当前位置： SCI文献检索 > PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA期刊下所有文献 > Primary structures of bovine liver low molecular weight kininogen precursors and their two mRNAs.

Primary structures of bovine liver low molecular weight kininogen precursors and their two mRNAs.

Abstract：

:By using a mixture of synthetic oligodeoxyribonucleotides as a probe, cloned cDNA sequences specific for low molecular weight (LMW) kininogen have been isolated from a cDNA library of bovine liver mRNA sequences. Nucleotide sequence analyses of cloned cDNA inserts have revealed that bovine liver LMW kininogens are encoded by at least two very similar but distinct mRNAs. The corresponding amino acid sequences show that the LMW kininogen precursors of the two types, composed of 436 and 434 amino acid residues, both contain two internally homologous sequences in the amino-terminal portion between a signal peptide and a bradykinin moiety. The two mRNAs exhibit 15 nucleotide substitutions and 6 nucleotide deletions/additions in their protein-coding regions. The replacement of 13 amino acid residues and the deletions/additions of 2 amino acid residues in the two LMW kininogen precursors are all localized within the internally homologous regions, implying that these regions may be biologically significant in relation to the existence of two LMW kininogens. The nucleotide changes in the two mRNAs also occur in the limited portions that principally encode the internally homologous amino acid sequences. This suggests that the mRNAs are transcribed from the same gene to generate two LMW kininogen precursors differing only in the internally homologous sequences.

journal_name

Proc Natl Acad Sci U S A

journal_title

Proceedings of the National Academy of Sciences of the United States of America

authors

Nawa H,Kitamura N,Hirose T,Asai M,Inayama S,Nakanishi S

doi

10.1073/pnas.80.1.90

subject

Has Abstract

pub_date

1983-01-01 00:00:00

pages

90-4

issue

1

eissn

0027-8424

issn

1091-6490

journal_volume

80

pub_type

杂志文章

相关文献

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA文献大全
  • Discovery of sulfated metabolites in mycobacteria with a genetic and mass spectrometric approach.

    abstract：:The study of the metabolome presents numerous challenges, first among them being the cataloging of its constituents. A step in this direction will be the development of tools to identify metabolites that share common structural features. The importance of sulfated molecules in cell-cell communication motivated us to d...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.252514899

    authors： Mougous JD,Leavell MD,Senaratne RH,Leigh CD,Williams SJ,Riley LW,Leary JA,Bertozzi CR

    更新日期：2002-12-24 00:00:00

  • Why we need to look beyond the glass transition temperature to characterize the dynamics of thin supported polymer films.

    abstract：:There is significant variation in the reported magnitude and even the sign of [Formula: see text] shifts in thin polymer films with nominally the same chemistry, film thickness, and supporting substrate. The implicit assumption is that methods used to estimate [Formula: see text] in bulk materials are relevant for inf...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1722024115

    authors： Zhang W,Douglas JF,Starr FW

    更新日期：2018-05-29 00:00:00

  • Inverse splicing of a group II intron.

    abstract：:I describe the self-splicing of an RNA that consists of exon sequences flanked by group II intron sequences. I find that this RNA undergoes accurate splicing in vitro, yielding an excised exon circle. This splicing reaction involves the joining of the 5' splice site at the end of an exon to the 3' splice site at the b...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.90.18.8624

    authors： Jarrell KA

    更新日期：1993-09-15 00:00:00

  • Observations of nucleation of new particles in a volcanic plume.

    abstract：:Volcanic eruptions caused major weather and climatic changes on timescales ranging from hours to centuries in the past. Volcanic particles are injected in the atmosphere both as primary particles rapidly deposited due to their large sizes on time scales of minutes to a few weeks in the troposphere, and secondary parti...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1104923108

    authors： Boulon J,Sellegri K,Hervo M,Laj P

    更新日期：2011-07-26 00:00:00

  • Variation in neural V1aR predicts sexual fidelity and space use among male prairie voles in semi-natural settings.

    abstract：:Although prairie voles (Microtus ochrogaster) are socially monogamous, males vary in both sexual and spatial fidelity. Most males form pairbonds, cohabit with one female, and defend territories. Wandering males, in contrast, have expansive home ranges that overlap many males and females. In the laboratory, pairing is ...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.0709116105

    authors： Ophir AG,Wolff JO,Phelps SM

    更新日期：2008-01-29 00:00:00

  • Human immunodeficiency virus 1 Tat binds to dipeptidyl aminopeptidase IV (CD26): a possible mechanism for Tat's immunosuppressive activity.

    abstract：:The human immunodeficiency virus 1 (HIV-1) Tat protein suppresses antigen-induced, but not mitogen-induced, activation of human T cells when added to T-cell cultures [Viscidi, R. P., Mayur, K., Lederman, H. M. & Frankel, A. D. (1989) Science 246, 1606-1608]. This activity is potentially pertinent to the development of...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.91.14.6594

    authors： Gutheil WG,Subramanyam M,Flentke GR,Sanford DG,Munoz E,Huber BT,Bachovchin WW

    更新日期：1994-07-05 00:00:00

  • Enantiomer excesses of rare and common sugar derivatives in carbonaceous meteorites.

    abstract：:Biological polymers such as nucleic acids and proteins are constructed of only one-the d or l-of the two possible nonsuperimposable mirror images (enantiomers) of selected organic compounds. However, before the advent of life, it is generally assumed that chemical reactions produced 50:50 (racemic) mixtures of enantio...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1603030113

    authors： Cooper G,Rios AC

    更新日期：2016-06-14 00:00:00

  • Site-specific genome editing for correction of induced pluripotent stem cells derived from dominant dystrophic epidermolysis bullosa.

    abstract：:Genome editing with engineered site-specific endonucleases involves nonhomologous end-joining, leading to reading frame disruption. The approach is applicable to dominant negative disorders, which can be treated simply by knocking out the mutant allele, while leaving the normal allele intact. We applied this strategy ...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1512028113

    authors： Shinkuma S,Guo Z,Christiano AM

    更新日期：2016-05-17 00:00:00

  • The increased level of beta1,4-galactosyltransferase required for lactose biosynthesis is achieved in part by translational control.

    abstract：:beta1,4-Galactosyltransferase (beta4GalT-I) participates in both glycoconjugate biosynthesis (ubiquitous activity) and lactose biosynthesis (mammary gland-specific activity). In somatic tissues, transcription of the mammalian beta4GalT-I gene results in a 4.1-kb mRNA and a 3.9-kb mRNA as a consequence of initiation at...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.95.25.14805

    authors： Charron M,Shaper JH,Shaper NL

    更新日期：1998-12-08 00:00:00

  • Mechanism of action and initial evaluation of a membrane active all-D-enantiomer antimicrobial peptidomimetic.

    abstract：:Development of therapy against infections caused by antibiotic-resistant pathogens is a major unmet need in contemporary medicine. In previous work, our group chemically modified an antimicrobial peptidomimetic motif for targeted applications against cancer and obesity. Here, we show that the modified motif per se is ...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1221924110

    authors： McGrath DM,Barbu EM,Driessen WH,Lasco TM,Tarrand JJ,Okhuysen PC,Kontoyiannis DP,Sidman RL,Pasqualini R,Arap W

    更新日期：2013-02-26 00:00:00

  • The solubilization of model Alzheimer tangles: reversing the beta-sheet conformation induced by aluminum with silicates.

    abstract：:Neurofibrillary tangles are one of two lesions found in the brain of Alzheimer disease victims. With synthetic peptide fragments of human neurofilament NF-M17 (Glu-Glu-Lys-Gly-Lys-Ser-Pro- Val-Pro-Lys-Ser-Pro-Val-Glu-Glu-Lys-Gly, phosphorylated and unphosphorylated), CD studies were done to examine the effect of sodiu...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.91.23.11232

    authors： Fasman GD,Moore CD

    更新日期：1994-11-08 00:00:00

  • Low-cost high-efficiency system for solar-driven conversion of CO2 to hydrocarbons.

    abstract：:Conversion of carbon dioxide into hydrocarbons using solar energy is an attractive strategy for storing such a renewable source of energy into the form of chemical energy (a fuel). This can be achieved in a system coupling a photovoltaic (PV) cell to an electrochemical cell (EC) for CO2 reduction. To be beneficial and...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1815412116

    authors： Huan TN,Dalla Corte DA,Lamaison S,Karapinar D,Lutz L,Menguy N,Foldyna M,Turren-Cruz SH,Hagfeldt A,Bella F,Fontecave M,Mougel V

    更新日期：2019-05-14 00:00:00

  • The antisense bcl-2-IgH transcript is an optimal target for synthetic oligonucleotides.

    abstract：:In most human follicular B cell lymphomas the bcl-2 gene is up-regulated as a result of the t(14;18) chromosomal translocation generating a hybrid bcl-2-IgH mRNA. Recently, we have identified in t(14;18)-positive cells a bcl-2-IgH mRNA in the antisense orientation, putatively responsible for the overexpression of bcl-...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.94.15.8150

    authors： Morelli S,Delia D,Capaccioli S,Quattrone A,Schiavone N,Bevilacqua A,Tomasini S,Nicolin A

    更新日期：1997-07-22 00:00:00

  • Multivalent weak interactions enhance selectivity of interparticle binding.

    abstract：:Targeted drug delivery critically depends on the binding selectivity of cargo-transporting colloidal particles. Extensive theoretical work has shown that two factors are necessary to achieve high selectivity for a threshold receptor density: multivalency and weak interactions. Here, we study a model system of DNA-coat...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.2003968117

    authors： Scheepers MRW,van IJzendoorn LJ,Prins MWJ

    更新日期：2020-09-15 00:00:00

  • Brief visual experience induces immediate early gene expression in the cat visual cortex.

    abstract：:Brief visual experience causes rapid physiological changes in the visual cortex during early postnatal development. A possible mediator of these effects is the immediate early genes whose protein products are involved in the rapid response of neurons to transsynaptic stimulation. Here we report evidence that the level...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.89.12.5437

    authors： Rosen KM,McCormack MA,Villa-Komaroff L,Mower GD

    更新日期：1992-06-15 00:00:00

  • Establishment of trophoblast stem cell lines from somatic cell nuclear-transferred embryos.

    abstract：:Placental abnormalities occur frequently in cloned animals. Here, we attempted to isolate trophoblast stem (TS) cells from mouse blastocysts produced by somatic cell nuclear transfer (NT) at the blastocyst stage (NT blastocysts). Despite the predicted deficiency of the trophoblast cell lineage, we succeeded in isolati...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.0908009106

    authors： Oda M,Tanaka S,Yamazaki Y,Ohta H,Iwatani M,Suzuki M,Ohgane J,Hattori N,Yanagimachi R,Wakayama T,Shiota K

    更新日期：2009-09-22 00:00:00

  • On the Fundamental Group of Manifolds of Non-positive Curvature.

    abstract：:We prove theorems on the structure of the fundamental group of a compact riemannian manifold of non-positive curvature. In particular, a conjecture of J. Wolf [J. Differential Geometry, 2, 421-446 (1968)] is proved. ...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.67.2.509

    authors： Yau ST

    更新日期：1970-10-01 00:00:00

  • Influence of spermine and reduced temperature on the ability of transplanted nuclei to promote normal development in eggs of Rana pipiens.

    abstract：:Previous work has shown that nuclei of young embryos (to gastrula stage) promote normal development when transplanted into enucleated eggs. As development proceeds to later stages, the nuclei become increasingly restricted in their capacity to promote normal cleavage and development, and the majority of the embryos th...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.66.3.630

    authors： Hennen S

    更新日期：1970-07-01 00:00:00

  • Fatty acid-requiring mutant of Saccharomyces cerevisiae defective in acetyl-CoA carboxylase.

    abstract：:The isolation and biochemical properties of a Saccharomyces cerevisiae mutant (acc1-167) defective in acetyl-CoA carboxylase [acetyl-CoA:carbon-dioxide ligase (ADP forming), EC 6.4.1.2] activity are described. The mutant is deficient in de novo biosynthesis of long-chain fatty acids and specifically requires a saturat...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.77.4.1814

    authors： Roggenkamp R,Numa S,Schweizer E

    更新日期：1980-04-01 00:00:00

  • Agonist-induced formation of unproductive receptor-G12 complexes.

    abstract：:G proteins are activated when they associate with G protein-coupled receptors (GPCRs), often in response to agonist-mediated receptor activation. It is generally thought that agonist-induced receptor-G protein association necessarily promotes G protein activation and, conversely, that activated GPCRs do not interact w...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.2003787117

    authors： Okashah N,Wright SC,Kawakami K,Mathiasen S,Zhou J,Lu S,Javitch JA,Inoue A,Bouvier M,Lambert NA

    更新日期：2020-09-01 00:00:00

  • A reversible molecular valve.

    abstract：:In everyday life, a macroscopic valve is a device with a movable control element that regulates the flow of gases or liquids by blocking and opening passageways. Construction of such a device on the nanoscale level requires (i) suitably proportioned movable control elements, (ii) a method for operating them on demand,...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.0504109102

    authors： Nguyen TD,Tseng HR,Celestre PC,Flood AH,Liu Y,Stoddart JF,Zink JI

    更新日期：2005-07-19 00:00:00

  • Gating of the proton-gated ion channel from Gloeobacter violaceus at pH 4 as revealed by X-ray crystallography.

    abstract：:Cryoelectron microscopy and X-ray crystallography have recently been used to generate structural models that likely represent the unliganded closed-channel conformation and the fully liganded open-channel conformation of different members of the nicotinic-receptor superfamily. To characterize the structure of the clos...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1313156110

    authors： Gonzalez-Gutierrez G,Cuello LG,Nair SK,Grosman C

    更新日期：2013-11-12 00:00:00

  • Specific regulation of c-myc oncogene expression in a murine B-cell lymphoma.

    abstract：:The c-myc oncogene has been implicated in a wide spectrum of B-cell neoplasias. In normal cells, the level of expression of the c-myc gene correlates with growth status. In the present study, we examined the effect of receptor-mediated inhibition of growth on c-myc expression in a B-cell lymphoma. The murine lymphoma ...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.81.17.5546

    authors： McCormack JE,Pepe VH,Kent RB,Dean M,Marshak-Rothstein A,Sonenshein GE

    更新日期：1984-09-01 00:00:00

  • New strategy for the synthesis of chemically modified RNA constructs exemplified by hairpin and hammerhead ribozymes.

    abstract：:The CuAAC reaction (click chemistry) has been used in conjunction with solid-phase synthesis to produce catalytically active hairpin ribozymes around 100 nucleotides in length. Cross-strand ligation through neighboring nucleobases was successful in covalently linking presynthesized RNA strands with high efficiency (tr...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1006447107

    authors： El-Sagheer AH,Brown T

    更新日期：2010-08-31 00:00:00

  • Wildfires and climate change push low-elevation forests across a critical climate threshold for tree regeneration.

    abstract：:Climate change is increasing fire activity in the western United States, which has the potential to accelerate climate-induced shifts in vegetation communities. Wildfire can catalyze vegetation change by killing adult trees that could otherwise persist in climate conditions no longer suitable for seedling establishmen...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1815107116

    authors： Davis KT,Dobrowski SZ,Higuera PE,Holden ZA,Veblen TT,Rother MT,Parks SA,Sala A,Maneta MP

    更新日期：2019-03-26 00:00:00

  • Hydrogenation of N over Fe{111}.

    abstract：:Over the past five decades, ultra high vacuum (uhv) techniques applied to well-defined single-crystal samples (the "surface science paradigm") have transformed our understanding of fundamental surface chemistry. To translate this success to the world of realistic heterogeneous catalysis, however, requires one seriousl...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1006634107

    authors： Iyngaran P,Madden DC,Jenkins SJ,King DA

    更新日期：2011-01-18 00:00:00

  • Cytokine-mediated Bax deficiency and consequent delayed neutrophil apoptosis: a general mechanism to accumulate effector cells in inflammation.

    abstract：:Neutrophils are important effector cells in immunity to microorganisms, particularly bacteria. Here, we show that the process of neutrophil apoptosis is delayed in several inflammatory diseases, suggesting that this phenomenon may represent a general feature contributing to the development of neutrophilia, and, theref...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.96.23.13330

    authors： Dibbert B,Weber M,Nikolaizik WH,Vogt P,Schöni MH,Blaser K,Simon HU

    更新日期：1999-11-09 00:00:00

  • Ribonucleotide reduction is a cytosolic process in mammalian cells independently of DNA damage.

    abstract：:Ribonucleotide reductase provides deoxynucleotides for nuclear and mitochondrial (mt) DNA replication and repair. The mammalian enzyme consists of a catalytic (R1) and a radical-generating (R2 or p53R2) subunit. During S-phase, a R1/R2 complex is the major provider of deoxynucleotides. p53R2 is induced by p53 after DN...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.0808198105

    authors： Pontarin G,Fijolek A,Pizzo P,Ferraro P,Rampazzo C,Pozzan T,Thelander L,Reichard PA,Bianchi V

    更新日期：2008-11-18 00:00:00

  • Base insertion and deletion mutations induced in an Escherichia coli plasmid by benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide.

    abstract：:Mutations induced by (+/-)trans-benzo-[a]pyrene-7,8-dihydrodiol-9,10-epoxide (BaP-diol epoxide-1) were selected by using a recombinant plasmid vector system designed for the study of transcription termination signals. The plasmid contains a transcription terminator positioned between a promotor signal and the Escheric...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.78.11.6817

    authors： Mizusawa H,Lee CH,Kakefuda T,McKenney K,Shimatake H,Rosenberg M

    更新日期：1981-11-01 00:00:00

  • First look at changes in flood hazard in the Inter-Sectoral Impact Model Intercomparison Project ensemble.

    abstract：:Climate change due to anthropogenic greenhouse gas emissions is expected to increase the frequency and intensity of precipitation events, which is likely to affect the probability of flooding into the future. In this paper we use river flow simulations from nine global hydrology and land surface models to explore unce...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1302078110

    authors： Dankers R,Arnell NW,Clark DB,Falloon PD,Fekete BM,Gosling SN,Heinke J,Kim H,Masaki Y,Satoh Y,Stacke T,Wada Y,Wisser D

    更新日期：2014-03-04 00:00:00