5'-CGA sequence is a strong motif for homo base-paired parallel-stranded DNA duplex as revealed by NMR analysis.

abstract：:The molecular basis of pathogen clone emergence is relatively poorly understood. Acquisition of a bacteriophage encoding a previously unknown secreted phospholipase A(2) (designated SlaA) has been implicated in the rapid emergence in the mid-1980s of a new hypervirulent clone of serotype M3 group A Streptococcus. Alth...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sitkiewicz I,Nagiec MJ,Sumby P,Butler SD,Cywes-Bentley C,Musser JM

更新日期：2006-10-24 00:00:00

abstract：:Methods for the construction of ordered nanoscale arrays have been implicated in fields ranging from separation technologies to microelectronics. Yet, despite the plethora of nanoscale structures assembled in nature that use a templating strategy, chemists have been unable to replicate this success. A technology is re...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Willis B,Eubanks LM,Wood MR,Janda KD,Dickerson TJ,Lerner RA

更新日期：2008-02-05 00:00:00

abstract：:The mRNA for organic anion transport protein (oatp) was previously shown to be present in abundance in liver and kidney, and in small amounts in brain. Data obtained from experiments with reverse transcriptase-PCR techniques and in situ hybridization analysis showed that the oatp mRNA is present within the brain, loca...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Angeletti RH,Novikoff PM,Juvvadi SR,Fritschy JM,Meier PJ,Wolkoff AW

更新日期：1997-01-07 00:00:00

abstract：:Liddle syndrome is a mendelian form of hypertension characterized by constitutively elevated renal Na reabsorption that can result from activating mutations in the beta or gamma subunit of the epithelial Na channel. All reported mutations have deleted the last 45-76 normal amino acids from the cytoplasmic C terminus o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hansson JH,Schild L,Lu Y,Wilson TA,Gautschi I,Shimkets R,Nelson-Williams C,Rossier BC,Lifton RP

更新日期：1995-12-05 00:00:00

abstract：:S-adenosyl-L-methionine (SAM)-dependent O-methyltransferases (OMTs) catalyze the methylation of hydroxycinnamic acid derivatives for the synthesis of methylated plant polyphenolics, including lignin. The distinction in the extent of methylation of lignins in angiosperms and gymnosperms, mediated by substrate-specific ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li L,Popko JL,Zhang XH,Osakabe K,Tsai CJ,Joshi CP,Chiang VL

更新日期：1997-05-13 00:00:00

abstract：:Galanin is a neuropeptide with a wide variety of biological functions, including that of a strong endogenous anticonvulsant. No nonpeptide ligands, capable of activating galanin receptors, are available today. Based on known pharmacophores of galanin, a combinatorial library was designed, synthesized, and screened at ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Saar K,Mazarati AM,Mahlapuu R,Hallnemo G,Soomets U,Kilk K,Hellberg S,Pooga M,Tolf BR,Shi TS,Hökfelt T,Wasterlain C,Bartfai T,Langel U

更新日期：2002-05-14 00:00:00

abstract：:The chloroplast coupling factor 1 consists of five nonidentical subunits, three of which (alpha, beta, and epsilon subunits) have been shown in several laboratories to be synthesized within chloroplasts. The site of synthesis of the remaining two (gamma and delta subunits) was investigated by analyzing products direct...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Watanabe A,Price CA

更新日期：1982-10-01 00:00:00

abstract：:Spider-like forms of purified reovirus RNA have been characterized by electron microscopy. These structures contained 11.3 +/- 0.8 mum of double-stranded RNA and up to 20 arms, each of distinct length. Length measurements of 64 "spiders" suggest that in these structures the viral genome is folded fairly specifically. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kavenoff R,Talcove D,Mudd JA

更新日期：1975-11-01 00:00:00

abstract：:Molecular adaptation is typically assumed to proceed by sequential fixation of beneficial mutations. In diploids, this picture presupposes that for most adaptive mutations, the homozygotes have a higher fitness than the heterozygotes. Here, we show that contrary to this expectation, a substantial proportion of adaptiv...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sellis D,Callahan BJ,Petrov DA,Messer PW

更新日期：2011-12-20 00:00:00

abstract：:Utilizing the bicistronic reporter transposon mini-Tn5 lacZ-tet/1, we have identified lacZ fusions to four Escherichia coli genes/operons that are strongly activated by the accumulation of self-produced extracellular signals. These fusions were designated cma9, cma48, cma113, and cma114 for conditioned medium activate...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Baca-DeLancey RR,South MM,Ding X,Rather PN

更新日期：1999-04-13 00:00:00

abstract：:Recently, a 29-residue cyclic peptide was synthesized (TrPepz) that was reported to possess nearly the same catalytic activity and specificity as the pancreatic serine protease, trypsin, for hydrolysis of a small ester substrate, N-tosyl-L-arginine methyl ester (TAME), and small and large peptides [Atassi, M. Z. & Man...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wells JA,Fairbrother WJ,Otlewski J,Laskowski M Jr,Burnier J

更新日期：1994-05-10 00:00:00

abstract：:The anti-Tac monoclonal antibody is known to bind to the p55 chain of the human interleukin 2 receptor and to inhibit proliferation of T cells by blocking interleukin 2 binding. However, use of anti-Tac as an immunosuppressant drug would be impaired by the human immune response against this murine antibody. We have th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Queen C,Schneider WP,Selick HE,Payne PW,Landolfi NF,Duncan JF,Avdalovic NM,Levitt M,Junghans RP,Waldmann TA

更新日期：1989-12-01 00:00:00

abstract：:When purified dimers of hemagglutinin-neuraminidase molecules released by protease digestion from three strains of human parainfluenza virus 1 were used in crystallization trials, long thin needle crystals formed. Electron microscopic analysis of these needle crystals revealed that they are composed of stacks of tripl...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Murti KG,Takimoto T,Laver WG,Portner A

更新日期：1993-02-15 00:00:00

abstract：:Age-related hearing loss and noise-induced hearing loss are major causes of human morbidity. Here we used genetics and functional studies to show that a shared cause of these disorders may be loss of function of the ATP-gated P2X(2) receptor (ligand-gated ion channel, purinergic receptor 2) that is expressed in sensor...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yan D,Zhu Y,Walsh T,Xie D,Yuan H,Sirmaci A,Fujikawa T,Wong AC,Loh TL,Du L,Grati M,Vlajkovic SM,Blanton S,Ryan AF,Chen ZY,Thorne PR,Kachar B,Tekin M,Zhao HB,Housley GD,King MC,Liu XZ

更新日期：2013-02-05 00:00:00

abstract：:A decade ago it was discovered that mature birds are able to regenerate hair cells, the receptors for auditory perception. This surprising finding generated hope in the field of auditory neuroscience that new hair cells someday may be coaxed to form in another class of warm-blooded vertebrates, mammals. We have made c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Stone JS,Rubel EW

更新日期：2000-10-24 00:00:00

abstract：:Colocalization of proteins that are part of the same signal transduction pathway via compartmentalization, scaffold, or anchor proteins is an essential aspect of the signal transduction system in eukaryotic cells. If interaction must occur via free diffusion, then the spatial separation between the sources of the two ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Batada NN,Shepp LA,Siegmund DO

更新日期：2004-04-27 00:00:00

abstract：:Methane seeps are widespread seafloor ecosystems shaped by the emission of gas from seabed reservoirs. The microorganisms inhabiting methane seeps transform the chemical energy in methane to products that sustain rich benthic communities around the gas leaks. Despite the biogeochemical relevance of microbial methane r...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ruff SE,Biddle JF,Teske AP,Knittel K,Boetius A,Ramette A

更新日期：2015-03-31 00:00:00

abstract：:Host-encoded factors play an important role in virus multiplication, acting in concert with virus-encoded factors. However, information regarding the host factors involved in this process is limited. Here we report the map-based cloning of an Arabidopsis thaliana gene, TOM1, which is necessary for the efficient multip...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yamanaka T,Ohta T,Takahashi M,Meshi T,Schmidt R,Dean C,Naito S,Ishikawa M

更新日期：2000-08-29 00:00:00

abstract：:Ascorbic acid metabolism is associated with a number of mechanisms known to be involved in host resistance to malignant disease. Cancer patients are significantly depleted of ascorbic acid, and in our opinion this demonstrable biochemical characteristic indicates a substantially increased requirement and utilization o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cameron E,Pauling L

更新日期：1976-10-01 00:00:00

abstract：:Homologs of the chromatin-bound yeast silent information regulator 2 (SIR2) protein are found in organisms from all biological kingdoms. SIR2 itself was originally discovered to influence mating-type control in haploid cells by locus-specific transcriptional silencing. Since then, SIR2 and its homologs have been sugge...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Landry J,Sutton A,Tafrov ST,Heller RC,Stebbins J,Pillus L,Sternglanz R

更新日期：2000-05-23 00:00:00

abstract：:How do regions acquire the knowledge they need to diversify their economic activities? How does the migration of workers among firms and industries contribute to the diffusion of that knowledge? Here we measure the industry-, occupation-, and location-specific knowledge carried by workers from one establishment to the...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jara-Figueroa C,Jun B,Glaeser EL,Hidalgo CA

更新日期：2018-12-11 00:00:00

abstract：:We created a high-throughput modality of photoactivated localization microscopy (PALM) that enables automated 3D PALM imaging of hundreds of synchronized bacteria during all stages of the cell cycle. We used high-throughput PALM to investigate the nanoscale organization of the bacterial cell division protein FtsZ in l...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Holden SJ,Pengo T,Meibom KL,Fernandez Fernandez C,Collier J,Manley S

更新日期：2014-03-25 00:00:00

abstract：:Flagellar polypeptides of Chlamydomonas reinhardtii were analyzed in two-dimensions by isoelectric focusing and electrophoresis in the presence of sodium dodecyl sulfate. In addition to flagellar tubulin, over 130 polypeptides were resolved and 100 of these were identified as axonemal components in wild-type organisms...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Piperno G,Huang B,Luck DJ

更新日期：1977-04-01 00:00:00

abstract：:Despite the increasing number of regulatory proteins identified in clathrin-independent endocytic (CIE) pathways, our understanding of the exact functions of these proteins and the sequential manner in which they function remains limited. In this study, using the Caenorhabditis elegans intestine as a model, we observe...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chen S,Li L,Li J,Liu B,Zhu X,Zheng L,Zhang R,Xu T

更新日期：2014-10-28 00:00:00

abstract：:Rearrangements of the RET receptor tyrosine kinase gene generating RET/PTC oncogenes are specific to papillary thyroid carcinoma (PTC), the most frequent thyroid tumor. Here, we show that the RET/PTC1 oncogene, when exogenously expressed in primary normal human thyrocytes, induces the expression of a large set of gene...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Borrello MG,Alberti L,Fischer A,Degl'innocenti D,Ferrario C,Gariboldi M,Marchesi F,Allavena P,Greco A,Collini P,Pilotti S,Cassinelli G,Bressan P,Fugazzola L,Mantovani A,Pierotti MA

更新日期：2005-10-11 00:00:00

abstract：:Vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase-activating polypeptide (PACAP) are two mediators synthesized by immune cells, specially under inflammatory and antigen stimulation conditions. Reports have shown that neuropeptides attenuate the deleterious consequences of septic shock both by down-re...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Martinez C,Abad C,Delgado M,Arranz A,Juarranz MG,Rodriguez-Henche N,Brabet P,Leceta J,Gomariz RP

更新日期：2002-01-22 00:00:00

abstract：:Structural information about rat enteroglucagon, intestinal peptides containing the pancreatic glucagon sequence, has been based previously on cDNA, immunologic, and chromatographic data. Our interests in testing the physiological actions of synthetic enteroglucagon peptides in rats required that we identify precisely...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Collie NL,Walsh JH,Wong HC,Shively JE,Davis MT,Lee TD,Reeve JR Jr

更新日期：1994-09-27 00:00:00

abstract：:Glutamic acid decarboxylase (GAD) 65 is one of the major pancreatic antigens targeted by self-reactive T cells in type I diabetes mellitus. T cells specific for GAD65 are among the first to enter inflamed islets and may be important for the initiation of autoimmune diabetes. However, we previously reported that nonobe...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kim SK,Tarbell KV,Sanna M,Vadeboncoeur M,Warganich T,Lee M,Davis M,McDevitt HO

更新日期：2004-09-28 00:00:00

abstract：:We have isolated overlapping phage genomic clones covering an area of 26 kilobases that encodes the human alpha 2-plasmin inhibitor. The alpha 2-plasmin inhibitor gene contains 10 exons and 9 introns distributed over approximately 16 kilobases of DNA. To our knowledge, the number of introns is the highest yet reported...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hirosawa S,Nakamura Y,Miura O,Sumi Y,Aoki N

更新日期：1988-09-01 00:00:00

abstract：:It is well established that pregnancy early in life reduces the risk of breast cancer in women and that this effect is universal. This phenomenon of parity protection against mammary cancer is also observed in rodents. Earlier studies have demonstrated that short-term administration of estradiol (E) in combination wit...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rajkumar L,Guzman RC,Yang J,Thordarson G,Talamantes F,Nandi S

更新日期：2001-09-25 00:00:00