Abstract:
:Clinical studies have revealed that genetic variations in metabotropic glutamate receptor 3 (mGlu3) affect performance on cognitive tasks dependent upon the prefrontal cortex (PFC) and may be linked to psychiatric conditions such as schizophrenia, bipolar disorder, and addiction. We have performed a series of studies aimed at understanding how mGlu3 influences PFC function and cognitive behaviors. In the present study, we found that activation of mGlu3 can induce long-term depression in the mouse medial PFC (mPFC) in vitro. Furthermore, in vivo administration of a selective mGlu3 negative allosteric modulator impaired learning in the mPFC-dependent fear extinction task. The results of these studies implicate mGlu3 as a major regulator of PFC function and cognition. Additionally, potentiators of mGlu3 may be useful in alleviating prefrontal impairments associated with several CNS disorders.
journal_name
Proc Natl Acad Sci U S Aauthors
Walker AG,Wenthur CJ,Xiang Z,Rook JM,Emmitte KA,Niswender CM,Lindsley CW,Conn PJdoi
10.1073/pnas.1416196112subject
Has Abstractpub_date
2015-01-27 00:00:00pages
1196-201issue
4eissn
0027-8424issn
1091-6490pii
1416196112journal_volume
112pub_type
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