A receptor guanylyl cyclase expressed specifically in olfactory sensory neurons.

abstract：:A remote labeling method has been developed to determine (18)O kinetic isotope effects (KIEs) in Ras-catalyzed GTP hydrolysis. Substrate mixtures consist of (13)C-depleted GTP and [(18)O,(13)C]GTP that contains (18)O at phosphoryl positions of mechanistic interest and (13)C at all carbon positions of the guanosine moi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Du X,Black GE,Lecchi P,Abramson FP,Sprang SR

更新日期：2004-06-15 00:00:00

abstract：:The effects of epinephrine (as low as 0.1 muM) on guanosine 3':5'-cyclic monophosphate (cGMP) and adenosine 3':5'-cyclic monophosphate (cAMP) in isolated fat cells were examined. Epinephrine increased both cGMP and cAMP levels, with the elevation of cAMP preceding the rise of cGMP. Maximal elevation was obtained with ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Asakawa T,Ruiz J,Ho RJ

更新日期：1978-06-01 00:00:00

abstract：:Decision-makers increasingly seek scientific guidance on investing in nature, but biodiversity remains difficult to estimate across diverse landscapes. Here, we develop empirically based models for quantifying biodiversity across space. We focus on agricultural lands in the tropical forest biome, wherein lies the grea...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mendenhall CD,Shields-Estrada A,Krishnaswami AJ,Daily GC

更新日期：2016-12-20 00:00:00

abstract：:During the developmental process of the Gram-negative soil bacterium Myxococcus xanthus, vegetatively growing rod cells differentiate to ultimately become metabolically quiescent and environmentally resistant myxospores encased within fruiting bodies. This program, initiated by nutrient deprivation, is propagated by b...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tzeng L,Singer M

更新日期：2005-10-04 00:00:00

abstract：:Animal development is remarkably robust; cell fates are specified with spatial and temporal precision despite physiological and environmental contingencies. Favorable conditions cause Caenorhabditis elegans to develop rapidly through four larval stages (L1-L4) to the reproductive adult. In unfavorable conditions, L2 l...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hammell CM,Karp X,Ambros V

更新日期：2009-11-03 00:00:00

abstract：:Optimal infectivity of HIV-1 virions requires synthesis of the HIV-1 regulatory protein Nef in some producer cells but not others. A survey of 18 lymphoid cell lines found that Nef was dispensable in three, each of which harbored gammaretroviruses. Nef-dependent cell lines were rendered Nef-independent by a cell-free ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pizzato M

更新日期：2010-05-18 00:00:00

abstract：:This paper reports that there are major differences between mammalian cell lines in the propensity to progress into subsequent cell cycles when mitosis is inhibited with agents that disrupt the assembly of the mitotic spindle apparatus (Colcemid, nocodazole, and taxol). Human HeLa S3 cells, which represent one extreme...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kung AL,Sherwood SW,Schimke RT

更新日期：1990-12-01 00:00:00

abstract：:Methylmercury (MeHg) is a potent neurotoxin that is biomagnified approximately 1-10 million-fold in aquatic carnivores such as the Northern elephant seal (Mirounga angustirostris), whose excreta and molted pelage, in turn, constitute a source of environmental MeHg contamination at the base of marine food chains. The p...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cossaboon JM,Ganguli PM,Flegal AR

更新日期：2015-09-29 00:00:00

abstract：:Plant steroid hormones, brassinosteroids (BRs), are of great importance for plant growth and development. BRs signal through a cell surface receptor kinase, BRI1, and a GSK3-like kinase, BIN2, to regulate the BES1/BZR1 family of transcription factors, which directly bind to target gene promoters to activate or repress...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yu X,Li L,Li L,Guo M,Chory J,Yin Y

更新日期：2008-05-27 00:00:00

abstract：:Endothelial cells (EC) play a central role in inflammatory immune responses and efficiently induce effector functions in T cells, despite lacking the classical costimulatory ligands CD80 and CD86. By using the mAb HIL-131 we now demonstrate that human inducible costimulator-ligand (ICOS-L), a molecule related to CD80/...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Khayyamian S,Hutloff A,Büchner K,Gräfe M,Henn V,Kroczek RA,Mages HW

更新日期：2002-04-30 00:00:00

abstract：:Model organism studies have demonstrated that cell fate specification decisions play an important role in normal brain development. Their role in human neurodevelopmental disorders, however, is poorly understood, with very few examples described. The cerebellum is an excellent system to study mechanisms of cell fate s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Millen KJ,Steshina EY,Iskusnykh IY,Chizhikov VV

更新日期：2014-04-29 00:00:00

abstract：:Tropomyosin is a key component of the contractile systems found in muscle and nonmuscle cells of higher eukaryotes. Based on properties common to all tropomyosins, we have purified a protein from Saccharomyces cerevisiae that resembles tropomyosins from higher cells. The yeast protein remains soluble after heat treatm...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liu HP,Bretscher A

更新日期：1989-01-01 00:00:00

abstract：:The oxygenation of the atmosphere ∼2.45-2.32 billion years ago (Ga) is one of the most significant geological events to have affected Earth's redox history. Our understanding of the timing and processes surrounding this key transition is largely dependent on the development of redox-sensitive proxies, many of which re...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chi Fru E,Rodríguez NP,Partin CA,Lalonde SV,Andersson P,Weiss DJ,El Albani A,Rodushkin I,Konhauser KO

更新日期：2016-05-03 00:00:00

abstract：:An expression in the exterior algebra of a Peano space yielding Pappus' theorem was originally given by Doubilet, Rota, and Stein [Doubilet, P., Rota, G.-C. & Stein, J. (1974) Stud. Appl. Math. 8, 185-216]. Motivated by an identity of Rota, I give an identity in a Grassmann-Cayley algebra of step 3, involving joins an...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hawrylycz M

更新日期：1994-04-12 00:00:00

abstract：:Antibodies were raised against two synthetic peptides whose sequences correspond respectively to the COOH-terminal end (residues 501-516) of the protein encoded by the gene for the delta chain and to a proposed cytoplasmic region (residues 350-358) of the beta chain of the acetylcholine receptor from Torpedo californi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Young EF,Ralston E,Blake J,Ramachandran J,Hall ZW,Stroud RM

更新日期：1985-01-01 00:00:00

abstract：:Dietary diversity often varies inversely with prey resource abundance. This pattern, although typically measured at the population level, is usually assumed to also characterize the behavior of individual animals within the population. However, the pattern might also be produced by changes in the degree of variation a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tinker MT,Bentall G,Estes JA

更新日期：2008-01-15 00:00:00

abstract：:Human Bestrophin 1 (hBest1) is a calcium-activated chloride channel that regulates neuronal excitability, synaptic activity, and retinal homeostasis. Mutations in hBest1 cause the autosomal-dominant Best macular dystrophy (BMD). Because hBest1 mutations cause BMD, but a knockout does not, we wondered if hBest1 mutants...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bharill S,Fu Z,Palty R,Isacoff EY

更新日期：2014-04-29 00:00:00

abstract：:In vitro translation of cellular poly(A)+ RNA coupled with immunoprecipitation was developed as a technique for characterizing 1,25-dihydroxyvitamin D3 [1,25-(OH)2D3] receptors and assessing receptor mRNA activity. Cell-free translation of poly(A)+ RNA isolated from chicken intestine revealed two immunoprecipitable fo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mangelsdorf DJ,Pike JW,Haussler MR

更新日期：1987-01-01 00:00:00

abstract：:Adoptive T cell therapy, involving the ex vivo selection and expansion of antigen-specific T cell clones, provides a means of augmenting antigen-specific immunity without the in vivo constraints that can accompany vaccine-based strategies. A phase I study was performed to evaluate the safety, in vivo persistence, and ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yee C,Thompson JA,Byrd D,Riddell SR,Roche P,Celis E,Greenberg PD

更新日期：2002-12-10 00:00:00

abstract：:Despite its popularity, chromatin immunoprecipitation followed by sequencing (ChIP-seq) remains a tedious (>2 d), manually intensive, low-sensitivity and low-throughput approach. Here, we combine principles of microengineering, surface chemistry, and molecular biology to address the major limitations of standard ChIP-...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dainese R,Gardeux V,Llimos G,Alpern D,Jiang JY,Meireles-Filho ACA,Deplancke B

更新日期：2020-06-16 00:00:00

abstract：:The yeast AAA-ATPase Cdc48 and the ubiquitin fusion degradation (UFD) proteins play important, evolutionarily conserved roles in ubiquitin dependent protein degradation. The N-terminal domain of Cdc48 interacts with substrate-recruiting cofactors, whereas the C terminus of Cdc48 binds to proteins such as Ufd3 that pro...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhao G,Li G,Schindelin H,Lennarz WJ

更新日期：2009-09-22 00:00:00

abstract：:IL-7 and thymic stromal lymphopoietin (TSLP) are two major cytokines controlling murine B cell development. IL-7 has been studied extensively, but only recently has it become possible to unravel the role of TSLP in detail. We studied the biological activities of TSLP in B cell development at distinct ages in the mouse...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vosshenrich CA,Cumano A,Müller W,Di Santo JP,Vieira P

更新日期：2004-07-27 00:00:00

abstract：:To attempt to locate functionally important regions of the interferon (IFN) molecule, recombinant human IFN-alpha 2 was subjected to proteolytic digestion. The bacterial proteinase thermolysin produced two major complementary fragments, HuIFN-alpha 2-(1-110) and HuIFN-alpha 2-(111-153). After reduction with 2-mercapto...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ackerman SK,Zur Nedden D,Heintzelman M,Hunkapiller M,Zoon K

更新日期：1984-02-01 00:00:00

abstract：:Influenza hemagglutinin (HA) glycoprotein is the primary surface antigen targeted by the host immune response and a focus for development of novel vaccines, broadly neutralizing antibodies (bnAbs), and therapeutics. HA enables viral entry into host cells via receptor binding and membrane fusion and is a validated targ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yao Y,Kadam RU,Lee CD,Woehl JL,Wu NC,Zhu X,Kitamura S,Wilson IA,Wolan DW

更新日期：2020-08-04 00:00:00

abstract：:Nerve cells depend on specific interactions with glial cells for proper function. Myelinating glial cells are thought to associate with neuronal axons, in part, via the cell-surface adhesion protein, myelin-associated glycoprotein (MAG). MAG is also thought to be a major inhibitor of neurite outgrowth (axon regenerati...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yang LJ,Zeller CB,Shaper NL,Kiso M,Hasegawa A,Shapiro RE,Schnaar RL

更新日期：1996-01-23 00:00:00

abstract：:A method is proposed for rapidly, quantitatively comparing protein structures of arbitrary sizes, based on the differential geometric representation. The method is applied to a group of 22 protein x-ray structures, and the resulting network of closest relationships is delineated. Several well-known fold types are auto...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rackovsky S,Goldstein DA

更新日期：1988-02-01 00:00:00

abstract：:The human gamma herpesviruses, Kaposi sarcoma-associated virus (KSHV) and EBV, are associated with multiple cancers. Recent evidence suggests that EBV and possibly other viruses can manipulate the tumor microenvironment through the secretion of specific viral and cellular components into exosomes, small endocytically ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Meckes DG Jr,Gunawardena HP,Dekroon RM,Heaton PR,Edwards RH,Ozgur S,Griffith JD,Damania B,Raab-Traub N

更新日期：2013-07-30 00:00:00

abstract：:In animals, successful production of the visual chromophore (11-cis-retinal or derivatives thereof such as 11-cis-3-hydroxy-retinal) is essential for photoreceptor cell function and survival. These carotenoid-derived compounds must combine with a protein moiety (the opsin) to establish functional visual pigments. Evid...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Oberhauser V,Voolstra O,Bangert A,von Lintig J,Vogt K

更新日期：2008-12-02 00:00:00

abstract：:The phosphorylation of protein I, a specific neuronal protein, has been found to be regulated both by cyclic AMP (cAMP) and by calcium, in intact as well as in lysed synaptosome preparations from rat brain. In order to determine the phosphorylation site(s) of protein I that were regulated by cAMP and calcium, protein ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Huttner WB,Greengard P

更新日期：1979-10-01 00:00:00

abstract：:Rift Valley fever (RVF) is a vector-borne viral disease widespread in Africa. The primary cycle involves mosquitoes and wild and domestic ruminant hosts. Humans are usually contaminated after contact with infected ruminants. As many environmental, agricultural, epidemiological, and anthropogenic factors are implicated...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lancelot R,Béral M,Rakotoharinome VM,Andriamandimby SF,Héraud JM,Coste C,Apolloni A,Squarzoni-Diaw C,de La Rocque S,Formenty PB,Bouyer J,Wint GR,Cardinale E

更新日期：2017-01-31 00:00:00