The inositol polyphosphate 4-phosphatase forms a complex with phosphatidylinositol 3-kinase in human platelet cytosol.

abstract：:How did language evolve? A popular approach points to the similarities between the ontogeny and phylogeny of language. Young children's language and nonhuman primates' signing both appear formulaic with limited syntactic combinations, thereby suggesting a degree of continuity in their cognitive abilities. To evaluate ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yang C

更新日期：2013-04-16 00:00:00

abstract：:The integrity of the endothelial barrier between circulating blood and tissue is important for blood vessel function and, ultimately, for organ homeostasis. Here, we developed a vessel-on-a-chip with perfused endothelialized channels lined with human bone marrow stromal cells, which adopt a mural cell-like phenotype t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Alimperti S,Mirabella T,Bajaj V,Polacheck W,Pirone DM,Duffield J,Eyckmans J,Assoian RK,Chen CS

更新日期：2017-08-15 00:00:00

abstract：:Transformation promotes genome plasticity in bacteria via RecA-driven homologous recombination. In the gram-positive human pathogen Streptococcus pneumoniae, the transformasome a multiprotein complex, internalizes, protects, and processes transforming DNA to generate chromosomal recombinants. Double-stranded DNA is in...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Quevillon-Cheruel S,Campo N,Mirouze N,Mortier-Barrière I,Brooks MA,Boudes M,Durand D,Soulet AL,Lisboa J,Noirot P,Martin B,van Tilbeurgh H,Noirot-Gros MF,Claverys JP,Polard P

更新日期：2012-09-11 00:00:00

abstract：:Two monoclonal antibodies directed against the native beta 2 subunit of Escherichia coli tryptophan synthase [L-serine hydro-lyase (adding indoleglycerol-phosphate), EC 4.2.1.20], one recognizing the C-terminal F1 domain and the other the N-terminal F2 domain, were used to detect immunoreactive intermediates in the fo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Blond S,Goldberg M

更新日期：1987-03-01 00:00:00

abstract：:The nucleus accumbens is a brain region in which limbic and motor inputs converge. How these information modalities shape accumbens output is not clearly understood. Here, we report that synaptic inputs from the prefrontal cortex and limbic structures interact differently depending on their timing. Coincident inputs m...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Goto Y,O'Donnell P

更新日期：2002-10-01 00:00:00

abstract：:Pseudomonas aeruginosa is an opportunistic pathogen that requires preexisiting epithelial injury to cause acute infections. We report that P. aeruginosa inhibits mammalian cytokinesis in a type III secretion system and exotoxin T (ExoT)-dependent manner. ExoT is a bifunctional type III secretion system effector protei...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shafikhani SH,Engel J

更新日期：2006-10-17 00:00:00

abstract：:Hydra interstitial stem cells continuously give rise to daughter stem cells as well as precursors for nerve and nematocyte differentiation. Growth of the stem cell population is controlled by the self-renewal probability (Ps): Ps is the fraction of stem cell daughters that remain stem cells in each generation. We have...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： David CN,MacWilliams H

更新日期：1978-02-01 00:00:00

abstract：:An analysis of taxonomic longevity for species of the two Cenozoic radiations of Caribbean planktonic foraminifera shows strong similarity in longevity for extinct taxa, though extant species of the latter radiation are biased towards longer-lived forms. In this case, the present is not the key to the past. A simple o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Levinton JS,Ginzburg L

更新日期：1984-09-01 00:00:00

abstract：:One goal of regenerative medicine is to repair damaged tissue. This requires not only generating new cells of the proper phenotype, but also selecting for those that properly integrate into sites of injury. In our laboratory we are using a cell-migration-based in vivo selection system to generate antibodies that induc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Han KH,Arlian BM,Macauley MS,Paulson JC,Lerner RA

更新日期：2018-01-16 00:00:00

abstract：:The chronic use of several drugs, including opiates, results in the stereotypical behaviors characteristic of addiction. Alterations in gene expression have been associated with the use of these addictive drugs. Previous studies, however, have been limited to describing changes in amounts of individual mRNAs from sing...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mackler SA,Eberwine JH

更新日期：1994-01-04 00:00:00

abstract：:The hydrodynamic properties of the detergent-solubilized, terminal membrane complex of serum complement components C5-C9 [C5b-9(m)] were studied to obtain an estimate of its molecular weight. In a solution of Triton X-100/deoxycholate, the protein complex binds 17% Triton X-100 and 11% deoxycholate by weight. The sedi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bhakdi S,Tranum-Jensen J

更新日期：1981-03-01 00:00:00

abstract：:Improper function of voltage-gated sodium channels (NaVs), obligatory membrane proteins for bioelectrical signaling, has been linked to a number of human pathologies. Small-molecule agents that target NaVs hold considerable promise for treatment of chronic disease. Absent a comprehensive understanding of channel struc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Thomas-Tran R,Du Bois J

更新日期：2016-05-24 00:00:00

abstract：:The high concentration of gonadotropin-releasing hormone (GnRH) in milk of several species implies that the mammary gland is either a site of synthesis for this neuropeptide or that it is efficiently concentrated from plasma by this organ. By PCR amplification of mammary gland cDNA, we have demonstrated expression of ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Palmon A,Ben Aroya N,Tel-Or S,Burstein Y,Fridkin M,Koch Y

更新日期：1994-05-24 00:00:00

abstract：:The potent muscarinic photoaffinity reagent N-methyl-4-piperidyl p-azidobenzilate (azido-4NMPB) was used to covalently label specific muscarinic binding sites in various brain regions and in the heart. In the cortex and hippocampus, a single specifically labeled protein with an apparent molecular mass of 86,000 dalton...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Avissar S,Amitai G,Sokolovsky M

更新日期：1983-01-01 00:00:00

abstract：:Fatty acid transport protein 4 (FATP4), a transmembrane protein in the endoplasmic reticulum (ER), is a recently identified negative regulator of the ER-associated retinal pigment epithelium (RPE)65 isomerase necessary for recycling 11-cis-retinal, the light-sensitive chromophore of both rod and cone opsin visual pigm...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li S,Gordon WC,Bazan NG,Jin M

更新日期：2020-12-15 00:00:00

abstract：:Streptococcus groups A and B cause serious infections, including early onset sepsis and meningitis in newborns. Rib domain-containing surface proteins are found associated with invasive strains and elicit protective immunity in animal models. Yet, despite their apparent importance in infection, the structure of the Ri...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Whelan F,Lafita A,Griffiths SC,Cooper REM,Whittingham JL,Turkenburg JP,Manfield IW,St John AN,Paci E,Bateman A,Potts JR

更新日期：2019-12-09 00:00:00

abstract：:3T3 cells that have undergone adipose differentiation in vitro secrete into the culture medium a potent growth stimulatory activity for bovine aortic endothelial cells. When medium containing 2% fetal calf serum, which does not support significant endothelial cell growth, is conditioned by 3T3-F442A adipocytes, the en...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Castellot JJ Jr,Karnovsky MJ,Spiegelman BM

更新日期：1980-10-01 00:00:00

abstract：:Tyrosine hydroxylase (EC 1.14.16.2), the enzyme catalyzing the rate-limiting step in catecholamine biosynthesis, was localized by electron microscopy within noradrenergic neurons of the nucleus locus coeruleus of the rat brain with a specific antibody to tyrosine hydroxylase labeled by the peroxidase-antiperoxidase im...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pickel VM,Joh TH,Reis DJ

更新日期：1975-02-01 00:00:00

abstract：:Environmental and anthropogenic factors often drive population declines in top predators, but how their influences may combine remains unclear. Albatrosses are particularly threatened. They breed in fast-changing environments, and their extensive foraging ranges expose them to incidental mortality (bycatch) in multipl...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pardo D,Forcada J,Wood AG,Tuck GN,Ireland L,Pradel R,Croxall JP,Phillips RA

更新日期：2017-12-12 00:00:00

abstract：:A mechanism of ion transport across membranes is reported. Microbial transport of Fe(3+) generally delivers iron, a growth-limiting nutrient, to cells via highly specific siderophore-mediated transport systems. In contrast, iron transport in the fresh water bacterium Aeromonas hydrophila is found to occur by means of ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Stintzi A,Barnes C,Xu J,Raymond KN

更新日期：2000-09-26 00:00:00

abstract：:Mutations in Pink1, a gene encoding a Ser/Thr kinase with a mitochondrial-targeting signal, are associated with Parkinson's disease (PD), the most common movement disorder characterized by selective loss of dopaminergic neurons. The mechanism by which loss of Pink1 leads to neurodegeneration is not understood. Here we...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yang Y,Gehrke S,Imai Y,Huang Z,Ouyang Y,Wang JW,Yang L,Beal MF,Vogel H,Lu B

更新日期：2006-07-11 00:00:00

abstract：:CPEB, a cytoplasmic polyadenylation element-binding protein, plays an important role in translational control of maternal mRNAs in early animal development. During Xenopus oocyte maturation, CPEB undergoes a Cdc2-mediated phosphorylation- and ubiquitin-dependent degradation that is required for proper entry into meios...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Setoyama D,Yamashita M,Sagata N

更新日期：2007-11-13 00:00:00

abstract：:Worldwide dissemination of antibiotic resistance in bacteria is facilitated by plasmids that encode postsegregational killing (PSK) systems. These produce a stable toxin (T) and a labile antitoxin (A) conditioning cell survival to plasmid maintenance, because only this ensures neutralization of toxicity. Shortage of a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pimentel B,Nair R,Bermejo-Rodríguez C,Preston MA,Agu CA,Wang X,Bernal JA,Sherratt DJ,de la Cueva-Méndez G

更新日期：2014-02-18 00:00:00

abstract：:Dematerialization, represented by declining consumption per GDP of energy or of goods, offers some hope for rising environmental quality with development. The declining proportion of income spent on staples as affluence grows, which income elasticity <1.0 measures, makes dematerialization widespread. Further, as learn...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ausubel JH,Waggoner PE

更新日期：2008-09-02 00:00:00

abstract：:Cellular differentiation leading to formation of the bradyzoite tissue cyst stage is the underlying cause of chronic toxoplasmosis. Consequently, mechanisms responsible for controlling development in the Toxoplasma intermediate life cycle have long been sought. Here, we identified 15 Toxoplasma mRNAs induced in early ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Radke JB,Lucas O,De Silva EK,Ma Y,Sullivan WJ Jr,Weiss LM,Llinas M,White MW

更新日期：2013-04-23 00:00:00

abstract：:The Hippo-YAP/TAZ signaling pathway plays a pivotal role in growth control during development and regeneration and its dysregulation is widely implicated in various cancers. To further understand the cellular and molecular mechanisms underlying Hippo signaling regulation, we have found that activities of core Hippo si...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kim W,Cho YS,Wang X,Park O,Ma X,Kim H,Gan W,Jho EH,Cha B,Jeung YJ,Zhang L,Gao B,Wei W,Jiang J,Chung KS,Yang Y

更新日期：2019-05-07 00:00:00

abstract：:The Ten-Eleven-Translocation 2 (TET2) gene encodes a member of TET family enzymes that alters the epigenetic status of DNA by oxidizing 5-methylcytosine to 5-hydroxymethylcytosine (5hmC). Somatic loss-of-function mutations of TET2 are frequently observed in patients with diverse myeloid malignancies, including myelody...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ko M,Bandukwala HS,An J,Lamperti ED,Thompson EC,Hastie R,Tsangaratou A,Rajewsky K,Koralov SB,Rao A

更新日期：2011-08-30 00:00:00

abstract：:Several authors have considered Markov processes defined by the motion of a particle on a fixed line with a random velocity(1, 6, 8, 10) or a random diffusivity.(5, 12) A "random evolution" is a natural but apparently new generalization of this notion. In this note we hope to show that this concept leads to simple and...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Griego RJ,Hersh R

更新日期：1969-02-01 00:00:00

abstract：:B-1a cells reside in both the peritoneal cavity and the spleen. LPS stimulates splenic B-1a to differentiate to plasma cells producing natural IgM specific for microbial and self antigens. However, there are conflicting views as to whether the B-1a cells divide before this differentiation occurs, and hence how the res...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yang Y,Tung JW,Ghosn EE,Herzenberg LA,Herzenberg LA

更新日期：2007-03-13 00:00:00

abstract：:Larval fishes suffer prodigious mortality rates, eliminating 99% of the brood within a few days after first feeding. Hjort (1914) famously attributed this "critical period" of low survival to the larvae's inability to obtain sufficient food [Hjort (1914) Rapp P-v Réun Cons Int Explor Mer 20:1-228]. However, the cause ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： China V,Holzman R

更新日期：2014-06-03 00:00:00