Partial similarities between yeast and liver alcohol dehydrogenases.

abstract：:Although some important advances in the modeling of sorption and hygrothermal deformations of nanoporous materials such as hydrated cement paste, shale, coal, and some other rocks and soils have already been made, a comprehensive nanoporomechanics theory remains elusive. Here we strive to formulate it based on Gibb's ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nguyen H,Rahimi-Aghdam S,Bažant ZP

更新日期：2020-02-18 00:00:00

abstract：:N-type Ca2+ channels mediate Ca2+ influx, which initiates fast exocytosis of neurotransmitters at synapses, and they interact directly with the SNARE proteins syntaxin and SNAP-25 (synaptosome-associated protein of 25 kDa) through a synaptic protein interaction (synprint) site in the intracellular loop connecting doma...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sheng ZH,Yokoyama CT,Catterall WA

更新日期：1997-05-13 00:00:00

abstract：:In a microarray-based gene profiling analysis of Müller glia-derived retinal stem cells in light-damaged retinas from adult zebrafish, we found that 2 genes required for regeneration of fin and heart tissues in zebrafish, hspd1 (heat shock 60-kDa protein 1) and mps1 (monopolar spindle 1), were up-regulated. Expression...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Qin Z,Barthel LK,Raymond PA

更新日期：2009-06-09 00:00:00

abstract：:Various biological processes exhibit characteristics that vary dramatically in response to different input conditions or changes in the history of the process itself. One of the examples studied here, the Ras-PKC-mitogen-activated protein kinase (MAPK) bistable pathway, follows two distinct dynamics (modes) depending ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Barbano PE,Spivak M,Feng J,Antoniotti M,Mishra B

更新日期：2005-05-03 00:00:00

abstract：:In normal vision, shifts of attention are usually followed by saccadic eye movements. Neurons in extrastriate area V4 are modulated by focal attention when eye movements are withheld, but they also respond in advance of visually guided saccadic eye movements. We have examined the visual selectivity of saccade-related ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Moore T,Tolias AS,Schiller PH

更新日期：1998-07-21 00:00:00

abstract：:We reported previously that human cells after neoplastic transformation in culture had acquired an increased susceptibility to chromatid damage induced by x-irradiation during the G2 phase of the cell cycle. Evidence suggested that this results from deficient DNA repair during G2 phase. Cells derived from human tumors...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Parshad R,Sanford KK,Jones GM

更新日期：1985-08-01 00:00:00

abstract：:Human genetic studies have given evidence of familial, disease-causing mutations in the analogous amino acid residue shared by three related RNA binding proteins causative of three neurological diseases. Alteration of aspartic acid residue 290 of hnRNPA2 to valine is believed to predispose patients to multisystem prot...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Murray DT,Zhou X,Kato M,Xiang S,Tycko R,McKnight SL

更新日期：2018-10-16 00:00:00

abstract：:An ammonia-oxidizing, carbon-fixing archaeon, Candidatus "Nitrosopumilus maritimus," recently was isolated from a salt-water aquarium, definitively confirming that chemoautotrophy exists among the marine archaea. However, in other incubation studies, pelagic archaea also were capable of using organic carbon. It has re...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ingalls AE,Shah SR,Hansman RL,Aluwihare LI,Santos GM,Druffel ER,Pearson A

更新日期：2006-04-25 00:00:00

abstract：:For almost a century, alcohols have been thought to produce their effects by actions on the membrane lipids of central nervous system neurons--the well known "lipid theory" of alcohol action. The rationale for this theory is the correlation of potency with oil/water or membrane/buffer partition coefficient. Although a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li C,Peoples RW,Weight FF

更新日期：1994-08-16 00:00:00

abstract：:Transcriptional activation of the HIV type 1 (HIV-1) long terminal repeat (LTR) promoter element by the viral Tat protein is an essential step in the HIV-1 life cycle. Tat function is mediated by the TAR RNA target element encoded within the LTR and is known to require the recruitment of a complex consisting of Tat an...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bieniasz PD,Grdina TA,Bogerd HP,Cullen BR

更新日期：1999-07-06 00:00:00

abstract：:The measurement of any nonchromosomal genetic contribution to the heritability of a trait is often confounded by the inability to control both the chromosomal and nonchromosomal information in a population. We have designed a unique system in yeast where we can control both sources of information so that the phenotype...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Edwards MD,Symbor-Nagrabska A,Dollard L,Gifford DK,Fink GR

更新日期：2014-05-27 00:00:00

abstract：:Experimental circular dichroic (CD) spectra of three proteins have been combined with estimates of the content of peptide-chain structural modes obtained from x-ray diffraction studies of the same proteins. Solution of the simultaneous equations at a series of wavelengths permits the construction of a CD spectrum for ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Saxena VP,Wetlaufer DB

更新日期：1971-05-01 00:00:00

abstract：:Although the role of APP and PSEN genes in genetic Alzheimer's disease (AD) cases is well established, fairly little is known about the molecular mechanisms affecting Abeta generation in sporadic AD. Deficiency in Abeta clearance is certainly a possibility, but increased expression of proteins like APP or BACE1/beta-s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hébert SS,Horré K,Nicolaï L,Papadopoulou AS,Mandemakers W,Silahtaroglu AN,Kauppinen S,Delacourte A,De Strooper B

更新日期：2008-04-29 00:00:00

abstract：:Mouse beta-globin in encoded in a discontinuous structural gene interrupted by a 550-base pair intervening sequence of DNA. Correspondingly, the mature beta-globin mRNA appears to be synthesized via a 15S precursor, the length of which roughly equals the total length of the coding and intervening sequences of the beta...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tilghman SM,Curtis PJ,Tiemeier DC,Leder P,Weissmann C

更新日期：1978-03-01 00:00:00

abstract：:Cocaine exposure in utero causes severe alterations in the development of the central nervous system. To study the basis of these teratogenic effects in vitro, we have used cocultures of neurons and glial cells from mouse embryonic brain. Cocaine selectively affected embryonic neuronal cells, causing first a dramatic ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nassogne MC,Evrard P,Courtoy PJ

更新日期：1995-11-21 00:00:00

abstract：:Cell proliferation is regulated by the induction of growth promoting genes and the suppression of growth inhibitory genes. Malignant growth can result from the altered balance of expression of these genes in favor of cell proliferation. Induction of the transcription factor, c-Myc, promotes cell proliferation and tran...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lee TC,Li L,Philipson L,Ziff EB

更新日期：1997-11-25 00:00:00

abstract：:A role for Notch in the elaboration of existing neural processes is emerging that is distinct from the increasingly well understood function of this gene in binary cell-fate decisions. Several research groups, by using a variety of organisms, have shown that Notch is important in the development of neural ultrastructu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Presente A,Boyles RS,Serway CN,de Belle JS,Andres AJ

更新日期：2004-02-10 00:00:00

abstract：:The acid-sensing ion channel-1 (ASIC1) contributes to synaptic plasticity and may influence the response to cerebral ischemia and acidosis. We found that cAMP-dependent protein kinase phosphorylated heterologously expressed ASIC1 and endogenous ASIC1 in brain slices. ASIC1 also showed significant phosphorylation under...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Leonard AS,Yermolaieva O,Hruska-Hageman A,Askwith CC,Price MP,Wemmie JA,Welsh MJ

更新日期：2003-02-18 00:00:00

abstract：:RNA-protein interactions underlie a wide range of cellular processes. Improved methods are needed to systematically map RNA-protein interactions in living cells in an unbiased manner. We used two approaches to target the engineered peroxidase APEX2 to specific cellular RNAs for RNA-centered proximity biotinylation of ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Han S,Zhao BS,Myers SA,Carr SA,He C,Ting AY

更新日期：2020-09-08 00:00:00

abstract：:Nitric oxide (NO) mediates several biological actions, including relaxation of blood vessels, cytotoxicity of activated macrophages, and formation of cGMP by activation of glutamate receptors in cerebellar slices. Nitric oxide synthase (EC 1.14.23.-) immunoreactivity is colocalized with nicotinamide adenine di-nucleot...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dawson VL,Dawson TM,London ED,Bredt DS,Snyder SH

更新日期：1991-07-15 00:00:00

abstract：:On a planet experiencing global environmental change, the governance of natural resources depends on sustained collective action by diverse populations. Engaging in such collective action can only build upon the foundation of human cognition in social-ecological settings. To help understand this foundation, we assess ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Freeman J,Baggio JA,Coyle TR

更新日期：2020-04-07 00:00:00

abstract：:When the Mn(2+) and Ca(2+) ions normally present in concanavalin A are removed, the protein becomes incapable of binding saccharides. To explore the structural differences between the native and demetallized forms and their effects on the saccharide-binding properties of the protein, we have refined and compared the c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Reeke GN Jr,Becker JW,Edelman GM

更新日期：1978-05-01 00:00:00

abstract：:We have measured the opioid receptor reserve in the guinea pig ileum myenteric plexus by means of the site-directed alkylating agent, beta-chlornaltrexamine. Treatment of the tissue with low (less than 10 nM) concentrations of beta-chlornaltrexamine caused a parallel shift of the log concentration-response curves for ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chavkin C,Goldstein A

更新日期：1984-11-01 00:00:00

abstract：:The members of the cytoplasmic 70-kDa heat shock protein family are involved in appropriate folding and trafficking of newly synthesized proteins in the cell. Hsc70, which is expressed constitutively, and Hsp70, the expression of which is stress- and heat shock-induced, are often considered to have similar cellular fu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Goldfarb SB,Kashlan OB,Watkins JN,Suaud L,Yan W,Kleyman TR,Rubenstein RC

更新日期：2006-04-11 00:00:00

abstract：:Genetic and biochemical studies on enzymes known to be involved in regulating DNA supercoiling yield a complex spectrum of effects on the Escherichia coli SOS system. Previous studies indicated that only inhibition of DNA gyrase by antibiotics that act on the DNA gyrase A subunit results in turning on the E. coli SOS ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Smith CL

更新日期：1983-05-01 00:00:00

abstract：:cDNA clones specific for the light subunit of porcine calpain I have been isolated from a porcine kidney cDNA library. The complete primary structure of the light subunit has been revealed by nucleotide sequence analysis of the cDNA clones isolated and amino acid sequence analysis of peptides isolated from the purifie...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sakihama T,Kakidani H,Zenita K,Yumoto N,Kikuchi T,Sasaki T,Kannagi R,Nakanishi S,Ohmori M,Takio K

更新日期：1985-09-01 00:00:00

abstract：:Thymidine kinase-deficient mouse L cells have been transformed with plasmid DNAs carrying 8-base-pair Xho I linker insertion mutations in the coding region of the herpes simplex virus type 1 thymidine kinase gene. When the mutant plasmids are introduced individually into LTK- cells, transformation efficiencies are gre...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shapira G,Stachelek JL,Letsou A,Soodak LK,Liskay RM

更新日期：1983-08-01 00:00:00

abstract：:Assembly of nitrogenase FeMoco is one of the key processes in bioinorganic chemistry. NifB and NifEN are two essential elements immediately adjacent to each other along the biosynthetic pathway of FeMoco. Previously, an 8Fe-precursor of FeMoco was identified on NifEN; however, the identity of the biosynthetic intermed...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wiig JA,Hu Y,Ribbe MW

更新日期：2011-05-24 00:00:00

abstract：:The evolutionary transition from single cells toward multicellular forms of life represents one of the major transitions in the evolution of complex organisms. In this transition, single autonomously reproducing cells became parts of larger reproducing entities that eventually constituted a new unit of selection. The ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pfeiffer T,Bonhoeffer S

更新日期：2003-02-04 00:00:00

abstract：:The cell-surface antigen detected by the monoclonal antibody JONES is expressed in the retina and a number of other central nervous system regions of the rat during the latter part of embryonic development and the early postnatal period. In addition to the expression on certain neuroblast populations it is found on so...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Blum AS,Barnstable CJ

更新日期：1987-12-01 00:00:00