Gene duplication and transposition linked to antigenic variation in Trypanosoma brucei.

abstract：:Neuronal progenitors and tumor cells possess propensity to proliferate and to migrate. Glutamate regulates proliferation and migration of neurons during development, but it is not known whether it influences proliferation and migration of tumor cells. We demonstrate that glutamate antagonists inhibit proliferation of ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rzeski W,Turski L,Ikonomidou C

更新日期：2001-05-22 00:00:00

abstract：:Arabinose-binding protein, maltose-binding protein, and lambda receptor are synthesized in vitro on membrane-bound polysomes from Escherichia coli. All three proteins are exported from the cytoplasm of E. coli and all three are made in vitro in a form a few thousand daltons larger than the authentic protein. The large...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Randall LL,Hardy SJ,Josefsson LG

更新日期：1978-03-01 00:00:00

abstract：:Many bacteria use N-acyl homoserine lactone (AHL) signals to coordinate the behavior of individual cells in a local population. The successful infection of eukaryotic hosts by bacteria seems to depend particularly on such AHL-mediated "quorum-sensing" regulation. We have used proteome analysis to show that a eukaryoti...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mathesius U,Mulders S,Gao M,Teplitski M,Caetano-Anolles G,Rolfe BG,Bauer WD

更新日期：2003-02-04 00:00:00

abstract：:A human craniofacial cDNA library was screened with a degenerate oligonucleotide probe based on the conserved third helix of homeobox genes. From this screening, we identified a homeobox gene, H6, which shared only 57-65% amino acid identity to previously reported homeodomains. H6 was physically mapped to the 4p16.1 r...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Stadler HS,Padanilam BJ,Buetow K,Murray JC,Solursh M

更新日期：1992-12-01 00:00:00

abstract：:Paraspeckles are subnuclear structures that form around nuclear paraspeckle assembly transcript 1 (NEAT1) long noncoding RNA (lncRNA). Recently, paraspeckles were shown to be functional nuclear bodies involved in stress responses and the development of specific organs. Paraspeckle formation is initiated by transcripti...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kawaguchi T,Tanigawa A,Naganuma T,Ohkawa Y,Souquere S,Pierron G,Hirose T

更新日期：2015-04-07 00:00:00

abstract：:Hatchlings of the painted turtle (Chrysemys picta marginata) are unique as the only reptile and highest vertebrate life form known to tolerate the natural freezing of extracellular body fluids during winter hibernation. Turtles survived frequent exposures to temperatures as low as -6 degrees C to -8 degrees C in their...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Storey KB,Storey JM,Brooks SP,Churchill TA,Brooks RJ

更新日期：1988-11-01 00:00:00

abstract：:The diabetogenic agent alloxan exerts a preferential cytotoxic effect on the pancreatic B cell. The determinants of such a tissue specificity were investigated. Alloxan accumulated rapidly in liver and pancreatic islets but much more slowly in muscle. The activity of glutathione peroxidase and the resistance to exogen...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Malaisse WJ,Malaisse-Lagae F,Sener A,Pipeleers DG

更新日期：1982-02-01 00:00:00

abstract：:A molecular dynamics study was performed to compare the differences in the active-site dynamics of the wild-type and W137F mutant enzymes of 4-chlorobenzoyl-CoA dehalogenase. Only in the wild-type simulation are conformations formed between the catalytic Asp-145 and 4-chlorobenzoyl-CoA, which resemble the ab initio ca...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lau EY,Bruice TC

更新日期：2001-08-14 00:00:00

abstract：:The effects of systemic PD134308 [0.1-3 mg/kg; an antagonist of the cholecystokinin (CCK) type B receptor], morphine, and intrathecal (i.t.) galanin (GAL) on the excitability of the spinal nociceptive flexor reflex and in the hot plate test were examined in rats. PD134308 caused a weak naloxone-reversible depression o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wiesenfeld-Hallin Z,Xu XJ,Hughes J,Horwell DC,Hökfelt T

更新日期：1990-09-01 00:00:00

abstract：:Superficial cells from early amphibian embryos display regional specializations of their cell surfaces. That portion of the plasma membrane facing the perivitelline space (apical surface) is nonadhesive, whereas, in the same cell, the lateral and basal portions of the plasma membrane will adhere to other cells. These ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Roberson MM,Armstrong PB

更新日期：1980-06-01 00:00:00

abstract：:The O(2) reduction site of cytochrome c oxidase (CcO), comprising iron (Fe(a3)) and copper (Cu(B)) ions, is probed by x-ray structural analyses of CO, NO, and CN(-) derivatives to investigate the mechanism of the complete reduction of O(2). Formation of the derivative contributes to the trigonal planar coordination of...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Muramoto K,Ohta K,Shinzawa-Itoh K,Kanda K,Taniguchi M,Nabekura H,Yamashita E,Tsukihara T,Yoshikawa S

更新日期：2010-04-27 00:00:00

abstract：:Aggregation of marine sponge cells (Microciona prolifera) resembles stimulus-response coupling of higher organisms in which activation of protein kinase C and movements of intracellular Ca provide twin signals. We now report that activators of protein kinase C (phorbol esters) and ionomycin act synergistically to aggr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Weissmann G,Azaroff L,Davidson S,Dunham P

更新日期：1986-05-01 00:00:00

abstract：:Injection of exogenous mRNA purified from various tissue preparations into cellular translation systems such as Xenopus oocytes has allowed expression of complex proteins (e.g., receptors for neurotransmitters). No evidence for expression of injected exogenous mRNA, however, has been reported in terminally differentia...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mochida S,Poulain B,Eisel U,Binz T,Kurazono H,Niemann H,Tauc L

更新日期：1990-10-01 00:00:00

abstract：:Melittin messenger RNA from queen bee venom glands has been translated in a cell-free system from wheat germ. A product larger than promelittin is formed which has the carboxy-terminal sequence-Gln-Gln-GlyCOOH. Melittin and promelittin from venom glands terminate in -Gln-GlnCONH2. The possible role of the extra glycin...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Suchanek G,Kreil G

更新日期：1977-03-01 00:00:00

abstract：:Cardiotoxin VII4 from Naja mossambica mossambica crystallizes in space group P61 (a = b = 73.9 A; c = 59.0 A) with two molecules of toxin (molecular mass = 6715 Da) in the asymmetric unit. The structure was solved by using a combination of multiple isomorphous replacement and density modification methods. Model buildi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rees B,Samama JP,Thierry JC,Gilibert M,Fischer J,Schweitz H,Lazdunski M,Moras D

更新日期：1987-05-01 00:00:00

abstract：:Electronic nematicity, a correlated state that spontaneously breaks rotational symmetry, is observed in several layered quantum materials. In contrast to their liquid-crystal counterparts, the nematic director cannot usually point in an arbitrary direction (XY nematics), but is locked by the crystal to discrete direct...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ishida K,Tsujii M,Hosoi S,Mizukami Y,Ishida S,Iyo A,Eisaki H,Wolf T,Grube K,V Löhneysen H,Fernandes RM,Shibauchi T

更新日期：2020-03-24 00:00:00

abstract：:Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of the ongoing coronavirus disease 2019 (COVID-19) pandemic that is a serious global health problem. Evasion of IFN-mediated antiviral signaling is a common defense strategy that pathogenic viruses use to replicate and propagate in the...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Miorin L,Kehrer T,Sanchez-Aparicio MT,Zhang K,Cohen P,Patel RS,Cupic A,Makio T,Mei M,Moreno E,Danziger O,White KM,Rathnasinghe R,Uccellini M,Gao S,Aydillo T,Mena I,Yin X,Martin-Sancho L,Krogan NJ,Chanda SK,Schot

更新日期：2020-11-10 00:00:00

abstract：:Radiation therapy is a widely used cancer treatment, but it causes side effects even when localized radiotherapy is used. Extensive apoptosis of microvascular endothelial cells of the lamina propria is the primary lesion initiating intestinal radiation damage after abdominal radiation therapy. Many in vitro studies su...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cho CH,Kammerer RA,Lee HJ,Yasunaga K,Kim KT,Choi HH,Kim W,Kim SH,Park SK,Lee GM,Koh GY

更新日期：2004-04-13 00:00:00

abstract：:We have generated RANK (receptor activator of NF-kappaB) nullizygous mice to determine the molecular genetic interactions between osteoprotegerin, osteoprotegerin ligand, and RANK during bone resorption and remodeling processes. RANK(-/-) mice lack osteoclasts and have a profound defect in bone resorption and remodeli...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li J,Sarosi I,Yan XQ,Morony S,Capparelli C,Tan HL,McCabe S,Elliott R,Scully S,Van G,Kaufman S,Juan SC,Sun Y,Tarpley J,Martin L,Christensen K,McCabe J,Kostenuik P,Hsu H,Fletcher F,Dunstan CR,Lacey DL,Boyle WJ

更新日期：2000-02-15 00:00:00

abstract：:Animals are associated with a microbiome that can affect their reproductive success. It is, therefore, important to understand how a host and its microbiome coevolve. According to the hologenome concept, hosts and their microbiome form an integrated evolutionary entity, a holobiont, on which selection can potentially ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： van Vliet S,Doebeli M

更新日期：2019-10-08 00:00:00

abstract：:Although the mechanisms of anterior-posterior axis formation are well understood in Drosophila, both embryological and molecular studies suggest significant variation in the mechanisms generating this axis within the Insecta class as a whole. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Patel NH

更新日期：2000-04-25 00:00:00

abstract：:An electron microscopic study of somatic hybrids resulting from a cross between hamster melanoma cells harboring R-type particles and mouse fibroblasts harboring intracisternal A-type and (mostly) immature C-type particles was performed. The major findings are: (a) hybrid cells that retain a large fraction of both ham...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yotsuyanagi Y,Ephrussi B

更新日期：1974-11-01 00:00:00

abstract：:Recombination is unknown in natural populations of Rivulus marmoratus, a selfing hermaphrodite, and genetic variation is likely due to mutation alone. DNA fingerprinting with an array of microsatellite [e.g., (CT)9] and minisatellite (e.g., the 33.15 core sequence) probes reveals very high clonal diversity within samp...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Turner BJ,Elder JF Jr,Laughlin TF,Davis WP,Taylor DS

更新日期：1992-11-15 00:00:00

abstract：:Although malignant astrocytomas are a leading cause of cancer-related death in children, rational therapeutic strategies are lacking. We previously identified activating mutations of v-raf murine sarcoma viral oncogene homolog B1 (BRAF) (BRAF(T1799A) encoding BRAF(V600E)) in association with homozygous cyclin-dependen...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Huillard E,Hashizume R,Phillips JJ,Griveau A,Ihrie RA,Aoki Y,Nicolaides T,Perry A,Waldman T,McMahon M,Weiss WA,Petritsch C,James CD,Rowitch DH

更新日期：2012-05-29 00:00:00

abstract：:Genetic switches based on the [Formula: see text] system are master regulators of an array of cellular responses. Recent kinetic experiments have shown that [Formula: see text] can actively remove NF-κB bound to its genetic sites via a process called "molecular stripping." This allows the [Formula: see text] switch to...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Potoyan DA,Zheng W,Komives EA,Wolynes PG

更新日期：2016-01-05 00:00:00

abstract：:The molecular mechanism of growth hormone release by synthetic somatocrinin was investigated on purified hog anterior pituitary secretory granules; the granules were found to contain a cAMP-dependent protein kinase that catalyzed [gamma-32P]-ATP histone phosphorylation with maximal rates ranging from 1 to 5 nmol of Pi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lewin MJ,Reyl-Desmars F,Ling N

更新日期：1983-11-01 00:00:00

abstract：:Following over 3 decades of gradual but uneven increases in sea ice coverage, the yearly average Antarctic sea ice extents reached a record high of 12.8 × 106 km2 in 2014, followed by a decline so precipitous that they reached their lowest value in the 40-y 1979-2018 satellite multichannel passive-microwave record, 10...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Parkinson CL

更新日期：2019-07-16 00:00:00

abstract：:Although potassium channels play a variety of roles in shaping the electrical properties of neurons, little is known about how these channels are constituted in neurons. To examine the assembly and physiological function of A-type K+ channels in mature differentiated neurons, we have developed a highly efficient gene ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kaang BK,Pfaffinger PJ,Grant SG,Kandel ER,Furukawa Y

更新日期：1992-02-01 00:00:00

abstract：:Infection of HeLa cells with poliovirus results in an inhibition of host-cell protein synthesis. Cytoplasmic extracts from infected cells contian an activity that inhibits initiation of protein synthesis in vitro by rabbit reticulocyte lysates. This inhibitory activity has been purified and characterized, and is shown...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ehrenfeld E,Hunt T

更新日期：1971-05-01 00:00:00

abstract：:A methylcholanthrene-induced glioblastoma of the C57BL/6 inbred mouse strain was used to raise antibodies in C57BL/6 and C57BL/10 inbred mice and in (C57BL/6 x DBA/2) and (C57BL/6 x Balb/c) F(1) hybrids. When examined by the cytotoxicity test, these antibodies define a cell-surface component (or components) found excl...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schachner M

更新日期：1974-05-01 00:00:00