Reduced fitness in progeny from old parents in a natural population.

abstract：:Colorectal cancer is the second leading cause of cancer-related deaths in the United States. Understanding the distinct genetic and epigenetic changes contributing to the establishment and growth of metastatic lesions is crucial for the development of novel therapeutic strategies. In a search for key regulators of col...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rychahou PG,Kang J,Gulhati P,Doan HQ,Chen LA,Xiao SY,Chung DH,Evers BM

更新日期：2008-12-23 00:00:00

abstract：:Comparisons of exon II HLA-DR beta sequences have shown that nucleotide variations are principally clustered within the following three regions: V1 (amino acid 8-15), V2 (25-32), and V3 (70-77). V1, V2, and V3-derived 24-mers have been synthesized, the DR beta sequences coming from DR1, DR3, Drw6, DR4, DR5, and DRw53 ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Le Gall I,Millasseau P,Dausset J,Cohen D

更新日期：1986-10-01 00:00:00

abstract：:In this paper is presented the theory of a class of locally convex lattices (L-lattices) of real functions which generalize the classical Lebesgue spaces. The monotone and dominated convergence theorems for convergence almost everywhere and sequential and order completeness of such lattices are established. These resu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bogdanowicz WM

更新日期：1970-06-01 00:00:00

abstract：:We describe a functional profiling strategy to identify and characterize subtypes of neurons present in a peripheral ganglion, which should be extendable to neurons in the CNS. In this study, dissociated dorsal-root ganglion neurons from mice were exposed to various pharmacological agents (challenge compounds), while ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Teichert RW,Smith NJ,Raghuraman S,Yoshikami D,Light AR,Olivera BM

更新日期：2012-01-31 00:00:00

abstract：:Chromosome 3p and 1p deletions are among the most frequent genetic changes in human lung cancer and although candidate tumor suppressor genes have been identified in these regions, no causative correlations have been drawn between deletion or mutation of these and lung carcinogenesis. We identify XPC and Gadd45a as ge...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hollander MC,Philburn RT,Patterson AD,Velasco-Miguel S,Friedberg EC,Linnoila RI,Fornace AJ Jr

更新日期：2005-09-13 00:00:00

abstract：:ADP activates a family of cell surface receptors that modulate signaling pathways in a broad range of cells. ADP receptor antagonists are widely used to treat cardiovascular disease states. These studies identify a critical role for the stable reactive oxygen species hydrogen peroxide (H2O2) in mediating cellular resp...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kalwa H,Sartoretto JL,Martinelli R,Romero N,Steinhorn BS,Tao M,Ozaki CK,Carman CV,Michel T

更新日期：2014-03-04 00:00:00

abstract：:Oxidants, such as those generated by metabolically activated phagocytes in inflammation, have been implicated in the metabolic activation of carcinogens, and in this study we demonstrate that the interaction of (+/-)-trans-7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene (BP 7,8-dihydrodiol) with phorbol ester-stimulated polym...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Trush MA,Seed JL,Kensler TW

更新日期：1985-08-01 00:00:00

abstract：:Nucleosomes are the fundamental structural unit of chromatin. In addition to stabilizing the DNA polymer, nucleosomes are modified in ways that reflect and affect gene expression in their vicinity. It has long been assumed that nucleosomes can transmit memory of gene expression through their covalent posttranslational...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schlissel G,Rine J

更新日期：2019-10-08 00:00:00

abstract：:Familial adenomatous polyposis (FAP) is an autosomal-dominant disease characterized by the development of hundreds of adenomatous polyps of the colorectum. Approximately 80% of FAP patients can be shown to have truncating mutations of the APC gene. To determine the cause of FAP in the other 20% of patients, MAMA (mono...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Laken SJ,Papadopoulos N,Petersen GM,Gruber SB,Hamilton SR,Giardiello FM,Brensinger JD,Vogelstein B,Kinzler KW

更新日期：1999-03-02 00:00:00

abstract：:A single, modified nucleoside in Escherichia coli tRNA, 6-(3-methyl-2-butenylamino)-2-methyl-thio-9-beta-D-ribofuranosylpurine, has been desulfurized with Raney nickel to afford its probable biosynthetic precursor. The limitations of the reaction at the nucleoside and tRNA levels and its lack of inhibition of the amin...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hecht SM,Kirkegaard LH,Bock RM

更新日期：1971-01-01 00:00:00

abstract：:A vitamin D(3) metabolite in intestine more polar than 25-hydroxy-vitamin D(3)(25-OH D(3)) has been detected by countercurrent distribution. The intestinal metabolite is found also after administration of labeled hydroxy D(3), indicating that it arises from vitamin D(3) via the intermediate 25-hydroxy derivative. The ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Haussler MR,Boyce DW,Littledike ET,Rasmussen H

更新日期：1971-01-01 00:00:00

abstract：:McKay et al. [(1996) Science 273, 924-930] suggested that carbonate globules in the meteorite ALH84001 contained the fossil remains of Martian microbes. We have characterized a subpopulation of magnetite (Fe(3)O(4)) crystals present in abundance within the Fe-rich rims of these carbonate globules. We find these Martia...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Thomas-Keprta KL,Clemett SJ,Bazylinski DA,Kirschvink JL,McKay DS,Wentworth SJ,Vali H,Gibson EK Jr,McKay MF,Romanek CS

更新日期：2001-02-27 00:00:00

abstract：:We discuss the pulling force f required to extrude a lipid tube from a living cell as a function of the extrusion velocity L. The main feature is membrane friction on the cytoskeleton. As recently observed for neutrophils, the tether force exhibits a "shear thinning" response over a large range of pulling velocities, ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Brochard-Wyart F,Borghi N,Cuvelier D,Nassoy P

更新日期：2006-05-16 00:00:00

abstract：:The non-long terminal repeat (LTR) retrotransposon, R2, encodes a sequence-specific endonuclease responsible for its insertion at a unique site in the 28S rRNA genes of arthropods. Although most non-LTR retrotransposons encode an apurinic-like endonuclease upstream of a common reverse transcriptase domain, R2 and many...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yang J,Malik HS,Eickbush TH

更新日期：1999-07-06 00:00:00

abstract：:pRK212.2, a derivative of the broad host range plasmid RK2, contains two EcoRI cleavage fragments, A and B, neither of which can replicate by itself in Escherichia coli. Fragment A (41.7 kilobases), but not fragment B (14.4 kilobases), can be cloned by insertion into the unrelated plasmids mini-F and ColE1. Fragment B...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Figurski DH,Helinski DR

更新日期：1979-04-01 00:00:00

abstract：:Dematerialization, represented by declining consumption per GDP of energy or of goods, offers some hope for rising environmental quality with development. The declining proportion of income spent on staples as affluence grows, which income elasticity <1.0 measures, makes dematerialization widespread. Further, as learn...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ausubel JH,Waggoner PE

更新日期：2008-09-02 00:00:00

abstract：:The ATP-dependent enzyme dethiobiotin synthetase from Escherichia coli catalyses the formation of dethiobiotin from CO2 and 7, 8-diaminopelargonic acid. The reaction is initiated by the formation of a carbamate and proceeds through a phosphorylated intermediate, a mixed carbamic phosphoric anhydride. Here, we report t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Käck H,Gibson KJ,Lindqvist Y,Schneider G

更新日期：1998-05-12 00:00:00

abstract：:Charcot-Marie-Tooth disease type 4C (CMT4C) is an early-onset, autosomal recessive form of demyelinating neuropathy. The clinical manifestations include progressive scoliosis, delayed age of walking, muscular atrophy, distal weakness, and reduced nerve conduction velocity. The gene mutated in CMT4C disease, SH3TC2/KIA...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Arnaud E,Zenker J,de Preux Charles AS,Stendel C,Roos A,Médard JJ,Tricaud N,Kleine H,Luscher B,Weis J,Suter U,Senderek J,Chrast R

更新日期：2009-10-13 00:00:00

abstract：:Fodrin, a protein composed of two polypeptides with molecular weights of 250,000 and 240,000, is concentrated in the cortical cytoplasm of neurons, and moves down the axons by the process of axonal transport. We have used immunofluorescence techniques to determine whether fodrin antigens also move in non-neuronal cell...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Levine J,Willard M

更新日期：1983-01-01 00:00:00

abstract：:We report on preparation of rhodopsin proteoliposomes with the cytoplasmic domain of rhodopsin facing the exterior of the proteoliposomes. Rhodopsin purified from rod outer segments of bovine retinae by immunoaffinity chromatography in octyl glucoside was reconstituted into liposomes prepared from soybean phospholipid...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Niu L,Kim JM,Khorana HG

更新日期：2002-10-15 00:00:00

abstract：:Tripeptidyl peptidase II (TPPII) is a eukaryotic protease acting downstream of the 26S proteasome; it removes tripeptides from the degradation products released by the proteasome. Structural studies in vitro have revealed the basic architecture of TPPII, a two-stranded linear polymer that assembles to form a spindle-s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fukuda Y,Beck F,Plitzko JM,Baumeister W

更新日期：2017-04-25 00:00:00

abstract：:The aspartate receptor involved in chemotaxis is modified by methyl esterification at four distinct glutamate residues during the adaptive response of this receptor. To explain the high degree of specificity of this modification, it has been proposed that the methyltransferase recognizes the sequence Glu-Glu-Xaa-Xaa-A...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Terwilliger TC,Wang JY,Koshland DE Jr

更新日期：1986-09-01 00:00:00

abstract：:Antiviral and macrophage-priming activities in the supernatant medium of a subclone of a concanavalin A-stimulated mouse T-cell hybridoma were investigated. The two activities were associated with a molecular weight of approximately 50,000 and could not be separated by various approaches. Both activities were eliminat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pace JL,Russell SW,Schreiber RD,Altman A,Katz DH

更新日期：1983-06-01 00:00:00

abstract：:The prefrontal cortex continues to mature after puberty and into early adulthood, mirroring the time course of maturation of cognitive abilities. However, the way in which prefrontal activity changes during peri- and postpubertal cortical maturation is largely unknown. To address this question, we evaluated the develo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhou X,Zhu D,Katsuki F,Qi XL,Lees CJ,Bennett AJ,Salinas E,Stanford TR,Constantinidis C

更新日期：2014-03-11 00:00:00

abstract：:The study of information-processing adaptations in the brain is controversial, in part because of disputes about the form such adaptations might take. Many psychologists assume that adaptations come in two kinds, specialized and general-purpose. Specialized mechanisms are typically thought of as innate, domain-specifi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Barrett HC

更新日期：2012-06-26 00:00:00

abstract：:Achieving label-free, molecular-specific imaging with high spatial resolution in deep tissue is often considered the grand challenge of optical imaging. To accomplish this goal, significant optical scattering in tissues has to be overcome while achieving molecular specificity without resorting to extrinsic labeling. W...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yakovlev VV,Zhang HF,Noojin GD,Denton ML,Thomas RJ,Scully MO

更新日期：2010-11-23 00:00:00

abstract：:Excitatory amino acid transporters (EAATs) buffer and remove synaptically released L-glutamate and maintain its concentrations below neurotoxic levels. EAATs also mediate a thermodynamically uncoupled substrate-gated anion conductance that may modulate cell excitability. Here, we demonstrate that modification of a cys...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Seal RP,Shigeri Y,Eliasof S,Leighton BH,Amara SG

更新日期：2001-12-18 00:00:00

abstract：:The rise of animals occurred during an interval of Earth history that witnessed dynamic marine redox conditions, potentially rapid plate motions, and uniquely large perturbations to global biogeochemical cycles. The largest of these perturbations, the Shuram carbon isotope excursion, has been invoked as a driving mech...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rooney AD,Cantine MD,Bergmann KD,Gómez-Pérez I,Al Baloushi B,Boag TH,Busch JF,Sperling EA,Strauss JV

更新日期：2020-07-21 00:00:00

abstract：:Gaseous HCl generated from a variety of sources is ubiquitous in both outdoor and indoor air. Oxides of nitrogen (NO(y)) are also globally distributed, because NO formed in combustion processes is oxidized to NO(2), HNO(3), N(2)O(5) and a variety of other nitrogen oxides during transport. Deposition of HCl and NO(y) o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Raff JD,Njegic B,Chang WL,Gordon MS,Dabdub D,Gerber RB,Finlayson-Pitts BJ

更新日期：2009-08-18 00:00:00

abstract：:Most variation in behavior has a genetic basis, but the processes determining the level of diversity at behavioral loci are largely unknown for natural populations. Expression of arginine vasopressin receptor 1a (Avpr1a) and oxytocin receptor (Oxtr) in specific regions of the brain regulates diverse social and reprodu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lonn E,Koskela E,Mappes T,Mokkonen M,Sims AM,Watts PC

更新日期：2017-04-04 00:00:00