Somatocrinin receptor coupled with cAMP-dependent protein kinase on anterior pituitary granules.

abstract：:Treatment strategies for severe cases of pandemic influenza have focused on antiviral therapies. In contrast, passive immunotherapy with convalescent blood products has received limited attention. We consider the hypothesis that a passive-immunotherapy program that collects plasma from a small percentage of recovered ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wu JT,Lee CK,Cowling BJ,Yuen KY

更新日期：2010-02-16 00:00:00

abstract：:Molecular junctions are essentially modified electrodes familiar to electrochemists where the electrolyte is replaced by a conducting "contact." It is generally hypothesized that changing molecular structure will alter system energy levels leading to a change in the transport barrier. Here, we show the conductance of ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sayed SY,Fereiro JA,Yan H,McCreery RL,Bergren AJ

更新日期：2012-07-17 00:00:00

abstract：:We present a model describing how Mg(2+) binds and stabilizes specific RNA structures. In this model, RNA stabilization arises from two energetically distinct modes of Mg(2+) binding: diffuse- and site-binding. Diffusely bound Mg(2+) are electrostatically attracted to the strong anionic field around the RNA and are ac...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Misra VK,Draper DE

更新日期：2001-10-23 00:00:00

abstract：:From our current understanding of the genetic basis of development and pattern formation in Drosophila and vertebrates it is commonly thought that clusters of Hox genes sculpt the morphology of animals in specific body regions. Based on Hox gene conservation throughout the animal kingdom it is proposed that these gene...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kmita-Cunisse M,Loosli F,Bièrne J,Gehring WJ

更新日期：1998-03-17 00:00:00

abstract：:Real-life decisions are often repeated. Whether considering taking a job in a new city, or doing something mundane like checking if the stove is off, decisions are frequently revisited even if no new information is available. This mode of behavior takes a particularly pathological form in obsessive-compulsive disorder...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Solway A,Lin Z,Vinaik E

更新日期：2021-01-05 00:00:00

abstract：:Approximately 15 per cent of the light chains from homogeneous immunoglobulins in patients with multiple myeloma contain an oligosaccharide group. Five human myeloma light chains that contained carbohydrate were studied. The sequence Asn-[unk]-Ser/Thr was at the site of carbohydrate attachment in all light chains. The...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sox HC Jr,Hood L

更新日期：1970-07-01 00:00:00

abstract：:We propose a conceptual model for the cytoskeletal organization of endothelial cells (ECs) based on a major dichotomy in structure and function at basal and apical aspects of the cells. Intracellular distributions of filamentous actin (F-actin), vinculin, paxillin, ZO-1, and Cx43 were analyzed from confocal micrograph...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Thi MM,Tarbell JM,Weinbaum S,Spray DC

更新日期：2004-11-23 00:00:00

abstract：:Certain mutations at the glaB locus result in the failure to fully derepress glutamine synthetase [L-glutamate:ammonia ligase (ADP-forming), EC 6.3.1.2] and to convert it to the active nonadenylylated form in response to nitrogen limitation. In these mutants the PII regulatory protein is altered such that it cannot be...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Foor F,Reuveny Z,Magasanik B

更新日期：1980-05-01 00:00:00

abstract：:Chlorarachniophytes are amoeboid algae with unusual chloroplasts. Instead of the usual two membranes that surround the chloroplasts of plants, green algae, and red algae, the chloroplasts of chlorarachniophytes have four bounding membranes. The extra membranes may reflect an unusual origin of chlorarachniophyte chloro...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： McFadden GI,Gilson PR,Hofmann CJ,Adcock GJ,Maier UG

更新日期：1994-04-26 00:00:00

abstract：:Figure-ground discrimination refers to the perception of an object, the figure, against a nondescript background. Neural mechanisms of figure-ground detection have been associated with feedback interactions between higher centers and primary visual cortex and have been held to index the effect of global analysis on lo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jones HE,Andolina IM,Shipp SD,Adams DL,Cudeiro J,Salt TE,Sillito AM

更新日期：2015-06-02 00:00:00

abstract：:Population expansion in space, or range expansion, is widespread in nature and in clinical settings. Space competition among heterogeneous subpopulations during range expansion is essential to population ecology, and it may involve the interplay of multiple factors, primarily growth and motility of individuals. Struct...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zuo W,Wu Y

更新日期：2020-03-03 00:00:00

abstract：:Caenorhabditis elegans explores its environment by interrupting its forward movement with occasional turns and reversals. Turns and reversals occur at stable frequencies but irregular intervals, producing probabilistic exploratory behaviors. Here we dissect the roles of individual sensory neurons, interneurons, and mo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gray JM,Hill JJ,Bargmann CI

更新日期：2005-03-01 00:00:00

abstract：:Banded iron formations (BIFs) record a time of extensive Fe deposition in the Precambrian oceans, but the sources and pathways for metals in BIFs remain controversial. Here, we present Fe- and Nd-isotope data that indicate two sources of Fe for the large BIF units deposited 2.5 billion y ago. High-εNd and -δ(56)Fe sig...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li W,Beard BL,Johnson CM

更新日期：2015-07-07 00:00:00

abstract：:An oligomeric intermediate in the biosynthetic pathway of peptidoglycan was isolated from B. megaterium. The oligomer has been identified as [disaccharide(pentapeptide)]12 pyrophosphoryl undecaprenol. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fuchs-Cleveland E,Gilvarg C

更新日期：1976-11-01 00:00:00

abstract：:N6-methyladenosine (m6A) represents one of the most common RNA modifications in eukaryotes. Specific m6A writer, eraser, and reader proteins have been identified. As an m6A eraser, ALKBH5 specifically removes m6A from target mRNAs and inactivation of Alkbh5 leads to male infertility in mice. However, the underlying mo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tang C,Klukovich R,Peng H,Wang Z,Yu T,Zhang Y,Zheng H,Klungland A,Yan W

更新日期：2018-01-09 00:00:00

abstract：:Calcium oxalate monohydrate (COM), which plays a functional role in plant physiology, is a source of chronic human disease, forming the major inorganic component of kidney stones. Understanding molecular mechanisms of biological control over COM crystallization is central to development of effective stone disease ther...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Qiu SR,Wierzbicki A,Orme CA,Cody AM,Hoyer JR,Nancollas GH,Zepeda S,De Yoreo JJ

更新日期：2004-02-17 00:00:00

abstract：:Murine mucopolysaccharidosis type VII is a heritable disease caused by a spontaneous mutation, gus(mps), closely linked to the beta-glucuronidase structural gene on chromosome 5. Mice homozygous for the mutation have a > 200-fold decrease in beta-glucuronidase mRNA levels and virtually no enzyme activity detectable by...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sands MS,Birkenmeier EH

更新日期：1993-07-15 00:00:00

abstract：:Chronic morphine administration is associated with the development of tolerance, both clinically and in animal models. Many assume that tolerance is a continually progressive response to chronic opioid dosing. However, clinicians have long appreciated the ability to manage cancer pain in patients for months on stable ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Xu J,Faskowitz AJ,Rossi GC,Xu M,Lu Z,Pan YX,Pasternak GW

更新日期：2015-01-06 00:00:00

abstract：:Mannan-binding protein (MBP), a Ca2+-dependent mammalian lectin specific for mannose and N-acetylglucosamine, is an important serum component associated with innate immunity. MBP activates complement and functions as a direct opsonin on binding to mannooligosaccharide-bearing pathogens. We have found that MBP recogniz...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ma Y,Uemura K,Oka S,Kozutsumi Y,Kawasaki N,Kawasaki T

更新日期：1999-01-19 00:00:00

abstract：:In the nitrogen-fixing symbiosis between legume hosts and rhizobia, the bacteria are engulfed by a plant cell membrane to become intracellular organelles. In the model legume Medicago truncatula, internalization and differentiation of Sinorhizobium (also known as Ensifer) meliloti is a prerequisite for nitrogen fixati...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kim M,Chen Y,Xi J,Waters C,Chen R,Wang D

更新日期：2015-12-08 00:00:00

abstract：:The role of intraspecific and interspecific interactions in structuring biotic communities at fine spatial scales is well documented, but the signature of species interactions at coarser spatial scales is unclear. We present evidence that species interactions may be a significant factor in mediating the regional assem...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gotelli NJ,Graves GR,Rahbek C

更新日期：2010-03-16 00:00:00

abstract：:It is generally acknowledged that cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4/CD152) plays a pivotal role in the regulation of T-cell activation and the establishment of self-tolerance in the periphery. CTLA-4-deficient (CTLA-4KO) mice develop a lymphoproliferative disorder and die within 4 weeks of birth, sug...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Verhagen J,Gabrysová L,Minaee S,Sabatos CA,Anderson G,Sharpe AH,Wraith DC

更新日期：2009-03-03 00:00:00

abstract：:Zinniol [1,2-bis(hydroxymethyl)-3-methoxy-4-methyl-5-(3-methyl-2-butenyloxy)benzene], a toxin produced by fungi of the Alternaria group, causes symptoms in plants that resemble those induced by the fungi. The phytotoxin binds to carrot protoplasts and isolated membranes in a saturable and reversible manner. Receptor o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Thuleau P,Graziana A,Rossignol M,Kauss H,Auriol P,Ranjeva R

更新日期：1988-08-01 00:00:00

abstract：:Tumor necrosis factor (TNF) is a macrophage product under active study as an anticancer drug. However, this agent can be very toxic and has been implicated in the pathogenesis of endotoxic shock. After intravenous injection of human recombinant TNF (4 micrograms/g), growing rats showed an unusual constellation of phys...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kettelhut IC,Fiers W,Goldberg AL

更新日期：1987-06-01 00:00:00

abstract：:Rad51 is a highly conserved eukaryotic homolog of the prokaryotic recombination protein RecA, which has been shown to function in both recombinational repair of DNA damage and meiotic recombination in yeast. In primary murine B cells cultured with lipopolysaccharide (LPS) to stimulate heavy chain class switch recombin...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li MJ,Peakman MC,Golub EI,Reddy G,Ward DC,Radding CM,Maizels N

更新日期：1996-09-17 00:00:00

abstract：:Nanometer-scale pores have demonstrated potential for the electrical detection, quantification, and characterization of molecules for biomedical applications and the chemical analysis of polymers. Despite extensive research in the nanopore sensing field, there is a paucity of theoretical models that incorporate the in...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Reiner JE,Kasianowicz JJ,Nablo BJ,Robertson JW

更新日期：2010-07-06 00:00:00

abstract：:Cultured hippocampal slices prepared from apolipoprotein E-deficient mice were exposed to an inhibitor of cathepsins B and L and then processed for immunocytochemistry using antibodies against human paired helical filaments. Dense, AT8-immunopositive deposits were found in the subiculum, stratum oriens of hippocampal ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bi X,Yong AP,Zhou J,Ribak CE,Lynch G

更新日期：2001-07-17 00:00:00

abstract：:The eukaryotic DNA sliding clamp that keeps DNA polymerase engaged at a replication fork, called proliferating cell nuclear antigen (PCNA), is loaded onto the 3' ends of primer DNA through its interaction with a heteropentameric protein complex called replication factor C (RFC). The ATPase activity of RFC is necessary...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shiomi Y,Usukura J,Masamura Y,Takeyasu K,Nakayama Y,Obuse C,Yoshikawa H,Tsurimoto T

更新日期：2000-12-19 00:00:00

abstract：:In the search for selective and long-acting analogs of somatostatin, nearly 200 compounds were synthesized by solid-phase methods, purified, and tested biologically. Among these octapeptides, some contained N-terminal (Formula: see text) were 177 times and 113 times more potent, respectively, than somatostatin in test...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cai RZ,Szoke B,Lu R,Fu D,Redding TW,Schally AV

更新日期：1986-03-01 00:00:00

abstract：:Gametocytes are nonreplicative sexual forms that mediate malaria transmission to a mosquito vector. They are generated from asexual blood-stage parasites that proliferate in the circulation. However, little is known about how this transition is genetically regulated. Here, we report that an Apetala2 (AP2) family trans...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yuda M,Iwanaga S,Kaneko I,Kato T

更新日期：2015-10-13 00:00:00