Gene encoding erythrocyte binding ligand linked to blood stage multiplication rate phenotype in Plasmodium yoelii yoelii.

abstract：:We have developed Differential Specificity and Energy Landscape (DiSEL) analysis to comprehensively compare DNA-protein interactomes (DPIs) obtained by high-throughput experimental platforms and cutting edge computational methods. While high-affinity DNA binding sites are identified by most methods, DiSEL uncovered nu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bhimsaria D,Rodríguez-Martínez JA,Pan J,Roston D,Korkmaz EN,Cui Q,Ramanathan P,Ansari AZ

更新日期：2018-11-06 00:00:00

abstract：:We have established empirical limits for the circular dichroism spectra appropriate for aqueous solutions of the B, C, and A forms of calf-thymus DNA and have analyzed DNA conformations in biological structures. The circular dichroism spectrum above 250 nm of purified calf-thymus chromatin can be satisfactorily accoun...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hanlon S,Johnson RS,Wolf B,Chan A

更新日期：1972-11-01 00:00:00

abstract：:Cholinergic neuromodulation is involved in all aspects of sensory processing and is crucial for processes such as attention, learning and memory, etc. However, despite the known roles of acetylcholine (ACh), we still do not how to disentangle ACh contributions from sensory or task-evoked changes in functional magnetic...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zaldivar D,Rauch A,Logothetis NK,Goense J

更新日期：2018-12-18 00:00:00

abstract：:alpha-1-Antitrypsin is a serum protein that inhibits many proteolytic enzymes. Recently, it was suggested that the alpha-1-antitrypsin-trypsin complex is an acyl ester analogous to the acyl intermediate that forms between trypsin and its substrates. In previous work we showed that the alpha-1-antitrypsin-trypsin compl...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cohen AB,Gruenke LD,Craig JC,Geczy D

更新日期：1977-10-01 00:00:00

abstract：:It has recently been recognized that human serum contains a protein that specifically binds human growth hormone (hGH). This protein has the same restricted specificity for hGH as the membrane-bound GH receptor. To determine whether the GH-binding protein is a derivative of, or otherwise related to, the GH receptor, w...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Daughaday WH,Trivedi B

更新日期：1987-07-01 00:00:00

abstract：:Microcalcifications geographically target the location of abnormalities within the breast and are of critical importance in breast cancer diagnosis. However, despite stereotactic guidance, core needle biopsy fails to retrieve microcalcifications in up to 15% of patients. Here, we introduce an approach based on diffuse...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Soares JS,Barman I,Dingari NC,Volynskaya Z,Liu W,Klein N,Plecha D,Dasari RR,Fitzmaurice M

更新日期：2013-01-08 00:00:00

abstract：:The expanding behavioral repertoire of the developing brain during childhood and adolescence is shaped by complex brain-environment interactions and flavored by unique life experiences. The transition into young adulthood offers opportunities for adaptation and growth but also increased susceptibility to environmental...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Alnæs D,Kaufmann T,Marquand AF,Smith SM,Westlye LT

更新日期：2020-06-02 00:00:00

abstract：:The cell surface of embryonic peripheral neurons provides a mitogenic stimulus for Schwann cells. We report (i) the solubilization of this mitogenic activity from rat dorsal root ganglion neurons grown in tissue culture and (ii) the solubilization and partial purification of mitogenic activity from neonatal rat brains...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ratner N,Hong DM,Lieberman MA,Bunge RP,Glaser L

更新日期：1988-09-01 00:00:00

abstract：:Several cDNA clones encoding the human immunoglobulin G receptor CD16 were isolated from human lung or peripheral blood leukocyte cDNA libraries. Nucleotide sequence comparisons revealed that the cDNAs could be divided into two groups. cDNA clones in one group encode a protein that terminates 4 amino acids after the p...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Scallon BJ,Scigliano E,Freedman VH,Miedel MC,Pan YC,Unkeless JC,Kochan JP

更新日期：1989-07-01 00:00:00

abstract：:This study demonstrates the presence of an N-acetyl-D-galactosaminyltransferase in human serum and in erythrocyte membranes. This enzyme catalyzes the transfer of N-acetyl-D-galactosamine from UDP-N-acetyl-D-galactosamine to a mucin receptor and 2'-fucosyllactose that have blood group H activity and may be responsible...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kim YS,Perdomo J,Bella A Jr,Nordberg J

更新日期：1971-08-01 00:00:00

abstract：:Extracts of Escherichia coli strains infected with bacteriophage phiX174 catalyze DNA synthesis dependent on double-stranded, circular phiX174 replicative form I (phiX RFI) by a semiconservative process. The reaction required Mg++, ATP, all four dNTP, and exogenous phiX RFI DNA as template and yielded phiX RFI and phi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sumida-Yasumoto C,Yudelevich A,Hurwitz J

更新日期：1976-06-01 00:00:00

abstract：:The influence of speech production on speech perception is well established in adults. However, because adults have a long history of both perceiving and producing speech, the extent to which the perception-production linkage is due to experience is unknown. We addressed this issue by asking whether articulatory confi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bruderer AG,Danielson DK,Kandhadai P,Werker JF

更新日期：2015-11-03 00:00:00

abstract：:By the combined use of DNase I footprinting, electrophoretic mobility-shift assay, and methylation interference analysis, we have identified a series of sequence-specific protein-DNA interactions in the 5' flanking region of the rat osteocalcin gene. Stimulation of osteocalcin gene expression by 1,25-dihydroxyvitamin ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Markose ER,Stein JL,Stein GS,Lian JB

更新日期：1990-03-01 00:00:00

abstract：:Little is known about the molecular mechanisms by which the embryo proper and suspensor of plant embryos activate specific gene sets shortly after fertilization. We analyzed the upstream region of the scarlet runner bean (Phaseolus coccineus) G564 gene to understand how genes are activated specifically within the susp...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kawashima T,Wang X,Henry KF,Bi Y,Weterings K,Goldberg RB

更新日期：2009-03-03 00:00:00

abstract：:Two-dimensional electron gases (2DEGs) are at the base of current nanoelectronics because of their exceptional mobilities. Often the accumulation layer forms at polar interfaces with longitudinal optical (LO) modes. In most cases, the many-body screening of the quasi-2DEGs dramatically reduces the Fröhlich scattering ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chen Z,Sjakste J,Dong J,Taleb-Ibrahimi A,Rueff JP,Shukla A,Peretti J,Papalazarou E,Marsi M,Perfetti L

更新日期：2020-09-08 00:00:00

abstract：:We solve a discrete version of the classic Plateau problem, which asks for a minimal surface spanning a given curve. Our algorithm is based on a network-flow formulation that finds minimal slabs, intuitively corresponding to minimal "surfaces" of prescribed thickness. We let the slab thickness approach zero in order t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hu TC,Kahng AB,Robins G

更新日期：1992-10-01 00:00:00

abstract：:Islet transplantation offers a potential therapy to restore glucose homeostasis in type 1 diabetes patients. However, islet transplantation is not routinely successful because most islet recipients gradually lose graft function. Furthermore, serological markers of islet function are insensitive to islet loss until the...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lu Y,Dang H,Middleton B,Zhang Z,Washburn L,Stout DB,Campbell-Thompson M,Atkinson MA,Phelps M,Gambhir SS,Tian J,Kaufman DL

更新日期：2006-07-25 00:00:00

abstract：:The swelling of secretory vesicles has been implicated in exocytosis, but the underlying mechanism of vesicle swelling remains largely unknown. Zymogen granules (ZGs), the membrane-bound secretory vesicles in exocrine pancreas, swell in response to GTP mediated by a G(alpha)i3 protein. Evidence is presented here that ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cho SJ,Sattar AK,Jeong EH,Satchi M,Cho JA,Dash S,Mayes MS,Stromer MH,Jena BP

更新日期：2002-04-02 00:00:00

abstract：:The λ exonuclease is an ATP-independent enzyme that binds to dsDNA ends and processively digests the 5'-ended strand to form 5' mononucleotides and a long 3' overhang. The crystal structure of λ exonuclease revealed a toroidal homotrimer with a central funnel-shaped channel for tracking along the DNA, and a mechanism ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhang J,McCabe KA,Bell CE

更新日期：2011-07-19 00:00:00

abstract：:Porcine aortic endothelial cells were isolated and maintained in Dulbecco's modified Eagle's medium (DME medium)/10% citrate-treated human plasma. They were stimulated by DME medium/10% human serum to grow from a density of 10,100 +/- 500 per well to a final density of 83,000 +/- 1,800 per well over a 9-day period. On...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Clemmons DR,Isley WL,Brown MT

更新日期：1983-03-01 00:00:00

abstract：:The protein encoded by the GAL4 gene of the yeast Saccharomyces cerevisiae binds to DNA upstream of several genes and activates transcription. To try to understand these processes, we have undertaken a genetic analysis of GAL4. Here we report that nearly all missense mutations in GAL4, selected in vivo to lack functio...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Johnston M,Dover J

更新日期：1987-04-01 00:00:00

abstract：:The Na,K-ATPase contains a binding site for cardiac glycosides, such as ouabain, digoxin, and digitoxin, which is highly conserved among species ranging from Drosophila to humans. Although advantage has been taken of this site to treat congestive heart failure with drugs such as digoxin, it is unknown whether this sit...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dostanic-Larson I,Van Huysse JW,Lorenz JN,Lingrel JB

更新日期：2005-11-01 00:00:00

abstract：:Understanding biological and physical processes involving nucleic acids, such as the binding of proteins to DNA and RNA, DNA condensation, and RNA folding, requires an understanding of the ion atmosphere that surrounds nucleic acids. We have used a simple model DNA system to determine how the ion atmosphere modulates ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bai Y,Das R,Millett IS,Herschlag D,Doniach S

更新日期：2005-01-25 00:00:00

abstract：:Proalbumins are rare genetic variants of human serum albumin containing a basic propeptide that is not removed during post-transcriptional processing because of a mutation in the site of excision, an Arg-Arg sequence. We have identified the amino acid substitutions in three different types of proalbumins designated Ga...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Takahashi N,Takahashi Y,Putnam FW

更新日期：1987-11-01 00:00:00

abstract：:Individuals with higher educational attainment live healthier and longer lives. However, not everyone benefits equally from higher education. In particular, the black-white gap in life expectancy is greater at higher levels of educational attainment. Furthermore, recent research suggests that disadvantaged African Ame...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gaydosh L,Schorpp KM,Chen E,Miller GE,Harris KM

更新日期：2018-01-02 00:00:00

abstract：:Conventional digital computers can execute advanced operations by a sequence of elementary Boolean functions of 2 or more bits. As a result, complicated tasks such as solving a linear system or solving a differential equation require a large number of computing steps and an extensive use of memory units to store indiv...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sun Z,Pedretti G,Ambrosi E,Bricalli A,Wang W,Ielmini D

更新日期：2019-03-05 00:00:00

abstract：:The bacterial pathogen Vibrio parahaemolyticus utilizes a type III secretion system to cause death of host cells within hours of infection. We report that cell death is completely independent of apoptosis and occurs by a mechanism in which injection of multiple type III effectors causes induction of autophagy, cell ro...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Burdette DL,Yarbrough ML,Orvedahl A,Gilpin CJ,Orth K

更新日期：2008-08-26 00:00:00

abstract：:FUS3 is functionally redundant with KSS1, a homologous yeast protein kinase, for a step(s) in signal transduction between the beta subunit of the guanine nucleotide binding protein (G protein), STE4, and the mating type-specific transcriptional activator, STE12. Either FUS3 or KSS1 can execute this function; when neit...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Elion EA,Brill JA,Fink GR

更新日期：1991-11-01 00:00:00

abstract：:To determine the importance of mitochondrial reactive oxygen species toxicity in aging and senescence, we analyzed changes in mitochondrial function with age in mice with partial or complete deficiencies in the mitochondrial antioxidant enzyme manganese superoxide dismutase (MnSOD). Liver mitochondria from homozygous ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kokoszka JE,Coskun P,Esposito LA,Wallace DC

更新日期：2001-02-27 00:00:00

abstract：:Ghrelin is a newly discovered peptide and an endogenous ligand for growth hormone (GH) secretagogue (GHS) receptor. It has been shown to possess various central and peripheral effects, including GH secretion, food intake, and gastric and cardiac effects. Ghrelin and the GHS receptor are expressed also in pancreatic is...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Doi A,Shono T,Nishi M,Furuta H,Sasaki H,Nanjo K

更新日期：2006-01-24 00:00:00