Oncogenic transformation by the tax gene of human T-cell leukemia virus type I in vitro.

abstract：:A derivative of Tn917 was constructed, referred to as Tn917-lac, which is capable of generating fusions that connect the transcripts of Bacillus subtilis chromosomal genes to the coding sequence of the lacZ gene of Escherichia coli. Two independent insertions of Tn917-lac into the gltA gene and one insertion into the ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Perkins JB,Youngman PJ

更新日期：1986-01-01 00:00:00

abstract：:The Alzheimer A beta amyloid peptide (A beta) is the principal proteinaceous component of amyloid associated with Alzheimer disease (AD). We have determined the relative abundance of A beta structural variants present in amyloid from brains of 10 individuals with sporadic AD, 2 individuals with familial AD carrying sp...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Näslund J,Schierhorn A,Hellman U,Lannfelt L,Roses AD,Tjernberg LO,Silberring J,Gandy SE,Winblad B,Greengard P

更新日期：1994-08-30 00:00:00

abstract：:Cointegrate DNA molecules containing two copies of a transposable element appear to be intermediates in the transposition process. These structures are resolved by site-specific recombination to yield the normal end products of transposition. The transposable element gamma delta (Tn1000) synthesizes a product intercha...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kitts P,Symington L,Burke M,Reed R,Sherratt D

更新日期：1982-01-01 00:00:00

abstract：:We construct counterexamples to classical calculus facts such as the inverse and implicit function theorems in scale calculus-a generalization of multivariable calculus to infinite-dimensional vector spaces, in which the reparameterization maps relevant to symplectic geometry are smooth. Scale calculus is a corner sto...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Filippenko B,Zhou Z,Wehrheim K

更新日期：2019-04-30 00:00:00

abstract：:English and Russian color terms divide the color spectrum differently. Unlike English, Russian makes an obligatory distinction between lighter blues ("goluboy") and darker blues ("siniy"). We investigated whether this linguistic difference leads to differences in color discrimination. We tested English and Russian spe...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Winawer J,Witthoft N,Frank MC,Wu L,Wade AR,Boroditsky L

更新日期：2007-05-08 00:00:00

abstract：:The structure of the non-self-complementary DNA heptamer d(CGACGAC) at low pH has been determined by the quantitative NMR refinement procedure designated SPEDREF (SPEctral-Driven REFinement). Acid-base titration of the molecule indicated a prominent n = 2 pKa near 6.8. In the pH range up to 6.0, the heptamer forms a r...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Robinson H,Wang AH

更新日期：1993-06-01 00:00:00

abstract：:To elucidate the molecular mechanism of frameshift suppression by the SUF2 gene of yeast, the sequences of DNA fragments carrying the SUF2-1 and suf2+ alleles of the gene and surrounding regions have been determined. Comparison of the suppressor and wild-type sequences indicates that the SUF2 gene product is a proline...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cummins CM,Donahue TF,Culbertson MR

更新日期：1982-06-01 00:00:00

abstract：:Pair-bond formation depends vitally on neuromodulatory signaling within the nucleus accumbens, but the neuronal dynamics underlying this behavior remain unclear. Using 1-photon in vivo Ca2+ imaging in monogamous prairie voles, we found that pair bonding does not elicit differences in overall nucleus accumbens Ca2+ act...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Scribner JL,Vance EA,Protter DSW,Sheeran WM,Saslow E,Cameron RT,Klein EM,Jimenez JC,Kheirbek MA,Donaldson ZR

更新日期：2020-05-19 00:00:00

abstract：:Most poxviruses, including variola, the causative agent of smallpox, express a secreted protein of 35 kDa, vCCI, which binds CC-chemokines with high affinity. This viral protein competes with the host cellular CC-chemokine receptors (CCRs), reducing inflammation and interfering with the host immune response. Such prot...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Carfí A,Smith CA,Smolak PJ,McGrew J,Wiley DC

更新日期：1999-10-26 00:00:00

abstract：:Human gene MAGE-1 encodes tumor-specific antigens that are recognized on melanoma cells by autologous cytolytic T lymphocytes. This gene is expressed in a significant proportion of tumors of various histological types, but not in normal tissues except male germ-line cells. We reported previously that reporter genes dr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： De Smet C,De Backer O,Faraoni I,Lurquin C,Brasseur F,Boon T

更新日期：1996-07-09 00:00:00

abstract：:On April 14, 2010, when meltwaters from the Eyjafjallajökull glacier mixed with hot magma, an explosive eruption sent unusually fine-grained ash into the jet stream. It quickly dispersed over Europe. Previous airplane encounters with ash resulted in sandblasted windows and particles melted inside jet engines, causing ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gislason SR,Hassenkam T,Nedel S,Bovet N,Eiriksdottir ES,Alfredsson HA,Hem CP,Balogh ZI,Dideriksen K,Oskarsson N,Sigfusson B,Larsen G,Stipp SL

更新日期：2011-05-03 00:00:00

abstract：:Albumin Redhill is an electrophoretically slow genetic variant of human serum albumin that does not bind 63Ni2+ and has a molecular mass 2.5 kDa higher than normal albumin. Its inability to bind Ni2+ was explained by the finding of an additional residue of Arg at position -1. This did not explain the molecular basis o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Brennan SO,Myles T,Peach RJ,Donaldson D,George PM

更新日期：1990-01-01 00:00:00

abstract：:Normal rat mast cells were stimulated by antibodies against IgE receptors (anti-RBL) or by anti-IgE, and [3H]methyl group incorporation into phospholipids, 45Ca uptake, and histamine release were examined. Anti-RBL or its F(ab')2 fragments and anti-IgE induced an increase in the incorporation of [3H]methyl into phosph...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ishizaka T,Hirata F,Ishizaka K,Axelrod J

更新日期：1980-04-01 00:00:00

abstract：:We posit that feasible reversal of the growth of atmospheric CH(4) and other trace gases would provide a vital contribution toward averting dangerous anthropogenic interference with global climate. Such trace gas reductions may allow stabilization of atmospheric CO(2) at an achievable level of anthropogenic CO(2) emis...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hansen J,Sato M

更新日期：2004-11-16 00:00:00

abstract：:Although sexual selection theory has proved successful in explaining a wide array of male ornaments, the function of ornaments occurring in females is largely unknown. Traditionally, female ornaments have been considered nonfunctional, being merely a genetically correlated response to selection for male ornamentation....

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Amundsen T,Forsgren E

更新日期：2001-11-06 00:00:00

abstract：:The accumulation of metal ions and amyloid-β (Aβ) aggregates found in the brain of patients with Alzheimer's disease (AD) has been suggested to be involved in AD pathogenesis. To investigate metal-Aβ-associated pathways in AD, development of chemical tools to target metal-Aβ species is desired. Only a few efforts, how...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Choi JS,Braymer JJ,Nanga RP,Ramamoorthy A,Lim MH

更新日期：2010-12-21 00:00:00

abstract：:Two features make the tooth an excellent model in the study of evolutionary innovations: the relative simplicity of its structure and the fact that the major tooth-forming genes have been identified in eutherian mammals. To understand the nature of the innovation at the molecular level, it is necessary to identify the...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Toyosawa S,O'hUigin C,Figueroa F,Tichy H,Klein J

更新日期：1998-10-27 00:00:00

abstract：:Alzheimer's disease (AD) comprises multifactorial ailments for which current therapeutic strategies remain insufficient to broadly address the underlying pathophysiology. Epigenetic gene regulation relies upon multifactorial processes that regulate multiple gene and protein pathways, including those involved in AD. We...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Volmar CH,Salah-Uddin H,Janczura KJ,Halley P,Lambert G,Wodrich A,Manoah S,Patel NH,Sartor GC,Mehta N,Miles NTH,Desse S,Dorcius D,Cameron MD,Brothers SP,Wahlestedt C

更新日期：2017-10-24 00:00:00

abstract：:A fragment of the cloned gene for the human myeloma ND epsilon chain, coding for the second, third, and fourth domains of the immunoglobulin, has been coupled to the tryptophan control region of an expression plasmid and subcloned in Escherichia coli. Induction of gene expression results in the synthesis of the expect...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kenten J,Helm B,Ishizaka T,Cattini P,Gould H

更新日期：1984-05-01 00:00:00

abstract：:Epitopes for 22 alloantibodies that inhibit factor VIII procoagulant protein (FVIII) from multitransfused individuals with severe hemophilia A and three autoantibodies from nonhemophilic individuals appeared to be restricted to two specific regions of the FVIII molecule. Immunoblotting of purified FVIII and purified t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fulcher CA,de Graaf Mahoney S,Roberts JR,Kasper CK,Zimmerman TS

更新日期：1985-11-01 00:00:00

abstract：:Glucose-regulated protein 94 (GRP94) is an endoplasmic reticulum (ER) chaperone for which only few client proteins and no cofactors are known and whose mode of action is unclear. To decipher the mode of GRP94 action in vivo, we exploited our finding that GRP94 is necessary for the production of insulin-like growth fac...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ostrovsky O,Makarewich CA,Snapp EL,Argon Y

更新日期：2009-07-14 00:00:00

abstract：:Rat adrenal mitochondria accumulated cholesterol during ether stress in vivo when side-chain cleavage was inhibited by aminoglutethimide (control = 14.6 vs. aminoglutethimide = 26.5 micrograms of cholesterol per mg of protein). This accumulation was insensitive to simultaneous administration of cycloheximide (24.2 mic...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Privalle CT,Crivello JF,Jefcoate CR

更新日期：1983-02-01 00:00:00

abstract：:Members of the caspase family of cysteine proteases play central roles in coordinating the stereotypical events that occur during apoptosis. Because the major executioner caspases, caspase-3 and caspase-7, exhibit almost indistinguishable activity toward certain synthetic peptide substrates, this has led to the widesp...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Walsh JG,Cullen SP,Sheridan C,Lüthi AU,Gerner C,Martin SJ

更新日期：2008-09-02 00:00:00

abstract：:Streptococcus groups A and B cause serious infections, including early onset sepsis and meningitis in newborns. Rib domain-containing surface proteins are found associated with invasive strains and elicit protective immunity in animal models. Yet, despite their apparent importance in infection, the structure of the Ri...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Whelan F,Lafita A,Griffiths SC,Cooper REM,Whittingham JL,Turkenburg JP,Manfield IW,St John AN,Paci E,Bateman A,Potts JR

更新日期：2019-12-09 00:00:00

abstract：:Tetherin/BST2 is a type-II membrane protein that inhibits the release of a range of enveloped viruses, including HIV-1. Here we report three crystal structures of human tetherin, including the full-length ectodomain, a triple cysteine mutant and an ectodomain truncation. These structures show that tetherin forms a con...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yang H,Wang J,Jia X,McNatt MW,Zang T,Pan B,Meng W,Wang HW,Bieniasz PD,Xiong Y

更新日期：2010-10-26 00:00:00

abstract：:Tobacco mosaic virus (TMV) was reconstituted from the RNA of a common strain (OM) and the protein of a watermelon strain of cucumber green mottle mosaic virus (CGMMV-W), which is a member of the tobamovirus group. In 0.25 M phosphate buffer at 25 degrees C, CGMMV-W protein existed mainly as 21S aggregates. When this p...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fukuda M,Okada Y

更新日期：1982-10-01 00:00:00

abstract：:Caenorhabditis elegans explores its environment by interrupting its forward movement with occasional turns and reversals. Turns and reversals occur at stable frequencies but irregular intervals, producing probabilistic exploratory behaviors. Here we dissect the roles of individual sensory neurons, interneurons, and mo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gray JM,Hill JJ,Bargmann CI

更新日期：2005-03-01 00:00:00

abstract：:Biological carbon fixation is limited by the supply of Fe in vast regions of the global ocean. Dissolved Fe in seawater is primarily sourced from continental mineral dust, submarine hydrothermalism, and sediment dissolution along continental margins. However, the relative contributions of these three sources to the Fe...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Horner TJ,Williams HM,Hein JR,Saito MA,Burton KW,Halliday AN,Nielsen SG

更新日期：2015-02-03 00:00:00

abstract：:Peroxiredoxins (Prx), a family of peroxidases that reduce intracellular peroxides with the thioredoxin system as the electron donor, are highly expressed in various cellular compartments. Among the antioxidant Prx enzymes, Prx2 is the most abundant in mammalian neurons, making it a prime candidate to defend against ox...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fang J,Nakamura T,Cho DH,Gu Z,Lipton SA

更新日期：2007-11-20 00:00:00

abstract：:Distinguishing tumor from normal glandular breast tissue is an important step in breast-conserving surgery. Because this distinction can be challenging in the operative setting, up to 40% of patients require an additional operation when traditional approaches are used. Here, we present a proof-of-concept study to dete...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Calligaris D,Caragacianu D,Liu X,Norton I,Thompson CJ,Richardson AL,Golshan M,Easterling ML,Santagata S,Dillon DA,Jolesz FA,Agar NY

更新日期：2014-10-21 00:00:00