,Wentworth P Jr,Yeager M,Gottlieb RA

更新日期：2004-02-03 00:00:00

abstract：:Human beings differ in their ability to master the sounds of their second language (L2). Phonetic training studies have proposed that differences in phonetic learning stem from differences in psychoacoustic abilities rather than speech-specific capabilities. We aimed at finding the origin of individual differences in ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Díaz B,Baus C,Escera C,Costa A,Sebastián-Gallés N

更新日期：2008-10-21 00:00:00

abstract：:Established T cell dysfunction is a barrier to antitumor responses, and checkpoint blockade presumably reverses this. Many patients fail to respond to treatment and/or develop autoimmune adverse events. The underlying reason for T cell responsiveness remains elusive. Here, we show that susceptibility to checkpoint blo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nelson CE,Mills LJ,McCurtain JL,Thompson EA,Seelig DM,Bhela S,Quarnstrom CF,Fife BT,Vezys V

更新日期：2019-02-12 00:00:00

abstract：:Progressive myoclonus epilepsy of Univerricht-Lundborg type is a clinically defined entity among the progressive myoclonus epilepsies. It is an autosomal recessive disorder. The underlying biochemical defect is unknown. We used linkage analysis to localize the gene in 12 families with the aid of polymorphic DNA marker...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lehesjoki AE,Koskiniemi M,Sistonen P,Miao J,Hästbacka J,Norio R,de la Chapelle A

更新日期：1991-05-01 00:00:00

abstract：:A photosensitizer conjugate, chlorin e6 (Ce6) covalently bound to 1-micron-diameter polystyrene microspheres, has been investigated in the photodynamic destruction of MGH-U1 human bladder carcinoma cells in vitro. The microspheres were taken up avidly by the carcinoma cells; confocal laser scanning fluorescence micros...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bachor R,Shea CR,Gillies R,Hasan T

更新日期：1991-02-15 00:00:00

abstract：:Macrophage responses to Francisella infection have been characterized previously by subdued proinflammatory responses; however, these studies have generally focused on macrophage cell lines or monocyte-derived macrophages. Therefore, we studied the ability of fresh human blood monocytes to engulf and respond to Franci...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gavrilin MA,Bouakl IJ,Knatz NL,Duncan MD,Hall MW,Gunn JS,Wewers MD

更新日期：2006-01-03 00:00:00

abstract：:Heparin is the most widely prescribed biopharmaceutical in production globally. Its potent anticoagulant activity and safety makes it the drug of choice for preventing deep vein thrombosis and pulmonary embolism. In 2008, adulterated material was introduced into the heparin supply chain, resulting in several hundred d...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Weiss RJ,Spahn PN,Toledo AG,Chiang AWT,Kellman BP,Li J,Benner C,Glass CK,Gordts PLSM,Lewis NE,Esko JD

更新日期：2020-04-28 00:00:00

abstract：:Sufficient conditions are found for a biinvariant operator on a compact Lie group to be bounded on L(p), 1 < p < infinity. The proof uses properties of g-functions on such a group, and an analog to the familiar relationship between differentiation and multiplication under the Fourier transform. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Weiss NJ

更新日期：1971-05-01 00:00:00

abstract：:The overall structure of the transition-state and intermediate ensembles observed experimentally for dihydrofolate reductase and interleukin-1beta can be obtained by using simplified models that have almost no energetic frustration. The predictive power of these models suggests that, even for these very large proteins...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Clementi C,Jennings PA,Onuchic JN

更新日期：2000-05-23 00:00:00

abstract：:There is now abundant evidence to substantiate an important role of hepatitis C virus (HCV) core protein in cellular gene expression as well as in the viral cycle. Thus the subcellular localization of this protein has important implications. However, several studies have shown controversial results: the HCV core has b...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Barba G,Harper F,Harada T,Kohara M,Goulinet S,Matsuura Y,Eder G,Schaff Z,Chapman MJ,Miyamura T,Bréchot C

更新日期：1997-02-18 00:00:00

abstract：:Incubation of rat calvaria for short times in the presence of a labeled amino acid revealed the existence of a collagen fraction (procollagen) that functions as a biosynthetic precursor of collagen. Procollagen contains an alpha1-like chain (pre-alpha1) that elutes earlier from CM-cellulose than does rat-bone alpha1 a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bellamy G,Bornstein P

更新日期：1971-06-01 00:00:00

abstract：:The common acute lymphoblastic leukemia antigen (CALLA) is a 749-amino acid type II integral membrane protein that has been identified recently as the neutral endopeptidase 24.11 [NEP (EC 3.4.24.11)]. Herein, we characterize the organization of the human CALLA/NEP gene and show that it spans more than 80 kilobases (kb...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： D'Adamio L,Shipp MA,Masteller EL,Reinherz EL

更新日期：1989-09-01 00:00:00

abstract：:Lipid droplets (LDs) are a conserved feature of most organisms. Vertebrate adipocytes have evolved to efficiently store and release lipids for the whole organism from a single droplet. Perilipin 1, the most abundant lipid-coat protein in adipocytes, plays a key role in regulating lipolysis. In other tissues such as li...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Patel S,Yang W,Kozusko K,Saudek V,Savage DB

更新日期：2014-06-24 00:00:00

abstract：:Exposure of Chinese hamster cells to reduced oxygen partial pressure results in a marked enhancement in the frequency of methotrexate resistance and dihydrofolate reductase gene amplification. The frequency of enhanced resistance is a function of the length of exposure to hypoxic conditions and the time after recovery...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rice GC,Hoy C,Schimke RT

更新日期：1986-08-01 00:00:00

abstract：:Given the widely noted increase in the warming effects of rising greenhouse gas concentrations, it has been unclear why global surface temperatures did not rise between 1998 and 2008. We find that this hiatus in warming coincides with a period of little increase in the sum of anthropogenic and natural forcings. Declin...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kaufmann RK,Kauppi H,Mann ML,Stock JH

更新日期：2011-07-19 00:00:00

abstract：:Cell adhesion molecules (CAMs) may act as regulators of morphogenesis by constraining cell motion, forming borders, and controlling intercellular communications that lead to embryonic induction. This postulated causal role of CAMs in inductive events was tested here in an in vitro system of feather induction. In the d...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gallin WJ,Chuong CM,Finkel LH,Edelman GM

更新日期：1986-11-01 00:00:00

abstract：:We reported in previous studies that prostaglandin E2 (PGE2) has central effects of augmenting wakefulness and suppressing slow-wave sleep (SWS) and paradoxical sleep (PS) in rats. In the present study, we tested the effect of AH 6809, an antagonist of PGE2 receptors, on sleep-wake activities. AH 6809 in saline was in...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Matsumura H,Honda K,Choi WS,Inoué S,Sakai T,Hayaishi O

更新日期：1989-07-01 00:00:00

abstract：:Chromatin becomes reorganized during mitosis each cell cycle. To identify genes potentially involved in these supramolecular events, we have used a colony-color assay to screen temperature-sensitive mutants of Saccharomyces cerevisiae. When a sequence that mediates attachment to the nuclear matrix in vitro was inserte...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fishel BR,Sperry AO,Garrard WT

更新日期：1993-06-15 00:00:00

abstract：:Biological organisms have evolved a wide range of immune mechanisms to defend themselves against pathogens. Beyond molecular details, these mechanisms differ in how protection is acquired, processed, and passed on to subsequent generations-differences that may be essential to long-term survival. Here, we introduce a m...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mayer A,Mora T,Rivoire O,Walczak AM

更新日期：2016-08-02 00:00:00

abstract：:The aldosterone-induced augmentation of Na+ transport in toad bladder was analyzed by comparing the hormonal actions on the transepithelial short-circuit current and on the amiloride-sensitive 22Na+ uptake in isolated membrane vesicles. Incubating bladders with 0.5 microM aldosterone for 3 hr evoked more than a 2-fold...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Asher C,Garty H

更新日期：1988-10-01 00:00:00

abstract：:The transmembrane precursor of tumor necrosis factor-alpha (TNF) exits the trans-Golgi network (TGN) in tubular carriers for subsequent trafficking and delivery to the cell surface; however, the molecular machinery responsible for Golgi export is unknown. We previously reported that members of the TGN golgin family ar...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lieu ZZ,Lock JG,Hammond LA,La Gruta NL,Stow JL,Gleeson PA

更新日期：2008-03-04 00:00:00

abstract：:Glioblastoma multiforme (GBM) is one of the most intractable of human cancers, principally because of the highly infiltrative nature of these neoplasms. Tracking and eradicating infiltrating GBM cells and tumor microsatellites is of utmost importance for the treatment of this devastating disease, yet effective strateg...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jiang X,Fitch S,Wang C,Wilson C,Li J,Grant GA,Yang F

更新日期：2016-11-29 00:00:00