Two motion perception mechanisms revealed through distance-driven reversal of apparent motion.

abstract：:We examine the IFN-alpha/beta-independent activation of cellular transcription that constitutes an early antiviral response of cells against influenza A and B viruses, which cause widespread epidemics in humans. We show that influenza B virus induces the synthesis in human cells of several mature mRNAs encoded by gene...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kim MJ,Latham AG,Krug RM

更新日期：2002-07-23 00:00:00

abstract：:Induction of differentiation and apoptosis in cancer cells through ligands of nuclear hormone receptors (NHRs) is a novel and promising approach to cancer therapy. All-trans-retinoic acid (ATRA), an RA receptor-specific NHR ligand, is now used for selective cancers. The NHR, peroxisome proliferator-activated receptor ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Elstner E,Müller C,Koshizuka K,Williamson EA,Park D,Asou H,Shintaku P,Said JW,Heber D,Koeffler HP

更新日期：1998-07-21 00:00:00

abstract：:In most human follicular B cell lymphomas the bcl-2 gene is up-regulated as a result of the t(14;18) chromosomal translocation generating a hybrid bcl-2-IgH mRNA. Recently, we have identified in t(14;18)-positive cells a bcl-2-IgH mRNA in the antisense orientation, putatively responsible for the overexpression of bcl-...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Morelli S,Delia D,Capaccioli S,Quattrone A,Schiavone N,Bevilacqua A,Tomasini S,Nicolin A

更新日期：1997-07-22 00:00:00

abstract：:Rhythmic, spontaneously pulsating cardiac cells cultured from newborn rats are immediately stimulated to beat faster by addition of a number of tubulin-binding agents but not by their non-tubulin-binding analogues. The tubulin-binding agents tested include vinblastine, vincristine, navelbine, two analogs of vinblastin...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lampidis TJ,Kolonias D,Savaraj N,Rubin RW

更新日期：1992-02-15 00:00:00

abstract：:A new class of Escherichia coli mutants, referred to as grn, has been isolated by localized mutagenesis. These mutations affect the sigma subunit of DNA-dependent RNA polymerase (ribonucleoside 5'-triphosphate:RNA nucleotidyltransferase, EC 2.7.7.6) by abolishing the expression of the lambda N gene, and they are close...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nakamura Y,Kurihara T,Saito H,Uchida H

更新日期：1979-09-01 00:00:00

abstract：:Voltage-gated KCNQ1 (Kv7.1) potassium channels are expressed abundantly in heart but they are also found in multiple other tissues. Differential coassembly with single transmembrane KCNE beta subunits in different cell types gives rise to a variety of biophysical properties, hence endowing distinct physiological roles...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yu H,Lin Z,Mattmann ME,Zou B,Terrenoire C,Zhang H,Wu M,McManus OB,Kass RS,Lindsley CW,Hopkins CR,Li M

更新日期：2013-05-21 00:00:00

abstract：:Blood viscosity decreases with shear stress, a property essential for an efficient perfusion of the vascular tree. Shear thinning is intimately related to the dynamics and mutual interactions of RBCs, the major component of blood. Because of the lack of knowledge about the behavior of RBCs under physiological conditio...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lanotte L,Mauer J,Mendez S,Fedosov DA,Fromental JM,Claveria V,Nicoud F,Gompper G,Abkarian M

更新日期：2016-11-22 00:00:00

abstract：:Epithelial tissues mechanically deform the surrounding extracellular matrix during embryonic development, wound repair, and tumor invasion. Ex vivo measurements of such multicellular tractions within three-dimensional (3D) biomaterials could elucidate collective dissemination during disease progression and enable prec...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Leggett SE,Patel M,Valentin TM,Gamboa L,Khoo AS,Williams EK,Franck C,Wong IY

更新日期：2020-03-17 00:00:00

abstract：:Human genetic studies have given evidence of familial, disease-causing mutations in the analogous amino acid residue shared by three related RNA binding proteins causative of three neurological diseases. Alteration of aspartic acid residue 290 of hnRNPA2 to valine is believed to predispose patients to multisystem prot...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Murray DT,Zhou X,Kato M,Xiang S,Tycko R,McKnight SL

更新日期：2018-10-16 00:00:00

abstract：:Fluctuations in resting-state functional connectivity occur but their behavioral significance remains unclear, largely because correlating behavioral state with dynamic functional connectivity states (DCS) engages probes that disrupt the very behavioral state we seek to observe. Observing spontaneous eyelid closures f...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang C,Ong JL,Patanaik A,Zhou J,Chee MW

更新日期：2016-08-23 00:00:00

abstract：:Karrikins are a class of seed germination stimulants identified in smoke from wildfires. Microarray analysis of imbibed Arabidopsis thaliana seeds was performed to identify transcriptional responses to KAR(1) before germination. A small set of genes that are regulated by KAR(1), even when germination is prevented by t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nelson DC,Flematti GR,Riseborough JA,Ghisalberti EL,Dixon KW,Smith SM

更新日期：2010-04-13 00:00:00

abstract：:Phototropin is a blue light photoreceptor for tropic responses, relocation of chloroplasts, and stomata opening in plants. Phototropin has two chromophoric domains named light-oxygen-voltage-sensing (LOV) 1 and 2 in the N-terminal half, and a serine/threonine (Ser/Thr) protein kinase motif in the C-terminal half. Conc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Matsuoka D,Tokutomi S

更新日期：2005-09-13 00:00:00

abstract：:Parathyroid cells have unusual responses to an increase in the external calcium concentration--a reduction in secretion and a depolarization. In an attempt to explain this behavior, we have studied voltage-clamped inside-out patches from bovine parathyroid cells. We found a potassium-selective channel that requires in...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jia M,Ehrenstein G,Iwasa K

更新日期：1988-10-01 00:00:00

abstract：:Pharmacological treatments designed to reactivate fetal γ-globin can lead to an effective and successful clinical outcome in patients with hemoglobinopathies. However, new approaches remain highly desired because such treatments are not equally effective for all patients, and toxicity issues remain. We have taken a sy...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chen J,Peterson KR,Iancu-Rubin C,Bieker JJ

更新日期：2010-09-28 00:00:00

abstract：:Transplantation of pancreatic islets for treating type 1 diabetes is restricted to patients with critical metabolic lability resulting from the need for immunosuppression and the shortage of donor organs. To overcome these barriers, we developed a strategy to macroencapsulate islets from different sources that allow t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ludwig B,Ludwig S,Steffen A,Knauf Y,Zimerman B,Heinke S,Lehmann S,Schubert U,Schmid J,Bleyer M,Schönmann U,Colton CK,Bonifacio E,Solimena M,Reichel A,Schally AV,Rotem A,Barkai U,Grinberg-Rashi H,Kaup FJ,Avni Y,J

更新日期：2017-10-31 00:00:00

abstract：:T cells are essential for immune defenses against pathogens, such that viability of naïve T cells before antigen encounter is critical to preserve a polyclonal repertoire and prevent immunodeficiencies. The viability of naïve T cells before antigen recognition is ensured by IL-7, which drives expression of the prosurv...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Miller ML,Mashayekhi M,Chen L,Zhou P,Liu X,Michelotti M,Tramontini Gunn N,Powers S,Zhu X,Evaristo C,Alegre ML,Molinero LL

更新日期：2014-05-20 00:00:00

abstract：:Chylomicron catabolism is known to be initiated by the enzyme lipoprotein lipase (triacylglycero-protein acylhydrolase, EC 3.1.1.34). Chylomicron remnants, produced by lipolysis, are rapidly taken up by the liver via an apolipoprotein E (apoE)-mediated, receptor-dependent process. The low density lipoprotein (LDL) rec...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Beisiegel U,Weber W,Bengtsson-Olivecrona G

更新日期：1991-10-01 00:00:00

abstract：:Toll-like receptors (TLRs) are expressed on innate immune cells and trigger inflammation upon detection of pathogens and host tissue injury. TLR-mediated proinflammatory-signaling pathways are counteracted by partially characterized anti-inflammatory mechanisms that prevent exaggerated inflammation and host tissue dam...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhou J,Wu R,High AA,Slaughter CA,Finkelstein D,Rehg JE,Redecke V,Häcker H

更新日期：2011-11-01 00:00:00

abstract：:Aberrant transcription of the pericentromeric human satellite II (HSATII) repeat is present in a wide variety of epithelial cancers. In deriving experimental systems to study its deregulation, we observed that HSATII expression is induced in colon cancer cells cultured as xenografts or under nonadherent conditions in ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bersani F,Lee E,Kharchenko PV,Xu AW,Liu M,Xega K,MacKenzie OC,Brannigan BW,Wittner BS,Jung H,Ramaswamy S,Park PJ,Maheswaran S,Ting DT,Haber DA

更新日期：2015-12-08 00:00:00

abstract：:Euarthropoda is one of the best-preserved fossil animal groups and has been the most diverse animal phylum for over 500 million years. Fossil Konservat-Lagerstätten, such as Burgess Shale-type deposits (BSTs), show the evolution of the euarthropod stem lineage during the Cambrian from 518 million years ago (Ma). The s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Daley AC,Antcliffe JB,Drage HB,Pates S

更新日期：2018-05-22 00:00:00

abstract：:Given their relatively small area, mangroves and their organic sediments are of disproportionate importance to global carbon sequestration and carbon storage. Peat deposition and preservation allows some mangroves to accrete vertically and keep pace with sea-level rise by growing on their own root remains. In this stu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ezcurra P,Ezcurra E,Garcillán PP,Costa MT,Aburto-Oropeza O

更新日期：2016-04-19 00:00:00

abstract：:Specific protein domains and amino acids responsible for the apparent capacity of P-glycoprotein (mdr) to recognize and transport a large group of structurally unrelated drugs have not been identified. We have introduced a single Ser----Phe substitution within the predicted TM11 domain of mdr1 (position 941) and mdr3 ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gros P,Dhir R,Croop J,Talbot F

更新日期：1991-08-15 00:00:00

abstract：:Cyclin E is an important regulator of cell cycle progression that together with cyclin-dependent kinase (cdk) 2 is crucial for the G1/S transition during the mammalian cell cycle. Previously, we showed that severe overexpression of cyclin E protein in tumor cells and tissues results in the appearance of lower molecula...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gray-Bablin J,Zalvide J,Fox MP,Knickerbocker CJ,DeCaprio JA,Keyomarsi K

更新日期：1996-12-24 00:00:00

abstract：:Human urokinase cDNA clones have been identified from a cDNA library prepared from total RNA of human fibroblasts transformed by simian virus 40 [Okayama, H. & Berg, P. (1983) Mol. Cell. Biol. 3, 280-289]. Synthetic oligonucleotides, corresponding to urokinase protein sequence, were used as probes. The cloned cDNA cov...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Verde P,Stoppelli MP,Galeffi P,Di Nocera P,Blasi F

更新日期：1984-08-01 00:00:00

abstract：:Expansins are unusual proteins discovered by virtue of their ability to mediate cell wall extension in plants. We identified cDNA clones for two cucumber expansins on the basis of peptide sequences of proteins purified from cucumber hypocotyls. The expansin cDNAs encode related proteins with signal peptides predicted ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shcherban TY,Shi J,Durachko DM,Guiltinan MJ,McQueen-Mason SJ,Shieh M,Cosgrove DJ

更新日期：1995-09-26 00:00:00

abstract：:A model of protein-ligand binding kinetics, in which slow solvent dynamics results from hydrophobic drying transitions, is investigated. Molecular dynamics simulations show that solvent in the receptor pocket can fluctuate between wet and dry states with lifetimes in each state that are long enough for the extraction ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mondal J,Morrone JA,Berne BJ

更新日期：2013-08-13 00:00:00

abstract：:Relaxin is a member of the insulin family of polypeptides that is best known as a reproductive hormone. In an effort to elucidate the mechanism of action of relaxin we previously localized the specific binding sites of a 32P-labeled relaxin in the rat uterus and brain. These studies suggested that, in addition to its ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Osheroff PL,Cronin MJ,Lofgren JA

更新日期：1992-03-15 00:00:00

abstract：:State-of-the-art NMR spectrometers using superconducting magnets have enabled, with their ultrafine spectral resolution, the determination of the structure of large molecules such as proteins, which is one of the most profound applications of modern NMR spectroscopy. Many chemical and biotechnological applications, ho...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ha D,Paulsen J,Sun N,Song YQ,Ham D

更新日期：2014-08-19 00:00:00

abstract：:The binding of thyroid hormone to the thyroid hormone receptor (TR) mediates important physiological effects. However, the transcriptional effects of TR mediated by the thyroid response element (TRE) cannot explain many actions of thyroid hormone. We postulate that TR can initiate rapid, non-TRE-mediated effects in th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hiroi Y,Kim HH,Ying H,Furuya F,Huang Z,Simoncini T,Noma K,Ueki K,Nguyen NH,Scanlan TS,Moskowitz MA,Cheng SY,Liao JK

更新日期：2006-09-19 00:00:00

abstract：:We present a method for designing a funnel-shaped free-energy surface that reproducibly assembles secondary structure elements of proteins into their native conformations from a random extended configuration. Assuming a priori knowledge of secondary structure, our method can design a funnel-shaped surface for folding ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fain B,Levitt M

更新日期：2003-09-16 00:00:00