Jupiter's decisive role in the inner Solar System's early evolution.

abstract：:Glioblastoma multiforme (GBM; grade IV astrocytoma) is the most prevalent and aggressive form of primary brain cancer. A subpopulation of multipotent cells termed GBM cancer stem cells (CSCs) play a critical role in tumor initiation, tumor maintenance, metastasis, drug resistance, and recurrence following surgery. Her...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lucki NC,Villa GR,Vergani N,Bollong MJ,Beyer BA,Lee JW,Anglin JL,Spangenberg SH,Chin EN,Sharma A,Johnson K,Sander PN,Gordon P,Skirboll SL,Wurdak H,Schultz PG,Mischel PS,Lairson LL

更新日期：2019-03-26 00:00:00

abstract：:Electron spectroscopic imaging, a new technique that permits the quantitative detection of the spatial distributions of atomic elements at high resolution, has been applied to the epiphyseal zone of hypertrophy in the mouse for the visualization of calcium, phosphorus, and sulfur. Longitudinally sectioned epiphyseal g...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Arsenault AL,Ottensmeyer FP

更新日期：1983-03-01 00:00:00

abstract：:The cellular replicative DNA polymerases cannot initiate DNA synthesis without a priming 3' OH. During DNA replication, this is supplied in the context of a short RNA primer molecule synthesized by DNA primase. The primase of archaea and eukaryotes, despite having varying subunit compositions, share sequence and struc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yan J,Holzer S,Pellegrini L,Bell SD

更新日期：2018-06-26 00:00:00

abstract：:In epithelia, a primary damage of tight junctions (TJ) always leads to a secondary disruption of adherens junction (AJ), and vice versa. This response, if occurring in the testis, would disrupt spermatogenesis because the blood-testis barrier (BTB) must remain intact during the transit of spermatids in the seminiferou...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lie PP,Chan AY,Mruk DD,Lee WM,Cheng CY

更新日期：2010-06-22 00:00:00

abstract：:Two genes have a synthetically lethal relationship when the silencing or inhibiting of 1 gene is only lethal in the context of a mutation or activation of the second gene. This situation offers an attractive therapeutic strategy, as inhibition of such a gene will only trigger cell death in tumor cells with an activate...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Molenaar JJ,Ebus ME,Geerts D,Koster J,Lamers F,Valentijn LJ,Westerhout EM,Versteeg R,Caron HN

更新日期：2009-08-04 00:00:00

abstract：:Metastasis of solid tumors is a key determinant of cancer patient survival. Targeting micrometastases using nanoparticles could offer a way to stop metastatic tumor growth before it causes excessive patient morbidity. However, nanoparticle delivery to micrometastases is difficult to investigate because micrometastases...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kingston BR,Syed AM,Ngai J,Sindhwani S,Chan WCW

更新日期：2019-07-23 00:00:00

abstract：:Rearrangements between tandem sequence homologies of various lengths are a major source of genomic change and can be deleterious to the organism. These rearrangements can result in either deletion or duplication of genetic material flanked by direct sequence repeats. Molecular genetic analysis of repetitive sequence i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bzymek M,Lovett ST

更新日期：2001-07-17 00:00:00

abstract：:The c-Raf-1 protein kinase plays a central role in the mitogenic response of cells to growth factors, cytokines, and many oncogenes. Despite the critical importance of this enzyme, very little is known of its biochemical properties or mechanisms of regulation. In these experiments, we used the only candidate physiolog...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Force T,Bonventre JV,Heidecker G,Rapp U,Avruch J,Kyriakis JM

更新日期：1994-02-15 00:00:00

abstract：:In Saccharomyces cerevisiae Mediator, a subgroup of proteins (Srb8, Srb9, Srb10, and Srb11) form a module, which is involved in negative regulation of transcription. Homologues of Srb10 and Srb11 are found in some mammalian Mediator preparations, whereas no clear homologues have been reported for Srb8 and Srb9. Here, ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Samuelsen CO,Baraznenok V,Khorosjutina O,Spahr H,Kieselbach T,Holmberg S,Gustafsson CM

更新日期：2003-05-27 00:00:00

abstract：:Dysregulation of cyclin-dependent kinase 5 (cdk5) per relative concentrations of its activators p35 and p25 is implicated in neurodegenerative diseases. P35 has a short t½ and undergoes rapid proteasomal degradation in its membrane-bound myristoylated form. P35 is converted by calpain to p25, which, along with an exte...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tsai SY,Pokrass MJ,Klauer NR,Nohara H,Su TP

更新日期：2015-05-26 00:00:00

abstract：:In most cervical carcinoma cells the E6 and E7 genes of specific human papillomaviruses are transcribed from viral sequences integrated into host cell chromosomes. Glucocorticoids activate the promoter elements of various human papillomaviruses in transient-expression assays. We have analyzed the effect of dexamethaso...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： von Knebel Doeberitz M,Bauknecht T,Bartsch D,zur Hausen H

更新日期：1991-02-15 00:00:00

abstract：:von Willebrand factor (VWF), a protein present in our circulatory system, is necessary to stop bleeding under high shear-stress conditions as found in small blood vessels. The results presented here help unravel how an increase in hydrodynamic shear stress activates VWF's adhesion potential, leading to the counterintu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schneider SW,Nuschele S,Wixforth A,Gorzelanny C,Alexander-Katz A,Netz RR,Schneider MF

更新日期：2007-05-08 00:00:00

abstract：:We report the optical conductivity in high-quality crystals of the chiral topological semimetal CoSi, which hosts exotic quasiparticles known as multifold fermions. We find that the optical response is separated into several distinct regions as a function of frequency, each dominated by different types of quasiparticl...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Xu B,Fang Z,Sánchez-Martínez MÁ,Venderbos JWF,Ni Z,Qiu T,Manna K,Wang K,Paglione J,Bernhard C,Felser C,Mele EJ,Grushin AG,Rappe AM,Wu L

更新日期：2020-11-03 00:00:00

abstract：:Vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase-activating polypeptide (PACAP) are two mediators synthesized by immune cells, specially under inflammatory and antigen stimulation conditions. Reports have shown that neuropeptides attenuate the deleterious consequences of septic shock both by down-re...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Martinez C,Abad C,Delgado M,Arranz A,Juarranz MG,Rodriguez-Henche N,Brabet P,Leceta J,Gomariz RP

更新日期：2002-01-22 00:00:00

abstract：:Visual transduction in Drosophila is a G protein-coupled phospholipase C-mediated process that leads to depolarization via activation of the transient receptor potential (TRP) calcium channel. Inactivation-no-afterpotential D (INAD) is an adaptor protein containing PDZ domains known to interact with TRP. Immunoprecipi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shieh BH,Zhu MY,Lee JK,Kelly IM,Bahiraei F

更新日期：1997-11-11 00:00:00

abstract：:Cells are exposed to changes in extracellular stimulus concentration that vary as a function of rate. However, how cells integrate information conveyed from stimulation rate along with concentration remains poorly understood. Here, we examined how varying the rate of stress application alters budding yeast mitogen-act...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Johnson AN,Li G,Jashnsaz H,Thiemicke A,Kesler BK,Rogers DC,Neuert G

更新日期：2021-01-12 00:00:00

abstract：:In Drosophila, Pumilio (Pum) is important for neuronal homeostasis as well as learning and memory. We have recently characterized a mammalian homolog of Pum, Pum2, which is found in discrete RNA-containing particles in the somatodendritic compartment of polarized neurons. In this study, we investigated the role of Pum...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vessey JP,Schoderboeck L,Gingl E,Luzi E,Riefler J,Di Leva F,Karra D,Thomas S,Kiebler MA,Macchi P

更新日期：2010-02-16 00:00:00

abstract：:Phyllosphere microbial communities were evaluated on leaves of field-grown plant species by culture-dependent and -independent methods. Denaturing gradient gel electrophoresis (DGGE) with 16S rDNA primers generally indicated that microbial community structures were similar on different individuals of the same plant sp...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yang CH,Crowley DE,Borneman J,Keen NT

更新日期：2001-03-27 00:00:00

abstract：:Molecular beacons are DNA probes that form a stem-and-loop structure and possess an internally quenched fluorophore. When they bind to complementary nucleic acids, they undergo a conformational transition that switches on their fluorescence. These probes recognize their targets with higher specificity than probes that...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bonnet G,Tyagi S,Libchaber A,Kramer FR

更新日期：1999-05-25 00:00:00

abstract：:The sense of body ownership represents a fundamental aspect of our self-awareness, but is disrupted in many neurological, psychiatric, and psychological conditions that are also characterized by disruption of skin temperature regulation, sometimes in a single limb. We hypothesized that skin temperature in a specific l...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Moseley GL,Olthof N,Venema A,Don S,Wijers M,Gallace A,Spence C

更新日期：2008-09-02 00:00:00

abstract：:We have isolated a segment of DNA from the eukaryote Saccharomyces cerevisiae (baker's yeast) as a viable molecular hybrid of bacteriophage lambda DNA which, when integrated into the chromosome of an E. coli histidine auxotroph, allows this bacterium to grow in the absence of histidine. The nonrevertable, histidine au...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Struhl K,Cameron JR,Davis RW

更新日期：1976-05-01 00:00:00

abstract：:Ancient societies are often used to illustrate the potential problems stemming from unsustainable land-use practices because the past seems rife with examples of sociopolitical "collapse" associated with the exhaustion of finite resources. Just as frequently, and typically in response to such presentations, archaeolog...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wills WH,Drake BL,Dorshow WB

更新日期：2014-08-12 00:00:00

abstract：:Oligodeoxyribonucleotides with site-specific modifications have been used as substrates for Escherichia coli DNA polymerase I holoenzyme and Klenow fragment. Modifications included the bulky guanine-8-aminofluorene adduct and a guanine oxidation product resembling the product of photosensitized DNA oxidation. By a com...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： O'Connor D,Stöhrer G

更新日期：1985-04-01 00:00:00

abstract：:Site-directed spin labeling EPR (SDSL-EPR) was used to determine the structure of the inhibitory region of TnI in the intact cardiac troponin ternary complex. Maeda and collaborators have modeled the inhibitory region of TnI (skeletal 96-112: the structural motif that communicates the Ca(2+) signal to actin) as a kink...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Brown LJ,Sale KL,Hills R,Rouviere C,Song L,Zhang X,Fajer PG

更新日期：2002-10-01 00:00:00

abstract：:The effect of 12-O-tetradecanoylphorbol 13-acetate (TPA), a potent tumor promoter, on the synthesis of proteins in BALB/c 3T3 mouse fibroblasts has been studied. When [35S]methionine-labeled proteins synthesized after the addition of TPA were analyzed by one- or two-dimensional polyacrylamide gel electrophoresis, the ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hiwasa T,Fujimura S,Sakiyama S

更新日期：1982-03-01 00:00:00

abstract：:Activation of the RET (rearranged during transfection) receptor by glial cell-line-derived neurotrophic factor (GDNF) has been identified as an important differentiation and survival factor for dopaminergic neurons of the midbrain in preclinical experiments. These encouraging results have led to clinical trials of GDN...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kowsky S,Pöppelmeyer C,Kramer ER,Falkenburger BH,Kruse A,Klein R,Schulz JB

更新日期：2007-12-11 00:00:00

abstract：:Voltage-dependent potassium channels (Kv) are homotetramers composed of four voltage sensors and one pore domain. Because of high-level structural flexibility, the first mammalian Kv structure, Kv1.2 at 2.9 A, has about 37% molecular mass of the transmembrane portion not resolved. In this study, by applying a novel no...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chen X,Wang Q,Ni F,Ma J

更新日期：2010-06-22 00:00:00

abstract：:We report the application of quantitative mass spectrometry to identify plasma membrane proteins differentially expressed in melanoma cells with high vs. low metastatic abilities. Using stable isotope labeling with amino acids in culture (SILAC) coupled with nanospray tandem mass spectrometry, we identified CUB-domain...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liu H,Ong SE,Badu-Nkansah K,Schindler J,White FM,Hynes RO

更新日期：2011-01-25 00:00:00

abstract：:Seemingly similar individuals often experience drastically different success trajectories, with some repeatedly failing and others consistently succeeding. One explanation is preexisting variability along unobserved fitness dimensions that is revealed gradually through differential achievement. Alternatively, positive...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： van de Rijt A,Kang SM,Restivo M,Patil A

更新日期：2014-05-13 00:00:00

abstract：:The fluorescence of the supposedly buried tryptophan in ribonuclease T1 has been found to be collisionally quenched by acrylamide with a rate constant of 3 X 10(8) M--1 sec--1. Only a slight decrease in the quenching rate is observed upon a 5-fold increase in the viscosity of the solution. For this to be the case, the...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Eftink MR,Ghiron CA

更新日期：1975-09-01 00:00:00