Selective blockage of initiation of host protein synthesis in RNA-virus-infected cells.

abstract：:The use of proteasome inhibitors to target cancer's dependence on altered protein homeostasis has been greatly limited by intrinsic and acquired resistance. Analyzing data from thousands of cancer lines and tumors, we find that those with suppressed expression of one or more 19S proteasome subunits show intrinsic prot...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tsvetkov P,Sokol E,Jin D,Brune Z,Thiru P,Ghandi M,Garraway LA,Gupta PB,Santagata S,Whitesell L,Lindquist S

更新日期：2017-01-10 00:00:00

abstract：:We have determined the localization and orientation of two genetic probes within the human major histocompatibility complex by chromosomal in situ hybridization. Our data indicate that a cloned genomic probe cross-hybridizing to HLA-A, -B, and -C heavy chain loci is homologous to sequences located on chromosome 6 at b...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Morton CC,Kirsch IR,Nance WE,Evans GA,Korman AJ,Strominger JL

更新日期：1984-05-01 00:00:00

abstract：:Hox5 genes (Hoxa5, Hoxb5, Hoxc5) are exclusively expressed in the lung mesenchyme during embryogenesis, and the most severe phenotypes result from constitutive loss of function of all three genes. Because Hox5 triple null mutants exhibit perinatal lethality, the contribution of this paralogous group to postembryonic l...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hrycaj SM,Marty-Santos L,Cebrian C,Rasky AJ,Ptaschinski C,Lukacs NW,Wellik DM

更新日期：2018-11-06 00:00:00

abstract：:Metals in one spatial dimension are described at the lowest energy scales by the Luttinger liquid theory. It is well understood that this free theory, and even interacting integrable models, can support ballistic transport of conserved quantities including energy. In contrast, realistic one-dimensional metals, even wi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bulchandani VB,Karrasch C,Moore JE

更新日期：2020-06-09 00:00:00

abstract：:At meiotic prophase, chromatin loops around a proteinaceous core, with the sizes of these loops varying between species. Comparison of the morphology of sequence-related inserts at different sites in transgenic mice demonstrates that loop size also varies with chromosomal geography. Similarly, chromatin loop lengths d...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Heng HH,Chamberlain JW,Shi XM,Spyropoulos B,Tsui LC,Moens PB

更新日期：1996-04-02 00:00:00

abstract：:Nonspecific histone deacetylase (HDAC) inhibition has been shown to facilitate the extinction of drug-seeking behavior in a manner resistant to reinstatement. A key open question is which specific HDAC is involved in the extinction of drug-seeking behavior. Using the selective HDAC3 inhibitor RGFP966, we investigated ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Malvaez M,McQuown SC,Rogge GA,Astarabadi M,Jacques V,Carreiro S,Rusche JR,Wood MA

更新日期：2013-02-12 00:00:00

abstract：:The Xlim-1 gene is activated in the late blastula stage of Xenopus embryogenesis in the mesoderm, and its RNA product becomes concentrated in the Spemann organizer at early gastrula stage. A major regulator of early expression of Xlim-1 is activin or an activin-like signal. We report experiments aiming to identify the...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rebbert ML,Dawid IB

更新日期：1997-09-02 00:00:00

abstract：:Observations from human microbiome studies are often conflicting or inconclusive. Many factors likely contribute to these issues including small cohort sizes, sample collection, and handling and processing differences. The field of microbiome research is moving from 16S rDNA gene sequencing to a more comprehensive gen...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jones MB,Highlander SK,Anderson EL,Li W,Dayrit M,Klitgord N,Fabani MM,Seguritan V,Green J,Pride DT,Yooseph S,Biggs W,Nelson KE,Venter JC

更新日期：2015-11-10 00:00:00

abstract：:Rat adrenal mitochondria accumulated cholesterol during ether stress in vivo when side-chain cleavage was inhibited by aminoglutethimide (control = 14.6 vs. aminoglutethimide = 26.5 micrograms of cholesterol per mg of protein). This accumulation was insensitive to simultaneous administration of cycloheximide (24.2 mic...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Privalle CT,Crivello JF,Jefcoate CR

更新日期：1983-02-01 00:00:00

abstract：:Earlier studies have shown that the DNA of herpes simplex virus 1 consists of two covalently linked components, L and S, each flanked by inverted repeats. The two components can invert, and viral DNA extracted from infected cells or virions consists of equimolar concentrations of four populations differing solely in t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Poffenberger KL,Tabares E,Roizman B

更新日期：1983-05-01 00:00:00

abstract：:Three types of protein kinase C were purified from rabbit brain cytosol. Each type has a molecular mass of approximately 80 kDa and serves as a receptor for phorbol esters. Polyclonal antibodies produced to two protein kinase C types were relatively type-specific, indicating that these proteins have unique antigenic d...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jaken S,Kiley SC

更新日期：1987-07-01 00:00:00

abstract：:Extracts of cultured human leukemic tissues increased the spleen focus-forming activity of Friend leukemia virus preparations in BALB/c and other partially resistant mice. Such mice carry the Fv-1(b) gene, which inhibits the expression of helper virus indigenous to the Friend virus complex, and allows co-infecting leu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Steeves RA,Fjelde A,Mirand EA

更新日期：1971-10-01 00:00:00

abstract：:A serpin was identified in normal mammary gland by differential cDNA sequencing. In situ hybridization has detected this serpin exclusively in the myoepithelial cells on the normal and noninvasive mammary epithelial side of the basement membrane and thus was named myoepithelium-derived serine proteinase inhibitor (MEP...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Xiao G,Liu YE,Gentz R,Sang QA,Ni J,Goldberg ID,Shi YE

更新日期：1999-03-30 00:00:00

abstract：:Transarterial chemoembolization (TACE) is the main treatment for intermediate stage hepatocellular carcinoma (HCC) with Barcelona Clinic Liver Cancer classification because of its exclusive arterial blood supply. Although TACE achieves substantial necrosis of the tumor, complete tumor necrosis is uncommon, and the res...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lin WH,Yeh SH,Yeh KH,Chen KW,Cheng YW,Su TH,Jao P,Ni LC,Chen PJ,Chen DS

更新日期：2016-10-18 00:00:00

abstract：:Loss-of-function mutations in the genes associated with primary microcephaly (MCPH) reduce human brain size by about two-thirds, without producing gross abnormalities in brain organization or physiology and leaving other organs largely unaffected [Woods CG, et al. (2005) Am J Hum Genet 76:717-728]. There is also evide...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rimol LM,Agartz I,Djurovic S,Brown AA,Roddey JC,Kähler AK,Mattingsdal M,Athanasiu L,Joyner AH,Schork NJ,Halgren E,Sundet K,Melle I,Dale AM,Andreassen OA,Alzheimer's Disease Neuroimaging Initiative.

更新日期：2010-01-05 00:00:00

abstract：:The cellular form of the Prion protein (PrPC) is necessary for prion replication in mice. To determine whether it is also sufficient, we expressed PrP under the control of various cell- or tissue-specific regulatory elements in PrP knockout mice. The interferon regulatory factor-1 promoter/Emu enhancer led to high PrP...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Raeber AJ,Sailer A,Hegyi I,Klein MA,Rülicke T,Fischer M,Brandner S,Aguzzi A,Weissmann C

更新日期：1999-03-30 00:00:00

abstract：:In adult mammalian brain, occurrence of the synthesis of estradiol from endogenous cholesterol has been doubted because of the inability to detect dehydroepiandrosterone synthase, P45017alpha. In adult male rat hippocampal formation, significant localization was demonstrated for both cytochromes P45017alpha and P450 a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hojo Y,Hattori TA,Enami T,Furukawa A,Suzuki K,Ishii HT,Mukai H,Morrison JH,Janssen WG,Kominami S,Harada N,Kimoto T,Kawato S

更新日期：2004-01-20 00:00:00

abstract：:The relative stabilities and structural properties of a representative set of 20 ALS-mutant Cu,Zn-superoxide dismutase apoproteins were examined by using differential scanning calorimetry and hydrogen-deuterium (H/D) exchange followed by MS. Contrary to recent reports from other laboratories, we found that ALS-mutant ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rodriguez JA,Shaw BF,Durazo A,Sohn SH,Doucette PA,Nersissian AM,Faull KF,Eggers DK,Tiwari A,Hayward LJ,Valentine JS

更新日期：2005-07-26 00:00:00

abstract：:An excised patch of embryonic muscle membrane was used as a probe for measuring the release of acetylcholine (AcCho) from growing spinal neurons in Xenopus cell culture. The neuron was stimulated extracellularly at the soma, and the evoked AcCho release was monitored at the growth cone, along the neurite, and near the...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sun YA,Poo MM

更新日期：1987-04-01 00:00:00

abstract：:Fusions with the bacterial gene for chloramphenicol acetyltransferase followed by P-element-mediated germ-line transformation in Drosophila have permitted localization of the DNA sequence that confers a high degree of developmental specificity on a pair of silkmoth eggshell (chorion) genes. The short, 272-base-pair, 5...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mitsialis SA,Spoerel N,Leviten M,Kafatos FC

更新日期：1987-11-01 00:00:00

abstract：:The blind Mexican cave tetra, Astyanax mexicanus, is a unique model system for the study of parallelism and the evolution of cave-adapted traits. Understanding the genetic basis for these traits has recently become feasible thanks to production of a genome-wide linkage map and quantitative trait association analyses. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gross JB,Protas M,Conrad M,Scheid PE,Vidal O,Jeffery WR,Borowsky R,Tabin CJ

更新日期：2008-12-23 00:00:00

abstract：:Host species have evolved mechanisms that can inhibit pathogen replication even after a cell has been successfully invaded. Here we show that tripartite-motif protein 21 (TRIM21), a ubiquitously expressed E3 ubiquitin ligase that targets viruses inside the cytosol, protects mice against fatal viral infection. Upon inf...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vaysburd M,Watkinson RE,Cooper H,Reed M,O'Connell K,Smith J,Cruickshanks J,James LC

更新日期：2013-07-23 00:00:00

abstract：:Mitochondrial cytochrome c oxidase plays an essential role in aerobic cellular respiration, reducing dioxygen to water in a process coupled with the pumping of protons across the mitochondrial inner membrane. An aspartate residue, Asp-51, located near the enzyme surface, undergoes a redox-coupled x-ray structural chan...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tsukihara T,Shimokata K,Katayama Y,Shimada H,Muramoto K,Aoyama H,Mochizuki M,Shinzawa-Itoh K,Yamashita E,Yao M,Ishimura Y,Yoshikawa S

更新日期：2003-12-23 00:00:00

abstract：:Estradiol-17beta administration to young (10- to 12-week-old) rabbits to produce the "estrogen-dominated" uterus increased the uterine contractile response to both oxytocin and methacholine in vitro. In "progesterone-dominated" uteri, obtained from rabbits that received progesterone for 4 days after estrogen pretreatm...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nissenson R,Fluoret G,Hechter O

更新日期：1978-04-01 00:00:00

abstract：:Children who are treated for congenital cataracts later exhibit impairments in configural face analysis. This has been explained in terms of a critical period for the acquisition of normal face processing. Here, we consider a more parsimonious account according to which deficits in configural analysis result from the ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vogelsang L,Gilad-Gutnick S,Ehrenberg E,Yonas A,Diamond S,Held R,Sinha P

更新日期：2018-10-30 00:00:00

abstract：:Phages of the Caudovirales order possess a tail that recognizes the host and ensures genome delivery upon infection. The X-ray structure of the approximately 1.8 MDa host adsorption device (baseplate) from the lactococcal phage TP901-1 shows that the receptor-binding proteins are pointing in the direction of the host,...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Veesler D,Spinelli S,Mahony J,Lichière J,Blangy S,Bricogne G,Legrand P,Ortiz-Lombardia M,Campanacci V,van Sinderen D,Cambillau C

更新日期：2012-06-05 00:00:00

abstract：:Alzheimer's disease (AD), characterized by cognitive decline, has emerged as a disease of synaptic failure. The present study reveals an unanticipated role of erythropoietin-producing hepatocellular A4 (EphA4) in mediating hippocampal synaptic dysfunctions in AD and demonstrates that blockade of the ligand-binding dom...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fu AK,Hung KW,Huang H,Gu S,Shen Y,Cheng EY,Ip FC,Huang X,Fu WY,Ip NY

更新日期：2014-07-08 00:00:00

abstract：:Because RNAs fold as they are being synthesized, their transcription rate can affect their folding. Here, we report the results of single-molecule fluorescence studies that characterize the ligand-dependent cotranscriptional folding of the Escherichia coli thiM riboswitch that regulates translation. We found that the ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Uhm H,Kang W,Ha KS,Kang C,Hohng S

更新日期：2018-01-09 00:00:00

abstract：:Nanobacteria-like objects evidenced at the surface of the orthopyroxenes of the Tataouine meteorite in South Tunisia have been studied by scanning and transmission electron microscopies. A method of micromanipulation has been developed to ensure that exactly the same objects were studied by both methods. We have shown...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Benzerara K,Menguy N,Guyot F,Dominici C,Gillet P

更新日期：2003-06-24 00:00:00

abstract：:The structurally diverse peroxisome proliferators ciprofibrate, clofibrate, and bis(2-ethylhexyl) phthalate [(EtHx)2 greater than Pht] increase the activities of hepatic catalase and peroxisomal fatty acid beta-oxidation enzymes in conjunction with profound proliferation of peroxisomes in hepatocytes. In order to deli...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Reddy JK,Goel SK,Nemali MR,Carrino JJ,Laffler TG,Reddy MK,Sperbeck SJ,Osumi T,Hashimoto T,Lalwani ND

更新日期：1986-03-01 00:00:00