A single-base-pair deletion in the beta-glucuronidase gene accounts for the phenotype of murine mucopolysaccharidosis type VII.

abstract：:Insufficient and disrupted sleep is linked with cardiovascular and metabolic dysregulation and morbidity. The current study examines the degree to which differences in sleep between black/African American (AA) and white/European American (EA) adults explain racial differences in cardiometabolic (CMB) disease risk. Tot...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Curtis DS,Fuller-Rowell TE,El-Sheikh M,Carnethon MR,Ryff CD

更新日期：2017-08-15 00:00:00

abstract：:Cigarette smoking causes emphysema, a fatal disease involving extensive structural and functional damage of the lung. Using a guinea pig model and human lung cells, we show that oxidant(s) present in tobacco smoke not only cause direct oxidative damage of lung proteins, contributing to the major share of lung injury, ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gupta I,Ganguly S,Rozanas CR,Stuehr DJ,Panda K

更新日期：2016-07-19 00:00:00

abstract：:Calcicludine (CaC) is a 60-amino acid polypeptide from the venom of Dendroaspis angusticeps. It is structurally homologous to the Kunitz-type protease inhibitor, to dendrotoxins, which block K+ channels, and to the protease inhibitor domain of the amyloid beta protein that accumulates in Alzheimer disease. Voltage-cla...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schweitz H,Heurteaux C,Bois P,Moinier D,Romey G,Lazdunski M

更新日期：1994-02-01 00:00:00

abstract：:The simultaneous addition of [D-Ala2, D-Leu5]-enkephalin and morphiceptin at concentrations at which 98% of enkephalin (delta) and morphine (mu) receptors are occupied only partially inhibits the binding of [3H]diprenorphine to rat brain membranes. These conditions, furthermore, do not affect the curves for displaceme...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chang KJ,Hazum E,Cuatrecasas P

更新日期：1981-07-01 00:00:00

abstract：:TNF superfamily death ligands are expressed on the surface of immune cells and can trigger apoptosis in susceptible cancer cells by engaging cognate death receptors. A recombinant soluble protein comprising the ectodomain of Apo2 ligand/TNF-related apoptosis-inducing ligand (Apo2L/TRAIL) has shown remarkable preclinic...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nair PM,Flores H,Gogineni A,Marsters S,Lawrence DA,Kelley RF,Ngu H,Sagolla M,Komuves L,Bourgon R,Settleman J,Ashkenazi A

更新日期：2015-05-05 00:00:00

abstract：:Drosophila heteroneura and D. silvestris are sympatric species living on the island of Hawaii, while D. planitibia is allopatric on the nearby island of Maui. A pronounced ethological isolation is found between the sympatric species, and none between allopatric ones, except that D. planitibia females discriminate agai...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ahearn JN,Carson HL,Dobzhansky T,Kaneshiro KY

更新日期：1974-03-01 00:00:00

abstract：:The glutathione S-transferases (GST) (glutathione transferase; EC 2.5.1.18) are a family of enzymes responsible for the metabolism of a broad range of xenobiotics and carcinogens. A cDNA clone containing the entire amino acid coding sequence of a human GST-2 subunit has been isolated using a lambda gt11 expression lib...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Board PG,Webb GC

更新日期：1987-04-01 00:00:00

abstract：:Effects of thyrotropin-releasing hormone (TRH; thyroliberin) on membrane electrical properties were studied in the clonal rat anterior pituitary cell (GH3) by continuous recording of the intracellular potential. Application of TRH, which stimulates the release of prolactin and growth hormone from the GH3 cell, elicite...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ozawa S,Kimura N

更新日期：1979-11-01 00:00:00

abstract：:Mutations in the dystrophin gene cause Duchenne muscular dystrophy (DMD) most commonly through loss of protein expression. In a small subpopulation of patients, missense mutations can cause DMD, Becker muscular dystrophy, or X-linked cardiomyopathy. Nearly one-half of disease-causing missense mutations are located in ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Henderson DM,Lee A,Ervasti JM

更新日期：2010-05-25 00:00:00

abstract：:Variation in the multiplication rate of blood stage malaria parasites is often positively correlated with the severity of the disease they cause. The rodent malaria parasite Plasmodium yoelii yoelii has strains with marked differences in multiplication rate and pathogenicity in the blood. We have used genetic analysis...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pattaradilokrat S,Culleton RL,Cheesman SJ,Carter R

更新日期：2009-04-28 00:00:00

abstract：:Activation of androgen receptor (AR) via androgen in muscle cells has been closely linked to their growth and differentiation. Here, we report the cloning and characterization of supervillin (SV), a 205-kDa actin-binding protein, as an AR coregulator from the skeletal muscle cDNA library. Mammalian two-hybrid and glut...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ting HJ,Yeh S,Nishimura K,Chang C

更新日期：2002-01-22 00:00:00

abstract：:Current issues pertaining to theoretical simulations of materials, with a focus on systems of nanometer-scale dimensions, are discussed. The use of atomistic simulations as high-resolution numerical experiments, enabling and guiding formulation and testing of analytic theoretical descriptions, is demonstrated through ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Landman U

更新日期：2005-05-10 00:00:00

abstract：:Human Creutzfeldt-Jakob disease (CJD) and similar neurodegenerative diseases such as sheep scrapie are caused by a variety of related infectious agents. They are associated with abnormal host prion protein (PrP), which is assessed by limited proteolysis to yield resistant PrP bands (PrP-res). Although PrP-res has been...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Arjona A,Simarro L,Islinger F,Nishida N,Manuelidis L

更新日期：2004-06-08 00:00:00

abstract：:Escherichia coli K12 2320(lambda)-15B has a mutation that results in ochre suppressor activity.(1) This mutation concomitantly causes a decreased growth rate in rich medium, an increased sensitivity to streptomycin,(1) and the production of some altered 30S ribosomes which are differentially sensitive to RNase.(2) The...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gartner TK,Orias E,Lannan JE,Beeson J,Reid PJ

更新日期：1969-03-01 00:00:00

abstract：:Larval fishes suffer prodigious mortality rates, eliminating 99% of the brood within a few days after first feeding. Hjort (1914) famously attributed this "critical period" of low survival to the larvae's inability to obtain sufficient food [Hjort (1914) Rapp P-v Réun Cons Int Explor Mer 20:1-228]. However, the cause ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： China V,Holzman R

更新日期：2014-06-03 00:00:00

abstract：:The microbiota is pivotal in the pathogenesis of inflammatory bowel disease (IBD)-associated inflammation-induced colorectal cancer (CRC), yet mechanisms for these effects remain poorly characterized. Here, we demonstrate that aberrant inflammasome-induced microbiota plays a critical role in CRC development, where mic...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hu B,Elinav E,Huber S,Strowig T,Hao L,Hafemann A,Jin C,Wunderlich C,Wunderlich T,Eisenbarth SC,Flavell RA

更新日期：2013-06-11 00:00:00

abstract：:The mountain pine beetle (Dendroctonus ponderosae Hopkins) is the most destructive pest of western North American pine forests. Adult males produce frontalin, an eight-carbon antiaggregation pheromone, via the mevalonate pathway, as part of several pheromones that initiate and modulate the mass attack of host trees. F...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Keeling CI,Chiu CC,Aw T,Li M,Henderson H,Tittiger C,Weng HB,Blomquist GJ,Bohlmann J

更新日期：2013-11-19 00:00:00

abstract：:Neutrophils are immune cells that bind to, engulf, and destroy bacterial and fungal pathogens in infected tissue, and their clearance by apoptosis is essential for the resolution of inflammation. Killing involves both oxidative and nonoxidative processes, the oxidative pathway requiring electrogenic production of supe...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fay AJ,Qian X,Jan YN,Jan LY

更新日期：2006-11-14 00:00:00

abstract：:The role played by oligodendrocytes (OLs), the myelinating cells of the CNS, during brain development has not been fully explored. We have addressed this question by inducing a temporal and reversible ablation of OLs on postnatal CNS development. OL ablation in newborn mice leads to a profound alteration in the struct...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Collin L,Usiello A,Erbs E,Mathis C,Borrelli E

更新日期：2004-01-06 00:00:00

abstract：:Clinical studies have revealed that genetic variations in metabotropic glutamate receptor 3 (mGlu3) affect performance on cognitive tasks dependent upon the prefrontal cortex (PFC) and may be linked to psychiatric conditions such as schizophrenia, bipolar disorder, and addiction. We have performed a series of studies ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Walker AG,Wenthur CJ,Xiang Z,Rook JM,Emmitte KA,Niswender CM,Lindsley CW,Conn PJ

更新日期：2015-01-27 00:00:00

abstract：:The DNA-binding protein CCCTC-binding factor (CTCF) and the cohesin complex function together to shape chromatin architecture in mammalian cells, but the molecular details of this process remain unclear. Here, we demonstrate that a 79-aa region within the CTCF N terminus is essential for cohesin positioning at CTCF bi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pugacheva EM,Kubo N,Loukinov D,Tajmul M,Kang S,Kovalchuk AL,Strunnikov AV,Zentner GE,Ren B,Lobanenkov VV

更新日期：2020-01-28 00:00:00

abstract：:A remote labeling method has been developed to determine (18)O kinetic isotope effects (KIEs) in Ras-catalyzed GTP hydrolysis. Substrate mixtures consist of (13)C-depleted GTP and [(18)O,(13)C]GTP that contains (18)O at phosphoryl positions of mechanistic interest and (13)C at all carbon positions of the guanosine moi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Du X,Black GE,Lecchi P,Abramson FP,Sprang SR

更新日期：2004-06-15 00:00:00

abstract：:Using a novel Escherichia coli in vitro decay system in which polysomes are the source of both enzymes and mRNA, we demonstrate a requirement for poly(A) polymerase I (PAP I) in mRNA turnover. The in vitro decay of two different mRNAs (trxA and lpp) is triggered by the addition of ATP only when polysomes are prepared ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ingle CA,Kushner SR

更新日期：1996-11-12 00:00:00

abstract：:Many "workers" in north temperate colonies of the eusocial paper wasp Polistes fuscatus disappear within a few days of eclosion. We provide evidence that these females are pursuing an alternative reproductive strategy, i.e., dispersing to overwinter and become nest foundresses the following spring, instead of helping ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Reeve HK,Peters JM,Nonacs P,Starks PT

更新日期：1998-11-10 00:00:00

abstract：:The induction of antigen-specific tolerance is critical for the prevention of autoimmunity and maintenance of immune tolerance. In addition to their classical role as sentinels of the immune response-inducing T cell reactivity, dendritic cells (DCs) play an important role in maintaining peripheral tolerance through th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chorny A,Gonzalez-Rey E,Fernandez-Martin A,Pozo D,Ganea D,Delgado M

更新日期：2005-09-20 00:00:00

abstract：:Neutrophil spontaneous death plays essential roles in neutrophil homeostasis and resolution of inflammation, whereas the underlying molecular mechanisms are still ill-defined. Neutrophils die because of programmed cell death or apoptosis. However, treatment with inhibitor of caspases, which are responsible for the maj...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhu D,Hattori H,Jo H,Jia Y,Subramanian KK,Loison F,You J,Le Y,Honczarenko M,Silberstein L,Luo HR

更新日期：2006-10-03 00:00:00

abstract：:Theories of general anesthesia have shifted in focus from bulk lipid effects to specific interactions with membrane proteins. Target receptors include several subtypes of pentameric ligand-gated ion channels; however, structures of physiologically relevant proteins in this family have yet to define anesthetic binding ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Heusser SA,Lycksell M,Wang X,McComas SE,Howard RJ,Lindahl E

更新日期：2018-10-16 00:00:00

abstract：:When assembled into 13--19S particles, the reovirus nonstructural protein sigma-NS selectively binds single-stranded RNAs. Sedimentation analyses combined with binding to nitrocellulose membrane filters showed that 1--2 pmol of reovirus mRNAs from the large, medium, or small size classes saturated in vitro the binding...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Stamatos NM,Gomatos PJ

更新日期：1982-06-01 00:00:00

abstract：:RecQ helicases are a widely conserved family of ATP-dependent motors with diverse roles in nearly every aspect of bacterial and eukaryotic genome maintenance. However, the physical mechanisms by which RecQ helicases recognize and process specific DNA replication and repair intermediates are largely unknown. Here, we s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pike AC,Gomathinayagam S,Swuec P,Berti M,Zhang Y,Schnecke C,Marino F,von Delft F,Renault L,Costa A,Gileadi O,Vindigni A

更新日期：2015-04-07 00:00:00

abstract：:Maternal infections during pregnancy are associated with increased risk of neurodevelopmental disorders, although the precise mechanisms remain to be elucidated. Previously, we established a maternal immune activation (MIA) model using swine, which results in altered social behaviors of piglet offspring. These behavio...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Antonson AM,Lawson MA,Caputo MP,Matt SM,Leyshon BJ,Johnson RW

更新日期：2019-10-01 00:00:00