Abstract:
:B-1 B cells have been proposed to be preferentially generated from fetal progenitors, but this view is challenged by studies concluding that B-1 production is sustained throughout adult life. To address this controversy, we compared the efficiency with which hematopoietic stem cells (HSCs) and common lymphoid progenitors (CLPs) from neonates and adults generated B-1 cells in vivo and developed a clonal in vitro assay to quantify B-1 progenitor production from CLPs. Adult HSCs and CLPs generated fewer B-1 cells in vivo compared with their neonatal counterparts, a finding corroborated by the clonal studies that showed that the CLP compartment includes B-1- and B-2-specified subpopulations and that the former cells decrease in number after birth. Together, these data indicate that B-1 lymphopoiesis is not sustained at constant levels throughout life and define a heretofore unappreciated developmental heterogeneity within the CLP compartment.
journal_name
Proc Natl Acad Sci U S Aauthors
Barber CL,Montecino-Rodriguez E,Dorshkind Kdoi
10.1073/pnas.1107172108subject
Has Abstractpub_date
2011-08-16 00:00:00pages
13700-4issue
33eissn
0027-8424issn
1091-6490pii
1107172108journal_volume
108pub_type
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