Abstract:
:A role for Notch in the elaboration of existing neural processes is emerging that is distinct from the increasingly well understood function of this gene in binary cell-fate decisions. Several research groups, by using a variety of organisms, have shown that Notch is important in the development of neural ultrastructure. Simultaneously, Presenilin (Psn) was identified both as a key mediator of Notch signaling and as a site of genetic lesions that cause early-onset Alzheimer's disease. Here we demonstrate that Notch loss of function produces memory deficits in Drosophila melanogaster. The effects are specific to long-term memory, which is thought to depend on ultrastructural remodeling. We propose that Notch plays an important role in the neural plasticity underlying consolidated memory.
journal_name
Proc Natl Acad Sci U S Aauthors
Presente A,Boyles RS,Serway CN,de Belle JS,Andres AJdoi
10.1073/pnas.0308259100keywords:
subject
Has Abstractpub_date
2004-02-10 00:00:00pages
1764-8issue
6eissn
0027-8424issn
1091-6490pii
0308259100journal_volume
101pub_type
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