Histone code pathway involving H3 S28 phosphorylation and K27 acetylation activates transcription and antagonizes polycomb silencing.

abstract：:Rat hepatoma cells infected with mouse mammary tumor virus contain multiple forms of unintegrated viral DNA when grown in the presence of glucocorticoids. Using the DNA transfer procedure of Southern, we have prepared restriction endonuclease fragment maps of these forms of viral DNA. The maps indicate that: (i) the m...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shank PR,Cohen JC,Varmus HE,Yamamoto KR,Ringold GM

更新日期：1978-05-01 00:00:00

abstract：:Gastrulation is a fundamental process in early development that results in the formation of three primary germ layers. During avian gastrulation, presumptive mesodermal cells in the dorsal epiblast ingress through a furrow called the primitive streak (PS), and subsequently move away from the PS and form adult tissues....

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zamir EA,Czirók A,Cui C,Little CD,Rongish BJ

更新日期：2006-12-26 00:00:00

abstract：:The adrenergic receptors (ARs) (subtypes alpha 1, alpha 2, beta 1, and beta 2) are a prototypic family of guanine nucleotide binding regulatory protein-coupled receptors that mediate the physiological effects of the hormone epinephrine and the neurotransmitter norepinephrine. We have previously assigned the genes for ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yang-Feng TL,Xue FY,Zhong WW,Cotecchia S,Frielle T,Caron MG,Lefkowitz RJ,Francke U

更新日期：1990-02-01 00:00:00

abstract：:Despite growing evidence for perceptual interactions between motion and position, no unifying framework exists to account for these two key features of our visual experience. We show that percepts of both object position and motion derive from a common object-tracking system--a system that optimally integrates sensory...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kwon OS,Tadin D,Knill DC

更新日期：2015-06-30 00:00:00

abstract：:Helicobacter pylori VacA, a pore-forming toxin secreted by an autotransporter pathway, causes multiple alterations in human cells, contributes to the pathogenesis of peptic ulcer disease and gastric cancer, and is a candidate antigen for inclusion in an H. pylori vaccine. Here, we present a 2.4-A crystal structure of ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gangwer KA,Mushrush DJ,Stauff DL,Spiller B,McClain MS,Cover TL,Lacy DB

更新日期：2007-10-09 00:00:00

abstract：:Free hydrogen (H2) is a basal energy source underlying chemosynthetic activity within igneous ocean crust. In an attempt to systematically account for all H2 within young oceanic lithosphere (<10 Ma) near the Mid-Ocean Ridge (MOR), we construct a box model of this environment. Within this control volume, we assess abi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Worman SL,Pratson LF,Karson JA,Schlesinger WH

更新日期：2020-06-16 00:00:00

abstract：:Positive lower bounds for pseudo-differential operators with nonnegative symbols are derived; the bounds in particular yield subelliptic estimates for operators arising as sums of squares of vector fields. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fefferman C,Phong DH

更新日期：1979-12-01 00:00:00

abstract：:Pseudomonas aeruginosa infects every type of host that has been examined by deploying multiple virulence factors. Previous studies of virulence regulation have largely focused on chemical cues, but P. aeruginosa may also respond to mechanical cues. Using a rapid imaging-based virulence assay, we demonstrate that P. ae...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Siryaporn A,Kuchma SL,O'Toole GA,Gitai Z

更新日期：2014-11-25 00:00:00

abstract：:Macrophage responses to Francisella infection have been characterized previously by subdued proinflammatory responses; however, these studies have generally focused on macrophage cell lines or monocyte-derived macrophages. Therefore, we studied the ability of fresh human blood monocytes to engulf and respond to Franci...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gavrilin MA,Bouakl IJ,Knatz NL,Duncan MD,Hall MW,Gunn JS,Wewers MD

更新日期：2006-01-03 00:00:00

abstract：:Homeostasis of intravascular volume, Na(+), Cl(-), and K(+) is interdependent and determined by the coordinated activities of structurally diverse mediators in the distal nephron and the distal colon. The behavior of these flux pathways is regulated by the renin-angiotensin-aldosterone system; however, the mechanisms ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ring AM,Cheng SX,Leng Q,Kahle KT,Rinehart J,Lalioti MD,Volkman HM,Wilson FH,Hebert SC,Lifton RP

更新日期：2007-03-06 00:00:00

abstract：:Ice streams are narrow corridors of fast-flowing ice that constitute the arterial drainage network of ice sheets. Therefore, changes in ice stream flow are key to understanding paleoclimate, sea level changes, and rapid disintegration of ice sheets during deglaciation. The dynamics of ice flow are tightly coupled to t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mantelli E,Bertagni MB,Ridolfi L

更新日期：2016-08-09 00:00:00

abstract：:A biological membrane is conceptualized as a system in which membrane proteins are naturally matched to the equilibrium thickness of the lipid bilayer. Cholesterol, in addition to lipid composition, has been suggested to be a major regulator of bilayer thickness in vivo because measurements in vitro have shown that ch...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mitra K,Ubarretxena-Belandia I,Taguchi T,Warren G,Engelman DM

更新日期：2004-03-23 00:00:00

abstract：:The importance of identifying VEGF-independent pathways in pathological angiogenesis is increasingly recognized as a result of the emerging drug resistance to anti-VEGF therapies. PDGF-CC is the third member of the PDGF family discovered after more than two decades of studies on PDGF-AA and PDGF-BB. The biological fun...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hou X,Kumar A,Lee C,Wang B,Arjunan P,Dong L,Maminishkis A,Tang Z,Li Y,Zhang F,Zhang SZ,Wardega P,Chakrabarty S,Liu B,Wu Z,Colosi P,Fariss RN,Lennartsson J,Nussenblatt R,Gutkind JS,Cao Y,Li X

更新日期：2010-07-06 00:00:00

abstract：:A human Burkitt lymphoma cell line, Raji-HN2, made 10-fold more resistant to nitrogen mustard (HN2) than the parental Raji cell line, exhibited the following characteristics when compared to the parental Raji cells: (i) decreased HN2-induced DNA interstrand crosslinking; (ii) increased (3-fold) DNA topoisomerase II [D...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tan KB,Mattern MR,Boyce RA,Schein PS

更新日期：1987-11-01 00:00:00

abstract：:High-resolution magnetic resonance microscopy (MRM) was used to determine regional brain volumetric changes in a mouse model of Alzheimer's disease. These transgenic (Tg) mice overexpress human mutant amyloid precursor protein (APP) V717F under control of platelet-derived growth factor promoter (PDAPP mice), and corti...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Redwine JM,Kosofsky B,Jacobs RE,Games D,Reilly JF,Morrison JH,Young WG,Bloom FE

更新日期：2003-02-04 00:00:00

abstract：:Fungal cell walls and fragments thereof (elicitors) induce the formation of low and high molecular weight defense compounds in plant cell suspension cultures. This induced synthesis requires a signal molecule transmitting the message between the elicitor plant cell wall receptor and gene activation. We demonstrate in ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mueller MJ,Brodschelm W,Spannagl E,Zenk MH

更新日期：1993-08-15 00:00:00

abstract：:Less than 100 cis-regulatory DNAs have been characterized in the context of transgenic metazoan embryos. Here we investigate the feasibility of conducting a genome-wide search for tissue-specific enhancers in the ascidian Ciona intestinalis. A total of 138 random genomic DNA fragments with an average size of 1.7 kb we...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Harafuji N,Keys DN,Levine M

更新日期：2002-05-14 00:00:00

abstract：:It is possible, by using Fourier-transform infrared (FTIR) difference spectroscopy, to detect the conformational changes occurring in both the protein and the chromophore of bacteriorhodopsin during the photocycle. In contrast to Raman spectroscopy, a laser is unnecessary and hence the problem of a perturbing probe be...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rothschild KJ,Marrero H

更新日期：1982-07-01 00:00:00

abstract：:In eukaryotes, RNA polymerase I transcription is controlled by DNA elements located within the spacers that separate the tandemly arranged rRNA genes. Unlike rRNA coding sequences, the intergenic spacers evolve rapidly and have little sequence similarity even among closely related species. Nonetheless, the arrangement...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Doelling JH,Gaudino RJ,Pikaard CS

更新日期：1993-08-15 00:00:00

abstract：:Two high molecular weight growth inhibitors have been isolated from the culture medium of BSC-1 cells, epithelial cells of African green monkey kidney. The purified kidney epithelial cell growth inhibitors, at ng/ml concentrations, reversibly arrest the growth of BSC-1 cells in the G1 phase of the cell cycle. Their ac...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Holley RW,Böhlen P,Fava R,Baldwin JH,Kleeman G,Armour R

更新日期：1980-10-01 00:00:00

abstract：:The cheA locus of Escherichia coli, which is required for chemotactic behavior, encodes two polypeptide products designated p[cheA]L and p[cheA]S. The mode of synthesis of these two proteins was investigated by transferring various missense and nonsense mutations to a lambda transducing phage and observing the mutant ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Smith RA,Parkinson JS

更新日期：1980-09-01 00:00:00

abstract：:Two continuous-suspension lymphocyte lines were isolated from the spleen and fibrosarcoma of a New Zealand Black female mouse. A C-type virus with a density of 1.16 g x cm(-3), 70S RNA, and RNA-directed DNA polymerase activity was isolated. The virus was infectious for NRK, NZB, (NZB x NZW)F(1), and (NZW x NZW)F(1) em...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lerner RA,Jensen F,Kennel SJ,Dixon FJ,Des Roches G,Francke U

更新日期：1972-10-01 00:00:00

abstract：:We introduce and analyze a general model of a population evolving over a network of selectively neutral genotypes. We show that the population's limit distribution on the neutral network is solely determined by the network topology and given by the principal eigenvector of the network's adjacency matrix. Moreover, the...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： van Nimwegen E,Crutchfield JP,Huynen M

更新日期：1999-08-17 00:00:00

abstract：:In the cell, proteins are synthesized from N to C terminus and begin to fold during translation. Cotranslational folding mechanisms are therefore linked to elongation rate, which varies as a function of synonymous codon usage. However, synonymous codon substitutions can affect many distinct cellular processes, which h...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Walsh IM,Bowman MA,Soto Santarriaga IF,Rodriguez A,Clark PL

更新日期：2020-02-18 00:00:00

abstract：:In mitosis, chromosome, cytoskeleton, and organelle dynamics must be coordinated for successful cell division. Here, we present evidence for a role for Arf1, a small GTPase associated with the Golgi apparatus, in the orchestration of mitotic Golgi breakdown, chromosome segregation, and cytokinesis. We show that early ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Altan-Bonnet N,Phair RD,Polishchuk RS,Weigert R,Lippincott-Schwartz J

更新日期：2003-11-11 00:00:00

abstract：:The triphenylmethane derivative aurintricarboxylic acid (ATA), but not aurin, selectively prevented the binding of OKT4A/Leu-3a monoclonal antibody (mAb) and, to a lesser extent, OKT4 mAb to the CD4 cell receptor for human immunodeficiency virus type 1 (HIV-1). The effect was seen within 1 min at an ATA concentration ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schols D,Baba M,Pauwels R,Desmyter J,De Clercq E

更新日期：1989-05-01 00:00:00

abstract：:Photoactivation of the retinal photoreceptor rhodopsin proceeds through a cascade of intermediates, resulting in protein-protein interactions catalyzing the activation of the G-protein transducin (Gt). Using stabilization and photoregeneration of the receptor's signaling state and Gt activation assays, we provide evid...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kisselev OG,Meyer CK,Heck M,Ernst OP,Hofmann KP

更新日期：1999-04-27 00:00:00

abstract：:In the presence of the S polypeptide, maize chloroplast DNA-dependent RNA polymerase preferentially transcribes sequences within the 2200-nucleotide-pair-long maize chloroplast chromosome fragment Eco [unk] from a supercoiled chimeric plasmid cloned in Escherichia coli [Jolly, S. O. & Bogorad, L. (1980) Proc. Natl. Ac...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schwarz Z,Jolly SO,Steinmetz AA,Bogorad L

更新日期：1981-06-01 00:00:00

abstract：:We used a high-titer recombinant adeno-associated virus (rAAV) vector to express WT or mutant human alpha-synuclein in the substantia nigra of adult marmosets. The alpha-synuclein protein was expressed in 90-95% of all nigral dopamine neurons and distributed by anterograde transport throughout their axonal and dendrit...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kirik D,Annett LE,Burger C,Muzyczka N,Mandel RJ,Björklund A

更新日期：2003-03-04 00:00:00

abstract：:A theoretical description of aqueous hydration in the minor groove of a B-form DNA is presented on the basis of a liquid-state Monte Carlo computer simulation on a system consisting of the oligonucleotide duplex d(CGCGAATTCGCG).d(GCGCTTAAGCGC) in a canonical B-form together with 1777 water molecules contained in a hex...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Subramanian PS,Ravishanker G,Beveridge DL

更新日期：1988-03-01 00:00:00