Orthogonal self-assembly of an organoplatinum(II) metallacycle and cucurbit[8]uril that delivers curcumin to cancer cells.

abstract：:Plant cutin monomers trigger, and glucose suppresses, the expression of the cutinase gene of pathogenic fungi. To identify the cutinase promoter region responsible for induction by the unique plant components, a promoter analysis was done with transformants. Plasmids were constructed that contained (i) the 5' flanking...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bajar A,Podila GK,Kolattukudy PE

更新日期：1991-09-15 00:00:00

abstract：:Heterotrimeric G proteins function as molecular relays that mediate signal transduction from heptahelical receptors in the cell membrane to intracellular effector proteins. Crystallographic studies have demonstrated that guanine nucleotide exchange on the Galpha subunit causes specific conformational changes in three ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Oldham WM,Van Eps N,Preininger AM,Hubbell WL,Hamm HE

更新日期：2007-05-08 00:00:00

abstract：:Extracellular vesicles (EVs) secreted by cells present an attractive strategy for developing new therapies, but progress in the field is limited by several issues: The quality of the EVs varies with the type and physiological status of the producer cells; protocols used to isolate the EVs are difficult to scale up; an...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kim DK,Nishida H,An SY,Shetty AK,Bartosh TJ,Prockop DJ

更新日期：2016-01-05 00:00:00

abstract：:Historical scenarios of evolution of avian plumage coloration have been called into question with the discoveries that most birds can see UV light (which normal humans cannot), and that UV-reflecting plumages are widespread in birds. Several examples of sexual dichromatism not detectable with human visual capabilities...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Eaton MD

更新日期：2005-08-02 00:00:00

abstract：:The data reported here demonstrate that a preparation extracted from nonpathogenic mycobacteria such as Mycobacterium smegmatis and hereafter referred to as interphase material protected mice against Ehrlich ascitic carcinoma, L-1210 leukemia, and another syngeneic lymphoid leukemia. Furthermore, mice treated by this ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lamensans A,Chedid L,Lederer E,Rosselet JP,Gustafson RH,Spencer HJ,Ludwig B,Berger FM

更新日期：1975-09-01 00:00:00

abstract：:The primary structure of about half of the protein chain of yeast alcohol dehydrogenase has been determined and compared with the amino-acid sequences of other dehydrogenases. The enzyme is found to be distantly related to horse-liver alcohol dehydrogenase, although these two proteins have different quaternary structu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jörnvall H

更新日期：1973-08-01 00:00:00

abstract：:Evidence of endoplasmic reticulum (ER) stress has been found in lungs of patients with familial and sporadic idiopathic pulmonary fibrosis. We tested whether ER stress causes or exacerbates lung fibrosis by (i) conditional expression of a mutant form of surfactant protein C (L188Q SFTPC) found in familial interstitial...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lawson WE,Cheng DS,Degryse AL,Tanjore H,Polosukhin VV,Xu XC,Newcomb DC,Jones BR,Roldan J,Lane KB,Morrisey EE,Beers MF,Yull FE,Blackwell TS

更新日期：2011-06-28 00:00:00

abstract：:The existence of immunoregulatory genes conferring dominant resistance to autoimmunity is well documented. In an effort to better understand the nature and mechanisms of action of these genes, we utilized the murine model of autoimmune orchitis as a prototype. When the orchitis-resistant strain DBA/2J is crossed with ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Meeker ND,Hickey WF,Korngold R,Hansen WK,Sudweeks JD,Wardell BB,Griffith JS,Teuscher C

更新日期：1995-06-06 00:00:00

abstract：:We have developed a low stringency polymerase chain reaction (LSPCR) to isolate the unknown neighboring region around a known DNA sequence, thus allowing efficient targeted gene walking. The method involves the polymerase chain reaction (PCR) with a single primer under conditions of low stringency for primer annealing...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Malo MS,Srivastava K,Andresen JM,Chen XN,Korenberg JR,Ingram VM

更新日期：1994-04-12 00:00:00

abstract：:The phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt) signaling pathway was recently shown to negatively regulate LPS-induced acute inflammatory responses. We previously observed that the metabolic thiol antioxidant alpha-lipoic acid (LA) inhibits LPS-induced expression of cellular adhesion molecules and adheren...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhang WJ,Wei H,Hagen T,Frei B

更新日期：2007-03-06 00:00:00

abstract：:In multicellular organisms, the higher order organization of chromatin during interphase and the reassembly of the nuclear envelope during mitosis are thought to involve an interaction between the nuclear lamina and chromatin. The nuclear distribution of lamins and of peripheral chromatin is highly correlated in vivo,...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Goldberg M,Harel A,Brandeis M,Rechsteiner T,Richmond TJ,Weiss AM,Gruenbaum Y

更新日期：1999-03-16 00:00:00

abstract：:Tight junctions (TJs) play a key role in mediating paracellular ion reabsorption in the kidney. The paracellular pathway in the collecting duct of the kidney is a predominant route for transepithelial chloride reabsorption that determines the extracellular NaCl content and the blood pressure. However, the molecular me...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hou J,Renigunta A,Yang J,Waldegger S

更新日期：2010-10-19 00:00:00

abstract：:Cyclin E is an important regulator of cell cycle progression that together with cyclin-dependent kinase (cdk) 2 is crucial for the G1/S transition during the mammalian cell cycle. Previously, we showed that severe overexpression of cyclin E protein in tumor cells and tissues results in the appearance of lower molecula...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gray-Bablin J,Zalvide J,Fox MP,Knickerbocker CJ,DeCaprio JA,Keyomarsi K

更新日期：1996-12-24 00:00:00

abstract：:Some of the most important impacts of global climate change will be felt among the populations, predominantly in developing countries, referred to as "subsistence" or "smallholder" farmers. Their vulnerability to climate change comes both from being predominantly located in the tropics, and from various socioeconomic,...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Morton JF

更新日期：2007-12-11 00:00:00

abstract：:The pattern of neurodegeneration in Alzheimer's disease (AD) is very distinctive: neurofibrillary tangles (NFTs) composed of hyperphosphorylated tau selectively affect pyramidal neurons of the aging association cortex that interconnect extensively through glutamate synapses on dendritic spines. In contrast, primary se...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Carlyle BC,Nairn AC,Wang M,Yang Y,Jin LE,Simen AA,Ramos BP,Bordner KA,Craft GE,Davies P,Pletikos M,Šestan N,Arnsten AF,Paspalas CD

更新日期：2014-04-01 00:00:00

abstract：:Inferring evolutionary relationships among highly divergent protein sequences is a daunting task. In particular, when pairwise sequence alignments between protein sequences fall <25% identity, the phylogenetic relationships among sequences cannot be estimated with statistical certainty. Here, we show that phylogenetic...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chang GS,Hong Y,Ko KD,Bhardwaj G,Holmes EC,Patterson RL,van Rossum DB

更新日期：2008-09-09 00:00:00

abstract：:Dominantly inherited mutations in the genes encoding presenilins (PS) and the amyloid precursor protein (APP) are the major causes of familial Alzheimer's disease (AD). The prevailing view of AD pathogenesis posits that accumulation of beta-amyloid (Abeta) peptides, particularly Abeta42, is the central event triggerin...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shen J,Kelleher RJ 3rd

更新日期：2007-01-09 00:00:00

abstract：:Cell aggregates are a tool for in vitro studies of morphogenesis, cancer invasion, and tissue engineering. They respond to mechanical forces as a complex rather than simple liquid. To change an aggregate's shape, cells have to overcome energy barriers. If cell shape fluctuations are active enough, the aggregate sponta...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Marmottant P,Mgharbel A,Käfer J,Audren B,Rieu JP,Vial JC,van der Sanden B,Marée AF,Graner F,Delanoë-Ayari H

更新日期：2009-10-13 00:00:00

abstract：:The rat mammary cell line Rama 25 [Bennett, D.C., Peachey, L.A., Durbin, H. & Rudland, P.S. (1978) Cell 15, 283--298] differentiates morphologically in vitro from a cuboidal form to a fusiform cell resembling myoepithelial cells. This differentiation occurs in all clonal isolates of the line. By using three different ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lennon VA,Unger M,Dulbecco R

更新日期：1978-12-01 00:00:00

abstract：:Human papillomavirus type 18 (HPV-18) infects genital squamous epithelium and is an etiological agent of cervical cancer. Cell-type-specific expression of HPV-18 is directed by the region upstream of the viral early genes that contains a transcriptional enhancer whose function is dependent solely on cellular factors. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mack DH,Laimins LA

更新日期：1991-10-15 00:00:00

abstract：:Two-electron oxidation of cobaltous octaethylporphyrin [Co(II)(Et)(8)P] yields a stable pi-cation radical [Co(III)(Et)(8)P](2+.), the optical spectrum of which exhibits spectral changes dependent upon the nature of the counterion. Comparison of these spectra with those of Compounds I of horseradish peroxidase and cata...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dolphin D,Forman A,Borg DC,Fajer J,Felton RH

更新日期：1971-03-01 00:00:00

abstract：:Niemann-Pick type C disease (NP-C) is an inherited neurovisceral lipid storage disorder characterized by progressive neurodegeneration. Most cases of NP-C result from inactivating mutations of NPC1, a recently identified member of a family of genes encoding membrane-bound proteins containing putative sterol sensing do...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Patel SC,Suresh S,Kumar U,Hu CY,Cooney A,Blanchette-Mackie EJ,Neufeld EB,Patel RC,Brady RO,Patel YC,Pentchev PG,Ong WY

更新日期：1999-02-16 00:00:00

abstract：:In a well networked community, there is intense social interaction, and information disseminates briskly and broadly. This is important if the environment is volatile (i.e., keeps changing) and individuals never stop searching for fresh opportunities. Here, we present a simple model that attributes the rise of a dynam...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Marsili M,Vega-Redondo F,Slanina F

更新日期：2004-02-10 00:00:00

abstract：:The E6 protein of the high-risk human papillomaviruses inactivates the tumor suppressor protein p53 by stimulating its ubiquitinylation and subsequent degradation. Ubiquitinylation is a multistep process involving a ubiquitin-activating enzyme, one of many distinct ubiquitin-conjugating enzymes, and in certain cases, ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rolfe M,Beer-Romero P,Glass S,Eckstein J,Berdo I,Theodoras A,Pagano M,Draetta G

更新日期：1995-04-11 00:00:00

abstract：:The decrease with age of the adrenal-secreted dehydroepiandrosterone sulfate (DHEAS) in serum has suggested that it may be causally related to longevity. For the PAQUID [People (Personnes) Aged (Agées) About What (Quid, in Latin)] cohort of elderly subjects, we have previously reported higher DHEAS in men than in wome...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mazat L,Lafont S,Berr C,Debuire B,Tessier JF,Dartigues JF,Baulieu EE

更新日期：2001-07-03 00:00:00

abstract：:The cAMP-dependent protein kinase (PKA) has been shown to play an important role in long-term potentiation (LTP) in the hippocampus, but little is known about the function of PKA in long-term depression (LTD). We have combined pharmacologic and genetic approaches to demonstrate that PKA activity is required for both h...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Brandon EP,Zhuo M,Huang YY,Qi M,Gerhold KA,Burton KA,Kandel ER,McKnight GS,Idzerda RL

更新日期：1995-09-12 00:00:00

abstract：:Despite substantial evidence that nitric oxide (NO) and/or endogenous S-nitrosothiols (SNOs) exert protective effects in a variety of cardiovascular diseases, the molecular details are largely unknown. Here we show that following left coronary artery ligation, mice with a targeted deletion of the S-nitrosoglutathione ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lima B,Lam GK,Xie L,Diesen DL,Villamizar N,Nienaber J,Messina E,Bowles D,Kontos CD,Hare JM,Stamler JS,Rockman HA

更新日期：2009-04-14 00:00:00

abstract：:Evidence for hydrogen bonding between 5'-ribonucleotides in water has been obtained from a 220-MHz proton magnetic resonance study of nitrogenous protons. The amino groups of GMP, AMP, and CMP exhibit proton resonance lines which are somewhat broadened by proton exchange with the solvent at 0 degrees ; their downfield...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Raszka M,Kaplan NO

更新日期：1972-08-01 00:00:00

abstract：:Residues important in the interaction between the 23-residue transmembrane (TM) domains of the integrin alpha(IIb)- and beta(3)-subunits were identified by mutating each non-Leu residue to Leu. Leu substitutions of alpha(IIb) at G972, G976, and T981, and of beta(3) at I693 and G708, increased ligand binding. Substitut...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Luo BH,Carman CV,Takagi J,Springer TA

更新日期：2005-03-08 00:00:00

abstract：:Serotonin (5-HT) plays a critical role in modulating synaptic plasticity in the marine mollusc Aplysia and in the mammalian nervous system. In Aplysia sensory neurons, 5-HT can activate several signal cascades, including PKA and PKC, presumably via distinct types of G protein-coupled receptors. However, the molecular ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lee YS,Choi SL,Lee SH,Kim H,Park H,Lee N,Lee SH,Chae YS,Jang DJ,Kandel ER,Kaang BK

更新日期：2009-08-25 00:00:00