Homozygosity and patch structure in plant populations as a result of nearest-neighbor pollination.

abstract：:Serum from bacillus Calmette-Guerin-infected mice injected with endotoxin induces the appearance of surface immunoglobulin, Ia antigen, and complement receptor on the surface of precursor bone-marrow-derived (B) cells. While endotoxin itself causes phenotypic conversion of both thymus-derived (T) cells and B cells in ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hoffmann MK,Oettgen HF,Old LJ,Chin AF,Hammerling U

更新日期：1977-03-01 00:00:00

abstract：:The mechanism of phospholipase C regulation by inhibitory receptors was analyzed both in intact and in permeabilized rat thyroid cells (FRTL5). In this system, the muscarinic agonist carbachol inhibited phospholipase C, as indicated by the decrease in the basal levels of inositol 1,4,5-trisphosphate as well as by the ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bizzarri C,Di Girolamo M,D'Orazio MC,Corda D

更新日期：1990-06-01 00:00:00

abstract：:Monoclonal antibodies (mAbs) against purified human placental insulin-like growth factor I (IGF-I) receptors were prepared and characterized. Three IgG mAbs were specific for the human IGF-I receptor and displayed negligible crossreactivity with the human insulin receptor. They stimulated 125I-labeled IGF-I (125I-IGF-...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Xiong L,Kasuya J,Li SL,Kato J,Fujita-Yamaguchi Y

更新日期：1992-06-15 00:00:00

abstract：:Behavioral models indicate that persistent small afferent input, as generated by tissue injury, results in a hyperalgesia at the site of injury and a tactile allodynia in areas adjacent to the injury site. Hyperalgesia reflects a sensitization of the peripheral terminal and a central facilitation evoked by the persist...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yaksh TL,Hua XY,Kalcheva I,Nozaki-Taguchi N,Marsala M

更新日期：1999-07-06 00:00:00

abstract：:The yeast SIN1 protein is a nuclear protein that together with other proteins behaves as a transcriptional repressor of a family of genes. In addition, sin1 mutants are defective in proper mitotic chromosome segregation. In an effort to understand the basis for these phenotypes, we employed the yeast two-hybrid system...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shpungin S,Liberzon A,Bangio H,Yona E,Katcoff DJ

更新日期：1996-08-06 00:00:00

abstract：:Despite sharing a common architecture with archetypal voltage-gated ion channels (VGICs), hyperpolarization- and cAMP-activated ion (HCN) channels open upon hyperpolarization rather than depolarization. The basic motions of the voltage sensor and pore gates are conserved, implying that these domains are inversely coup...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cowgill J,Klenchin VA,Alvarez-Baron C,Tewari D,Blair A,Chanda B

更新日期：2019-01-08 00:00:00

abstract：:Although the applicability of small subunit ribosomal RNA (16S rRNA) sequences for bacterial classification is now well accepted, the general use of these molecules has been hindered by the technical difficulty of obtaining their sequences. A protocol is described for rapidly generating large blocks of 16S rRNA sequen...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lane DJ,Pace B,Olsen GJ,Stahl DA,Sogin ML,Pace NR

更新日期：1985-10-01 00:00:00

abstract：:Circadian timekeeping by intracellular molecular clocks is evident widely in prokaryotes and eukaryotes. The clockworks are driven by autoregulatory feedback loops that lead to oscillating levels of components whose maxima are in fixed phase relationships with one another. These phase relationships are the key metric ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mirsky HP,Liu AC,Welsh DK,Kay SA,Doyle FJ 3rd

更新日期：2009-07-07 00:00:00

abstract：:The sudden appearance of calcified skeletons among many different invertebrate taxa at the Precambrian-Cambrian transition may have required minor reorganization of preexisting secretory functions. In particular, features of the skeletal organic matrix responsible for regulating crystal growth by inhibition may be der...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Marin F,Smith M,Isa Y,Muyzer G,Westbroek P

更新日期：1996-02-20 00:00:00

abstract：:A key idea in Lashley's formulation of the problem of serial order in behavior is the postulated neural representation of all serial elements before the action begins. We studied this question by recording the activity of individual neurons simultaneously in small ensembles in prefrontal cortex while monkeys copied ge...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Averbeck BB,Chafee MV,Crowe DA,Georgopoulos AP

更新日期：2002-10-01 00:00:00

abstract：:Mutations in the human DYNC1H1 gene are associated with neurological diseases. DYNC1H1 encodes the heavy chain of cytoplasmic dynein-1, a 1.4-MDa motor complex that traffics organelles, vesicles, and macromolecules toward microtubule minus ends. The effects of the DYNC1H1 mutations on dynein motility, and consequently...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hoang HT,Schlager MA,Carter AP,Bullock SL

更新日期：2017-02-28 00:00:00

abstract：:Monocytes originate from precursors made in the bone and remain in the circulation for nearly 24 h. Much effort has been done to identify the molecules regulating transendothelial migration of monocytes during inflammatory conditions. In contrast, considerably less is known about the process of constitutive monocyte e...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Thomas-Ecker S,Lindecke A,Hatzmann W,Kaltschmidt C,Zänker KS,Dittmar T

更新日期：2007-03-27 00:00:00

abstract：:We report on label-free imaging, detection, and mass/size measurement of single viral particles in solution by high-resolution surface plasmon resonance microscopy. Diffraction of propagating plasmon waves along a metal surface by the viral particles creates images of the individual particles, which allow us to detect...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang S,Shan X,Patel U,Huang X,Lu J,Li J,Tao N

更新日期：2010-09-14 00:00:00

abstract：:The ability of a series of anions to inhibit [(3)H]strychnine binding to spinal cord synaptic membranes correlates closely with their neurophysiologic capacity to reverse inhibitory postsynaptic potentials in the mammalian spinal cord. Seven neurophysiologically active anions are also effective inhibitors of [(3)H]str...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Young AB,Snyder SH

更新日期：1974-10-01 00:00:00

abstract：:By using a mixture of synthetic oligodeoxyribonucleotides as a probe, cloned cDNA sequences specific for low molecular weight (LMW) kininogen have been isolated from a cDNA library of bovine liver mRNA sequences. Nucleotide sequence analyses of cloned cDNA inserts have revealed that bovine liver LMW kininogens are enc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nawa H,Kitamura N,Hirose T,Asai M,Inayama S,Nakanishi S

更新日期：1983-01-01 00:00:00

abstract：:We have purified a protein from Necturus maculosus gallbladder cells that forms chloride channels in an artificial membrane. The same protein apparently can form channels that are highly selective for chloride but can have conductances varying from 9 to about 150 pS. The high-conductance channels are blocked by the mo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Finn AL,Dillard M,Gaido M

更新日期：1993-06-15 00:00:00

abstract：:[(3)H]DNA copies of avian, feline, murine, and primate RNA tumor virus genomes were synthesized in vitro by an RNA-dependent DNA polymerase reaction. These DNAs were hybridized to 60-70S RNA that had been purified from the viruses. The amount of the [(3)H]DNA hybridized yielded a measure of the genetic relatedness amo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Miller NR,Saxinger WC,Reitz MS,Gallagher RE,Wu AM,Gallo RC,Gillespie D

更新日期：1974-08-01 00:00:00

abstract：:Advanced personalized medical diagnostics depend on the availability of high-quality biological samples. These are typically biofluids, such as blood, saliva, or urine; and their collection and storage is critical to obtain reliable results. Without proper temperature regulation, protein biomarkers in particular can d...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kluge JA,Li AB,Kahn BT,Michaud DS,Omenetto FG,Kaplan DL

更新日期：2016-05-24 00:00:00

abstract：:In the human, cone photoreceptors (L, M, and S) and the melanopsin-containing, intrinsically photosensitive retinal ganglion cells (ipRGCs) are active at daytime light intensities. Signals from cones are combined both additively and in opposition to create the perception of overall light and color. Similar mechanisms ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Spitschan M,Jain S,Brainard DH,Aguirre GK

更新日期：2014-10-28 00:00:00

abstract：:Heterosis is widely applied in agriculture; however, the underlying molecular mechanisms for superior performance are not well understood. Ethylene biosynthesis and signaling genes are shown to be down-regulated in Arabidopsis interspecific hybrids. Ethylene is a plant hormone that promotes fruit ripening and maturati...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Song Q,Ando A,Xu D,Fang L,Zhang T,Huq E,Qiao H,Deng XW,Chen ZJ

更新日期：2018-05-22 00:00:00

abstract：:The tat protein encoded by the human immunodeficiency virus type 1 is a potent trans-activator of gene expression from the viral long terminal repeat. The domains that are essential for trans-activation, a Pro-Xaa3-Pro triad, a cysteine-rich metal-binding sequence motif, and a cluster of basic residues, are present wi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jeyapaul J,Reddy MR,Khan SA

更新日期：1990-09-01 00:00:00

abstract：:Type 1A diabetes (T1D) is an autoimmune disorder the risk of which is increased by specific HLA DR/DQ alleles [e.g., DRB1*03-DQB1*0201 (DR3) or DRB1*04-DQB1*0302 (DR4)]. The genotype associated with the highest risk for T1D is the DR3/4-DQ8 (DQ8 is DQA1*0301, DQB1*0302) heterozygous genotype. We determined HLA-DR and ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Aly TA,Ide A,Jahromi MM,Barker JM,Fernando MS,Babu SR,Yu L,Miao D,Erlich HA,Fain PR,Barriga KJ,Norris JM,Rewers MJ,Eisenbarth GS

更新日期：2006-09-19 00:00:00

abstract：:Development of therapy against infections caused by antibiotic-resistant pathogens is a major unmet need in contemporary medicine. In previous work, our group chemically modified an antimicrobial peptidomimetic motif for targeted applications against cancer and obesity. Here, we show that the modified motif per se is ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： McGrath DM,Barbu EM,Driessen WH,Lasco TM,Tarrand JJ,Okhuysen PC,Kontoyiannis DP,Sidman RL,Pasqualini R,Arap W

更新日期：2013-02-26 00:00:00

abstract：:After exposure of segments of rabbit taenia coli to the nonionic detergent Triton X-100, tension could be induced by increasing the [Ca2+] in the micromolar range. In the presence of a saturating [Ca2+], this preparation developed nearly 100% of the control tetanus tension recorded from the intact muscle prior to the ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gordon AR

更新日期：1978-07-01 00:00:00

abstract：:The high-potential iron-sulfur center associated with the g = 1.89-1.90 electron paramagnetic resonance signal in spinach chloroplasts is fully reduced in the dark. It is photooxidized in the presence of 3-(3,4-dichlorophenyl)-1,1-dimethylurea and reduced after illumination with red actinic light in the absence of inh...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Whitmarsh J,Cramer WA

更新日期：1979-09-01 00:00:00

abstract：:The extinction of a species is inevitably preceded by the extirpation of a series of local populations. Ecological theory predicts that vulnerability to extirpation varies between populations and is ultimately linked to environmental heterogeneity. If populations of a species are present in multiple regions separated ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yackulic CB,Sanderson EW,Uriarte M

更新日期：2011-03-08 00:00:00

abstract：:We characterize a sonic hedgehog (Shh) signaling domain restricted to the adventitial layer of artery wall that supports resident Sca1-positive vascular progenitor cells (AdvSca1). Using patched-1 (Ptc1(lacZ)) and patched-2 (Ptc2(lacZ)) reporter mice, adventitial Shh signaling activity was first detected at embryonic ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Passman JN,Dong XR,Wu SP,Maguire CT,Hogan KA,Bautch VL,Majesky MW

更新日期：2008-07-08 00:00:00

abstract：:Magnetic field fluctuations arising from fundamental spins are ubiquitous in nanoscale biology, and are a rich source of information about the processes that generate them. However, the ability to detect the few spins involved without averaging over large ensembles has remained elusive. Here, we demonstrate the detect...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kaufmann S,Simpson DA,Hall LT,Perunicic V,Senn P,Steinert S,McGuinness LP,Johnson BC,Ohshima T,Caruso F,Wrachtrup J,Scholten RE,Mulvaney P,Hollenberg L

更新日期：2013-07-02 00:00:00

abstract：:Energy-storing artificial-photosynthetic systems for CO2 reduction must derive the reducing equivalents from a renewable source rather than from sacrificial donors. To this end, a homogeneous, integrated chromophore/two-catalyst system is described that is thermodynamically capable of photochemically driving the energ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： La Porte NT,Moravec DB,Hopkins MD

更新日期：2014-07-08 00:00:00

abstract：:New experiments using scanning probe microcopies and advanced optical methods allow us to study molecules as individuals, not just as populations. The findings of these studies not only include the confirmation of results expected from studies of bulk matter, but also give substantially new information concerning the ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bai C,Wang C,Xie XS,Wolynes PG

更新日期：1999-09-28 00:00:00