Diversity of immune strategies explained by adaptation to pathogen statistics.

Abstract:

:Biological organisms have evolved a wide range of immune mechanisms to defend themselves against pathogens. Beyond molecular details, these mechanisms differ in how protection is acquired, processed, and passed on to subsequent generations-differences that may be essential to long-term survival. Here, we introduce a mathematical framework to compare the long-term adaptation of populations as a function of the pathogen dynamics that they experience and of the immune strategy that they adopt. We find that the two key determinants of an optimal immune strategy are the frequency and the characteristic timescale of the pathogens. Depending on these two parameters, our framework identifies distinct modes of immunity, including adaptive, innate, bet-hedging, and CRISPR-like immunities, which recapitulate the diversity of natural immune systems.

authors

Mayer A,Mora T,Rivoire O,Walczak AM

doi

10.1073/pnas.1600663113

subject

Has Abstract

pub_date

2016-08-02 00:00:00

pages

8630-5

issue

31

eissn

0027-8424

issn

1091-6490

pii

1600663113

journal_volume

113

pub_type

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