Regulation of meiotic chromatin loop size by chromosomal position.

Abstract:

:At meiotic prophase, chromatin loops around a proteinaceous core, with the sizes of these loops varying between species. Comparison of the morphology of sequence-related inserts at different sites in transgenic mice demonstrates that loop size also varies with chromosomal geography. Similarly, chromatin loop lengths differ dramatically for interstitially and terminally located hamster telomeric sequences. Sequences, telomeric or otherwise, located at chromosome termini, closely associate with the meiotic proteinaceous core, forming shorter loops than identical interstitial sequences. Thus, we present evidence that different chromatin packaging mechanisms exist for interstitial versus terminal chromosomal regions, which act separately from those operating at the level of the DNA sequence. Chromosomal position plays the dominant role in chromatin packaging.

authors

Heng HH,Chamberlain JW,Shi XM,Spyropoulos B,Tsui LC,Moens PB

doi

10.1073/pnas.93.7.2795

subject

Has Abstract

pub_date

1996-04-02 00:00:00

pages

2795-800

issue

7

eissn

0027-8424

issn

1091-6490

journal_volume

93

pub_type

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