Abstract:
:A molecular model of poorly understood hydrophobic effects is heuristically developed using the methods of information theory. Because primitive hydrophobic effects can be tied to the probability of observing a molecular-sized cavity in the solvent, the probability distribution of the number of solvent centers in a cavity volume is modeled on the basis of the two moments available from the density and radial distribution of oxygen atoms in liquid water. The modeled distribution then yields the probability that no solvent centers are found in the cavity volume. This model is shown to account quantitatively for the central hydrophobic phenomena of cavity formation and association of inert gas solutes. The connection of information theory to statistical thermodynamics provides a basis for clarification of hydrophobic effects. The simplicity and flexibility of the approach suggest that it should permit applications to conformational equilibria of nonpolar solutes and hydrophobic residues in biopolymers.
journal_name
Proc Natl Acad Sci U S Aauthors
Hummer G,Garde S,García AE,Pohorille A,Pratt LRdoi
10.1073/pnas.93.17.8951keywords:
subject
Has Abstractpub_date
1996-08-20 00:00:00pages
8951-5issue
17eissn
0027-8424issn
1091-6490journal_volume
93pub_type
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