Multiple phosphorylation sites in protein I and their differential regulation by cyclic AMP and calcium.

abstract：:This study presents, to our knowledge, the first on-line measurement of acetylcholinesterase (AcChoEase) release from brain tissue. It is now well established that a soluble form of the enzyme is released from central nervous system neurons, and it has been proposed on indirect grounds that such release may occur not ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Llinás RR,Greenfield SA

更新日期：1987-05-01 00:00:00

abstract：:Androgens and the androgen receptor (AR) play important roles in the testes. Previously we have shown that male total AR knockout (T-AR-/y) mice revealed incomplete germ cell development and lowered serum testosterone levels, which resulted in azoospermia and infertility. However, the consequences of AR loss in partic...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhang C,Yeh S,Chen YT,Wu CC,Chuang KH,Lin HY,Wang RS,Chang YJ,Mendis-Handagama C,Hu L,Lardy H,Chang C

更新日期：2006-11-21 00:00:00

abstract：:Genetic and taxonomic distances were computed for 3466 samples of human populations in Europe based on 97 allele frequencies and 10 cranial variables. Since the actual samples employed differed among the genetic systems studied, the genetic distances were computed separately for each system, as were matrices of geogra...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sokal RR

更新日期：1988-03-01 00:00:00

abstract：:Blood viscosity decreases with shear stress, a property essential for an efficient perfusion of the vascular tree. Shear thinning is intimately related to the dynamics and mutual interactions of RBCs, the major component of blood. Because of the lack of knowledge about the behavior of RBCs under physiological conditio...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lanotte L,Mauer J,Mendez S,Fedosov DA,Fromental JM,Claveria V,Nicoud F,Gompper G,Abkarian M

更新日期：2016-11-22 00:00:00

abstract：:August-Copenhagen-Irish (ACI) rats are unique in that the ovary-intact females develop high incidence of mammary cancers induced solely by hormones upon prolonged exposure to high levels of estrogen alone. Studies have also shown that such prolonged exposure to high-dose estrogen results in human-like aneuploid mammar...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Blank EW,Wong PY,Lakshmanaswamy R,Guzman R,Nandi S

更新日期：2008-03-04 00:00:00

abstract：:B-1a cells, an anatomically, phenotypically, and functionally distinct subset of B cells that produce the bulk of natural serum IgM and much of gut-associated IgA, are an important component of the early response to pathogens. Because the induced expression of CD5, a hallmark of B-1a cells, requires a nuclear factor o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Berland R,Wortis HH

更新日期：2003-11-11 00:00:00

abstract：:This paper is a theoretical study of dynamic self assembly in a system of millimeter-sized magnetized disks floating at a liquid-air interface and spinning under the influence of a rotating magnetic field. Equations of motions are derived that account for the hydrodynamic and magnetic forces acting in the system. Nume...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Grzybowski BA,Stone HA,Whitesides GM

更新日期：2002-04-02 00:00:00

abstract：:It is a well known fact that stirring keeps particles suspended in fluids. This is apparent, for instance, when shaking medicine flasks, when agitating tea deposits in a mug, or when heavy winds fill the air with dust particles. The commonplace nature of such observations makes it easy to accept that this feature will...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ruiz J,Macías D,Peters F

更新日期：2004-12-21 00:00:00

abstract：:The DnaE intein in Synechocystis sp. strain PCC6803 is the first and only naturally split intein that has been identified so far. It is capable of catalyzing a protein trans-splicing mechanism to assemble a mature protein from two separate precursors. Therefore, it is a powerful tool for protein modification and engin...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yang J,Fox GC Jr,Henry-Smith TV

更新日期：2003-03-18 00:00:00

abstract：:As a second-order nonlinear optical process, sum-frequency generation is highly surface-specific and accordingly has been developed into a very powerful and versatile surface spectroscopic tool. It has found many unique applications in different disciplines and thus provided many exciting new research opportunities in...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shen YR

更新日期：1996-10-29 00:00:00

abstract：:The peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α) is a transcriptional coactivator that controls expression of metabolic/energetic genes, programming cellular responses to nutrient and environmental adaptations such as fasting, cold, or exercise. Unlike other coactivators, PGC-1α contai...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tavares CDJ,Aigner S,Sharabi K,Sathe S,Mutlu B,Yeo GW,Puigserver P

更新日期：2020-09-08 00:00:00

abstract：:Accurate real-time tracking of influenza outbreaks helps public health officials make timely and meaningful decisions that could save lives. We propose an influenza tracking model, ARGO (AutoRegression with GOogle search data), that uses publicly available online search data. In addition to having a rigorous statistic...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yang S,Santillana M,Kou SC

更新日期：2015-11-24 00:00:00

abstract：:The solution conformations of 2-substituted derivatives of 1-(beta-D-ribofuranosyl)benzimidazole have been determined by circular dichroism spectroscopy in aqueous solutions. It is shown that analogs with methyl, amino, or methylamino substituents at position 2 of the benzimidazole ring (position 8 of the purine ring)...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Miles DW,Townsend LB,Miles DL,Eyring H

更新日期：1979-02-01 00:00:00

abstract：:A high proportion of human B cells carry B-cell receptors (BCRs) that are autoreactive. Inhibitory receptors such as CD22 can downmodulate autoreactive BCR responses. With its extracellular domain, CD22 binds to sialic acids in α2,6 linkages in cis, on the surface of the same B cell or in trans, on other cells. Sialic...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Müller J,Obermeier I,Wöhner M,Brandl C,Mrotzek S,Angermüller S,Maity PC,Reth M,Nitschke L

更新日期：2013-07-23 00:00:00

abstract：:The fifth exons of major histocompatibility complex (MHC) class I genes encode a transmembrane domain (TM) that is largely responsible for class I antigen cell-surface expression usually through conventional hydrophobic amino acid-membrane interactions or, less often, through phosphatidylinositol linkage. In this repo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Crew MD,Filipowsky ME,Neshat MS,Smith GS,Walford RL

更新日期：1991-06-01 00:00:00

abstract：:Herpes simplex virus 1 (HSV-1) specifies in the infected cell a set of polypeptides (alpha) whose mRNAs are made in the absence of protein synthesis. The individual mRNAs specifying alpha polypeptides 0, 4, 22, and 27 were purified by hybridization to strand-separated or total HSV-1 DNA fragments cloned in pBR322 plas...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mackem S,Roizman B

更新日期：1980-12-01 00:00:00

abstract：:Terrestrial solar UVB radiation ( approximately 295-320 nm) readily induces cyclobutane pyrimidine dimers (CPDs) in human skin DNA that result in characteristic mutations associated with nonmelanoma skin cancer. The proinflammatory cytokine TNFalpha is important in mouse skin chemical carcinogenesis and is thought to ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Walker SL,Young AR

更新日期：2007-11-27 00:00:00

abstract：:The patch-clamp technique allows currents to be recorded through single ion channels in patches of cell membrane in the tips of glass pipettes. When recording, voltage is typically applied across the membrane patch to drive ions through open channels and to probe the voltage-sensitivity of channel activity. In this st...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gil Z,Silberberg SD,Magleby KL

更新日期：1999-12-07 00:00:00

abstract：:The neural pathway that governs an escape response of Drosophila to sudden changes in light intensity can be artificially induced by electrical stimulation of the brain and monitored by electrical recording from the effector muscles. We have refined previous work in this system to permit reliable ascertainment of two ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lin M,Nash HA

更新日期：1996-09-17 00:00:00

abstract：:Prenatal stress exposure is associated with risk for psychiatric disorders later in life. This may be mediated in part via enhanced exposure to glucocorticoids (GCs), which are known to impact neurogenesis. We aimed to identify molecular mediators of these effects, focusing on long-lasting epigenetic changes. In a hum...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Provençal N,Arloth J,Cattaneo A,Anacker C,Cattane N,Wiechmann T,Röh S,Ködel M,Klengel T,Czamara D,Müller NS,Lahti J,PREDO team.,Räikkönen K,Pariante CM,Binder EB

更新日期：2020-09-22 00:00:00

abstract：:The abelian sandpile is a cellular automaton which serves as the archetypical model to study self-organized criticality, a phenomenon occurring in various biological, physical, and social processes. Its recurrent configurations form an abelian group, whose identity is a fractal composed of self-similar patches. Here, ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lang M,Shkolnikov M

更新日期：2019-02-19 00:00:00

abstract：:The live cold-adapted (ca) A/AA/6/60 influenza vaccine is being commercially developed for worldwide use in children and is being used as a model for other live vaccines. Although it has been proven safe and immunogenic, the molecular basis of cold adaptation has never been determined. To identify sequence changes res...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Herlocher ML,Maassab HF,Webster RG

更新日期：1993-07-01 00:00:00

abstract：:Double immunofluorescent labeling experiments for lysosomes and either microtubules or vimentin intermediate filaments in cultured well-spread fibroblasts show a remarkable degree of superposition of the lysosomes and the microtubules. Under two different sets of conditions where the microtubules and intermediate fila...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Collot M,Louvard D,Singer SJ

更新日期：1984-02-01 00:00:00

abstract：:Perceptual decisions are better when they take uncertainty into account. Uncertainty arises not only from the properties of sensory input but also from cognitive sources, such as different levels of attention. However, it is unknown whether humans appropriately adjust for such cognitive sources of uncertainty during p...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Denison RN,Adler WT,Carrasco M,Ma WJ

更新日期：2018-10-23 00:00:00

abstract：:Dopamine causes a significant retraction of neurites of bull-head catfish horizontal cells maintained in culture. The effects of dopamine are blocked by haloperidol and SCH 23390, a D1 antagonist, but not by sulpiride, a D2 antagonist. The dopamine-induced morphological changes were mimicked by SKF 38393, a D1 agonist...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rodrigues Pdos S,Dowling JE

更新日期：1990-12-01 00:00:00

abstract：:III-V compound semiconductors are widely used for electronic and optoelectronic applications. However, interfacing III-Vs with other materials has been fundamentally limited by the high growth temperatures and lattice-match requirements of traditional deposition processes. Recently, we developed the templated liquid-p...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hettick M,Li H,Lien DH,Yeh M,Yang TY,Amani M,Gupta N,Chrzan DC,Chueh YL,Javey A

更新日期：2020-01-14 00:00:00

abstract：:Focal electric stimulation of the auditory cortex is well suited for exploration of the function of the corticofugal (descending) system and the neural mechanism of plasticity in the central auditory system, because it evokes changes in frequency-tuning, called best frequency (BF) shifts, as does auditory fear conditi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Xiao Z,Suga N

更新日期：2005-12-27 00:00:00

abstract：:Asexual freshwater planarians reproduce by tearing themselves into two pieces by a process called binary fission. The resulting head and tail pieces regenerate within about a week, forming two new worms. Understanding this process of ripping oneself into two parts poses a challenging biomechanical problem. Because pla...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Malinowski PT,Cochet-Escartin O,Kaj KJ,Ronan E,Groisman A,Diamond PH,Collins ES

更新日期：2017-10-10 00:00:00

abstract：:To study the role of the interferon- (IFN) gammaR2 chain in IFN-gamma signaling and immune function, IFN-gammaR2-deficient mice have been generated and characterized. Cells derived from IFN-gammaR2 -/- mice are unable to activate either JAK/STAT signaling proteins or gene transcription in response to IFN-gamma. The la...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lu B,Ebensperger C,Dembic Z,Wang Y,Kvatyuk M,Lu T,Coffman RL,Pestka S,Rothman PB

更新日期：1998-07-07 00:00:00

abstract：:Ubiquitin carboxyl-terminal hydrolase L1 (UCH-L1) has been implicated in Parkinson's disease (PD) and is present in neurofibrillary tangles or Lewy bodies. However, the molecular basis for UCH-L1s involvement in proteinacious fibril formation is still elusive, especially in regard to the pathogenicity of the I93M muta...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Koharudin LM,Liu H,Di Maio R,Kodali RB,Graham SH,Gronenborn AM

更新日期：2010-04-13 00:00:00