Abstract:
:IL-7 and thymic stromal lymphopoietin (TSLP) are two major cytokines controlling murine B cell development. IL-7 has been studied extensively, but only recently has it become possible to unravel the role of TSLP in detail. We studied the biological activities of TSLP in B cell development at distinct ages in the mouse. On the one hand, TSLP is able to give rise to a measurable B1 cell compartment derived from fetal liver pro-B cells, although, as is the case for B2 cells, it does not play a prevalent role in the development of this subset. On the other hand, TSLP drives the proliferation of pro-B cells from the fetal and neonatal liver, but in the bone marrow environment, B cell precursors require pre-B cell receptor expression for TSLP responsiveness.
journal_name
Proc Natl Acad Sci U S Aauthors
Vosshenrich CA,Cumano A,Müller W,Di Santo JP,Vieira Pdoi
10.1073/pnas.0402919101keywords:
subject
Has Abstractpub_date
2004-07-27 00:00:00pages
11070-5issue
30eissn
0027-8424issn
1091-6490pii
0402919101journal_volume
101pub_type
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