当前位置： SCI文献检索 > PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA期刊下所有文献 > Specific interaction of aurintricarboxylic acid with the human immunodeficiency virus/CD4 cell receptor.

Specific interaction of aurintricarboxylic acid with the human immunodeficiency virus/CD4 cell receptor.

Abstract：

:The triphenylmethane derivative aurintricarboxylic acid (ATA), but not aurin, selectively prevented the binding of OKT4A/Leu-3a monoclonal antibody (mAb) and, to a lesser extent, OKT4 mAb to the CD4 cell receptor for human immunodeficiency virus type 1 (HIV-1). The effect was seen within 1 min at an ATA concentration of 10 microM in various T4+ cells (MT-4, U-937, peripheral blood lymphocytes, and monocytes). It was dose-dependent and reversible. ATA prevented the attachment of radiolabeled HIV-1 particles to MT-4 cells, which could be expected as the result of its specific binding to the HIV/CD4 receptor. Other HIV inhibitors such as suramin, fuchsin acid, azidothymidine, dextran sulfate, heparin, and pentosan polysulfate did not affect OKT4A/Leu-3a mAb binding to the CD4 receptor, although the sulfated polysaccharides suppressed HIV-1 adsorption to the cells at concentrations required for complete protection against HIV-1 cytopathogenicity. Thus, ATA is a selective marker molecule for the CD4 receptor. ATA also interfered with the staining of membrane-associated HIV-1 glycoprotein gp120 by a mAb against it. These unusual properties of a small molecule of nonimmunological origin may have important implications for the study of CD4/HIV/AIDS pathogenesis and possibly treatment.

journal_name

Proc Natl Acad Sci U S A

journal_title

Proceedings of the National Academy of Sciences of the United States of America

authors

Schols D,Baba M,Pauwels R,Desmyter J,De Clercq E

doi

10.1073/pnas.86.9.3322

subject

Has Abstract

pub_date

1989-05-01 00:00:00

pages

3322-6

issue

9

eissn

0027-8424

issn

1091-6490

journal_volume

86

pub_type

杂志文章

相关文献

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA文献大全
  • Electron transfer pathways in a multiheme cytochrome MtrF.

    abstract：:In MtrF, an outer-membrane multiheme cytochrome, the 10 heme groups are arranged in heme binding domains II and IV along the pseudo-C2 axis, forming the electron transfer (ET) pathways. Previous reports based on molecular dynamics simulations showed that the redox potential (Em) values for the heme pairs located in sy...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1617615114

    authors： Watanabe HC,Yamashita Y,Ishikita H

    更新日期：2017-03-14 00:00:00

  • Cross-talk of insulin-like peptides, juvenile hormone, and 20-hydroxyecdysone in regulation of metabolism in the mosquito Aedes aegypti.

    abstract：:Female mosquitoes feed sequentially on carbohydrates (nectar) and proteins (blood) during each gonadotrophic cycle to become reproductively competent and effective disease vectors. Accordingly, metabolism is synchronized to support this reproductive cyclicity. However, regulatory pathways linking metabolism to reprodu...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.2023470118

    authors： Ling L,Raikhel AS

    更新日期：2021-02-09 00:00:00

  • Transcription of cloned tRNA gene fragments and subfragments injected into the oocyte nucleus of Xenopus laevis.

    abstract：:Cloned 3.18 kilobase fragments of Xenopus laevis DNA containing genes for tRNAMet1 and for at least one other 4S RNA species are transcribed rapidly after their injection into the nucleus of X. laevis oocytes. The newly synthesized RNA can be resolved by gel electrophoresis into a few predominant 4S RNA species and a ...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.75.3.1176

    authors： Kressmann A,Clarkson SG,Pirrotta V,Birnstiel ML

    更新日期：1978-03-01 00:00:00

  • The effect of climate variations on the dynamics of pasture-livestock interactions under cooperative and noncooperative management.

    abstract：:It is well known from Hardin's "Tragedy of the Commons" [Hardin G (1968) Science 162:1243-1248] that, if open access is allowed, overgrazing typically results. Hardin, and most authors of the subsequent literature, adopted a static view of the underlying ecosystem. Here we extend this tragedy of the commons to conside...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.0706553104

    authors： Brekke KA,Øksendal B,Stenseth NC

    更新日期：2007-09-11 00:00:00

  • X-ray structure of glutathione S-transferase from the malarial parasite Plasmodium falciparum.

    abstract：:GSTs catalyze the conjugation of glutathione with a wide variety of hydrophobic compounds, generally resulting in nontoxic products that can be readily eliminated. In contrast to many other organisms, the malarial parasite Plasmodium falciparum possesses only one GST isoenzyme (PfGST). This GST is highly abundant in t...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.2333763100

    authors： Fritz-Wolf K,Becker A,Rahlfs S,Harwaldt P,Schirmer RH,Kabsch W,Becker K

    更新日期：2003-11-25 00:00:00

  • Two motion perception mechanisms revealed through distance-driven reversal of apparent motion.

    abstract：:We demonstrate two kinds of visual stimuli that exhibit motion in one direction when viewed from near and in the opposite direction from afar. These striking reversals occur because each kind of stimulus is constructed to simultaneously activate two different mechanisms: a short-range mechanism that computes motion fr...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.86.8.2985

    authors： Chubb C,Sperling G

    更新日期：1989-04-01 00:00:00

  • Proteins with H-bond packing defects are highly interactive with lipid bilayers: Implications for amyloidogenesis.

    abstract：:We noticed that disease-related amyloidogenic proteins and especially cellular prion proteins have the highest proportion of incompletely desolvated backbone H bonds among soluble proteins. Such bonds are vulnerable to water attack and thus represent structural weaknesses. We have measured the adsorption of proteins o...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.0335642100

    authors： Fernández A,Berry RS

    更新日期：2003-03-04 00:00:00

  • Mechanisms determining aerobic or anaerobic growth in the facultative anaerobe Salmonella typhimurium.

    abstract：:We isolated mutant strains of the facultative anaerobe Salmonella typhimurium that grow either aerobically or anaerobically. Strict anaerobic mutants contained a defective DNA topoisomerase I gene (topI), while strict aerobic mutants contained a defective DNA gyrase subunit A gene (gyrA, also nalA). Topoisomerase I ac...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.82.7.2077

    authors： Yamamoto N,Droffner ML

    更新日期：1985-04-01 00:00:00

  • Developmental studies of phospholipid-sensitive Ca2+-dependent protein kinase and its substrates and of phosphoprotein phosphatases in rat brain.

    abstract：:Ontogenetic changes in the protein phosphorylation/dephosphorylation systems in rat brain were investigated. It was found that the activity level of phospholipid-sensitive Ca2+-dependent protein kinase (PL-Ca-PK) in the particulate fraction of grey and white matter and the soluble fraction of grey matter increased rap...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.81.10.3143

    authors： Turner RS,Raynor RL,Mazzei GJ,Girard PR,Kuo JF

    更新日期：1984-05-01 00:00:00

  • Experimental constraints on mate preferences in Drosophila pseudoobscura decrease offspring viability and fitness of mated pairs.

    abstract：:Using Drosophila pseudoobscura, we tested the hypothesis that social constraints on the free expression of mate preferences, by both females and males, decrease offspring viability and reproductive success of mating pairs. Mate preference arenas eliminated intrasexual combat and intersexual coercion. The time female a...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.0611152104

    authors： Anderson WW,Kim YK,Gowaty PA

    更新日期：2007-03-13 00:00:00

  • Coarse-grained analysis of stochasticity-induced switching between collective motion states.

    abstract：:A single animal group can display different types of collective motion at different times. For a one-dimensional individual-based model of self-organizing group formation, we show that repeated switching between distinct ordered collective states can occur entirely because of stochastic effects. We introduce a framewo...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.0608270104

    authors： Kolpas A,Moehlis J,Kevrekidis IG

    更新日期：2007-04-03 00:00:00

  • Trust, cooperation, and market formation in the U.S. and Japan.

    abstract：:Compared with the U.S., Japan is believed to have a collectivist culture that nurtures high trust. Results from laboratory and survey research, however, show that Americans are more likely to trust strangers than are Japanese. Why would trust be lower in a collectivist culture? We use an agent-based computational mode...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.082097399

    authors： Macy MW,Sato Y

    更新日期：2002-05-14 00:00:00

  • Molecular mechanisms of substrate-controlled ring dynamics and substepping in a nucleic acid-dependent hexameric motor.

    abstract：:Ring-shaped hexameric helicases and translocases support essential DNA-, RNA-, and protein-dependent transactions in all cells and many viruses. How such systems coordinate ATPase activity between multiple subunits to power conformational changes that drive the engagement and movement of client substrates is a fundame...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1616745113

    authors： Thomsen ND,Lawson MR,Witkowsky LB,Qu S,Berger JM

    更新日期：2016-11-29 00:00:00

  • Kinetoplast DNA minicircles: regions of extensive sequence divergence.

    abstract：:Previous work has shown that the kinetoplast minicircle DNA of Leishmania species exhibits species-specific sequence divergence and this observation has led to the development of a DNA probe-based diagnostic test for leishmaniasis. In the work reported here, we demonstrate that the minicircle is composed of three type...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.84.2.565

    authors： Rogers WO,Wirth DF

    更新日期：1987-01-01 00:00:00

  • Real-time imaging of calcium influx in mammalian cerebellar Purkinje cells in vitro.

    abstract：:Real-time visualization of intracellular calcium concentration ([Ca2+]i) changes in mammalian Purkinje cells in vitro, utilizing the dye Fura-2, indicates that calcium action potentials are generated in the dendritic tree and follow a particular activation sequence. During spontaneous oscillations or after direct curr...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.87.13.5084

    authors： Sugimori M,Llinás RR

    更新日期：1990-07-01 00:00:00

  • Short-term exposure to pregnancy levels of estrogen prevents mammary carcinogenesis.

    abstract：:It is well established that pregnancy early in life reduces the risk of breast cancer in women and that this effect is universal. This phenomenon of parity protection against mammary cancer is also observed in rodents. Earlier studies have demonstrated that short-term administration of estradiol (E) in combination wit...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.201393798

    authors： Rajkumar L,Guzman RC,Yang J,Thordarson G,Talamantes F,Nandi S

    更新日期：2001-09-25 00:00:00

  • BCL6 promoter interacts with far upstream sequences with greatly enhanced activating histone modifications in germinal center B cells.

    abstract：:BCL6 encodes a transcriptional repressor that is essential for the germinal center (GC) reaction and important in lymphomagenesis. Although its promoter has been well studied, little is known concerning its possible regulation by more distal elements. To gain such information, we mapped critical histone modifications ...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1004962107

    authors： Ramachandrareddy H,Bouska A,Shen Y,Ji M,Rizzino A,Chan WC,McKeithan TW

    更新日期：2010-06-29 00:00:00

  • Male-specific transcription initiation of the C4-Slp gene in mouse liver follows activation of STAT5.

    abstract：:The mouse genes encoding the constitutively expressed complement component C4 and its closely related isoform C4-Slp (sex-limited protein), which is expressed only in male animals of several strains, provide a unique model to study sequence elements and trans-acting factors responsible for androgen responsiveness. Our...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.95.15.8750

    authors： Varin-Blank N,Dondi E,Tosi M,Hernandez C,Boucontet L,Gotoh H,Shiroishi T,Moriwaki K,Meo T

    更新日期：1998-07-21 00:00:00

  • Smooth muscle myosin mutants containing a single tryptophan reveal molecular interactions at the actin-binding interface.

    abstract：:Elucidation of the molecular details of the cyclic actomyosin interaction requires the ability to examine structural changes at specific sites in the actin-binding interface of myosin. To study these changes dynamically, we have expressed two mutants of a truncated fragment of chicken gizzard smooth muscle myosin, whi...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.95.22.12944

    authors： Yengo CM,Fagnant PM,Chrin L,Rovner AS,Berger CL

    更新日期：1998-10-27 00:00:00

  • Rice-based mucosal vaccine as a global strategy for cold-chain- and needle-free vaccination.

    abstract：:Capable of inducing antigen-specific immune responses in both systemic and mucosal compartments without the use of syringe and needle, mucosal vaccination is considered ideal for the global control of infectious diseases. In this study, we developed a rice-based oral vaccine expressing cholera toxin B subunit (CTB) un...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.0703766104

    authors： Nochi T,Takagi H,Yuki Y,Yang L,Masumura T,Mejima M,Nakanishi U,Matsumura A,Uozumi A,Hiroi T,Morita S,Tanaka K,Takaiwa F,Kiyono H

    更新日期：2007-06-26 00:00:00

  • Stable nematic droplets with handles.

    abstract：:We stabilize nematic droplets with handles against surface tension-driven instabilities, using a yield-stress material as outer fluid, and study the complex nematic textures and defect structures that result from the competition between topological constraints and the elasticity of the nematic liquid crystal. We uncov...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1221380110

    authors： Pairam E,Vallamkondu J,Koning V,van Zuiden BC,Ellis PW,Bates MA,Vitelli V,Fernandez-Nieves A

    更新日期：2013-06-04 00:00:00

  • The N-terminal amino-acid sequence of bovine proparathyroid hormone.

    abstract：:Proparathyroid hormone (calcemic fraction-A) is a biosynthetic precursor of parathyroid hormone in bovine glands. Limited amounts of the isolated prohormone have been obtained for the purpose of initial structural studies. The results of automated sequence analysis on two separate preparations indicate that the N-term...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.71.3.653

    authors： Hamilton JW,Niall HD,Jacobs JW,Keutmann HT,Potts JT Jr,Cohn DV

    更新日期：1974-03-01 00:00:00

  • Aire unleashes stalled RNA polymerase to induce ectopic gene expression in thymic epithelial cells.

    abstract：:Aire is a transcriptional regulator that induces expression of peripheral tissue antigens (PTA) in thymic medullary epithelial cells (MECs), driving immunological self-tolerance in differentiating T cells. To elucidate its mechanistic pathways, we examined its transcriptional impact in MECs in vivo by microarray analy...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1119351109

    authors： Giraud M,Yoshida H,Abramson J,Rahl PB,Young RA,Mathis D,Benoist C

    更新日期：2012-01-10 00:00:00

  • Wireless, soft electronics for rapid, multisensor measurements of hydration levels in healthy and diseased skin.

    abstract：:Precise, quantitative measurements of the hydration status of skin can yield important insights into dermatological health and skin structure and function, with additional relevance to essential processes of thermoregulation and other features of basic physiology. Existing tools for determining skin water content expl...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.2020398118

    authors： Kwon K,Wang H,Lim J,Chun KS,Jang H,Yoo I,Wu D,Chen AJ,Gu CG,Lipschultz L,Kim JU,Kim J,Jeong H,Luan H,Park Y,Su CJ,Ishida Y,Madhvapathy SR,Ikoma A,Kwak JW,Yang DS,Banks A,Xu S,Huang Y,Chang JK,Rogers JA

    更新日期：2021-02-02 00:00:00

  • Lysinuric protein intolerance mutation is expressed in the plasma membrane of cultured skin fibroblasts.

    abstract：:Lysinuric protein intolerance (LPI) is an autosomal recessive phenotype consistent with impaired transport of cationic amino acids at the basolateral membrane of intestinal and renal epithelia. On the assumption that the basolateral membrane of epithelial cells and plasma membrane of parenchymal cells are functional a...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.84.21.7711

    authors： Smith DW,Scriver CR,Tenenhouse HS,Simell O

    更新日期：1987-11-01 00:00:00

  • Nanoscale imaging reveals laterally expanding antimicrobial pores in lipid bilayers.

    abstract：:Antimicrobial peptides are postulated to disrupt microbial phospholipid membranes. The prevailing molecular model is based on the formation of stable or transient pores although the direct observation of the fundamental processes is lacking. By combining rational peptide design with topographical (atomic force microsc...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1222824110

    authors： Rakowska PD,Jiang H,Ray S,Pyne A,Lamarre B,Carr M,Judge PJ,Ravi J,Gerling UI,Koksch B,Martyna GJ,Hoogenboom BW,Watts A,Crain J,Grovenor CR,Ryadnov MG

    更新日期：2013-05-28 00:00:00

  • Purification of erythropoietin.

    abstract：:Erythropoietin, the hormone that is the primary regulator of erythrocyte production, has been purified from anemic-sheep plasma, with a purification factor of more than 1 million. Gel electrophoresis shows that the major contaminant is desialated erythropoietin. ...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.68.4.697

    authors： Goldwasser E,Kung CK

    更新日期：1971-04-01 00:00:00

  • Reduced production of B-1-specified common lymphoid progenitors results in diminished potential of adult marrow to generate B-1 cells.

    abstract：:B-1 B cells have been proposed to be preferentially generated from fetal progenitors, but this view is challenged by studies concluding that B-1 production is sustained throughout adult life. To address this controversy, we compared the efficiency with which hematopoietic stem cells (HSCs) and common lymphoid progenit...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1107172108

    authors： Barber CL,Montecino-Rodriguez E,Dorshkind K

    更新日期：2011-08-16 00:00:00

  • Role of loop-helix interactions in stabilizing four-helix bundle proteins.

    abstract：:One of the critical issues regarding proteins with a four-helix bundle motif is which interactions play the major role in stabilizing this type of folded structure: the interaction among the four alpha-helices or the interaction between the loop and helix segments. To answer this question, an energetic analysis has be...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.89.16.7315

    authors： Chou KC,Maggiora GM,Scheraga HA

    更新日期：1992-08-15 00:00:00

  • Enhanced anticancer activity of nanopreparation containing an MMP2-sensitive PEG-drug conjugate and cell-penetrating moiety.

    abstract：:In response to the challenges of cancer chemotherapeutics, including poor physicochemical properties, low tumor targeting, insufficient tumor cell internalization/bioavailability, and side effects, we developed a unique tumor-targeted micellar drug-delivery platform. Using paclitaxel as a model therapeutic, a nanoprep...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1304987110

    authors： Zhu L,Wang T,Perche F,Taigind A,Torchilin VP

    更新日期：2013-10-15 00:00:00