Unusual calcium-activated potassium channels of bovine parathyroid cells.

abstract：:The inability to perceive and coordinate both internal and external signals that function to regulate cellular growth and proliferation is a hallmark of oncogenic transformation. To examine the effects of the v-mos oncogene on distinct signal transduction pathways, the 6m2 cell line was used, in which expression of th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hamilton BJ,DeFranco D

更新日期：1989-01-01 00:00:00

abstract：:During sporulation of the Gram-positive bacterium Bacillus subtilis, transcription of genes encoding spore coat proteins in the mother-cell compartment of the sporangium is controlled by RNA polymerase containing the sigma subunit called sigma K. Based on comparison of the N-terminal amino acid sequence of sigma K wit...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lu S,Halberg R,Kroos L

更新日期：1990-12-01 00:00:00

abstract：:The acetylcholine receptor is a protein that contains certain critical disulfide bonds. Experiments were designed to determine the role such bonds might play in the physiological activity of the receptor. Modification of the receptor with sodium bisulfite and diamide produced an increase in the time constants of the m...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Steinacker A,Zuazaga DC

更新日期：1981-12-01 00:00:00

abstract：:Diabetic peripheral neuropathy (DPN) is the most common complication in both type 1 and type 2 diabetes. Here we studied some phenotypic features of a well-established animal model of type 2 diabetes, the leptin receptor-deficient db(-)/db(-) mouse, and also the effect of long-term (6 mo) treatment with coenzyme Q10 (...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shi TJ,Zhang MD,Zeberg H,Nilsson J,Grünler J,Liu SX,Xiang Q,Persson J,Fried KJ,Catrina SB,Watanabe M,Arhem P,Brismar K,Hökfelt TG

更新日期：2013-01-08 00:00:00

abstract：:Comparisons of exon II HLA-DR beta sequences have shown that nucleotide variations are principally clustered within the following three regions: V1 (amino acid 8-15), V2 (25-32), and V3 (70-77). V1, V2, and V3-derived 24-mers have been synthesized, the DR beta sequences coming from DR1, DR3, Drw6, DR4, DR5, and DRw53 ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Le Gall I,Millasseau P,Dausset J,Cohen D

更新日期：1986-10-01 00:00:00

abstract：:The transthyretin amyloidoses (ATTR) are invariably fatal diseases characterized by progressive neuropathy and/or cardiomyopathy. ATTR are caused by aggregation of transthyretin (TTR), a natively tetrameric protein involved in the transport of thyroxine and the vitamin A-retinol-binding protein complex. Mutations with...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bulawa CE,Connelly S,Devit M,Wang L,Weigel C,Fleming JA,Packman J,Powers ET,Wiseman RL,Foss TR,Wilson IA,Kelly JW,Labaudinière R

更新日期：2012-06-12 00:00:00

abstract：:The evolution of cooperation has a well established theoretical framework based on game theory. This approach has made valuable contributions to a wide variety of disciplines, including political science, economics, and evolutionary biology. Existing cancer theory suggests that individual clones of cancer cells evolve...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Axelrod R,Axelrod DE,Pienta KJ

更新日期：2006-09-05 00:00:00

abstract：:The mature gag and pol proteins of human immunodeficiency virus (HIV) and all retroviruses derive from large gag and gag-pol polyprotein precursors by posttranslational cleavage. A highly specific, virally encoded protease is required for this essential proteolytic processing. In this study, the HIV protease gene prod...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Debouck C,Gorniak JG,Strickler JE,Meek TD,Metcalf BW,Rosenberg M

更新日期：1987-12-01 00:00:00

abstract：:Neuronal specificity in retinal ganglion cells of Xenopus subserves the orderly connections of the optic nerve fibers in the tectum. This specificity derives from positional information acquired by the developing retina at embryonic stages 28-31. Here we report that ganglion cells of embryonic stage 28 eyes can acquir...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hunt RK,Jacobson M

更新日期：1972-04-01 00:00:00

abstract：:We have constructed 26-amino acid transmembrane proteins that specifically transform cells but consist of only two different amino acids. Most proteins are long polymers of amino acids with 20 or more chemically distinct side-chains. The artificial transmembrane proteins reported here are the simplest known proteins w...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Heim EN,Marston JL,Federman RS,Edwards AP,Karabadzhak AG,Petti LM,Engelman DM,DiMaio D

更新日期：2015-08-25 00:00:00

abstract：:Tangier disease is a familial disorder characterized by orange tonsils, cholesterol ester deposition in reticuloendothelial cells, abnormal chylomicron remnants, and a marked reduction in high density lipoproteins. Plasma concentrations of the apolipoproteins apo-A-I and apoA-II in patients with Tangier disease are ap...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kay LL,Ronan R,Schaefer EJ,Brewer HB Jr

更新日期：1982-04-01 00:00:00

abstract：:Numerous neuroimaging studies have implicated default mode network (DMN) involvement in both internally driven processes and memory. Nevertheless, it is unclear whether memory operations reflect a particular case of internally driven processing or alternatively involve the DMN in a distinct manner, possibly depending ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shapira-Lichter I,Oren N,Jacob Y,Gruberger M,Hendler T

更新日期：2013-03-26 00:00:00

abstract：:Telomeres are specialized structures located at the ends of linear eukaryotic chromosomes that ensure their complete replication and protect them from fusion and degradation. We report here the characterization of the telomeres of the nematode Caenorhabditis elegans. We show that the chromosomes terminate in 4-9 kb of...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wicky C,Villeneuve AM,Lauper N,Codourey L,Tobler H,Müller F

更新日期：1996-08-20 00:00:00

abstract：:The AG dinucleotide at the 3' splice sites of metazoan nuclear pre-mRNAs plays a critical role in catalytic step II of the splicing reaction. Previous studies have shown that replacement of the guanine by adenine in the AG (AG --> GG) inhibits this step. We find that the second step was even more severely inhibited by...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gaur RK,Beigelman L,Haeberli P,Maniatis T

更新日期：2000-01-04 00:00:00

abstract：:The transforming protein of avian sarcoma virus UR2, p68v-ros, has an associated tyrosine-specific protein kinase activity similar to that of p60v-src and several other oncogene products. However, this activity has not been linked unequivocally to transformation, and the physiological action of these proteins remains ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Macara IG,Marinetti GV,Balduzzi PC

更新日期：1984-05-01 00:00:00

abstract：:Intracellular calcium-binding proteins are abundantly expressed in many neuronal populations. Previous evidence suggests that calcium-binding proteins can modulate various neuronal properties, presumably by their action as calcium buffers. The importance of calcium-binding proteins for nervous system function in an in...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Airaksinen MS,Eilers J,Garaschuk O,Thoenen H,Konnerth A,Meyer M

更新日期：1997-02-18 00:00:00

abstract：:The female germ cell stage of primary importance in radiation genetic hazards is the immature, arrested oocyte. In the mouse, this stage has a near zero or zero sensitivity to mutation induction by radiation. However, the application of these mouse results to women has been questioned on the ground that the mouse arre...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Russell WL

更新日期：1977-08-01 00:00:00

abstract：:An RNA-directed DNA polymerase was isolated from the peripheral blood leukocytes of a patient with acute myelomonocytic leukemia by successive purification of a particulate cytoplasmic fraction with endogenous, ribonuclease-sensitive DNA polymerase activity. Like RNA-directed DNA polymerase from mammalian type-C virus...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gallagher RE,Todaro GJ,Smith RG,Livingston DM,Gallo RC

更新日期：1974-04-01 00:00:00

abstract：:Two decades after the discovery of the first animal microRNA (miRNA), the number of miRNAs in animal genomes remains a vexing question. Here, we report findings from analyzing 1,323 short RNA sequencing samples (RNA-seq) from 13 different human tissue types. Using stringent thresholding criteria, we identified 3,707 s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Londin E,Loher P,Telonis AG,Quann K,Clark P,Jing Y,Hatzimichael E,Kirino Y,Honda S,Lally M,Ramratnam B,Comstock CE,Knudsen KE,Gomella L,Spaeth GL,Hark L,Katz LJ,Witkiewicz A,Rostami A,Jimenez SA,Hollingsworth MA,

更新日期：2015-03-10 00:00:00

abstract：:A natural (evolutionary) classification is provided for 242 basic helix-loop-helix (bHLH) motif-containing proteins. Phylogenetic analyses of amino acid sequences describe the patterns of evolutionary change within the motif and delimit evolutionary lineages. These evolutionary lineages represent well known functional...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Atchley WR,Fitch WM

更新日期：1997-05-13 00:00:00

abstract：:We demonstrate theoretically and experimentally the spontaneous clustering of solitons in partially coherent wavefronts during the final stages of pattern formation initiated by modulation instability and noise. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chen Z,Sears SM,Martin H,Christodoulides DN,Segev M

更新日期：2002-04-16 00:00:00

abstract：:In Caenorhabditis elegans, the small nuclear ribonucleoprotein (snRNP)-associated proteins U1A and U2B'' are approximately 50% identical to each other, and neither bears signature characteristics of mammalian U1A or U2B'' or the single Drosophila homolog, SNF. We show here that the genes that encode these proteins (rn...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Saldi T,Wilusz C,MacMorris M,Blumenthal T

更新日期：2007-06-05 00:00:00

abstract：:CCAAT enhancer-binding protein-alpha (C/EBPalpha) functions as a pleiotropic transcriptional activator of adipocyte genes during adipogenesis. Nuclear factor C/EBP undifferentiated protein (CUP), an isoform of activator protein-2alpha (AP-2alpha), binds to repressive elements in the C/EBPalpha gene promoter, silencing...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jiang MS,Lane MD

更新日期：2000-11-07 00:00:00

abstract：:In 1989, populations of North American gypsy moth, Lymantria dispar, in seven contiguous northeastern states were severely reduced by a fungal pathogen. Based on morphology, development, and pathology, this organism appeared to be Entomophaga maimaiga. We have now used allozyme and restriction fragment length polymorp...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hajek AE,Humber RA,Elkinton JS,May B,Walsh SR,Silver JC

更新日期：1990-09-01 00:00:00

abstract：:Several models have been proposed for the infectious agents that cause human Creutzfeldt-Jakob disease (CJD) and sheep scrapie. Purified proteins and extracted nucleic acids are not infectious. To further identify the critical molecular components of the CJD agent, 120S infectious material with reduced prion protein (...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Manuelidis L,Sklaviadis T,Akowitz A,Fritch W

更新日期：1995-05-23 00:00:00

abstract：:Phytosulfokine-alpha [PSK-alpha, Tyr(SO(3)H)-Ile-Tyr(SO(3)H)-Thr-Gln], a sulfated mitogenic peptide found in plants, strongly promotes proliferation of plant cells in culture at very low concentrations. Oryza sativa PSK (OsPSK) cDNA encoding a PSK-alpha precursor has been isolated. The cDNA is 725 base pairs long, and...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yang H,Matsubayashi Y,Nakamura K,Sakagami Y

更新日期：1999-11-09 00:00:00

abstract：:We have previously shown that geographic differences in cancer mortalities in Europe are related to (in order of importance): geographic distances (reflecting environmental differences), ethnohistoric distances (encompassing cultural and genetic attributes), and genetic distances of the populations in the areas studie...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sokal RR,Oden NL,Rosenberg MS,Thomson BA

更新日期：2000-05-23 00:00:00

abstract：:A codon-optimized mouse LINE-1 element, ORFeus, exhibits dramatically higher retrotransposition frequencies compared with its native long interspersed element 1 counterpart. To establish a retrotransposon-mediated mouse model with regulatable and potent mutagenic capabilities, we generated a tetracycline (tet)-regulat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： O'Donnell KA,An W,Schrum CT,Wheelan SJ,Boeke JD

更新日期：2013-07-16 00:00:00

abstract：:From the types of ring chromosomes induced in x-irradiated Chinese hamster ovary (CHO) cells, we deduce the existence of switches in the polarity of chromosomal DNA; if there is a continuous DNA double helix along the full length of the chromosome then the polarity switches imply 3'-3' and 5'-5' phosphodiester linkage...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wolff S,Lindsley DL,Peacock WJ

更新日期：1976-03-01 00:00:00

abstract：:Water autoionization reaction 2H2O --> H3O- + OH- is a textbook process of basic importance, resulting in pH = 7 for pure water. However, pH of pure water surface is shown to be significantly lower, the reduction being caused by proton stabilization at the surface. The evidence presented here includes ab initio and cl...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Buch V,Milet A,Vácha R,Jungwirth P,Devlin JP

更新日期：2007-05-01 00:00:00