Evolution of cooperation among tumor cells.

abstract：:Society makes substantial investments in biomedical research, searching for ways to better human health. The product of this research is principally information published in scientific journals. Continued investment in science relies on society's confidence in the accuracy, honesty, and utility of research results. A ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bowen A,Casadevall A

更新日期：2015-09-08 00:00:00

abstract：:Agricultural landscape homogenization has detrimental effects on biodiversity and key ecosystem services. Increasing agricultural landscape heterogeneity by increasing seminatural cover can help to mitigate biodiversity loss. However, the amount of seminatural cover is generally low and difficult to increase in many i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sirami C,Gross N,Baillod AB,Bertrand C,Carrié R,Hass A,Henckel L,Miguet P,Vuillot C,Alignier A,Girard J,Batáry P,Clough Y,Violle C,Giralt D,Bota G,Badenhausser I,Lefebvre G,Gauffre B,Vialatte A,Calatayud F,Gil-T

更新日期：2019-08-13 00:00:00

abstract：:Nerve growth factor (NGF) serum levels were measured in 49 patients with asthma and/or rhinoconjunctivitis and/or urticaria-angioedema. Clinical and biochemical parameters, such as bronchial reactivity, total and specific serum IgE levels, and circulating eosinophil cationic protein levels, were evaluated in relation ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bonini S,Lambiase A,Bonini S,Angelucci F,Magrini L,Manni L,Aloe L

更新日期：1996-10-01 00:00:00

abstract：:Gene expression in higher organisms is thought to be regulated by a complex network of transcription factor binding and chromatin modifications, yet the relative importance of these two factors remains a matter of debate. Here, we show that a computational approach allows surprisingly accurate prediction of histone mo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Benveniste D,Sonntag HJ,Sanguinetti G,Sproul D

更新日期：2014-09-16 00:00:00

abstract：:Degradation of the most abundant membrane protein on earth, the light-harvesting complex of Photosystem II (LHC II), is highly regulated under various environmental conditions, e.g., light stress, to prevent photochemical damage to the reaction center. We identified the LHC II degrading protease in Arabidopsis thalian...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zelisko A,García-Lorenzo M,Jackowski G,Jansson S,Funk C

更新日期：2005-09-20 00:00:00

abstract：:The Wiskott-Aldrich syndrome protein (WASp) plays a major role in coupling T cell antigen receptor (TCR) stimulation to induction of actin cytoskeletal changes required for T cell activation. Here, we report that WASp inducibly binds the sorting nexin 9 (SNX9) in T cells and that WASp, SNX9, p85, and CD28 colocalize w...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Badour K,McGavin MK,Zhang J,Freeman S,Vieira C,Filipp D,Julius M,Mills GB,Siminovitch KA

更新日期：2007-01-30 00:00:00

abstract：:We report a combined thermodynamic and structural characterization of a DNA tetraplex. Using spectroscopic and calorimetric techniques, we demonstrate that d(TG3T) and d(TG3T2G3T), in the presence of K+, form stable tetramolecular complexes. From differential scanning calorimetry measurements, we obtain the following ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jin R,Gaffney BL,Wang C,Jones RA,Breslauer KJ

更新日期：1992-09-15 00:00:00

abstract：:The water channel aquaporin 1 (AQP1) and certain Rh-family members are permeable to CO(2) and NH(3). Here, we use changes in surface pH (pH(S)) to assess relative CO(2) vs. NH(3) permeability of Xenopus oocytes expressing members of the AQP or Rh family. Exposed to CO(2) or NH(3), AQP1 oocytes exhibit a greater maxima...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Musa-Aziz R,Chen LM,Pelletier MF,Boron WF

更新日期：2009-03-31 00:00:00

abstract：:A murine monoclonal antibody (OKT9) raised against human leukemic cells binds to a wide variety of leukemia and tumor cell lines and to a minority of leukemia cells taken directly from patients. Fetal thymus and liver are strongly reactive as are some normal, immature hemopoietic cells and activated lymphocytes. React...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sutherland R,Delia D,Schneider C,Newman R,Kemshead J,Greaves M

更新日期：1981-07-01 00:00:00

abstract：:The functions of individual basal transcription factors during the formation of an initiation complex by RNA polymerase II remain largely unknown. Transcription factor IIE (TFIIE) has recently been shown to bind to multiple targets in the initiation complex. To assess the role of zinc binding in basal transcription, w...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Maxon ME,Tjian R

更新日期：1994-09-27 00:00:00

abstract：:Due to its remarkably long half-life, together with its wide in vivo distribution and its lack of enzymatic or immunological functions, human serum albumin (HSA) represents an optimal carrier for therapeutic peptides/proteins aimed at interacting with cellular or molecular components of the vascular and interstitial c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yeh P,Landais D,Lemaître M,Maury I,Crenne JY,Becquart J,Murry-Brelier A,Boucher F,Montay G,Fleer R

更新日期：1992-03-01 00:00:00

abstract：:Larval fishes suffer prodigious mortality rates, eliminating 99% of the brood within a few days after first feeding. Hjort (1914) famously attributed this "critical period" of low survival to the larvae's inability to obtain sufficient food [Hjort (1914) Rapp P-v Réun Cons Int Explor Mer 20:1-228]. However, the cause ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： China V,Holzman R

更新日期：2014-06-03 00:00:00

abstract：:The class II transactivator (CIITA) is the master integrator of expression of MHC class II genes. It interacts with variety of basal transcription factors to initiate and elongate transcription of these genes. Among others, it recruits positive transcription elongation factor b (P-TEFb) to MHC class II promoters. In c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kohoutek J,Blazek D,Peterlin BM

更新日期：2006-11-14 00:00:00

abstract：:Human urokinase cDNA clones have been identified from a cDNA library prepared from total RNA of human fibroblasts transformed by simian virus 40 [Okayama, H. & Berg, P. (1983) Mol. Cell. Biol. 3, 280-289]. Synthetic oligonucleotides, corresponding to urokinase protein sequence, were used as probes. The cloned cDNA cov...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Verde P,Stoppelli MP,Galeffi P,Di Nocera P,Blasi F

更新日期：1984-08-01 00:00:00

abstract：:The steroid cholesterol is an essential component of eukaryotic membranes, and it functionally modulates membrane proteins, including G protein-coupled receptors. To reveal insight into how cholesterol modulates G protein-coupled receptors, we have used dynamic single-molecule force spectroscopy to quantify the mechan...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zocher M,Zhang C,Rasmussen SG,Kobilka BK,Müller DJ

更新日期：2012-12-11 00:00:00

abstract：:Germ-line mutations of tumor suppressor genes confer strong predisposition to tumor formation. In the rat, a form of dominantly inherited renal carcinoma (RC) results in multiple chromophobe cell tumors that resemble the human disease, and heterozygous carriers (RC/+) are highly susceptible to environmental agents (ra...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yeung RS,Buetow KH,Testa JR,Knudson AG Jr

更新日期：1993-09-01 00:00:00

abstract：:Transgenic overexpression of Cu(+2)/Zn(+2) superoxide dismutase 1 (SOD1) harboring an amyotrophic lateral sclerosis (ALS)-linked familial genetic mutation (SOD1(G93A)) in a Sprague-Dawley rat results in ALS-like motor neuron disease. Motor neuron disease in these rats depended on high levels of mutant SOD1 expression,...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Howland DS,Liu J,She Y,Goad B,Maragakis NJ,Kim B,Erickson J,Kulik J,DeVito L,Psaltis G,DeGennaro LJ,Cleveland DW,Rothstein JD

更新日期：2002-02-05 00:00:00

abstract：:During protein synthesis, elongation factor G (EF-G) binds to the ribosome and promotes the step of translocation, a process in which tRNA moves from the A to the P site of the ribosome and the mRNA is advanced by one codon. By using three-dimensional cryo-electron microscopy, we have visualized EF-G in a ribosome-EF-...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Agrawal RK,Penczek P,Grassucci RA,Frank J

更新日期：1998-05-26 00:00:00

abstract：:Molecular landers are molecules comprising of a central rigid molecular wire maintained above a metallic surface by organic spacers, which allows specific ultrahigh vacuum-scanning tunneling microscopy experiments to be performed at the single-molecule level. The understanding of the molecule-surface interactions, int...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Moresco F,Gourdon A

更新日期：2005-06-21 00:00:00

abstract：:Titania, which exhibits superwetting under light illumination, has been widely used as an ideal material for environmental solution such as self-cleaning, water-air purification, and antifogging. There have been various studies to understand such superhydrophilic conversion. The origin of superwetting has not been cla...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lee K,Kim Q,An S,An J,Kim J,Kim B,Jhe W

更新日期：2014-04-22 00:00:00

abstract：:Stearic acid is toxic for T lymphocytes in vitro but has little effect on B lymphocytes. To investigate the molecular basis for this difference, purified murine T and B lymphocytes were compared for their abilities to incorporate and metabolize stearic acid. Unstimulated T and B cells incorporated identical amounts of...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Buttke TM,Van Cleave S,Steelman L,McCubrey JA

更新日期：1989-08-01 00:00:00

abstract：:The occurrence and sequelae of disorders that lead to hypoxic spells such as asthma, chronic obstructive pulmonary disease, and obstructive sleep apnea (OSA) exhibit daily variance. This prompted us to examine the interaction between the hypoxic response and the circadian clock in vivo. We found that the global transc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Manella G,Aviram R,Bolshette N,Muvkadi S,Golik M,Smith DF,Asher G

更新日期：2020-01-07 00:00:00

abstract：:The Tap protein mediates the sequence nonspecific nuclear export of cellular mRNAs as well as the sequence-specific export of retroviral mRNAs bearing the constitutive transport element (CTE). Previously, the structures of individual Tap subdomains, including ribonucleoprotein and leucine-rich repeat domains, have bee...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ho DN,Coburn GA,Kang Y,Cullen BR,Georgiadis MM

更新日期：2002-02-19 00:00:00

abstract：:In contrast to observations in bacteria and fungi, frameshift mutations in bacteriophage T4 do not arise during genetic recombination. Nascent mutants, captured in the heterozygous condition, exhibit properties which indicate that the new lesions are located at the extreme tips of the chromosomes, and are segregated b...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lindstrom DM,Drake JW

更新日期：1970-03-01 00:00:00

abstract：:The vertical occipital fasciculus (VOF) is the only major fiber bundle connecting dorsolateral and ventrolateral visual cortex. Only a handful of studies have examined the anatomy of the VOF or its role in cognition in the living human brain. Here, we trace the contentious history of the VOF, beginning with its origin...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yeatman JD,Weiner KS,Pestilli F,Rokem A,Mezer A,Wandell BA

更新日期：2014-12-02 00:00:00

abstract：:Multiple independent mutations in neuroligin genes were identified in patients with familial autism, including the R451C substitution in neuroligin-3 (NL3). Previous studies showed that NL3(R451C) knock-in mice exhibited modestly impaired social behaviors, enhanced water maze learning abilities, and increased synaptic...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Etherton M,Földy C,Sharma M,Tabuchi K,Liu X,Shamloo M,Malenka RC,Südhof TC

更新日期：2011-08-16 00:00:00

abstract：:Experiments were designed to determine the interrelationship between cyclic AMP and Ca(2+) during the processes of sperm capacitation and the acrosome reaction. In minimal culture media containing pyruvate and lactate as substrates, guinea pig spermatozoa required a minimum of 1.0-1.5 hr to capacitate in the presence ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hyne RV,Garbers DL

更新日期：1979-11-01 00:00:00

abstract：:Curcumin (Cur) is a naturally occurring anticancer drug isolated from the Curcuma longa plant. It is known to exhibit anticancer properties via inhibiting the STAT3 phosphorylation process. However, its poor water solubility and low bioavailability impede its clinical application. Herein, we used organoplatinum(II) ← ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Datta S,Misra SK,Saha ML,Lahiri N,Louie J,Pan D,Stang PJ

更新日期：2018-08-07 00:00:00

abstract：:The mammalian protein ZnT3 resides on synaptic vesicle membranes of zinc-containing neurons, suggesting its possible role in vesicular zinc transport. We show here that histochemically reactive zinc, corresponding to the zinc found within synaptic vesicles, was undetectable in the brains of mice with targeted disrupti...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cole TB,Wenzel HJ,Kafer KE,Schwartzkroin PA,Palmiter RD

更新日期：1999-02-16 00:00:00

abstract：:Throughout time, operational laws and concepts from complex systems have been employed to quantitatively model important aspects and interactions in nature and society. Nevertheless, it remains enigmatic and challenging, yet inspiring, to predict the actual interdependencies that comprise the structure of such systems...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Stavroglou SK,Pantelous AA,Stanley HE,Zuev KM

更新日期：2020-04-07 00:00:00