An in vivo correlate of exercise-induced neurogenesis in the adult dentate gyrus.

abstract：:Bacterial capsules are surface layers made of long-chain polysaccharides. They are anchored to the outer membrane of many Gram-negative bacteria, including pathogens such as Escherichia coli, Neisseria meningitidis, Haemophilus influenzae, and Pasteurella multocida. Capsules protect pathogens from host defenses includ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Willis LM,Stupak J,Richards MR,Lowary TL,Li J,Whitfield C

更新日期：2013-05-07 00:00:00

abstract：:Amyloid beta (Aβ) is a major pathological marker in Alzheimer's disease (AD), which is principally regulated by the rate-limiting β-secretase (i.e., BACE1) cleavage of amyloid precursor protein (APP). However, how BACE1 activity is posttranslationally regulated remains incompletely understood. Here, we show that BACE1...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bao J,Qin M,Mahaman YAR,Zhang B,Huang F,Zeng K,Xia Y,Ke D,Wang Q,Liu R,Wang JZ,Ye K,Wang X

更新日期：2018-04-10 00:00:00

abstract：:Membrane-mediated particle interactions depend both on the properties of the particles themselves and the membrane environment in which they are suspended. Experiments have shown that chiral rod-like inclusions dissolved in a colloidal membrane of opposite handedness assemble into colloidal rafts, which are finite-siz...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Miller JM,Joshi C,Sharma P,Baskaran A,Baskaran A,Grason GM,Hagan MF,Dogic Z

更新日期：2019-08-06 00:00:00

abstract：:A chimeric transforming growth factor beta (TGF-beta) molecule has been synthesized to map the amino acids responsible for the substantially greater activity of TGF-beta 1 than TGF-beta 2 on growth and migration of endothelial cells. This chimera consists of a dimer of a monomeric unit composed of amino acids 1-39 of ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Qian SW,Burmester JK,Merwin JR,Madri JA,Sporn MB,Roberts AB

更新日期：1992-07-15 00:00:00

abstract：:The immune defense against viral infections involves cytotoxic T lymphocytes that recognize viral products in the context of class I major histocompatibility complex (MHC) antigens. To evade such immune surveillance viruses may have evolved various strategies to manipulate the expression of class I antigens. Adenoviru...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pääbo S,Nilsson T,Peterson PA

更新日期：1986-12-01 00:00:00

abstract：:Xenopus oocytes express a gene encoding bovine rhodopsin as well as its SP6 RNA polymerase-derived transcripts and total retinal mRNA. The opsin produced is in unglycosylated (30 kDa) and two glycosylated (35 kDa and 41 kDa) forms. Incubation of the cells expressing the above proteins with 11-cis-retinal generates rho...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Khorana HG,Knox BE,Nasi E,Swanson R,Thompson DA

更新日期：1988-11-01 00:00:00

abstract：:Recombinant adenoviral mediated delivery of suicide and cytokine genes has been investigated as a treatment for hepatic metastases of colon carcinoma in mice. Liver tumors were established by intrahepatic implantation of a poorly immunogenic colon carcinoma cell line (MCA-26), which is syngeneic in BALB/c mice. Intrat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Caruso M,Pham-Nguyen K,Kwong YL,Xu B,Kosai KI,Finegold M,Woo SL,Chen SH

更新日期：1996-10-15 00:00:00

abstract：:Metazoan arrestins bind to seven-transmembrane (7TM) receptors to regulate function. Aspergillus nidulans PalF, a protein involved in the fungal ambient pH signaling pathway, contains arrestin N-terminal and C-terminal domains and binds strongly to two different regions within the C-terminal cytoplasmic tail of the 7T...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Herranz S,Rodríguez JM,Bussink HJ,Sánchez-Ferrero JC,Arst HN Jr,Peñalva MA,Vincent O

更新日期：2005-08-23 00:00:00

abstract：:An expression is produced for the Casimir energy of a dielectric medium with a spherically symmetrical dielectric discontinuity. Tests based on dielectric and geometrical limits are successful. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schwinger J

更新日期：1992-12-01 00:00:00

abstract：:Social decisions require evaluation of costs and benefits to oneself and others. Long associated with emotion and vigilance, the amygdala has recently been implicated in both decision-making and social behavior. The amygdala signals reward and punishment, as well as facial expressions and the gaze of others. Amygdala ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chang SW,Fagan NA,Toda K,Utevsky AV,Pearson JM,Platt ML

更新日期：2015-12-29 00:00:00

abstract：:The technique of single-strand conformation polymorphism (SSCP) was used to screen a series of 37 established colorectal cell lines, 22 fresh tumor samples, and 22 normal DNA samples for mutations in the beta 2-microglobulin gene. Exon 1 (including the leader peptide sequence) and exon 2 were screened separately. Six ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bicknell DC,Rowan A,Bodmer WF

更新日期：1994-05-24 00:00:00

abstract：:We have measured the fidelity of bidirectional, semiconservative DNA synthesis by a human DNA replication complex in vitro. Replication was performed by extracts of HeLa cells in the presence of simian virus 40 (SV40) large tumor antigen by using a double-stranded phage M13mp2 DNA template containing the SV40 origin o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Roberts JD,Kunkel TA

更新日期：1988-10-01 00:00:00

abstract：:Inflammatory destruction of insulin-producing beta cells in the pancreatic islets is the hallmark of insulin-dependent diabetes mellitus, a spontaneous autoimmune disease of non-obese diabetic mice resembling human juvenile (type I) diabetes. Histochemical analysis of diabetic pancreata revealed that mononuclear cells...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Weiss L,Slavin S,Reich S,Cohen P,Shuster S,Stern R,Kaganovsky E,Okon E,Rubinstein AM,Naor D

更新日期：2000-01-04 00:00:00

abstract：:Invading organisms may spread through local movements (giving rise to a diffusion-like process) and by long-distance jumps, which are often human-mediated. The local spread of invading organisms has been fit with varying success to models that couple local population growth with diffusive spread, but to date no quanti...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Suarez AV,Holway DA,Case TJ

更新日期：2001-01-30 00:00:00

abstract：:The low-energy conformations for a series of peptides based on the sequence of the ras P21 protein from position 55 to position 67 have been computed using conformational energy analysis. These sequences differed at position 61 and contained Gln, Pro, Leu, Lys, and Arg at this position. P21 proteins with Gln, Glu, or ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pincus MR,Brandt-Rauf PW,Carty RP,Lubowsky J,Avitable M,Gibson KD,Scheraga HA

更新日期：1987-12-01 00:00:00

abstract：:We report a comprehensive cartography of selective responses to visual letters and words in the human ventral occipito-temporal cortex (VOTC) with direct neural recordings, clarifying key aspects of the neural basis of reading. Intracerebral recordings were performed in a large group of patients (n = 37) presented wit...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lochy A,Jacques C,Maillard L,Colnat-Coulbois S,Rossion B,Jonas J

更新日期：2018-08-07 00:00:00

abstract：:Papillomaviruses are small DNA viruses that are associated with benign and malignant epithelial lesions, including >95% of cervical cancers and approximately 20% of head and neck cancers. Because papillomavirus replication and virion production are tied to epithelial cell differentiation, infectious papillomavirus vir...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pyeon D,Lambert PF,Ahlquist P

更新日期：2005-06-28 00:00:00

abstract：:Arc repressor forms a homodimer in which the subunits intertwine to create a single globular domain. To obtain Arc sequences that fold preferentially as heterodimers, variants with surface patches of excess positive or negative charge were designed. Several but not all oppositely charged sequence pairs showed preferen...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nohaile MJ,Hendsch ZS,Tidor B,Sauer RT

更新日期：2001-03-13 00:00:00

abstract：:l-tryptophan (Trp), an essential amino acid for mammals, is the precursor of a wide array of immunomodulatory metabolites produced by the kynurenine and serotonin pathways. The kynurenine pathway is a paramount source of several immunoregulatory metabolites, including l-kynurenine (Kyn), the main product of indoleamin...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mondanelli G,Coletti A,Greco FA,Pallotta MT,Orabona C,Iacono A,Belladonna ML,Albini E,Panfili E,Fallarino F,Gargaro M,Manni G,Matino D,Carvalho A,Cunha C,Maciel P,Di Filippo M,Gaetani L,Bianchi R,Vacca C,Iamandii

更新日期：2020-02-18 00:00:00

abstract：:Transcription factor TFIID consists of TATA binding protein (TBP) and at least eight TBP-associated factors (TAFs). As TAFs are required for activated but not basal transcription, we have proposed that TAFs act as coactivators to mediate signals between activators and the basal transcription machinery. Here we report ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Klemm RD,Goodrich JA,Zhou S,Tjian R

更新日期：1995-06-20 00:00:00

abstract：:Caseinolytic proteases (ClpPs) are large oligomeric protein complexes that contribute to cell homeostasis as well as virulence regulation in bacteria. Although most organisms possess a single ClpP protein, some organisms encode two or more ClpP isoforms. Here, we elucidated the crystal structures of ClpP1 and ClpP2 fr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zeiler E,List A,Alte F,Gersch M,Wachtel R,Poreba M,Drag M,Groll M,Sieber SA

更新日期：2013-07-09 00:00:00

abstract：:Molecular analyses of Na,K-ATPase abundance and alpha-subunit isoform distribution were performed to determine whether pump expression varies at different points through the thickness of the circular layer of colonic smooth muscle. The mRNA and polypeptides of Na,K-ATPase alpha 1 and beta subunits were twice as abunda...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Burke EP,Sanders KM,Horowitz B

更新日期：1991-03-15 00:00:00

abstract：:To achieve the mission of personalized medicine, centering on delivering the right drug to the right patient at the right dose, therapeutic drug monitoring solutions are necessary. In that regard, wearable biosensing technologies, capable of tracking drug pharmacokinetics in noninvasively retrievable biofluids (e.g., ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lin S,Yu W,Wang B,Zhao Y,En K,Zhu J,Cheng X,Zhou C,Lin H,Wang Z,Hojaiji H,Yeung C,Milla C,Davis RW,Emaminejad S

更新日期：2020-08-11 00:00:00

abstract：:Pronounced bright and dark bands are seen at the bright and dark edges of half-shadows and similar distributions of illumination. These are the so-called Mach bands. A pair of vertical Mach bands was generated with a ramp pattern in the central strip of a horizontal tripartite oscilloscope display. This pattern consis...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ratliff F,Milkman N,Rennert N

更新日期：1983-07-01 00:00:00

abstract：:The phosphorylation and dephosphorylation of the dihydropyridine-sensitive Ca2+ channel was studied in transverse-tubule membranes isolated from rabbit skeletal muscle. Exposure of these membranes to either the cAMP-dependent protein kinase or a Ca2+/calmodulin-dependent protein kinase resulted in a rapid phosphorylat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hosey MM,Borsotto M,Lazdunski M

更新日期：1986-06-01 00:00:00

abstract：:Malaria, caused by Plasmodium sp, results in almost one million deaths and over 200 million new infections annually. The World Health Organization has recommended that artemisinin-based combination therapies be used for treatment of malaria. Artemisinin is a sesquiterpene lactone isolated from the plant Artemisia annu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Westfall PJ,Pitera DJ,Lenihan JR,Eng D,Woolard FX,Regentin R,Horning T,Tsuruta H,Melis DJ,Owens A,Fickes S,Diola D,Benjamin KR,Keasling JD,Leavell MD,McPhee DJ,Renninger NS,Newman JD,Paddon CJ

更新日期：2012-01-17 00:00:00

abstract：:The recombinant plasmid p102 based on pBR322 carrying approximately equal to 50% of the replicator proximal early region of simian virus 40 (SV40) DNA, including the viral origin of replication, has been constructed. It lacks a major part of the large tumor (T) antigen 3'-coding region, the T-antigen termination codon...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Horst J,Weckler C,Jacob E,Aulehla-Scholz C,Deppert W

更新日期：1982-08-01 00:00:00

abstract：:The embryonic development of the optic nerve of the zebrafish, Brachydanio rerio, was studied by three-dimensional computer reconstruction from serial section electron micrographs. Growing fibers from retinal ganglion cells had growth cones in contact with more mature fibers from adjacent cell bodies. In the observed ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bodick N,Levinthal C

更新日期：1980-07-01 00:00:00

abstract：:The molecular mechanism of tolerance to opiate drugs is poorly understood. We have used single-channel patch-clamp recordings to study opiate receptor effects on dissociated neurons from rat amygdala, a limbic region implicated in addiction processes. A 130-pS inwardly rectifying K(+)-preferring cation channel was act...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chen X,Marrero HG,Murphy R,Lin YJ,Freedman JE

更新日期：2000-12-19 00:00:00

abstract：:The regular spacing of somites during vertebrate embryogenesis involves a dynamic gradient of FGF signaling that controls the timing of maturation of cells in the presomitic mesoderm (PSM). How the FGF signal is transduced by PSM cells is unclear. Here, we first show that the FGF gradient is translated into graded act...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Delfini MC,Dubrulle J,Malapert P,Chal J,Pourquié O

更新日期：2005-08-09 00:00:00