Human response against NP-4, a mouse antibody to carcinoembryonic antigen: human anti-idiotype antibodies mimic an epitope on the tumor antigen.

Abstract:

:Anti-idiotype antibodies (Ab2) were purified from a cancer patient treated with NP-4, a murine monoclonal antibody to carcinoembryonic antigen (CEA). These Ab2 were specific for NP-4 and inhibited the binding between NP-4 and CEA. BALB/c mice immunized with these human Ab2 produced anti-Ab2 antibodies that were also reactive with the CEA epitope recognized by NP-4. These results indicate that human Ab2 to NP-4 can antigenically mimic the CEA epitope recognized by NP-4.

authors

Losman MJ,Hansen HJ,Sharkey RM,Goldenberg DM,Monestier M

doi

10.1073/pnas.88.8.3421

subject

Has Abstract

pub_date

1991-04-15 00:00:00

pages

3421-5

issue

8

eissn

0027-8424

issn

1091-6490

journal_volume

88

pub_type

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