A circuit for navigation in Caenorhabditis elegans.

Abstract:

:Caenorhabditis elegans explores its environment by interrupting its forward movement with occasional turns and reversals. Turns and reversals occur at stable frequencies but irregular intervals, producing probabilistic exploratory behaviors. Here we dissect the roles of individual sensory neurons, interneurons, and motor neurons in exploratory behaviors under different conditions. After animals are removed from bacterial food, they initiate a local search behavior consisting of reversals and deep omega-shaped turns triggered by AWC olfactory neurons, ASK gustatory neurons, and AIB interneurons. Over the following 30 min, the animals disperse as reversals and omega turns are suppressed by ASI gustatory neurons and AIY interneurons. Interneurons and motor neurons downstream of AIB and AIY encode specific aspects of reversal and turn frequency, amplitude, and directionality. SMD motor neurons help encode the steep amplitude of omega turns, RIV motor neurons specify the ventral bias of turns that follow a reversal, and SMB motor neurons set the amplitude of sinusoidal movement. Many of these sensory neurons, interneurons, and motor neurons are also implicated in chemotaxis and thermotaxis. Thus, this circuit may represent a common substrate for multiple navigation behaviors.

authors

Gray JM,Hill JJ,Bargmann CI

doi

10.1073/pnas.0409009101

keywords:

subject

Has Abstract

pub_date

2005-03-01 00:00:00

pages

3184-91

issue

9

eissn

0027-8424

issn

1091-6490

pii

0409009101

journal_volume

102

pub_type

杂志文章
  • Core disgust is attenuated by ingroup relations.

    abstract::We present the first experimental evidence to our knowledge that ingroup relations attenuate core disgust and that this helps explain the ability of groups to coact. In study 1, 45 student participants smelled a sweaty t-shirt bearing the logo of another university, with either their student identity (ingroup conditio...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.1517027113

    authors: Reicher SD,Templeton A,Neville F,Ferrari L,Drury J

    更新日期:2016-03-08 00:00:00

  • Free energy landscape for the binding process of Huperzine A to acetylcholinesterase.

    abstract::Drug-target residence time (t = 1/k(off), where k(off) is the dissociation rate constant) has become an important index in discovering better- or best-in-class drugs. However, little effort has been dedicated to developing computational methods that can accurately predict this kinetic parameter or related parameters, ...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.1301814110

    authors: Bai F,Xu Y,Chen J,Liu Q,Gu J,Wang X,Ma J,Li H,Onuchic JN,Jiang H

    更新日期:2013-03-12 00:00:00

  • Herpes simplex virus glycoproteins gB and gH function in fusion between the virion envelope and the outer nuclear membrane.

    abstract::Herpesviruses must traverse the nuclear envelope to gain access to the cytoplasm and, ultimately, to exit cells. It is believed that herpesvirus nucleocapsids enter the perinuclear space by budding through the inner nuclear membrane (NM). To reach the cytoplasm these enveloped particles must fuse with the outer NM and...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.0703790104

    authors: Farnsworth A,Wisner TW,Webb M,Roller R,Cohen G,Eisenberg R,Johnson DC

    更新日期:2007-06-12 00:00:00

  • MLL repression domain interacts with histone deacetylases, the polycomb group proteins HPC2 and BMI-1, and the corepressor C-terminal-binding protein.

    abstract::The MLL (mixed-lineage leukemia) gene is involved in many chromosomal translocations associated with acute myeloid and lymphoid leukemia. We previously identified a transcriptional repression domain in MLL, which contains a region with homology to DNA methyltransferase. In chromosomal translocations, the MLL repressio...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.1436338100

    authors: Xia ZB,Anderson M,Diaz MO,Zeleznik-Le NJ

    更新日期:2003-07-08 00:00:00

  • Gelation-driven component selection in the generation of constitutional dynamic hydrogels based on guanine-quartet formation.

    abstract::The guanosine hydrazide 1 yields a stable supramolecular hydrogel based on the formation of a guanine quartet (G-quartet) in presence of metal cations. The effect of various parameters (concentration, nature of metal ion, and temperature) on the properties of this gel has been studied. Proton NMR spectroscopy is shown...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.0501663102

    authors: Sreenivasachary N,Lehn JM

    更新日期:2005-04-26 00:00:00

  • A male germ cell tumor-susceptibility-determining locus, pgct1, identified on murine chromosome 13.

    abstract::Inbred 129 strain mice are predisposed to developing male germ cell tumors (GCTs) of the testes. The inherent genetic defects that underlie male GCT susceptibility in the 129 mouse strain are unknown. GCT incidence is increased in 129 strain males that lack functional p53 protein, and we have used this finding to faci...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.140208197

    authors: Muller AJ,Teresky AK,Levine AJ

    更新日期:2000-07-18 00:00:00

  • Correction of proximal tubule phosphate transport defect in Hyp mice in vivo and in vitro with indomethacin.

    abstract::X-linked hypophosphatemia is the most prevalent inherited form of rickets. In this disorder, rickets results from hyperphosphaturia and inappropriately normal levels of 1,25(OH)2-vitamin D. Current therapy with oral phosphate and vitamin D improves the rickets, but has significant morbidity and does not significantly ...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.1834060100

    authors: Baum M,Loleh S,Saini N,Seikaly M,Dwarakanath V,Quigley R

    更新日期:2003-09-16 00:00:00

  • An attempt to locate the non-helical and permissively helical sequences of proteins: application to the variable regions of immunoglobulin light and heavy chains.

    abstract::From a consideration of (varphi, Psi) values of the amino acids of myoglobin, lysozyme, the alpha and beta chains of horse oxyhemoglobin, tosyl-alpha-chymotrypsin, and carboxypeptidase A, an empirical procedure of predicting whether amino-acid residues in proteins are in a non-helical or may be in a helical conformati...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.68.7.1501

    authors: Wu TT,Kabat EA

    更新日期:1971-07-01 00:00:00

  • Increased CNS levels of apolipoprotein D in schizophrenic and bipolar subjects: implications for the pathophysiology of psychiatric disorders.

    abstract::Chronic administration of the atypical antipsychotic drug, clozapine, to rodents has been shown to increase the concentration of apolipoprotein D (apoD) in several area of the brain, suggesting that apoD could be involved in the therapeutic effects of antipsychotic drugs and/or the pathology of psychotic illnesses. He...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.071056198

    authors: Thomas EA,Dean B,Pavey G,Sutcliffe JG

    更新日期:2001-03-27 00:00:00

  • Target inference from collections of genomic intervals.

    abstract::Finding regions of the genome that are significantly recurrent in noisy data are a common but difficult problem in present day computational biology. Cores of recurrent events (CORE) is a computational approach to solving this problem that is based on a formalized notion by which "core" intervals explain the observed ...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.1306909110

    authors: Krasnitz A,Sun G,Andrews P,Wigler M

    更新日期:2013-06-18 00:00:00

  • Multivalent weak interactions enhance selectivity of interparticle binding.

    abstract::Targeted drug delivery critically depends on the binding selectivity of cargo-transporting colloidal particles. Extensive theoretical work has shown that two factors are necessary to achieve high selectivity for a threshold receptor density: multivalency and weak interactions. Here, we study a model system of DNA-coat...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.2003968117

    authors: Scheepers MRW,van IJzendoorn LJ,Prins MWJ

    更新日期:2020-09-15 00:00:00

  • Mutational analysis of Kaposica reveals that bridging of MG2 and CUB domains of target protein is crucial for the cofactor activity of RCA proteins.

    abstract::The complement system has evolved to annul pathogens, but its improper regulation is linked with diseases. Efficient regulation of the system is primarily provided by a family of proteins termed regulators of complement activation (RCA). The knowledge of precise structural determinants of RCA proteins critical for imp...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.1506449112

    authors: Gautam AK,Panse Y,Ghosh P,Reza MJ,Mullick J,Sahu A

    更新日期:2015-10-13 00:00:00

  • Biologic activity in a fragment of recombinant human interferon alpha.

    abstract::To attempt to locate functionally important regions of the interferon (IFN) molecule, recombinant human IFN-alpha 2 was subjected to proteolytic digestion. The bacterial proteinase thermolysin produced two major complementary fragments, HuIFN-alpha 2-(1-110) and HuIFN-alpha 2-(111-153). After reduction with 2-mercapto...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.81.4.1045

    authors: Ackerman SK,Zur Nedden D,Heintzelman M,Hunkapiller M,Zoon K

    更新日期:1984-02-01 00:00:00

  • Aire-expressing thymic medullary epithelial cells originate from β5t-expressing progenitor cells.

    abstract::The thymus provides multiple microenvironments that are essential for the development and repertoire selection of T lymphocytes. The thymic cortex induces the generation and positive selection of T lymphocytes, whereas the thymic medulla establishes self-tolerance among the positively selected T lymphocytes. Cortical ...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.1301799110

    authors: Ohigashi I,Zuklys S,Sakata M,Mayer CE,Zhanybekova S,Murata S,Tanaka K,Holländer GA,Takahama Y

    更新日期:2013-06-11 00:00:00

  • Reduced amounts of cartilage collagen fibrils and growth plate anomalies in transgenic mice harboring a glycine-to-cysteine mutation in the mouse type II procollagen alpha 1-chain gene.

    abstract::We have generated transgenic mice harboring a glycine-to-cysteine mutation in residue 85 of the triple helical domain of mouse type II collagen. The offspring of different founders displayed a phenotype of severe chondrodysplasia characterized by short limbs and trunk, cranio-facial deformities, and cleft palate. The ...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.88.21.9648

    authors: Garofalo S,Vuorio E,Metsaranta M,Rosati R,Toman D,Vaughan J,Lozano G,Mayne R,Ellard J,Horton W

    更新日期:1991-11-01 00:00:00

  • The tomato ethylene receptors NR and LeETR4 are negative regulators of ethylene response and exhibit functional compensation within a multigene family.

    abstract::The plant hormone ethylene is involved in many developmental processes, including fruit ripening, abscission, senescence, and leaf epinasty. Tomato contains a family of ethylene receptors, designated LeETR1, LeETR2, NR, LeETR4, and LeETR5, with homology to the Arabidopsis ETR1 ethylene receptor. Transgenic plants with...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.090550597

    authors: Tieman DM,Taylor MG,Ciardi JA,Klee HJ

    更新日期:2000-05-09 00:00:00

  • Irreversibility of cellular aging and neoplastic transformation: a clonal analysis.

    abstract::Prolonged incubation of NIH 3T3 cells under the growth constraint of confluence results in a persistent impairment of proliferation when the cells are subcultured at low density and a greatly increased probability of neoplastic transformation in assays for transformation. These properties, along with the large accumul...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.93.18.9793

    authors: Chow M,Rubin H

    更新日期:1996-09-03 00:00:00

  • Orthogonal self-assembly of an organoplatinum(II) metallacycle and cucurbit[8]uril that delivers curcumin to cancer cells.

    abstract::Curcumin (Cur) is a naturally occurring anticancer drug isolated from the Curcuma longa plant. It is known to exhibit anticancer properties via inhibiting the STAT3 phosphorylation process. However, its poor water solubility and low bioavailability impede its clinical application. Herein, we used organoplatinum(II) ← ...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.1803800115

    authors: Datta S,Misra SK,Saha ML,Lahiri N,Louie J,Pan D,Stang PJ

    更新日期:2018-08-07 00:00:00

  • Energy-dependent processing of cytoplasmically made precursors to mitochondrial proteins.

    abstract::Earlier work has shown that mitochondrial proteins synthesized in the cytosol are initially made as larger precursors which are then transferred into the organelles and processed to their mature size in the absence of protein synthesis. It is now demonstrated that depletion of the mitochondrial matrix ATP in intact ye...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.76.9.4365

    authors: Nelson N,Schatz G

    更新日期:1979-09-01 00:00:00

  • Molecular analysis of the amphioxus frontal eye unravels the evolutionary origin of the retina and pigment cells of the vertebrate eye.

    abstract::The origin of vertebrate eyes is still enigmatic. The "frontal eye" of amphioxus, our most primitive chordate relative, has long been recognized as a candidate precursor to the vertebrate eyes. However, the amphioxus frontal eye is composed of simple ciliated cells, unlike vertebrate rods and cones, which display more...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.1207580109

    authors: Vopalensky P,Pergner J,Liegertova M,Benito-Gutierrez E,Arendt D,Kozmik Z

    更新日期:2012-09-18 00:00:00

  • Human HA and polymerase subunit PB2 proteins confer transmission of an avian influenza virus through the air.

    abstract::The influenza virus genes that confer efficient transmission of epidemic and pandemic strains in humans have not been identified. The rapid spread and severe disease caused by the 1918 influenza pandemic virus makes it an ideal virus to study the transmissibility of potentially pandemic influenza strains. Here, we use...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.0813172106

    authors: Van Hoeven N,Pappas C,Belser JA,Maines TR,Zeng H,García-Sastre A,Sasisekharan R,Katz JM,Tumpey TM

    更新日期:2009-03-03 00:00:00

  • Identification of DNMT1 (DNA methyltransferase 1) hypomorphs in somatic knockouts suggests an essential role for DNMT1 in cell survival.

    abstract::Previous studies have shown that DNA methyltransferase (Dnmt) 1 is required for maintenance of bulk DNA methylation and is essential for mouse development. However, somatic disruption of DNMT1 in the human cancer cell line HCT116 was not lethal and caused only minor decreases in methylation. Here, we report the identi...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.0604602103

    authors: Egger G,Jeong S,Escobar SG,Cortez CC,Li TW,Saito Y,Yoo CB,Jones PA,Liang G

    更新日期:2006-09-19 00:00:00

  • Attenuation of thermal nociception and hyperalgesia by VR1 blockers.

    abstract::Vanilloid receptor subunit 1 (VR1) appears to play a critical role in the transduction of noxious chemical and thermal stimuli by sensory nerve endings in peripheral tissues. Thus, VR1 antagonists are useful compounds to unravel the contribution of this receptor to pain perception, as well as to induce analgesia. We h...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.022285899

    authors: García-Martinez C,Humet M,Planells-Cases R,Gomis A,Caprini M,Viana F,De La Pena E,Sanchez-Baeza F,Carbonell T,De Felipe C,Pérez-Paya E,Belmonte C,Messeguer A,Ferrer-Montiel A

    更新日期:2002-02-19 00:00:00

  • Moth chemosensory protein exhibits drastic conformational changes and cooperativity on ligand binding.

    abstract::Chemosensory proteins (CSPs) have been proposed to transport hydrophobic chemicals from air to olfactory or taste receptors. They have been isolated from several sensory organs of a wide range of insect species. The x-ray structure of CSPMbraA6, a 112-aa antennal protein from the moth Mamestra brassicae (Mbra), was sh...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.0836654100

    authors: Campanacci V,Lartigue A,Hällberg BM,Jones TA,Giudici-Orticoni MT,Tegoni M,Cambillau C

    更新日期:2003-04-29 00:00:00

  • Aberrant AKT activation drives well-differentiated liposarcoma.

    abstract::Well-differentiated liposarcoma (WDLPS), one of the most common human sarcomas, is poorly responsive to radiation and chemotherapy, and the lack of animal models suitable for experimental analysis has seriously impeded functional investigation of its pathobiology and development of effective targeted therapies. Here, ...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.1106127108

    authors: Gutierrez A,Snyder EL,Marino-Enriquez A,Zhang YX,Sioletic S,Kozakewich E,Grebliunaite R,Ou WB,Sicinska E,Raut CP,Demetri GD,Perez-Atayde AR,Wagner AJ,Fletcher JA,Fletcher CD,Look AT

    更新日期:2011-09-27 00:00:00

  • Her6 regulates the neurogenetic gradient and neuronal identity in the thalamus.

    abstract::During vertebrate brain development, the onset of neuronal differentiation is under strict temporal control. In the mammalian thalamus and other brain regions, neurogenesis is regulated also in a spatially progressive manner referred to as a neurogenetic gradient, the underlying mechanism of which is unknown. Here we ...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.0910894106

    authors: Scholpp S,Delogu A,Gilthorpe J,Peukert D,Schindler S,Lumsden A

    更新日期:2009-11-24 00:00:00

  • MITF drives endolysosomal biogenesis and potentiates Wnt signaling in melanoma cells.

    abstract::Canonical Wnt signaling plays an important role in development and disease, regulating transcription of target genes and stabilizing many proteins phosphorylated by glycogen synthase kinase 3 (GSK3). We observed that the MiT family of transcription factors, which includes the melanoma oncogene MITF (micropthalmia-asso...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.1424576112

    authors: Ploper D,Taelman VF,Robert L,Perez BS,Titz B,Chen HW,Graeber TG,von Euw E,Ribas A,De Robertis EM

    更新日期:2015-02-03 00:00:00

  • Dissecting the antigenic mosaic of the Archaebacterium Methanobacterium thermoautotrophicum by monoclonal antibodies of defined molecular specificity.

    abstract::The antigenic mosaic of the Archaebacterium Methanobacterium thermoautotrophicum, strain delta H, was analyzed with a panel of six monoclonal antibodies. Five antigenic determinants were identified. One contains N-acetyl-D-glucosamine, another contains N-acetyl-D-galactosamine, and a third contains gamma-glutamylalani...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.80.20.6346

    authors: Conway de Macario E,Macario AJ,Magariños MC,König H,Kandler O

    更新日期:1983-10-01 00:00:00

  • E2F4-RB and E2F4-p107 complexes suppress gene expression by transforming growth factor beta through E2F binding sites.

    abstract::Transforming growth factor beta (TGF-beta) causes growth arrest in most cell types. TGF-beta induces hypophosphorylation of retinoblastoma susceptibility gene 1 product (RB), which sequesters E2F factors needed for progression into S phase of the cell cycle, thereby leading to cell cycle arrest at G1. It is possible, ...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.94.10.4948

    authors: Li JM,Hu PP,Shen X,Yu Y,Wang XF

    更新日期:1997-05-13 00:00:00

  • Obligatory role in GTP hydrolysis for the amide carbonyl oxygen of the Mg(2+)-coordinating Thr of regulatory GTPases.

    abstract::When G-protein alpha subunits binds GTP and Mg(2+), they transition from their inactive to their active conformation. This transition is accompanied by completion of the coordination shell of Mg(2+) with electrons from six oxygens: two water molecules, the ss and gamma phosphoryls of GTP, a helix-alpha1 Ser, and a swi...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.1004803107

    authors: Zurita A,Zhang Y,Pedersen L,Darden T,Birnbaumer L

    更新日期:2010-05-25 00:00:00