The rise and fall of a networked society: a formal model.

abstract：:A simple model is proposed to account for large increases in transporter-mediated ion flux across cell membranes that are elicited by small fractional changes of cell volume. The model is based upon the concept that, as a result of large excluded volume effects in cytoplasm (macromolecular crowding), the tendency of s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Minton AP,Colclasure GC,Parker JC

更新日期：1992-11-01 00:00:00

abstract：:Inactivating mutations in chromodomain helicase DNA binding protein 7 (CHD7) cause CHARGE syndrome, a severe multiorgan system disorder of which Isolated gonadotropin-releasing hormone (GnRH) deficiency (IGD) is a minor feature. Recent reports have described predominantly missense CHD7 alleles in IGD patients, but it ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Balasubramanian R,Choi JH,Francescatto L,Willer J,Horton ER,Asimacopoulos EP,Stankovic KM,Plummer L,Buck CL,Quinton R,Nebesio TD,Mericq V,Merino PM,Meyer BF,Monies D,Gusella JF,Al Tassan N,Katsanis N,Crowley WF Jr

更新日期：2014-12-16 00:00:00

abstract：:Overexpression of the p53 protein, resulting from gene mutations that increase protein stability, has been detected in greater than 25% of primary human breast cancers. In addition, approximately 10% of breast cancer patients have circulating antibodies to the p53 protein. In this study, the anti-p53 humoral response ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Davidoff AM,Iglehart JD,Marks JR

更新日期：1992-04-15 00:00:00

abstract：:Wild and managed bees are well documented as effective pollinators of global crops of economic importance. However, the contributions by pollinators other than bees have been little explored despite their potential to contribute to crop production and stability in the face of environmental change. Non-bee pollinators ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rader R,Bartomeus I,Garibaldi LA,Garratt MP,Howlett BG,Winfree R,Cunningham SA,Mayfield MM,Arthur AD,Andersson GK,Bommarco R,Brittain C,Carvalheiro LG,Chacoff NP,Entling MH,Foully B,Freitas BM,Gemmill-Herren B,Ghazoul

更新日期：2016-01-05 00:00:00

abstract：:We have used oligonucleotide-directed mutagenesis to make a specific change in the beta-lactamase (EC 3.5.2.6) (ampicillin resistance) gene of the plasmid pBR322. Evidence suggests that the active site for this enzyme may include a serine-threonine dyad (residues 70 and 71). By priming in vitro DNA synthesis with a ch...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dalbadie-McFarland G,Cohen LW,Riggs AD,Morin C,Itakura K,Richards JH

更新日期：1982-11-01 00:00:00

abstract：:Achieving long-term pancellular expression of a transferred gene at therapeutic level in a given hematopoietic lineage remains an important goal of gene therapy. Advances have recently been made in the genetic correction of the hemoglobinopathies by means of lentiviral vectors and large locus control region (LCR) deri...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Imren S,Payen E,Westerman KA,Pawliuk R,Fabry ME,Eaves CJ,Cavilla B,Wadsworth LD,Beuzard Y,Bouhassira EE,Russell R,London IM,Nagel RL,Leboulch P,Humphries RK

更新日期：2002-10-29 00:00:00

abstract：:Tumor-specific molecules are needed across diverse areas of oncology for use in early detection, diagnosis, prognosis and therapy. Large and growing public databases of transcriptome sequencing data (RNA-seq) derived from tumors and normal tissues hold the potential of yielding tumor-specific molecules, but because th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Barrett CL,DeBoever C,Jepsen K,Saenz CC,Carson DA,Frazer KA

更新日期：2015-06-09 00:00:00

abstract：:The use of proteasome inhibitors to target cancer's dependence on altered protein homeostasis has been greatly limited by intrinsic and acquired resistance. Analyzing data from thousands of cancer lines and tumors, we find that those with suppressed expression of one or more 19S proteasome subunits show intrinsic prot...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tsvetkov P,Sokol E,Jin D,Brune Z,Thiru P,Ghandi M,Garraway LA,Gupta PB,Santagata S,Whitesell L,Lindquist S

更新日期：2017-01-10 00:00:00

abstract：:Recent cryoEM density maps of Abeta(42) fibrils obtained at low pH revealed two protofilaments winding around a hollow core raising the question if such tubular structures also exist at physiological pH. Based on the cryoEM measurements and on NMR data, we probe amyloid fibril organizations corresponding to the observ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Miller Y,Ma B,Tsai CJ,Nussinov R

更新日期：2010-08-10 00:00:00

abstract：:A fibroblast growth regulator, which inhibits the growth and division of proliferating fibroblasts, has been isolated from medium conditioned by exposure to density-inhibited mouse 3T3 cells. This partially purified preparation of the growth-inhibitory activity, termed FGR-s, contained two major polypeptides (Mrs, 10,...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hsu YM,Barry JM,Wang JL

更新日期：1984-04-01 00:00:00

abstract：:Steep topography, a tropical climate, and mafic lithologies contribute to efficient chemical weathering and carbon sequestration in the Southeast Asian islands. Ongoing arc-continent collision between the Sunda-Banda arc system and Australia has increased the area of subaerially exposed land in the region since the mi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Park Y,Maffre P,Goddéris Y,Macdonald FA,Anttila ESC,Swanson-Hysell NL

更新日期：2020-10-13 00:00:00

abstract：:Adoptive cellular immunotherapy, infusions of interleukin 2 (IL-2) in conjunction with in vitro-activated killer cells, has brought new hope to patients with cancer. The broad application of this strategy, however, is constrained by the need for repeated leukapheresis and by the labor-intensive process of in vitro act...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nakajima F,Khanna A,Xu G,Lagman M,Haschemeyer R,Mouradian J,Wang JC,Stenzel KH,Rubin AL,Suthanthiran M

更新日期：1994-08-16 00:00:00

abstract：:African trypanosomes are protected by a densely packed surface monolayer of variant surface glycoprotein (VSG). A haptoglobin-hemoglobin receptor (HpHbR) within this VSG coat mediates heme acquisition. HpHbR is also exploited by the human host to mediate endocytosis of trypanolytic factor (TLF)1 from serum, contributi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Higgins MK,Tkachenko O,Brown A,Reed J,Raper J,Carrington M

更新日期：2013-01-29 00:00:00

abstract：:Faithful transmission of genetic material to daughter cells involves a characteristic temporal order of DNA replication, which may play a significant role in the inheritance of epigenetic states. We developed a genome-scale approach--Repli Seq--to map temporally ordered replicating DNA using massively parallel sequenc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hansen RS,Thomas S,Sandstrom R,Canfield TK,Thurman RE,Weaver M,Dorschner MO,Gartler SM,Stamatoyannopoulos JA

更新日期：2010-01-05 00:00:00

abstract：:The cochlear implant (CI) is a neuroprosthesis that allows profoundly deaf patients to recover speech intelligibility. This recovery goes through long-term adaptative processes to build coherent percepts from the coarse information delivered by the implant. Here we analyzed the longitudinal postimplantation evolution ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rouger J,Lagleyre S,Fraysse B,Deneve S,Deguine O,Barone P

更新日期：2007-04-24 00:00:00

abstract：:We have earlier proposed a molecular mechanism for the translocation of hydrophilic proteins across membranes that accounts for the experimental facts and meets the restrictions that we stipulate for such a mechanism. In particular, the restrictions are that translocation occurs by successive segments of the polypepti...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Singer SJ,Maher PA,Yaffe MP

更新日期：1987-04-01 00:00:00

abstract：:Human Creutzfeldt-Jakob disease (CJD) and similar neurodegenerative diseases such as sheep scrapie are caused by a variety of related infectious agents. They are associated with abnormal host prion protein (PrP), which is assessed by limited proteolysis to yield resistant PrP bands (PrP-res). Although PrP-res has been...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Arjona A,Simarro L,Islinger F,Nishida N,Manuelidis L

更新日期：2004-06-08 00:00:00

abstract：:The fate of two recently described human B lymphocyte-specific antigens (B1 and B2) was studied after B-cell activation in vivo and in vitro. Whereas both B1 and B2 were present on virtually all B cells from normal lymph nodes, B2 was absent from approximately 50% of B cells from hyperplastic lymph nodes. When B cells...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Stashenko P,Nadler LM,Hardy R,Schlossman SF

更新日期：1981-06-01 00:00:00

abstract：:Insects have diversified through more than 450 million y of Earth's changeable climate, yet rapidly shifting patterns of temperature and precipitation now pose novel challenges as they combine with decades of other anthropogenic stressors including the conversion and degradation of land. Here, we consider how insects ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Halsch CA,Shapiro AM,Fordyce JA,Nice CC,Thorne JH,Waetjen DP,Forister ML

更新日期：2021-01-12 00:00:00

abstract：:Antibody to poly(ADP-ribose) has been covalently coupled to Sepharose and utilized to isolate selectively oligonucleosomes undergoing the poly(ADP-ribosyl)ation reaction from the bulk of chromatin. Approximately 12% of the unfractionated oligonucleosomes were bound to the immunoaffinity column and these represented es...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Malik N,Miwa M,Sugimura T,Thraves P,Smulson M

更新日期：1983-05-01 00:00:00

abstract：:The science around the use of masks by the public to impede COVID-19 transmission is advancing rapidly. In this narrative review, we develop an analytical framework to examine mask usage, synthesizing the relevant literature to inform multiple areas: population impact, transmission characteristics, source control, wea...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Howard J,Huang A,Li Z,Tufekci Z,Zdimal V,van der Westhuizen HM,von Delft A,Price A,Fridman L,Tang LH,Tang V,Watson GL,Bax CE,Shaikh R,Questier F,Hernandez D,Chu LF,Ramirez CM,Rimoin AW

更新日期：2021-01-26 00:00:00

abstract：:YC-1 [3-(5'-hydroxymethyl-2'furyl)-1-benzyl indazole] is an allosteric activator of soluble guanylyl cyclase (sGC). YC-1 increases the catalytic rate of the enzyme and sensitizes the enzyme toward its gaseous activators nitric oxide or carbon monoxide. In other studies the administration of YC-1 to experimental animal...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Martin E,Lee YC,Murad F

更新日期：2001-11-06 00:00:00

abstract：:Mechanical signals are important influences on the development and morphology of higher plants. Using tobacco transformed with the Ca(2+)-sensitive luminescent protein aequorin, we recently reported the effects of mechanical signals of touch and wind on the luminescence and thus intracellular calcium of young seedling...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Haley A,Russell AJ,Wood N,Allan AC,Knight M,Campbell AK,Trewavas AJ

更新日期：1995-05-09 00:00:00

abstract：:We have recently shown that the Alzheimer disease 40-residue amyloid beta-protein [A beta P-(1-40)] can form cation-selective channels when incorporated into planar lipid bilayers by fusion of liposomes containing the peptide. Since A beta P-(1-40) comprises portions of the putative extracellular and membrane-spanning...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Arispe N,Pollard HB,Rojas E

更新日期：1993-11-15 00:00:00

abstract：:Long-term plasticity can differ from short-term in recruiting the growth of new synaptic connections, a process that requires the participation of both the presynaptic and postsynaptic components of the synapse. How does information about synaptic plasticity spread from its site of origin to recruit the other componen...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jin I,Puthanveettil S,Udo H,Karl K,Kandel ER,Hawkins RD

更新日期：2012-06-05 00:00:00

abstract：:The elucidation of the mechanisms of antigen presentation by major histocompatibility complex class I molecules has stimulated the search for nonreplicative vectors that could deliver CD8+ T cell epitopes to the cytosol of antigen-presenting cells to trigger the activation of specific cytotoxic T lymphocytes (CTLs) in...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Saron MF,Fayolle C,Sebo P,Ladant D,Ullmann A,Leclerc C

更新日期：1997-04-01 00:00:00

abstract：:The GTPase-activating protein (GAP) has been postulated to function either as a negative regulator or as a possible target protein of Ras in mammalian cells and Xenopus oocytes. Ras must be localized in the plasma membrane of vertebrate cells to function, but GAP is localized in the cytosol. To test whether Ras functi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gibbs JB,Schaber MD,Schofield TL,Scolnick EM,Sigal IS

更新日期：1989-09-01 00:00:00

abstract：:An experimental study of the configurational thermodynamics for a series of near-eutectic Pt80-x Cu x P20 bulk metallic glass-forming alloys is reported where 14 < x < 27. The undercooled liquid alloys exhibit very high fragility that increases as x decreases, resulting in...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Na JH,Corona SL,Hoff A,Johnson WL

更新日期：2020-02-11 00:00:00

abstract：:AMPA-type glutamate receptor (AMPAR) trafficking is essential for modulating synaptic transmission strength. Prior studies that have characterized signaling pathways underlying AMPAR trafficking have identified the cAMP/PKA-mediated phosphorylation of GluA1, an AMPAR subunit, as a key step in the membrane insertion of...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Song RS,Massenburg B,Wenderski W,Jayaraman V,Thompson L,Neves SR

更新日期：2013-09-17 00:00:00

abstract：:Evidence based on a study of alanine-resistant (Alar), constitutive mutants of CHO-K1 cells and the conditions that favor stimulation of the A system of amino acid activity supports the model that the A system of amino acid transport in these cells is repressible and under negative control of regulatory gene R1. In th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Moffett J,Périer F,Jones M,Englesberg E

更新日期：1987-11-01 00:00:00