Biphasic regulation of InsP3 receptor gating by dual Ca2+ release channel BH3-like domains mediates Bcl-xL control of cell viability.

abstract：:The recent development of small-molecule tyrosine kinase (TK) inhibitors offers increasing opportunities for the treatment of autoimmune diseases. In this study, we investigated the potential of this new class of drugs to treat and cure type 1 diabetes (T1D) in the NOD mouse. Treatment of prediabetic and new onset dia...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Louvet C,Szot GL,Lang J,Lee MR,Martinier N,Bollag G,Zhu S,Weiss A,Bluestone JA

更新日期：2008-12-02 00:00:00

abstract：:The guanosine hydrazide 1 yields a stable supramolecular hydrogel based on the formation of a guanine quartet (G-quartet) in presence of metal cations. The effect of various parameters (concentration, nature of metal ion, and temperature) on the properties of this gel has been studied. Proton NMR spectroscopy is shown...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sreenivasachary N,Lehn JM

更新日期：2005-04-26 00:00:00

abstract：:Infection during the neonatal period commonly induces apnea episodes, and the proinflammatory cytokine IL-1beta may serve as a critical mediator between these events. To determine the mechanism by which IL-1beta depresses respiration, we examined a prostaglandin E(2) (PGE(2))-dependent pathway in newborn mice and huma...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hofstetter AO,Saha S,Siljehav V,Jakobsson PJ,Herlenius E

更新日期：2007-06-05 00:00:00

abstract：:This study quantifies and maps the water footprint (WF) of humanity at a high spatial resolution. It reports on consumptive use of rainwater (green WF) and ground and surface water (blue WF) and volumes of water polluted (gray WF). Water footprints are estimated per nation from both a production and consumption perspe...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hoekstra AY,Mekonnen MM

更新日期：2012-02-28 00:00:00

abstract：:We report the molecular cloning of the first beta-1,3 glucanase from animal tissue. Three peptide sequences were obtained from beta-1,3 glucanase that had been purified from eggs of the sea urchin Strongylocentrotus purpuratus and the gene was cloned by PCR using oligonucleotides deduced from the peptide sequences. Th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bachman ES,McClay DR

更新日期：1996-06-25 00:00:00

abstract：:The transcription factor SRY (sex-determining region)-box 2 (SOX2) is an important functional marker of neural precursor cells (NPCs) and plays a critical role in self-renewal and neuronal differentiation; however, the molecular mechanisms underlying its functions are poorly understood. Using human embryonic stem cell...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cimadamore F,Amador-Arjona A,Chen C,Huang CT,Terskikh AV

更新日期：2013-08-06 00:00:00

abstract：:Neutrophils are immune cells that bind to, engulf, and destroy bacterial and fungal pathogens in infected tissue, and their clearance by apoptosis is essential for the resolution of inflammation. Killing involves both oxidative and nonoxidative processes, the oxidative pathway requiring electrogenic production of supe...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fay AJ,Qian X,Jan YN,Jan LY

更新日期：2006-11-14 00:00:00

abstract：:The allocation of carbon and nitrogen resources to the synthesis of plant proteins, carbohydrates, and lipids is complex and under the control of many genes; much remains to be understood about this process. QQS (Qua-Quine Starch; At3g30720), an orphan gene unique to Arabidopsis thaliana, regulates metabolic processes...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li L,Zheng W,Zhu Y,Ye H,Tang B,Arendsee ZW,Jones D,Li R,Ortiz D,Zhao X,Du C,Nettleton D,Scott MP,Salas-Fernandez MG,Yin Y,Wurtele ES

更新日期：2015-11-24 00:00:00

abstract：:The role of the cerebellar cortex in motor learning was investigated by comparing the paramedian lobule of adult rats given difficult acrobatic training to that of rats that had been given extensive physical exercise or had been inactive. The paramedian lobule is activated during limb movements used in both acrobatic ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Black JE,Isaacs KR,Anderson BJ,Alcantara AA,Greenough WT

更新日期：1990-07-01 00:00:00

abstract：:In animal cells, exogenous DNA recombines into random chromosomal sites much more frequently than it recombines into homologous sites. Free DNA ends are "recombinogenic" in both processes. To test the effects of specific ends on analogous extrachromosomal processes, we constructed a linear genome of simian virus 40 wi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chang XB,Wilson JH

更新日期：1987-07-01 00:00:00

abstract：:The free energy difference between complexes of the restriction nuclease EcoRI with nonspecific DNA and with the enzyme's recognition sequence is linearly dependent on the water chemical potential of the solution, set using several very different solutes, ranging from glycine and glycerol to triethylene glycol and suc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sidorova NY,Rau DC

更新日期：1996-10-29 00:00:00

abstract：:Bacterial outer membrane porins have a robust beta-barrel structure and therefore show potential for use as stochastic sensors based on single-molecule detection. The monomeric porin OmpG is especially attractive compared with multisubunit proteins because appropriate modifications of the pore can be easily achieved b...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chen M,Khalid S,Sansom MS,Bayley H

更新日期：2008-04-29 00:00:00

abstract：:Young male baboons born in captivity were immunized with an attenuated, cryopreserved schistosomular vaccine derived from gamma-irradiated (50 krad) cercariae of the Puerto Rican strain of Schistosoma mansoni. Protection against a heterologous Kenyan strain of S. mansoni, after percutaneous infection, was assessed. Pa...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Damian RT,Roberts ML,Powell MR,Clark JD,Lewis FA,Stirewalt MA

更新日期：1984-06-01 00:00:00

abstract：:The present investigation studied the influence of the blastocyst's state of activity on the "window" of implantation in the receptive uterus in the mouse. The receptive state of the uterus is defined as the limited time when the uterine milieu is favorable to blastocyst acceptance and implantation. In the mouse, impl...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Paria BC,Huet-Hudson YM,Dey SK

更新日期：1993-11-01 00:00:00

abstract：:By comparing the amino acid sequences of 11 mammalian and 1 avian prion proteins (PrP), structural analyses predicted four alpha-helical regions. Peptides corresponding to these regions of Syrian hamster PrP were synthesized, and, contrary to predictions, three of the four spontaneously formed amyloids as shown by ele...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gasset M,Baldwin MA,Lloyd DH,Gabriel JM,Holtzman DM,Cohen F,Fletterick R,Prusiner SB

更新日期：1992-11-15 00:00:00

abstract：:We describe a 98-base-pair region (-38 to +60) in the long terminal repeat of the Drosophila gypsy retrotransposon that is sufficient for accurate normal-level transcription. We find that, unlike most RNA polymerase II (pol II) promoters, the gypsy promoter includes downstream sequences that are required for full acti...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jarrell KA,Meselson M

更新日期：1991-01-01 00:00:00

abstract：:Nonspecific histone deacetylase (HDAC) inhibition has been shown to facilitate the extinction of drug-seeking behavior in a manner resistant to reinstatement. A key open question is which specific HDAC is involved in the extinction of drug-seeking behavior. Using the selective HDAC3 inhibitor RGFP966, we investigated ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Malvaez M,McQuown SC,Rogge GA,Astarabadi M,Jacques V,Carreiro S,Rusche JR,Wood MA

更新日期：2013-02-12 00:00:00

abstract：:Thiostrepton (TSR), an archetypal bimacrocyclic thiopeptide antibiotic that arises from complex posttranslational modifications of a genetically encoded precursor peptide, possesses a quinaldic acid (QA) moiety within the side-ring system of a thiopeptide-characteristic framework. Focusing on selective engineering of ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zheng Q,Wang S,Duan P,Liao R,Chen D,Liu W

更新日期：2016-12-13 00:00:00

abstract：:The accuracy of dynamical models for reactive scattering of molecular hydrogen, H(2), from metal surfaces is relevant to the validation of first principles electronic structure methods for molecules interacting with metal surfaces. The ability to validate such methods is important to progress in modeling heterogeneous...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kroes GJ,Díaz C,Pijper E,Olsen RA,Auerbach DJ

更新日期：2010-12-07 00:00:00

abstract：:The gene EPXH2 encodes for the soluble epoxide hydrolase (sEH), an enzyme involved in the regulation of cardiovascular and renal physiology containing two distinct domains connected via a proline-rich linker. The C-terminal domain containing the EH catalytic activity has been well studied. In contrast, a function for ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Newman JW,Morisseau C,Harris TR,Hammock BD

更新日期：2003-02-18 00:00:00

abstract：:This study challenges the paradigm that salt marsh plants prevent lateral wave-induced erosion along wetland edges by binding soil with live roots and clarifies the role of vegetation in protecting the coast. In both laboratory flume studies and controlled field experiments, we show that common salt marsh plants do no...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Feagin RA,Lozada-Bernard SM,Ravens TM,Möller I,Yeager KM,Baird AH

更新日期：2009-06-23 00:00:00

abstract：:Immunoprecipitation followed by mass spectrometry (IP/MS) has recently emerged as a preferred method in the analysis of protein complex components and cellular protein networks. Targeting endogenous protein complexes of higher eukaryotes, particularly in large-scale efforts, has been challenging due to cellular hetero...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Malovannaya A,Li Y,Bulynko Y,Jung SY,Wang Y,Lanz RB,O'Malley BW,Qin J

更新日期：2010-02-09 00:00:00

abstract：:The plant aquaporin plasma membrane intrinsic proteins (PIP) subfamily represents one of the main gateways for water exchange at the plasma membrane (PM). A fraction of this subfamily, known as PIP1, does not reach the PM unless they are coexpressed with a PIP2 aquaporin. Although ubiquitous and abundantly expressed, ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yaneff A,Sigaut L,Marquez M,Alleva K,Pietrasanta LI,Amodeo G

更新日期：2014-01-07 00:00:00

abstract：:Long-range conformational changes in proteins are ubiquitous in biology for the transmission and amplification of signals; such conformational changes can be triggered by small-amplitude, nanosecond protein domain motion. Understanding how conformational changes are initiated requires the characterization of protein d...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bu Z,Biehl R,Monkenbusch M,Richter D,Callaway DJ

更新日期：2005-12-06 00:00:00

abstract：:In normal adult rats anesthetized with urethane, intravenous injections of beta-endorphin (30--150 micrograms kg-1) induced a transient fall of blood pressure followed by a small hypertension and a prolonged hypotension. Prior administration of naloxone completely blocked these effects, whereas naloxone, given 1 hr af...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lemaire I,Tseng R,Lemaire S

更新日期：1978-12-01 00:00:00

abstract：:The tau and gamma subunits of DNA polymerase III holoenzyme are both products of the dnaX gene. Since tau and gamma are required as stoichiometric components of the replicative complex, a mechanism must exist for the cell to coordinate their synthesis and ensure that both subunits are present in an adequate quantity a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Flower AM,McHenry CS

更新日期：1990-05-01 00:00:00

abstract：:Here we study the effects of many-body interactions on rate and mechanism in protein folding by using the results of molecular dynamics simulations on numerous coarse-grained Calpha-model single-domain proteins. After adding three-body interactions explicitly as a perturbation to a Gō-like Hamiltonian with native pair...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ejtehadi MR,Avall SP,Plotkin SS

更新日期：2004-10-19 00:00:00

abstract：:Silicon, with its great abundance and mature infrastructure, is a foundational material for a range of applications, such as electronics, sensors, solar cells, batteries, and thermoelectrics. These applications rely on the purification of Si to different levels. Recently, it has been shown that nanosized silicon can o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zong L,Zhu B,Lu Z,Tan Y,Jin Y,Liu N,Hu Y,Gu S,Zhu J,Cui Y

更新日期：2015-11-03 00:00:00

abstract：:Continuous and intensive exploitation of wildlife resources by early agricultural societies had major ecological consequences in the ancient Near East. In particular, hunting strategies of post-Neolithic societies involving the mass killing of wild ungulates contributed to the eventual extirpation of a number of wild ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bar-Oz G,Zeder M,Hole F

更新日期：2011-05-03 00:00:00

abstract：:Hypomagnesemia affects insulin resistance and is a risk factor for diabetes mellitus type 2 (DM2) and gestational diabetes mellitus (GDM). Two single nucleotide polymorphisms (SNPs) in the epithelial magnesium channel TRPM6 (V(1393)I, K(1584)E) were predicted to confer susceptibility for DM2. Here, we show using patch...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nair AV,Hocher B,Verkaart S,van Zeeland F,Pfab T,Slowinski T,Chen YP,Schlingmann KP,Schaller A,Gallati S,Bindels RJ,Konrad M,Hoenderop JG

更新日期：2012-07-10 00:00:00