Unified cochlear model for low- and high-frequency mammalian hearing.

abstract：:Time courses of 13C labeling from alanine and ethanol in perfused mouse livers have been followed by NMR. The enrichment at specific carbons of glucose, glutamate, glutamine, aspartate, acetate, acetoacetate, beta-hydroxybutyrate, and lactate has been measured. The specific labeling of glutamate in the presence of lab...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cohen SM,Shulman RG,McLaughlin AC

更新日期：1979-10-01 00:00:00

abstract：:The antigen recognition of a profoundly immunosuppressive mAb, mAb 2E1, in vivo was investigated. In addition to the 62-kDa effector cell protease receptor 1, mAb 2E1 bound the 32-kDa T cell adhesion receptor E2 (CD99) and the 86-kDa p80 subunit of the nuclear antigen complex Ku. These molecules share no overall seque...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rothermel AL,Altieri DC

更新日期：1998-03-31 00:00:00

abstract：:In human adults, learning and memory under acute stress are characterized by an increased use of rigid habitual response strategies at the cost of flexible cognitive strategies. The immediate effects of stress on cognitive functioning early in life are not well understood. Here we show experimentally that acute stress...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Seehagen S,Schneider S,Rudolph J,Ernst S,Zmyj N

更新日期：2015-10-13 00:00:00

abstract：:In Caenorhabditis elegans, the small nuclear ribonucleoprotein (snRNP)-associated proteins U1A and U2B'' are approximately 50% identical to each other, and neither bears signature characteristics of mammalian U1A or U2B'' or the single Drosophila homolog, SNF. We show here that the genes that encode these proteins (rn...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Saldi T,Wilusz C,MacMorris M,Blumenthal T

更新日期：2007-06-05 00:00:00

abstract：:Absolute pitch (AP) is the rare ability to identify the pitch of a tone without the aid of a reference tone. Understanding both the nature and genesis of AP can provide insights into neuroplasticity in the auditory system. We explored factors that may influence the accuracy of pitch perception in AP subjects both duri...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Athos EA,Levinson B,Kistler A,Zemansky J,Bostrom A,Freimer N,Gitschier J

更新日期：2007-09-11 00:00:00

abstract：:Defining bacterial species remains a challenging problem even for the model bacterium Escherichia coli and has major practical consequences for reliable diagnosis of infectious disease agents and regulations for transport and possession of organisms of economic importance. E. coli traditionally is thought to live with...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Luo C,Walk ST,Gordon DM,Feldgarden M,Tiedje JM,Konstantinidis KT

更新日期：2011-04-26 00:00:00

abstract：:Most human cancers are aneuploid and have chromosomal instability, which contrasts to the inability of human cells to normally tolerate aneuploidy. Noting that aneuploidy in human breast cancer correlates with increased expression levels of the Mps1 checkpoint gene, we investigated whether these high levels of Mps1 co...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Daniel J,Coulter J,Woo JH,Wilsbach K,Gabrielson E

更新日期：2011-03-29 00:00:00

abstract：:The distribution of enkephalin-like immunoreactivity within the avian retina was studied by immunofluorescence and immunoperoxidase techniques with antiserum to [Met5]enkephalin and [Leu5]enkephalin. Formaldehyde-fixed retinae were sectioned and incubated in antiserum to either [Met5]- or [Leu5]enkephalin. Specificity...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Brecha N,Karten HJ,Laverack C

更新日期：1979-06-01 00:00:00

abstract：:In the cytoplasm of well-spread cultured normal fibroblasts, actin is organized into a network of cables that run the length of the cell just inside the adherent cell membrane. A diffuse matrix replaces the cables in fibroblasts that have become tumorigenic as a result of oncogenic transformation. We have found a simi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kopelovich L,Conlon S,Pollack R

更新日期：1977-07-01 00:00:00

abstract：:Regulation of the turnover of triglycerides in adipose tissue requires the continuous provision of 3-glycerophosphate, which may be supplied by the metabolism of glucose or by glyceroneogenesis, the de novo synthesis of 3-glycerophosphate from sources other than hexoses or glycerol. The importance of glyceroneogenesis...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Olswang Y,Cohen H,Papo O,Cassuto H,Croniger CM,Hakimi P,Tilghman SM,Hanson RW,Reshef L

更新日期：2002-01-22 00:00:00

abstract：:We have previously shown that surfactant protein A (SP-A) mediates in vitro killing of mycoplasmas by alveolar macrophages (AMs) from resistant C57BL/6 mice through a nitric oxide (.NO)-dependent mechanism. Herein, SP-A-deficient [SP-A(-/-)] and inducible.NO synthase-deficient [iNOS(-/-)] mice were infected intranasal...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hickman-Davis J,Gibbs-Erwin J,Lindsey JR,Matalon S

更新日期：1999-04-27 00:00:00

abstract：:Antischizophrenic neuroleptic drugs of the diphenylbutylpiperidine class, which includes pimozide, fluspirilene, penfluridol, and clopimozide, inhibit [3H]nitrendipine binding with IC50 values of 13-30 nM. This inhibition involves receptors for the verapamil/prenylamine class of calcium channel antagonists. These diph...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gould RJ,Murphy KM,Reynolds IJ,Snyder SH

更新日期：1983-08-01 00:00:00

abstract：:An examination of life expectancy in 1963 reveals twin peaks in the empirical distribution across countries: one group of countries clustered around a life expectancy of 40 years and a second group clustered around a life expectancy of 65 years. By 2003, the mode of each cluster had moved up by approximately 10 years....

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bloom DE,Canning D

更新日期：2007-10-09 00:00:00

abstract：:In skeletal muscle, transcription of the gene encoding the mouse type Ialpha (RIalpha) subunit of the cAMP-dependent protein kinase is initiated from the alternative noncoding first exons 1a and 1b. Here, we report that activity of the promoter upstream of exon 1a (Pa) depends on two adjacent E boxes (E1 and E2) in NI...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Barradeau S,Imaizumi-Scherrer T,Weiss MC,Faust DM

更新日期：2001-04-24 00:00:00

abstract：:Coatomer, the coat protein of coat protein complex (COP)I-vesicles, is a soluble protein complex made up of seven subunits, alpha-, beta-, beta'-, gamma-, delta-, epsilon-, and zeta-COP. Higher eukaryotes have two paralogous versions of the gamma- and zeta- subunits, termed gamma1- and gamma2-COP and zeta1- and zeta2-...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Moelleken J,Malsam J,Betts MJ,Movafeghi A,Reckmann I,Meissner I,Hellwig A,Russell RB,Söllner T,Brügger B,Wieland FT

更新日期：2007-03-13 00:00:00

abstract：:Glycan-protein interactions are emerging as important modulators of membrane protein organization and dynamics, regulating multiple cellular functions. In particular, it has been postulated that glycan-mediated interactions regulate surface residence time of glycoproteins and endocytosis. How this precisely occurs is ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Torreno-Pina JA,Castro BM,Manzo C,Buschow SI,Cambi A,Garcia-Parajo MF

更新日期：2014-07-29 00:00:00

abstract：:Container-shaped molecules provide structured environments that impart geometric bounds on the motions and conformations of smaller molecular occupants. Moreover, they provide "solvation" that is constrained in time and space. When inwardly directed functional groups are present, they can interact chemically with the ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Purse BW,Rebek J Jr

更新日期：2005-08-02 00:00:00

abstract：:Phospholamban (PLN) is an effective inhibitor of the sarco(endo)plasmic reticulum Ca(2+) ATPase (SERCA). Here, we examined PLN stability and degradation in primary cultured mouse neonatal cardiomyocytes (CMNCs) and mouse hearts using immunoblotting, molecular imaging, and [(35)S]methionine pulse-chase experiments, tog...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Teng AC,Miyake T,Yokoe S,Zhang L,Rezende LM Jr,Sharma P,MacLennan DH,Liu PP,Gramolini AO

更新日期：2015-06-09 00:00:00

abstract：:The current study identifies CCR8+ regulatory T cells (Treg cells) as drivers of immunosuppression. We show that in human peripheral blood cells, more than 30% of Treg up-regulate CCR8 following activation in the presence of CCL1. This interaction induces STAT3-dependent up-regulation of FOXp3, CD39, IL-10, and granzy...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Barsheshet Y,Wildbaum G,Levy E,Vitenshtein A,Akinseye C,Griggs J,Lira SA,Karin N

更新日期：2017-06-06 00:00:00

abstract：:Recent advances in high-field MRI have dramatically improved the visualization of human brain anatomy in vivo. Most notably, in cortical gray matter, strong contrast variations have been observed that appear to reflect the local laminar architecture. This contrast has been attributed to subtle variations in the magnet...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fukunaga M,Li TQ,van Gelderen P,de Zwart JA,Shmueli K,Yao B,Lee J,Maric D,Aronova MA,Zhang G,Leapman RD,Schenck JF,Merkle H,Duyn JH

更新日期：2010-02-23 00:00:00

abstract：:Total chemical synthesis was used to prepare the mirror image (D-protein) form of the angiogenic protein vascular endothelial growth factor (VEGF-A). Phage display against D-VEGF-A was used to screen designed libraries based on a unique small protein scaffold in order to identify a high affinity ligand. Chemically syn...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mandal K,Uppalapati M,Ault-Riché D,Kenney J,Lowitz J,Sidhu SS,Kent SB

更新日期：2012-09-11 00:00:00

abstract：:Bordetella pertussis secretes a calmodulin-activated adenylate cyclase toxin, CyaA, that is able to deliver its N-terminal catalytic domain (400-aa residues) into the cytosol of eukaryotic target cells, directly through the cytoplasmic membrane. We have previously shown that CyaA can be used as a vehicle to deliver T ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Karimova G,Fayolle C,Gmira S,Ullmann A,Leclerc C,Ladant D

更新日期：1998-10-13 00:00:00

abstract：:The amino acid sequence of blastokinin, also called uteroglobin, has been determined by a combined study of both the intact native molecule and the peptide fragments resulting from tryptic and chymotryptic digestions. Sequence analyses performed by automated methods and by sequential digestion with leucine aminopeptid...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Popp RA,Foresman KR,Wise LD,Daniel JC Jr

更新日期：1978-11-01 00:00:00

abstract：:Human T lymphotropic virus type 1 (HTLV-1) -associated myelopathy/tropic spastic paraparesis is a demyelinating inflammatory neurologic disease associated with HTLV-1 infection. HTLV-1 Tax11-19-specific cytotoxic T cells have been isolated from HLA-A2-positive patients. We have used a peptide-loaded soluble HLA-A2-Ig ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Greten TF,Slansky JE,Kubota R,Soldan SS,Jaffee EM,Leist TP,Pardoll DM,Jacobson S,Schneck JP

更新日期：1998-06-23 00:00:00

abstract：:To assess the contribution to immunoglobulin heavy chain diversity made by recombination between variable region (VH) genes and joining region (JH) genes, we have determined the sequence of about 2000 nucleotides spanning the rearranged JH gene cluster associated with the VH gene expressed in plasmacytoma HPC76. The a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gough NM,Bernard O

更新日期：1981-01-01 00:00:00

abstract：:We previously isolated a mutant of Escherichia coli that is preferentially affected in the synthesis of rRNA and has a mutation in the gene (accD) encoding a subunit of acetyl-CoA carboxylase. Using this mutant and other mutants of the pathway for fatty acid and phospholipid biosynthesis as well as cerulenin, a specif...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Seyfzadeh M,Keener J,Nomura M

更新日期：1993-12-01 00:00:00

abstract：:The phosphatidylinositol phosphate kinase (PIPK) family of enzymes is primarily responsible for converting singly phosphorylated phosphatidylinositol derivatives to phosphatidylinositol bisphosphates. As such, these kinases are central to many signaling and membrane trafficking processes in the eukaryotic cell. The th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Muftuoglu Y,Xue Y,Gao X,Wu D,Ha Y

更新日期：2016-08-02 00:00:00

abstract：:Preadipocytes can give rise to either white adipocytes or beige adipocytes. Owing to their distinct abilities in nutrient storage and energy expenditure, strategies that specifically promote "beiging" of adipocytes hold great promise for counterbalancing obesity and metabolic diseases. Yet, factors dictating the diffe...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liu K,Lin L,Li Q,Xue Y,Zheng F,Wang G,Zheng C,Du L,Hu M,Huang Y,Shao C,Kong X,Melino G,Shi Y,Wang Y

更新日期：2020-02-04 00:00:00

abstract：:Parvalbumin (PV) is a Ca2+-binding protein found only in vertebrates. It is postulated to serve as a soluble relaxing factor in fast mammalian muscle. We have isolated a rat PV cDNA clone and used this as a probe to examine changes in PV mRNA during muscle and brain development. A cDNA library was constructed in PUC8/...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Berchtold MW,Means AR

更新日期：1985-03-01 00:00:00

abstract：:In eukaryotic cells the concentration of dNTP is highest in S phase and lowest in G1 phase and is controlled by ribonucleotide reductase (RNR). RNR activity is eliminated in all eukaryotes in G1 phase by a variety of mechanisms: transcriptional regulation, small inhibitory proteins, and protein degradation. After acti...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chabes A,Stillman B

更新日期：2007-01-23 00:00:00