Abstract:
:Biological organisms have evolved a wide range of immune mechanisms to defend themselves against pathogens. Beyond molecular details, these mechanisms differ in how protection is acquired, processed, and passed on to subsequent generations-differences that may be essential to long-term survival. Here, we introduce a mathematical framework to compare the long-term adaptation of populations as a function of the pathogen dynamics that they experience and of the immune strategy that they adopt. We find that the two key determinants of an optimal immune strategy are the frequency and the characteristic timescale of the pathogens. Depending on these two parameters, our framework identifies distinct modes of immunity, including adaptive, innate, bet-hedging, and CRISPR-like immunities, which recapitulate the diversity of natural immune systems.
journal_name
Proc Natl Acad Sci U S Aauthors
Mayer A,Mora T,Rivoire O,Walczak AMdoi
10.1073/pnas.1600663113subject
Has Abstractpub_date
2016-08-02 00:00:00pages
8630-5issue
31eissn
0027-8424issn
1091-6490pii
1600663113journal_volume
113pub_type
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