Stress impairs cognitive flexibility in infants.

abstract：:The uterine epithelium of mice and humans undergoes cyclical waves of cell proliferation and differentiation under the regulation of estradiol-17β (E2) and progesterone (P4). These epithelial cells respond to E2 with increased protein and DNA synthesis, whereas P4 inhibits only the E2-induced DNA synthetic response. H...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang Y,Zhu L,Kuokkanen S,Pollard JW

更新日期：2015-03-17 00:00:00

abstract：:NADH:quinone oxidoreductase (complex I) plays a pivotal role in cellular energy production. It employs a series of redox cofactors to couple electron transfer to the generation of a proton-motive force across the inner mitochondrial or bacterial cytoplasmic membrane. Complex I contains a noncovalently bound flavin mon...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yakovlev G,Reda T,Hirst J

更新日期：2007-07-31 00:00:00

abstract：:Allostery, the coupling between ligand binding and protein conformational change, is the heart of biological network and it has often been explained by two representative models, the induced-fit and the population-shift models. Here, we clarified for what systems one model fits better than the other by performing mole...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Okazaki K,Takada S

更新日期：2008-08-12 00:00:00

abstract：:Junctional Adhesion Molecule-A (JAM-A) is a transmembrane adhesive protein expressed at endothelial junctions and in leukocytes. Here we report that JAM-A is required for the correct infiltration of polymorphonuclear leukocytes (PMN) into an inflamed peritoneum or in the heart upon ischemia-reperfusion injury. The def...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Corada M,Chimenti S,Cera MR,Vinci M,Salio M,Fiordaliso F,De Angelis N,Villa A,Bossi M,Staszewsky LI,Vecchi A,Parazzoli D,Motoike T,Latini R,Dejana E

更新日期：2005-07-26 00:00:00

abstract：:Energy-coupling factor (ECF) transporters are a recently discovered family of primary active transporters for micronutrients and vitamins, such as biotin, thiamine, and riboflavin. Found exclusively in archaea and bacteria, including the human pathogens Listeria, Streptococcus, and Staphylococcus, ECF transporters may...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Karpowich NK,Wang DN

更新日期：2013-02-12 00:00:00

abstract：:A phylogeny of marine Rhodophyta has been inferred by a number of methods from nucleotide sequences of nuclear genes encoding small subunit rRNA from 39 species in 15 orders. Sequence divergences are relatively large, especially among bangiophytes and even among congeners in this group. Subclass Bangiophycidae appears...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ragan MA,Bird CJ,Rice EL,Gutell RR,Murphy CA,Singh RK

更新日期：1994-07-19 00:00:00

abstract：:Division of labor among the workers of insect societies is a conspicuous feature of their biology. Social tasks are commonly shared among age groups but not between larvae and adults with completely different morphologies, as in bees, wasps, ants, and beetles (i.e., Holometabola). A unique yet hardly studied holometab...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Biedermann PH,Taborsky M

更新日期：2011-10-11 00:00:00

abstract：:Leptin is an adipocytokine that plays a key role in the modulation of immune responses and the development and maintenance of inflammation. Circulating levels of leptin are elevated in systemic lupus erythematosus (SLE) patients, but it is not clear whether this association can reflect a direct influence of leptin on ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lourenço EV,Liu A,Matarese G,La Cava A

更新日期：2016-09-20 00:00:00

abstract：:The region of the murine major histocompatibility complex (MHC) between the Pb (A beta 3) and Ob (A beta 2) genes controls the expression of an intracellular complex named the LMP (low molecular weight polypeptide) complex. DNA probes for at least seven different genes mapping to this region were isolated. These hybri...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cho S,Attaya M,Brown MG,Monaco JJ

更新日期：1991-06-15 00:00:00

abstract：:A broad program of freezing species in threatened ecospheres could preserve biodiversity for eventual use by future generations. Sampling without studying can lower costs dramatically. Local labor can do most of the gathering. Plausible costs of collecting and cryogenically suspending the tropical rain forest species,...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Benford G

更新日期：1992-11-15 00:00:00

abstract：:Attention to a stimulus enhances both neuronal responses and gamma frequency synchrony in visual area V4, both of which should increase the impact of attended information on downstream neurons. To determine whether gamma synchrony is common throughout the ventral stream, we recorded from neurons in the superficial and...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Buffalo EA,Fries P,Landman R,Buschman TJ,Desimone R

更新日期：2011-07-05 00:00:00

abstract：:The effects of messages initiated by one receptor on the covalent modification of a second receptor were studied by use of a technique for rapidly separating the receptors. Methylation of the bacterial-chemotactic serine receptor increases as a result of aspartate binding to the aspartate receptor. The aspartate-induc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sanders DA,Koshland DE Jr

更新日期：1988-11-01 00:00:00

abstract：:The three-dimensional structure of alpha-cobra-toxin, the "long" neurotoxin from the venom of Naja naja siamensis, has been determined at 2.8-A resolution. Crystals grown as hexagonal needles have space group P6522 with unit cell parameters a = b = 74.59 A, c = 42.89 A; one molecule per asymmetric unit. Phases were de...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Walkinshaw MD,Saenger W,Maelicke A

更新日期：1980-05-01 00:00:00

abstract：:Interleukin 2 (IL-2) receptors on activated T cells exist in high- and low-affinity configurations, both of which share a ligand-binding component known as the Tac protein. Although almost all binding of IL-2 to such cells was inhibited by an antibody to Tac, the predominant component of binding on the natural killer ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Robb RJ,Rusk CM,Yodoi J,Greene WC

更新日期：1987-04-01 00:00:00

abstract：:Melittin messenger RNA from queen bee venom glands has been translated in a cell-free system from wheat germ. A product larger than promelittin is formed which has the carboxy-terminal sequence-Gln-Gln-GlyCOOH. Melittin and promelittin from venom glands terminate in -Gln-GlnCONH2. The possible role of the extra glycin...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Suchanek G,Kreil G

更新日期：1977-03-01 00:00:00

abstract：:The modern Old World Monkeys (Superfamily Cercopithecoidea, Family Cercopithecidae) can be traced back into the late Miocene, but their origin and subsequent diversification is obscured by the scarcity of terrestrial fossil sites in Africa between 15 and 6 Ma. Here, we document the presence of cercopithecids at 12.5 M...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rossie JB,Gilbert CC,Hill A

更新日期：2013-04-09 00:00:00

abstract：:The binding of killer cell Ig-like Receptors (KIR) to their Class I MHC ligands was shown previously to be characterized by extremely rapid association and dissociation rate constants. During experiments to investigate the biochemistry of receptor-ligand binding in more detail, the kinetic parameters of the interactio...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Valés-Gómez M,Erskine RA,Deacon MP,Strominger JL,Reyburn HT

更新日期：2001-02-13 00:00:00

abstract：:Climate change impacts island communities all over the world. Sea-level rise, an increase in the frequency and intensity of severe weather events, and changes in distribution and health of marine organisms are among the most significant processes affecting island communities worldwide. On islands of the Caribbean and ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Douglass K,Cooper J

更新日期：2020-04-14 00:00:00

abstract：:Many processes in nature are modeled using compartmental systems (reservoir/pool/box systems). Usually, they are expressed as a set of first-order differential equations describing the transfer of matter across a network of compartments. The concepts of age of matter in compartments and the time required for particles...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Metzler H,Müller M,Sierra CA

更新日期：2018-02-06 00:00:00

abstract：:Antarctic ozone depletion is associated with enhanced chlorine from anthropogenic chlorofluorocarbons and heterogeneous chemistry under cold conditions. The deep Antarctic "hole" contrasts with the generally weaker depletions observed in the warmer Arctic. An unusually cold Arctic stratospheric season occurred in 2011...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Solomon S,Haskins J,Ivy DJ,Min F

更新日期：2014-04-29 00:00:00

abstract：:The apoprotein corresponding to the mammalian photoreceptor rhodopsin has been expressed by using suspension cultures of HEK293S cells in defined media that contained 6-15N-lysine and 2-13C-glycine. Typical yields were 1.5-1.8 mg/liter. Incorporation of 6-15N-lysine was quantitative, whereas that of 2-13C-glycine was ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Eilers M,Reeves PJ,Ying W,Khorana HG,Smith SO

更新日期：1999-01-19 00:00:00

abstract：:Human cytomegalovirus (HCMV) strains that have been passaged in vitro rapidly acquire mutations that impact viral growth. These laboratory-adapted strains of HCMV generally exhibit restricted tropism, produce high levels of cell-free virus, and develop susceptibility to natural killer cells. To permit experimentation ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Murrell I,Bedford C,Ladell K,Miners KL,Price DA,Tomasec P,Wilkinson GWG,Stanton RJ

更新日期：2017-06-06 00:00:00

abstract：:The cyclic enzymatic function of a cytochrome P450, as it catalyzes the oxygen-dependent metabolism of many organic chemicals, requires the delivery of two electrons to the hemeprotein. In general these electrons are transferred from NADPH to the P450 via an FMN- and FAD-containing flavoprotein (NADPH-P450 reductase)....

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Faulkner KM,Shet MS,Fisher CW,Estabrook RW

更新日期：1995-08-15 00:00:00

abstract：:Helping and sharing among humans is often motivated by empathy and accompanied by a sense of satisfaction. To determine whether similar self-rewarding mechanisms may underpin assistance among nonhuman primates, eight female brown capuchin monkeys (Cebus apella) underwent testing in a simple choice paradigm. Paired wit...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： de Waal FB,Leimgruber K,Greenberg AR

更新日期：2008-09-09 00:00:00

abstract：:In the absence of lasers approaching trapped ion clock transitions in sharpness we propose to replace the 12.49 m laser field exciting the D3/2-D5/2 transition of the single Ba+ ion A in D3/2 with the near-field of a close by identical ion B in the excited D5/2 state. We tune the frequency of the near-field by the dif...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dehmelt H,Zhao X,Yu N,Nagourney W

更新日期：1996-07-09 00:00:00

abstract：:Xenogeneic monoclonal antibodies were prepared to the murine interleukin 2 (IL-2)-dependent HT2 cell line. One rat IgM monoclonal antibody (7D4) was identified that inhibited proliferation of the HT2 cells and of IL-2-dependent CTLL cells in the presence of crude rat IL-2 as well as of purified human IL-2. The level o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Malek TR,Robb RJ,Shevach EM

更新日期：1983-09-01 00:00:00

abstract：:Trafficking and turnover of transmitter receptors required to maintain and modify the strength of chemical synapses have been characterized extensively. In contrast, little is known regarding trafficking of gap junction components at electrical synapses. By combining ultrastructural and in vivo physiological analysis ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Flores CE,Nannapaneni S,Davidson KG,Yasumura T,Bennett MV,Rash JE,Pereda AE

更新日期：2012-02-28 00:00:00

abstract：:We have studied the genetic interactions between mutant alleles in 12 genes, designated PER1-PER12, which are essential for peroxisome biogenesis in the yeast Hansenula polymorpha. Recessive mutations in any of these genes determined three different morphological phenotypes: (i) complete absence of peroxisomes (Per-);...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Titorenko VI,Waterham HR,Cregg JM,Harder W,Veenhuis M

更新日期：1993-08-15 00:00:00

abstract：:The absorption spectrum of an activesite specific chromophoric acyl enzyme, sturgeon beta-(2-furyl)-acryloyl-glyceraldehyde-3-phosphate dehydrogenase, is reported. This acyl enzyme undergoes all of the catalyzed reactions characteristic of the intermediate of the physiological acyl enzyme, 3-phospho-D-glyceroyl-glycer...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Malhotra OP,Bernhard SA

更新日期：1973-07-01 00:00:00

abstract：:MacArthur and Wilson [MacArthur, R. H. & Wilson, E. O. (1967) The Theory of Island Biogeography (Princeton Univ. Press, Princeton, NJ)] used the rate of recolonization of the Krakatau Islands (sterilized in the cataclysmic 1883 eruption) by birds and vascular plants to test their equilibrium model of immigration and e...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Thornton IW,Zann RA,Rawlinson PA,Tidemann CR,Adikerana AS,Widjoya AH

更新日期：1988-01-01 00:00:00