Cellular studies of auditory hair cell regeneration in birds.

abstract：:Cryptococcus neoformans (Cn) is a soil fungus that causes life-threatening meningitis in immunocompromised patients and is a facultative intracellular pathogen capable of replication inside macrophages. The mechanism by which environmental fungi acquire and maintain virulence for mammalian hosts is unknown. We hypothe...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Steenbergen JN,Shuman HA,Casadevall A

更新日期：2001-12-18 00:00:00

abstract：:In Arabidopsis, the two-dimensional expansion of leaves is regulated via the polarized elongation of cells. The ROTUNDIFOLIA3 (ROT3) protein, a member of the family of cytochromes P450, is involved in this process and regulates leaf length. Transgenic plants that overexpressed a wild-type ROT3 gene had longer leaves t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kim GT,Tsukaya H,Saito Y,Uchimiya H

更新日期：1999-08-03 00:00:00

abstract：:Antiviral and macrophage-priming activities in the supernatant medium of a subclone of a concanavalin A-stimulated mouse T-cell hybridoma were investigated. The two activities were associated with a molecular weight of approximately 50,000 and could not be separated by various approaches. Both activities were eliminat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pace JL,Russell SW,Schreiber RD,Altman A,Katz DH

更新日期：1983-06-01 00:00:00

abstract：:We have grown crystals of a soluble recombinant form of human CD4, a transmembrane glycoprotein found predominantly on the surface of helper T cells. Crystals composed of the entire extracellular portion of CD4 exhibit extensive polymorphism. Of the five crystal types that have been grown, the best diffracts to Bragg ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kwong PD,Ryu SE,Hendrickson WA,Axel R,Sweet RM,Folena-Wasserman G,Hensley P,Sweet RW

更新日期：1990-08-01 00:00:00

abstract：:Exposure of human monocyte-macrophages to as little as 50 microliters of cultured medium from lymphocytes stimulated by concanavalin A (Con A) resulted in a dramatic decrease in the activities of the low density lipoprotein (LDL) receptor pathway, the LDL-dextran sulfate pathway, and the scavenger receptor pathway. Th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fogelman AM,Seager J,Haberland ME,Hokom M,Tanaka R,Edwards PA

更新日期：1982-02-01 00:00:00

abstract：:The sequence of spontaneous Epstein-Barr virus activation was studied in P3HR-1 carrier cells and in P3HR-1(BrdU) cells made resistant to 5-bromodeoxyuridine. Virus activation was initiated during the normal cell cycle, and recruitment of additional virus-activated cells was prevented by the DNA inhibitors, 1-beta-D-a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hampar B,Derge JG,Martos LM,Tagamets MA,Burroughs MA

更新日期：1972-09-01 00:00:00

abstract：:Seven clones encoding interferon response element binding factors have been isolated from a mouse fibroblast lambda gt11 cDNA library by using a 32P end-labeled tandem trimer of the mouse (2'-5')oligoadenylate synthetase gene interferon response element as a probe. Clone 16 shares strong similarity (95%) at both DNA a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yan C,Tamm I

更新日期：1991-01-01 00:00:00

abstract：:A mol of creatine kinase (EC 2.7.3.2), an enzyme with two identical subunits can be titrated very rapidly and stoichiometrically with 2 mol of 2-chloromercuri-4-nitrophenol, an environmentally sensitive chromophoric probe specific for thiols. Chemical modification does not inactivate the enzyme nor can the reaction be...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Quiocho FE,Thomson JW

更新日期：1973-10-01 00:00:00

abstract：:Stimulation of the region antero-ventral to the third cerebral ventricle (AV3V) by a cholinergic drug, carbachol, and lesions of the AV3V have been demonstrated in previous studies to either augment or decrease sodium excretion, respectively. Atrial natriuretic peptide (ANP) dramatically increases renal sodium excreti...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Baldissera S,Menani JW,dos Santos LF,Favaretto AL,Gutkowska J,Turrin MQ,McCann SM,Antunes-Rodrigues J

更新日期：1989-12-01 00:00:00

abstract：:The Mecp2 gene has been shown to be mutated in most cases of human Rett syndrome, and mouse models deleted for the ortholog have been generated. Lineage-specific deletion of the gene indicated that the Rett-like phenotype is caused by Mecp2 deficiency in neurons. Biochemical evidence suggests that Mecp2 acts as a glob...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tudor M,Akbarian S,Chen RZ,Jaenisch R

更新日期：2002-11-26 00:00:00

abstract：:Glioblastoma is the most common primary malignant brain tumor of adults and one of the most lethal of all cancers. Patients with this disease have a median survival of 15 months from the time of diagnosis despite surgery, radiation, and chemotherapy. New treatment approaches are needed. Recent works suggest that gliob...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Horvath S,Zhang B,Carlson M,Lu KV,Zhu S,Felciano RM,Laurance MF,Zhao W,Qi S,Chen Z,Lee Y,Scheck AC,Liau LM,Wu H,Geschwind DH,Febbo PG,Kornblum HI,Cloughesy TF,Nelson SF,Mischel PS

更新日期：2006-11-14 00:00:00

abstract：:A molecular model of poorly understood hydrophobic effects is heuristically developed using the methods of information theory. Because primitive hydrophobic effects can be tied to the probability of observing a molecular-sized cavity in the solvent, the probability distribution of the number of solvent centers in a ca...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hummer G,Garde S,García AE,Pohorille A,Pratt LR

更新日期：1996-08-20 00:00:00

abstract：:We explore the interactions of CYT-19, a DExD/H-box protein that functions in folding of group I RNAs, with a well characterized misfolded species of the Tetrahymena ribozyme. Consistent with its function, CYT-19 accelerates refolding of the misfolded RNA to its native state. Unexpectedly, CYT-19 performs another reac...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tijerina P,Bhaskaran H,Russell R

更新日期：2006-11-07 00:00:00

abstract：:Research has previously shown that, without methionine supplements, neural tube proteins of rat embryos cultured on bovine sera were hypomethylated and neural tubes failed to close. In the present study, to identify the proteins that became methylated during neurulation, rat embryos were first cultured on methionine-d...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Moephuli SR,Klein NW,Baldwin MT,Krider HM

更新日期：1997-01-21 00:00:00

abstract：:The radial distributions of the Calpha and side-chain atoms in a sample of 13 native proteins have been examined. It is found that there are substantial differences in behavior between different atoms of the same amino acid. In particular, the Calpha atoms of polar residues show no particular preference for being far ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rackovsky S,Scheraga HA

更新日期：1977-12-01 00:00:00

abstract：:Acute glaucoma is a sight-threatening condition characterized by a sudden and substantial rise in intraocular pressure (IOP) and consequent retinal ganglion cell (RGC) death. Angle closure glaucoma, a common cause of glaucoma in Asia that affects tens of millions of people worldwide, often presents acutely with loss o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chi W,Li F,Chen H,Wang Y,Zhu Y,Yang X,Zhu J,Wu F,Ouyang H,Ge J,Weinreb RN,Zhang K,Zhuo Y

更新日期：2014-07-29 00:00:00

abstract：:Antifreeze proteins (AFPs) are a diverse class of proteins that depress the kinetically observable freezing point of water. AFPs have been of scientific interest for decades, but the lack of an accurate model for predicting AFP activity has hindered the logical design of novel antifreeze systems. To address this, we p...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kozuch DJ,Stillinger FH,Debenedetti PG

更新日期：2018-12-26 00:00:00

abstract：:Previous studies have shown that the effect of language on categorical perception of color is stronger when stimuli are presented in the right visual field than in the left. To examine whether this lateralized effect occurs preattentively at an early stage of processing, we monitored the visual mismatch negativity, wh...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mo L,Xu G,Kay P,Tan LH

更新日期：2011-08-23 00:00:00

abstract：:The lack of genetic means has been a serious limitation in studying mosquito immunity. We generated Relish-mediated immune deficiency (RMID) by transforming Aedes aegypti with the Delta Rel transgene driven by the vitellogenin (Vg) promoter using the pBac[3xP3-EGFP, afm] vector. A stable transformed line had a single ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shin SW,Kokoza V,Lobkov I,Raikhel AS

更新日期：2003-03-04 00:00:00

abstract：:Fungi of the recently defined order Sebacinales (Basidiomycota) are involved in a wide spectrum of mutualistic symbioses (including mycorrhizae) with various plants, thereby exhibiting a unique potential for biocontrol strategies. The axenically cultivable root endophyte Piriformospora indica is a model organism of th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Deshmukh S,Hückelhoven R,Schäfer P,Imani J,Sharma M,Weiss M,Waller F,Kogel KH

更新日期：2006-12-05 00:00:00

abstract：:We model experience-dependent plasticity in the cortical representation of whiskers (the barrel cortex) in normal adult rats, and in adult rats that were prenatally exposed to alcohol. Prenatal exposure to alcohol (PAE) caused marked deficits in experience-dependent plasticity in a cortical barrel-column. Cortical pla...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Benusková L,Rema V,Armstrong-James M,Ebner FF

更新日期：2001-02-27 00:00:00

abstract：:Fibrosis is caused by scar tissue formation in internal organs and is associated with 45% of deaths in the United States. Two closely related human serum proteins, serum amyloid P (SAP) and C-reactive protein (CRP), strongly affect fibrosis. In multiple animal models, and in Phase 1 and Phase 2 clinical trials, SAP af...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cox N,Pilling D,Gomer RH

更新日期：2015-07-07 00:00:00

abstract：:An epithelial cell line, designated COMMA-1D, was derived from mammary tissue of BALB/c mice in the middle of pregnancy. This line, in continuous cell culture for 12 months, exhibits several characteristics distinctive of normal mammary epithelial cells, including induction of casein synthesis in vitro and normal duct...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Danielson KG,Oborn CJ,Durban EM,Butel JS,Medina D

更新日期：1984-06-01 00:00:00

abstract：:Documented cases of convergent molecular evolution due to selection are fairly unusual, and examples to date have involved only a few amino acid positions. However, because convergence mimics shared ancestry and is not accommodated by current phylogenetic methods, it can strongly mislead phylogenetic inference when it...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Castoe TA,de Koning AP,Kim HM,Gu W,Noonan BP,Naylor G,Jiang ZJ,Parkinson CL,Pollock DD

更新日期：2009-06-02 00:00:00

abstract：:A cardinal symptom of major depressive disorder (MDD) is the disruption of circadian patterns. However, to date, there is no direct evidence of circadian clock dysregulation in the brains of patients who have MDD. Circadian rhythmicity of gene expression has been observed in animals and peripheral human tissues, but i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li JZ,Bunney BG,Meng F,Hagenauer MH,Walsh DM,Vawter MP,Evans SJ,Choudary PV,Cartagena P,Barchas JD,Schatzberg AF,Jones EG,Myers RM,Watson SJ Jr,Akil H,Bunney WE

更新日期：2013-06-11 00:00:00

abstract：:Diffusion in the plasma membrane of living cells is often found to display anomalous dynamics. However, the mechanism underlying this diffusion pattern remains highly controversial. Here, we study the physical mechanism underlying Kv2.1 potassium channel anomalous dynamics using single-molecule tracking. Our analysis ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Weigel AV,Simon B,Tamkun MM,Krapf D

更新日期：2011-04-19 00:00:00

abstract：:Cl- channels in the apical membranes of salt-secreting epithelia are activated by both cAMP and Ca2+ second-messenger systems, and dysfunctions in their hormonal regulation have been demonstrated in patients with cystic fibrosis. We have transfected the epithelial cell line T84 with an expression vector containing a m...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rogers KV,Goldman PS,Frizzell RA,McKnight GS

更新日期：1990-11-01 00:00:00

abstract：:To prevent the spread of coronavirus disease 2019 (COVID-19), some types of public spaces have been shut down while others remain open. These decisions constitute a judgment about the relative danger and benefits of those locations. Using mobility data from a large sample of smartphones, nationally representative cons...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Benzell SG,Collis A,Nicolaides C

更新日期：2020-06-30 00:00:00

abstract：:The phosphatidylinositol phosphate kinase (PIPK) family of enzymes is primarily responsible for converting singly phosphorylated phosphatidylinositol derivatives to phosphatidylinositol bisphosphates. As such, these kinases are central to many signaling and membrane trafficking processes in the eukaryotic cell. The th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Muftuoglu Y,Xue Y,Gao X,Wu D,Ha Y

更新日期：2016-08-02 00:00:00

abstract：:We present a common allosteric mechanism for control of inflammatory and apoptotic caspases. Highly specific thiol-containing inhibitors of the human inflammatory caspase-1 were identified by using disulfide trapping, a method for site-directed small-molecule discovery. These compounds became trapped by forming a disu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Scheer JM,Romanowski MJ,Wells JA

更新日期：2006-05-16 00:00:00