SOX2-LIN28/let-7 pathway regulates proliferation and neurogenesis in neural precursors.

abstract：:H2O2, in concentrations achieved in the proximity of stimulated leukocytes, induces injury and lysis of target cells. This may be an important aspect of inflammatory injury of tissues. Cell lysis in two target cells, the murine macrophage-like tumor cell line P388D1 and human peripheral lymphocytes, was found to be as...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schraufstatter IU,Hyslop PA,Hinshaw DB,Spragg RG,Sklar LA,Cochrane CG

更新日期：1986-07-01 00:00:00

abstract：:Interleukin 1 (IL-1) and tumor necrosis factor alpha are thought to contribute to the inflammatory response associated with autoimmune diseases. Transforming growth factor beta 1 (TGF-beta 1) counteracts many effects of these cytokines and has various immunosuppressive properties. In the present study, it is shown tha...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kuruvilla AP,Shah R,Hochwald GM,Liggitt HD,Palladino MA,Thorbecke GJ

更新日期：1991-04-01 00:00:00

abstract：:Neutrophils are important effector cells in immunity to microorganisms, particularly bacteria. Here, we show that the process of neutrophil apoptosis is delayed in several inflammatory diseases, suggesting that this phenomenon may represent a general feature contributing to the development of neutrophilia, and, theref...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dibbert B,Weber M,Nikolaizik WH,Vogt P,Schöni MH,Blaser K,Simon HU

更新日期：1999-11-09 00:00:00

abstract：:Members of the LEF-1/TCF family of transcription factors have been implicated in mediating a nuclear response to Wnt signals by association with beta-catenin. Consistent with this view, mice carrying mutations in either the Wnt3a gene or in both transcription factor genes Lef1 and Tcf1 were previously found to show a ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Galceran J,Hsu SC,Grosschedl R

更新日期：2001-07-17 00:00:00

abstract：:A key component of scientific communication is sufficient information for other researchers in the field to reproduce published findings. For computational and data-enabled research, this has often been interpreted to mean making available the raw data from which results were generated, the computer code that generate...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Stodden V,Seiler J,Ma Z

更新日期：2018-03-13 00:00:00

abstract：:Oligomerization of members of the p53 family of transcription factors (p53, p63, and p73) is essential for their distinct functions in cell-cycle control and development. To elucidate the molecular basis for tetramer formation of the various family members, we solved the crystal structure of the human p73 tetramerizat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Joerger AC,Rajagopalan S,Natan E,Veprintsev DB,Robinson CV,Fersht AR

更新日期：2009-10-20 00:00:00

abstract：:During the late Pleistocene, early anatomically modern humans coexisted in Europe with the anatomically archaic Neandertals for some thousand years. Under the recent variants of the multiregional model of human evolution, modern and archaic forms were different but related populations within a single evolving species,...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Caramelli D,Lalueza-Fox C,Vernesi C,Lari M,Casoli A,Mallegni F,Chiarelli B,Dupanloup I,Bertranpetit J,Barbujani G,Bertorelle G

更新日期：2003-05-27 00:00:00

abstract：:The F(1)F(0) ATP synthase is the smallest motor enzyme known. Previous studies had established that the central stalk, made of the gamma and epsilon subunits in the F(1) part and c subunit ring in the F(0) part, rotates relative to a stator composed of alpha(3)beta(3)deltaab(2) during ATP hydrolysis and synthesis. How...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tsunoda SP,Rodgers AJ,Aggeler R,Wilce MC,Yoshida M,Capaldi RA

更新日期：2001-06-05 00:00:00

abstract：:We have isolated a major integral membrane protein from Golgi-derived coatomer-coated vesicles. This 24-kDa protein, p24, defines a family of integral membrane proteins with homologs present in yeast and humans. In addition to sequence similarity, all p24 family members contain a motif with the characteristic heptad r...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Stamnes MA,Craighead MW,Hoe MH,Lampen N,Geromanos S,Tempst P,Rothman JE

更新日期：1995-08-15 00:00:00

abstract：:Proinflammatory signaling pathways are commonly up-regulated in breast cancer. In estrogen receptor-negative (ER-) and triple-negative breast cancer (TNBC), nitric oxide synthase-2 (NOS2) and cyclooxygenase-2 (COX2) have been described as independent predictors of disease outcome. We further explore these findings by ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Basudhar D,Glynn SA,Greer M,Somasundaram V,No JH,Scheiblin DA,Garrido P,Heinz WF,Ryan AE,Weiss JM,Cheng RYS,Ridnour LA,Lockett SJ,McVicar DW,Ambs S,Wink DA

更新日期：2017-12-05 00:00:00

abstract：:One of the critical issues regarding proteins with a four-helix bundle motif is which interactions play the major role in stabilizing this type of folded structure: the interaction among the four alpha-helices or the interaction between the loop and helix segments. To answer this question, an energetic analysis has be...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chou KC,Maggiora GM,Scheraga HA

更新日期：1992-08-15 00:00:00

abstract：:Prions are thought to consist mainly or entirely of misfolded PrP, a constitutively expressed host protein. Prions associated with the same PrP sequence may occur in the form of different strains; the strain phenotype is believed to be encoded by the conformation of the PrP. Some cell lines can be persistently infecte...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mahal SP,Baker CA,Demczyk CA,Smith EW,Julius C,Weissmann C

更新日期：2007-12-26 00:00:00

abstract：:High-resolution maps integrated with the enhanced location data base software (LDB+) give improved estimates of genetic parameters and reveal characteristics of cytogenetic bands. Chiasma interference is intermediate between Kosambi and Carter-Falconer levels, as in Drosophila and the mouse. The autosomal genetic map ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Collins A,Frezal J,Teague J,Morton NE

更新日期：1996-12-10 00:00:00

abstract：:Two Chinese hamster cell lines, G1+-1 and CHO, have been grown in the presence of low concentrations of hydroxyurea to determine how a slowing DNA synthesis (i.e., a lengthening of the S period) affects the length of the G1 period. Hydroxyurea concentrations of approximately 10 microM do not alter the generation times...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Stancel GM,Prescott DM,Liskay RM

更新日期：1981-10-01 00:00:00

abstract：:Five DNA fragments have been cloned from yeast, chicken, and mouse DNA that titrate lac repressor in an Escherichia coli lac+ I+Z+ wild-type strain when on a multi-copy plasmid. The five repressor-binding sequences have been identified by DNA sequence determinations and DNase cleavage-inhibition patterns. They share t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Simons A,Tils D,von Wilcken-Bergmann B,Müller-Hill B

更新日期：1984-03-01 00:00:00

abstract：:Transcription is a central step in gene expression, in which the DNA template is processively read by RNA polymerase II (Pol II), synthesizing a complementary messenger RNA transcript. At each cycle, Pol II moves exactly one register along the DNA, a process known as translocation. Although X-ray crystal structures ha...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Silva DA,Weiss DR,Pardo Avila F,Da LT,Levitt M,Wang D,Huang X

更新日期：2014-05-27 00:00:00

abstract：:Human T lymphotropic virus type 1 (HTLV-1) -associated myelopathy/tropic spastic paraparesis is a demyelinating inflammatory neurologic disease associated with HTLV-1 infection. HTLV-1 Tax11-19-specific cytotoxic T cells have been isolated from HLA-A2-positive patients. We have used a peptide-loaded soluble HLA-A2-Ig ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Greten TF,Slansky JE,Kubota R,Soldan SS,Jaffee EM,Leist TP,Pardoll DM,Jacobson S,Schneck JP

更新日期：1998-06-23 00:00:00

abstract：:We obtain a classification of the irreducible (nonunitary) representations of a connected semisimple Lie group G, in terms of their restriction to a maximal compact subgroup K of G. (A classification in terms of analytic properties of the representations has been given by R. P. Langlands [(1973), mimeographed notes, I...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vogan DA

更新日期：1977-07-01 00:00:00

abstract：:IL-17A is a therapeutic target in many autoimmune diseases. Most nonhematopoietic cells express IL-17A receptors and respond to extracellular IL-17A by inducing proinflammatory cytokines. The IL-17A signal transduction triggers two broad, TRAF6- and TRAF5-dependent, intracellular signaling pathways to produce represen...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： McGowan J,Peter C,Kim J,Popli S,Veerman B,Saul-McBeth J,Conti H,Pruett-Miller SM,Chattopadhyay S,Chakravarti R

更新日期：2020-10-06 00:00:00

abstract：:The liver plays a key role in the regulation of circulating levels of low density lipoproteins (LDL) because it is both the site for the production of and the major organ for the degradation of this class of lipoproteins. In this study, the effects of feeding polyunsaturated or saturated triacylglycerols on receptor-d...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Spady DK,Dietschy JM

更新日期：1985-07-01 00:00:00

abstract：:Fusions of the lac operon to genes induced by treatment with sublethal levels of alkylating agents have been selected from random insertions of the Mu-dl(ApRlac) phage by screening for induction of beta-galactosidase activity in the presence of methyl methanesulfonate. Genetic analysis reveals that these fusions resul...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Volkert MR,Nguyen DC

更新日期：1984-07-01 00:00:00

abstract：:Synthetic oligonucleotide probes can be easily obtained and used, in contrast to cDNA cloning to develop probes, and thus the present study was carried out to determine whether such probes could also be useful for in situ hybridization. A 24-base synthetic oligonucleotide complementary to part of the alpha-melanocyte-...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lewis ME,Sherman TG,Burke S,Akil H,Davis LG,Arentzen R,Watson SJ

更新日期：1986-08-01 00:00:00

abstract：:Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of the ongoing coronavirus disease 2019 (COVID-19) pandemic that is a serious global health problem. Evasion of IFN-mediated antiviral signaling is a common defense strategy that pathogenic viruses use to replicate and propagate in the...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Miorin L,Kehrer T,Sanchez-Aparicio MT,Zhang K,Cohen P,Patel RS,Cupic A,Makio T,Mei M,Moreno E,Danziger O,White KM,Rathnasinghe R,Uccellini M,Gao S,Aydillo T,Mena I,Yin X,Martin-Sancho L,Krogan NJ,Chanda SK,Schot

更新日期：2020-11-10 00:00:00

abstract：:The approximately 30-kb coronavirus (+)RNA genome is replicated and transcribed by a membrane-bound replicase complex made up of 16 viral nonstructural proteins (nsp) with multiple enzymatic activities. The complex includes an RNA endonuclease, NendoU, that is conserved among nidoviruses but no other RNA virus, making...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ricagno S,Egloff MP,Ulferts R,Coutard B,Nurizzo D,Campanacci V,Cambillau C,Ziebuhr J,Canard B

更新日期：2006-08-08 00:00:00

abstract：:The effect of 12-O-tetradecanoylphorbol 13-acetate (TPA), a potent tumor promoter, on the synthesis of proteins in BALB/c 3T3 mouse fibroblasts has been studied. When [35S]methionine-labeled proteins synthesized after the addition of TPA were analyzed by one- or two-dimensional polyacrylamide gel electrophoresis, the ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hiwasa T,Fujimura S,Sakiyama S

更新日期：1982-03-01 00:00:00

abstract：:Much debate has revolved around the question of whether the mode of evolutionary and ecological turnover in the fossil record of African mammals was continuous or pulsed, and the degree to which faunal turnover tracked changes in global climate. Here, we assembled and analyzed large specimen databases of the fossil re...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bibi F,Kiessling W

更新日期：2015-08-25 00:00:00

abstract：:How cells achieve their final sizes is a pervasive biological question. One strategy to increase cell size is for the cell to amplify its chromosomal DNA content through endoreduplication cycles. Although endoreduplication is widespread in eukaryotes, we know very little about its molecular mechanisms. Successful prog...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sugimoto-Shirasu K,Roberts GR,Stacey NJ,McCann MC,Maxwell A,Roberts K

更新日期：2005-12-20 00:00:00

abstract：:Expansins are unusual proteins discovered by virtue of their ability to mediate cell wall extension in plants. We identified cDNA clones for two cucumber expansins on the basis of peptide sequences of proteins purified from cucumber hypocotyls. The expansin cDNAs encode related proteins with signal peptides predicted ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shcherban TY,Shi J,Durachko DM,Guiltinan MJ,McQueen-Mason SJ,Shieh M,Cosgrove DJ

更新日期：1995-09-26 00:00:00

abstract：:DNA sequence complementary to Trypanosoma brucei mRNAs coding for the synthesis of the variant-specific antigens AnTat 1.1 and AnTat 1.8 have been cloned and characterized. These sequences have been used as probes to analyze the corresponding genes in the nuclear DNA. The two genes seem to be represented in several (t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pays E,Van Meirvenne N,Le Ray D,Steinert M

更新日期：1981-05-01 00:00:00

abstract：:We describe here the 1.7-A resolution structure of a single-chain antibody variable domain (scFv) molecule, based on the carbohydrate-binding antibody Se155-4, complexed with the trisaccharide ligand alpha-D-Gal(1-->2)[alpha-D-Abe(1-->3)]alpha-D-Manp1-->OMe, where Abe is abequose. The scFv expressed in Escherichia col...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zdanov A,Li Y,Bundle DR,Deng SJ,MacKenzie CR,Narang SA,Young NM,Cygler M

更新日期：1994-07-05 00:00:00