Detection of atomic spin labels in a lipid bilayer using a single-spin nanodiamond probe.

abstract：:In Arabidopsis thaliana, biosynthesis of the essential thiol antioxidant, glutathione (GSH), is plastid-regulated, but many GSH functions, including heavy metal detoxification and plant defense activation, depend on cytosolic GSH. This finding suggests that plastid and cytosol thiol pools are closely integrated and we...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Maughan SC,Pasternak M,Cairns N,Kiddle G,Brach T,Jarvis R,Haas F,Nieuwland J,Lim B,Müller C,Salcedo-Sora E,Kruse C,Orsel M,Hell R,Miller AJ,Bray P,Foyer CH,Murray JA,Meyer AJ,Cobbett CS

更新日期：2010-02-02 00:00:00

abstract：:An increasing number of protein structures are found to encompass multiple folding nuclei, allowing their structures to be formed by several competing pathways. A typical example is the ribosomal protein S6, which comprises two folding nuclei (sigma1 and sigma2) defining two competing pathways in the folding energy la...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Haglund E,Lind J,Oman T,Ohman A,Mäler L,Oliveberg M

更新日期：2009-12-22 00:00:00

abstract：:Leptin acts as a potent inhibitory factor against obesity by regulating energy expenditure, food intake, and adiposity. The obese diabetic db/db mouse, which has defects in leptin receptor, displays enhanced neural responses and elevated behavioral preference to sweet stimuli. Here, we show the effects of leptin on th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kawai K,Sugimoto K,Nakashima K,Miura H,Ninomiya Y

更新日期：2000-09-26 00:00:00

abstract：:We have used a microfluidic mass sensor to measure the density of single living cells. By weighing each cell in two fluids of different densities, our technique measures the single-cell mass, volume, and density of approximately 500 cells per hour with a density precision of 0.001 g mL(-1). We observe that the intrins...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Grover WH,Bryan AK,Diez-Silva M,Suresh S,Higgins JM,Manalis SR

更新日期：2011-07-05 00:00:00

abstract：:Ras is a guanine nucleotide-binding protein that cycles between inactive GDP-bound and active GTP-bound states to regulate a diverse array of cellular processes, including cell growth, apoptosis, and differentiation. The guanine nucleotide-bound state of Ras is tightly maintained by regulatory factors to promote regul...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Williams JG,Pappu K,Campbell SL

更新日期：2003-05-27 00:00:00

abstract：:Seed germination is regulated by endogenous hormonal cues and external environmental stimuli such as water, low temperature, and light. After germination, the young seedling must rapidly establish its root system and the photoautotrophic capability appropriate to its surrounding environment. Light and the phytohormone...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chen H,Zhang J,Neff MM,Hong SW,Zhang H,Deng XW,Xiong L

更新日期：2008-03-18 00:00:00

abstract：:Multiple epidemic diseases have been designated as emerging or reemerging because the numbers of clinical cases have increased. Emerging diseases are often suspected to be driven by increased virulence or fitness, possibly associated with the gain of novel genes or mutations. However, the time period over which humans...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhou Z,McCann A,Weill FX,Blin C,Nair S,Wain J,Dougan G,Achtman M

更新日期：2014-08-19 00:00:00

abstract：:We have cloned an additional member (GC-D) of the membrane receptor guanylyl cyclase [GTP pyrophosphate-lyase (cyclizing), EC 4.6.1.2] family that is specifically expressed in a subpopulation of olfactory sensory neurons. The extracellular, putative ligand-binding domain of the olfactory cyclase is similar in primary ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fülle HJ,Vassar R,Foster DC,Yang RB,Axel R,Garbers DL

更新日期：1995-04-11 00:00:00

abstract：:Anti-idiotype antibodies (Ab2) were purified from a cancer patient treated with NP-4, a murine monoclonal antibody to carcinoembryonic antigen (CEA). These Ab2 were specific for NP-4 and inhibited the binding between NP-4 and CEA. BALB/c mice immunized with these human Ab2 produced anti-Ab2 antibodies that were also r...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Losman MJ,Hansen HJ,Sharkey RM,Goldenberg DM,Monestier M

更新日期：1991-04-15 00:00:00

abstract：:Diphtheria toxin ( DTx ) is an extremely potent inhibitor of protein synthesis. It is secreted as a linear polypeptide, which is cleaved to produce disulfide-linked A and B fragments. Fragment A, the inhibitor of protein synthesis, requires fragment B, the recognition subunit, for entry into intact cells. Fragment B h...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zalman LS,Wisnieski BJ

更新日期：1984-06-01 00:00:00

abstract：:A single-nucleotide polymorphism in the human arylamine N-acetyltransferase 2 (Nat2) gene has recently been identified as associated with insulin resistance in humans. To understand the cellular and molecular mechanisms by which alterations in Nat2 activity might cause insulin resistance, we examined murine ortholog N...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Camporez JP,Wang Y,Faarkrog K,Chukijrungroat N,Petersen KF,Shulman GI

更新日期：2017-12-26 00:00:00

abstract：:The formation of nerve-muscle junctions in monolayer cultures of embryonic muscle and spinal cord cells is described. Muscle-forming cells (myoblasts) from leg muscles of 12-day chick embryos were separated with trypsin and cultured on a collagen substrate for two days. Suspensions of ventral spinal cord cells from si...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shimada Y,Fischman DA,Moscona AA

更新日期：1969-03-01 00:00:00

abstract：:The murine mast cell line PB-3c is dependent on interleukin 3 (IL-3) with respect to survival and proliferation. These cells also require IL-3 to display antigen-mediated serotonin release, which is coupled to a transient increase of cytosolic free calcium ([Ca2+]i). The antigen-mediated exocytosis is inhibited by pho...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mazurek N,Regazzi R,Borner C,Wyss R,Conscience JF,Erne P,Eppenberger U,Fabbro D

更新日期：1987-03-01 00:00:00

abstract：:Charge transport (CT) through the DNA base pairs provides a means to promote redox reactions at a remote site and potentially to effect signaling between molecules bound to DNA. Here we describe the oxidation of a cell-cycle regulatory protein, p53, from a distance through DNA-mediated CT. A consensus p53 binding site...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Augustyn KE,Merino EJ,Barton JK

更新日期：2007-11-27 00:00:00

abstract：:Message passing is a fundamental technique for performing calculations on networks and graphs with applications in physics, computer science, statistics, and machine learning, including Bayesian inference, spin models, satisfiability, graph partitioning, network epidemiology, and the calculation of matrix eigenvalues....

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cantwell GT,Newman MEJ

更新日期：2019-11-19 00:00:00

abstract：:Morphine is one of the most prescribed and effective drugs used for the treatment of acute and chronic pain conditions. In addition to its central effects, morphine can also produce peripheral analgesia. However, the mechanisms underlying this peripheral action of morphine have not yet been fully elucidated. Here, we ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cunha TM,Roman-Campos D,Lotufo CM,Duarte HL,Souza GR,Verri WA Jr,Funez MI,Dias QM,Schivo IR,Domingues AC,Sachs D,Chiavegatto S,Teixeira MM,Hothersall JS,Cruz JS,Cunha FQ,Ferreira SH

更新日期：2010-03-02 00:00:00

abstract：:Epithelia in animals are colonized by complex communities of microbes. Although a topic of long-standing interest, understanding the evolution of the microbial communities and their role in triggering innate immune responses has resisted analysis. Cnidaria are among the simplest animals at the tissue grade of organiza...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fraune S,Bosch TC

更新日期：2007-08-07 00:00:00

abstract：:If H denotes the classical Hilbert transform and Hu(x) = v(x), then the functions u(x) and v(x) are the values on the real axis of a pair of conjugate functions, harmonic in the upper half-plane. This note gives a generalization of the above concepts in which the Laplace equation Deltau = 0 is replaced by the Yukawa e...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Duffin RJ

更新日期：1972-12-01 00:00:00

abstract：:Mechanoelectrical transduction in the inner ear is a biophysical process underlying the senses of hearing and balance. The key players involved in this process are mechanosensitive ion channels. They are located in the stereocilia of hair cells and opened by the tension in specialized molecular springs, the tip links,...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gianoli F,Risler T,Kozlov AS

更新日期：2017-12-19 00:00:00

abstract：:Mitochondrial dysfunctions cause numerous human disorders. A platform technology based on biodegradable polymers for carrying bioactive molecules to the mitochondrial matrix could be of enormous potential benefit in treating mitochondrial diseases. Here we report a rationally designed mitochondria-targeted polymeric n...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Marrache S,Dhar S

更新日期：2012-10-02 00:00:00

abstract：:X-chromosome inactivation (XCI) is initiated by the long noncoding RNA Xist, which coats the inactive X (Xi) and targets Polycomb repressive complex 2 (PRC2) in cis. Epigenomic analyses have provided significant insight into Xist binding patterns and chromatin organization of the Xi. However, such epigenomic analyses ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sunwoo H,Wu JY,Lee JT

更新日期：2015-08-04 00:00:00

abstract：:Transcriptional network evolution is central to the development of complex biological systems. Networks can evolve through variation of master regulators and/or by changes in regulation of genes within networks. To gain insight into meaningful evolutionary differences in large networks, it is essential to address the ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jegga AG,Inga A,Menendez D,Aronow BJ,Resnick MA

更新日期：2008-01-22 00:00:00

abstract：:Endogenous circadian rhythms have been described in a wide range of organisms from prokaryotes to man. Although basic circadian mechanisms at the molecular level are genetically fixed, certain properties of circadian rhythms at the organismic level can be modified by environmental conditions and subsequently retained ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Brandstätter R,Kumar V,Abraham U,Gwinner E

更新日期：2000-10-24 00:00:00

abstract：:When various wild strains of Penicillium lanosum and Aspergillus niger were placed in the same mild laboratory environment, their frequencies of new spontaneous mutations were clearly related to whether they had been isolated from a region of high or low microclimatic stress. In the mild environment, the total frequen...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lamb BC,Mandaokar S,Bahsoun B,Grishkan I,Nevo E

更新日期：2008-04-15 00:00:00

abstract：:With 13C NMR, phosphoglucose isomerase (PGI; D-glucose-6-phosphate ketol-isomerase, EC 5.3.1.9) is shown to produce mannose 6-phosphate (M6P) slowly from a much more rapidly catalyzed equilibrium between glucose 6-phosphate (G6P) and fructose 6-phosphate (F6P). The identity of M6P and its formation from G6P plus F6P a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Seeholzer SH

更新日期：1993-02-15 00:00:00

abstract：:Two RNA fractions have been isolated and purified from both oncogenic and nononcogenic strains of Agrobacterium tumefaciens. Both RNAs are capable of inducing the formation of transplantable tumors when introduced at wound sites in stems of Datura stramonium plants. One of these RNA fractions was found to be bound to ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Beljanski M,Aaron-da Cunha MI,Beljanski MS,Manigault P,Bourgarel P

更新日期：1974-05-01 00:00:00

abstract：:To study the structure and function of the gene for parathyroid hormone, we obtained recombinant plasmids containing bovine parathyroid hormone cDNA. The nucleotide sequence at the 5' terminus (relative to the sense strand) of the cDNA insert in a recombinant plasmid, pPTHi4, was different from that previously reporte...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Weaver CA,Gordon DF,Kemper B

更新日期：1981-07-01 00:00:00

abstract：:Understanding the causes and consequences of wildfires in forests of the western United States requires integrated information about fire, climate changes, and human activity on multiple temporal scales. We use sedimentary charcoal accumulation rates to construct long-term variations in fire during the past 3,000 y in...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Marlon JR,Bartlein PJ,Gavin DG,Long CJ,Anderson RS,Briles CE,Brown KJ,Colombaroli D,Hallett DJ,Power MJ,Scharf EA,Walsh MK

更新日期：2012-02-28 00:00:00

abstract：:Extracellular stimuli regulate neuronal differentiation and subtype specification during brain development, although the intracellular signaling pathways that mediate these processes remain largely unclear. We now show that the PDK1-Akt pathway regulates differentiation of telencephalic neural precursor cells (NPCs). ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Oishi K,Watatani K,Itoh Y,Okano H,Guillemot F,Nakajima K,Gotoh Y

更新日期：2009-08-04 00:00:00

abstract：:We investigate the roles of the pseudospin and the valley degeneracy in electron scattering at graphene edges. It is found that they are strongly correlated with charge density modulations of short-wavelength oscillations and slowly decaying beat patterns in the electronic density profile. Theoretical analyses using n...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Park C,Yang H,Mayne AJ,Dujardin G,Seo S,Kuk Y,Ihm J,Kim G

更新日期：2011-11-15 00:00:00