Brief visual experience induces immediate early gene expression in the cat visual cortex.

abstract：:Bordetella pertussis secretes a calmodulin-activated adenylate cyclase toxin, CyaA, that is able to deliver its N-terminal catalytic domain (400-aa residues) into the cytosol of eukaryotic target cells, directly through the cytoplasmic membrane. We have previously shown that CyaA can be used as a vehicle to deliver T ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Karimova G,Fayolle C,Gmira S,Ullmann A,Leclerc C,Ladant D

更新日期：1998-10-13 00:00:00

abstract：:Despite growing evidence for perceptual interactions between motion and position, no unifying framework exists to account for these two key features of our visual experience. We show that percepts of both object position and motion derive from a common object-tracking system--a system that optimally integrates sensory...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kwon OS,Tadin D,Knill DC

更新日期：2015-06-30 00:00:00

abstract：:Rifamycin antibiotics, which inhibit RNA-directed DNA polymerase of Rauscher leuckemia virus, prevent the leukemogenic activity of the virus, and the effect of leukemogenesis correlates with the magnitude of inhibition of the purified enzyme. This inhibition of enzyme activity by rifamycin SV derivatives is due to a r...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wu AM,Ting RC,Gallo RC

更新日期：1973-05-01 00:00:00

abstract：:Skeletal muscle L-type Ca2+ channels respond to trains of brief depolarizations with a strong shift of the voltage dependence of channel activation toward more negative membrane potentials and slowing of channel deactivation. Increased Ca2+ entry resulting from this potentiation of channel activity may increase contra...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Johnson BD,Scheuer T,Catterall WA

更新日期：1994-11-22 00:00:00

abstract：:beta-Adrenergic receptors on Friend erythroleukemic cells were identified by the use of 125I-labeled hydroxybenzylpindolol, a potent beta-adrenergic antagonist. Binding of this ligand was saturable and stereospecific. The relative orders of potency of isoproterenol, epinephrine, and norepinephrine to displace bound hy...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schmitt H,Guyaux M,Pochet R,Kram R

更新日期：1980-07-01 00:00:00

abstract：:In Arabidopsis, the two-dimensional expansion of leaves is regulated via the polarized elongation of cells. The ROTUNDIFOLIA3 (ROT3) protein, a member of the family of cytochromes P450, is involved in this process and regulates leaf length. Transgenic plants that overexpressed a wild-type ROT3 gene had longer leaves t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kim GT,Tsukaya H,Saito Y,Uchimiya H

更新日期：1999-08-03 00:00:00

abstract：:The superparamagnetic behavior of very small particles of metallic iron (ca 1.5 nm), with about half of their atoms at the surface, is changed reversibly by adsorption and desorption of hydrogen below the superparamagnetic transition temperature. The change after adsorption implies a lowering of the anisotropy energy ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Boudart M,Dumesic JA,Topsøe H

更新日期：1977-03-01 00:00:00

abstract：:Tropical forest degradation emits carbon at a rate of approximately 0.5 Pgxy(-1), reduces biodiversity, and facilitates forest clearance. Understanding degradation drivers and patterns is therefore crucial to managing forests to mitigate climate change and reduce biodiversity loss. Putative patterns of degradation aff...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ahrends A,Burgess ND,Milledge SA,Bulling MT,Fisher B,Smart JC,Clarke GP,Mhoro BE,Lewis SL

更新日期：2010-08-17 00:00:00

abstract：:Methane emissions in the Arctic are important, and may be contributing to global warming. While methane emission rates from Arctic lakes are well documented, methods are needed to quantify the relative contribution of active layer groundwater to the overall lake methane budget. Here we report measurements of natural t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Paytan A,Lecher AL,Dimova N,Sparrow KJ,Kodovska FG,Murray J,Tulaczyk S,Kessler JD

更新日期：2015-03-24 00:00:00

abstract：:We study the physical origins of phase contrast in dynamic atomic force microscopy (dAFM) in liquids where low-stiffness microcantilever probes are often used for nanoscale imaging of soft biological samples with gentle forces. Under these conditions, we show that the phase contrast derives primarily from a unique ene...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Melcher J,Carrasco C,Xu X,Carrascosa JL,Gómez-Herrero J,José de Pablo P,Raman A

更新日期：2009-08-18 00:00:00

abstract：:Plants adapt to alterations in light conditions by controlling their gene expression profiles. Expression of light-inducible genes is transcriptionally induced by transcription factors such as HY5. However, few detailed analyses have been carried out on the control of transcription start sites (TSSs). Of the various w...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kurihara Y,Makita Y,Kawashima M,Fujita T,Iwasaki S,Matsui M

更新日期：2018-07-24 00:00:00

abstract：:Ig class-switch recombination (CSR) is a region-specific process that exchanges the constant Ig heavy-chain region and thus modifies an antibody's effector function. DNA lesions in switch (S) regions are induced by activation-induced cytidine deaminase (AID) and uracil-DNA glycosylase 2 (UNG2), subsequently processed ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kracker S,Imai K,Gardès P,Ochs HD,Fischer A,Durandy AH

更新日期：2010-12-21 00:00:00

abstract：:Three types of protein kinase C were purified from rabbit brain cytosol. Each type has a molecular mass of approximately 80 kDa and serves as a receptor for phorbol esters. Polyclonal antibodies produced to two protein kinase C types were relatively type-specific, indicating that these proteins have unique antigenic d...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jaken S,Kiley SC

更新日期：1987-07-01 00:00:00

abstract：:Cultured rat embryo cells are resistant to neoplastic transformation by chemical carcinogens unless they are extensively subcultured or infected with a murine leukemia virus (MuLV) first. We found that, in normal cultured cells, MuLV activates expression of rat genes that are the progenitors of sarcoma virus genes, b...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kimball PC,Simon MC,Mishra NK

更新日期：1980-06-01 00:00:00

abstract：:The self-association of gene-32 protein has been studied by sedimentation equilibrium centrifugation and polyacrylamide gel electrophoresis, in order to better understand its role in DNA replication and genetic recombination. The monomer molecular weight of gene-32 protein is 38,000 in guanidine hydrochloride and 34,0...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Carroll RB,Neet KE,Goldthwait DA

更新日期：1972-09-01 00:00:00

abstract：:Human T-cell leukemia virus type I (HTLV-I) is a causative agent of adult T-cell leukemia (ATL). To elucidate the role of HTLV-I in leukemogenesis, we examined the biological activity of a defective HTLV-I provirus with the env-pX 3' long terminal repeat region cloned from leukemic cells of an ATL patient. Transfectio...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tanaka A,Takahashi C,Yamaoka S,Nosaka T,Maki M,Hatanaka M

更新日期：1990-02-01 00:00:00

abstract：:Eosinophils have been associated with fibrosis. To investigate their direct role in fibrosis, human peripheral blood eosinophil sonicate was added to human lung or dermal fibroblasts, and proliferation ([(3)H]thymidine) and collagen synthesis ([(3)H]proline) were evaluated. Proliferation was enhanced significantly in ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Levi-Schaffer F,Garbuzenko E,Rubin A,Reich R,Pickholz D,Gillery P,Emonard H,Nagler A,Maquart FA

更新日期：1999-08-17 00:00:00

abstract：:Recent advances in coherent x-ray diffractive imaging have paved the way to reliable and quantitative imaging of noncompact specimens at the nanometer scale. Introduced a year ago, an advanced implementation of ptychographic coherent diffractive imaging has removed much of the previous limitations regarding sample pre...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Giewekemeyer K,Thibault P,Kalbfleisch S,Beerlink A,Kewish CM,Dierolf M,Pfeiffer F,Salditt T

更新日期：2010-01-12 00:00:00

abstract：:There is a hypothesis that dangerous diseases such as bovine spongiform encephalopathy, Creutzfeldt-Jakob, Alzheimer's, fatal familial insomnia, and several others are induced by propagation of wrong or misfolded conformations of some vital proteins. If for some reason the misfolded conformations were acquired by many...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Małolepsza E,Boniecki M,Kolinski A,Piela L

更新日期：2005-05-31 00:00:00

abstract：:Remembering is a complex process that involves recalling specific details, such as who you were with when you celebrated your last birthday, as well as contextual information, such as the place where you celebrated. It is well established that the act of remembering enhances long-term retention of the retrieved inform...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jonker TR,Dimsdale-Zucker H,Ritchey M,Clarke A,Ranganath C

更新日期：2018-10-23 00:00:00

abstract：:The detection, stabilization, and repair of stress-induced damage are essential requirements for cellular life. All cells respond to osmotic stress-induced water loss with increased expression of genes that mediate accumulation of organic osmolytes, solutes that function as chemical chaperones and restore osmotic home...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lamitina T,Huang CG,Strange K

更新日期：2006-08-08 00:00:00

abstract：:We used digital fluorescence microscopy to make real-time observations of anaphase chromosome movement and changes in microtubule organization in spindles assembled in Xenopus egg extracts. Anaphase chromosome movement in these extracts resembled that seen in living vertebrate cells. During anaphase chromosomes moved ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Murray AW,Desai AB,Salmon ED

更新日期：1996-10-29 00:00:00

abstract：:Natural environments can present diverse challenges, but some genotypes remain fit across many environments. Such "generalists" can be hard to evolve, outcompeted by specialists fitter in any particular environment. Here, inspired by the search for broadly neutralizing antibodies during B cell affinity maturation, we ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sachdeva V,Husain K,Sheng J,Wang S,Murugan A

更新日期：2020-06-09 00:00:00

abstract：:During cytokinesis, a cleavage furrow generated by actomyosin ring contraction is restructured into the midbody, a platform for the assembly of the abscission machinery that controls the final separation of daughter cells. The polymerization state of F-actin is important during assembly, ingression, disassembly, and c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Terry SJ,Donà F,Osenberg P,Carlton JG,Eggert US

更新日期：2018-02-27 00:00:00

abstract：:The effect of 6 days' s.c. infusions of angiotensin II at increasing doses was determined on the uptake of rat or human low density lipoprotein (LDL) and of human fibrinogen by aorta in normal and spontaneously hypertensive rats. Rat or human LDL or human fibrinogen was injected i.v. 5 days after the start of infusion...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cardona-Sanclemente LE,Medina R,Born GV

更新日期：1994-04-12 00:00:00

abstract：:The RAD6 gene of Saccharomyces cerevisiae encodes a ubiquitin-conjugating enzyme (E2) that is required for DNA repair, damage-induced mutagenesis, and sporulation. We have cloned the two human RAD6 homologs, designated HHR6A and HHR6B. The two 152-amino acid human proteins share 95% sequence identity with each other a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Koken MH,Reynolds P,Jaspers-Dekker I,Prakash L,Prakash S,Bootsma D,Hoeijmakers JH

更新日期：1991-10-15 00:00:00

abstract：:Low density lipoprotein (LDL) isolated from human plasma anticoagulated with EDTA (EDTA/LDL) was 4-fold more resistant to oxidation by reagent H2O2, as assayed by the thiobarbituric acid (TBA) assay, than LDL prepared from plasma anticoagulated with citrate (CDP/LDL). The LDLs required 1-3 mM H2O2 for maximal oxidatio...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Montgomery RR,Nathan CF,Cohn ZA

更新日期：1986-09-01 00:00:00

abstract：:Earth's water cycle enables the incorporation of water (hydration) in mantle minerals that can influence the physical properties of the mantle. Lattice thermal conductivity of mantle minerals is critical for controlling the temperature profile and dynamics of the mantle and subducting slabs. However, the effect of hyd...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chang YY,Hsieh WP,Tan E,Chen J

更新日期：2017-04-18 00:00:00

abstract：:Replication through a diverse array of DNA lesions occurs by the sequential action of two translesion synthesis (TLS) DNA polymerases (Pols), in which one inserts the nucleotide opposite the lesion and the other carries out the subsequent extension. By extending from the nucleotide inserted by another Pol, Polζ plays ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Johnson RE,Prakash L,Prakash S

更新日期：2012-07-31 00:00:00

abstract：:Bicistronic cassettes under control of a single promoter have recently been suggested as useful tools for coordinate expression of two different foreign proteins in mammalian cells. Using the long 5' untranslated region of encephalomyocarditis virus as translational enhancer of the second gene, a bicistronic unit comp...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Aran JM,Gottesman MM,Pastan I

更新日期：1994-04-12 00:00:00