Abstract:
:We have isolated a major integral membrane protein from Golgi-derived coatomer-coated vesicles. This 24-kDa protein, p24, defines a family of integral membrane proteins with homologs present in yeast and humans. In addition to sequence similarity, all p24 family members contain a motif with the characteristic heptad repeats found in coiled coils. When the yeast p24 isoform, yp24A, is knocked out in a strain defective for vesicle fusion, a dramatic reduction in the accumulation of transport vesicles is observed. Together, these results indicate a role for this protein family in the budding of coatamer-coated and other species of coated vesicles.
journal_name
Proc Natl Acad Sci U S Aauthors
Stamnes MA,Craighead MW,Hoe MH,Lampen N,Geromanos S,Tempst P,Rothman JEdoi
10.1073/pnas.92.17.8011subject
Has Abstractpub_date
1995-08-15 00:00:00pages
8011-5issue
17eissn
0027-8424issn
1091-6490journal_volume
92pub_type
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更新日期:1979-07-01 00:00:00