Identification and initial characterization of a rat monoclonal antibody reactive with the murine interleukin 2 receptor-ligand complex.

abstract：:The nucleotide sequences of the complementary strands of two human diversity region (D) minigenes, D2 and D4, show stretches of homology with two human variable region kappa chain (V kappa) genes, NG9 and HK101, respectively, in the first complementarity-determining region. In one V kappa sequence, the homology includ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chen PP,Kabat EA,Wu TT,Fong S,Carson DA

更新日期：1985-04-01 00:00:00

abstract：:In a coupled system consisting of RNA polymerase and DNA polymerase I of Escherichia coli, the four deoxyribo- and the four ribonucleoside triphosphates, and DNA of bacteriophage f1 as template, DNA synthesis depends on the concomitant synthesis of RNA. Over a wide range of concentrations of the two polymerases, RNA s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Karkas JD

更新日期：1972-08-01 00:00:00

abstract：:The glucose transporter isoform GLUT4 is found only in cells that exhibit insulin-sensitive glucose transport. To investigate the function of this transporter, L6 myoblasts were stably transfected with GLUT4 cDNA. GLUT4 underwent insulin-dependent movement to the cell surface in myoblasts overexpressing the transporte...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lawrence JC Jr,Piper RC,Robinson LJ,James DE

更新日期：1992-04-15 00:00:00

abstract：:Leukocyte adherence to endothelium is in part mediated by the transient expression of endothelial-leukocyte adhesion molecule 1 (ELAM-1) on endothelial surfaces stimulated by tumor necrosis factor alpha (TNF), interleukin (IL) 1, or bacterial lipopolysaccharide (LPS). The intracellular factors controlling induction of...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Montgomery KF,Osborn L,Hession C,Tizard R,Goff D,Vassallo C,Tarr PI,Bomsztyk K,Lobb R,Harlan JM

更新日期：1991-08-01 00:00:00

abstract：:Adenosine 3':5'-cyclic monophosphate added to exponentially growing cells of Hemophilus influenzae strain Rd increases competence for transformation 100- to 10,000-fold. Cyclic AMP added to near-stationary or stationary cells does not increase competence over the high level normally found in the early stationary phase...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wise EM Jr,Alexander SP,Powers M

更新日期：1973-02-01 00:00:00

abstract：:Innervation of skeletal muscle by motor neurons occurs through the neuromuscular junction, a cholinergic synapse essential for normal muscle growth and function. Defects in nerve-muscle signaling cause a variety of neuromuscular disorders with features of ataxia, paralysis, skeletal muscle wasting, and degeneration. H...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Anderson DM,Cannavino J,Li H,Anderson KM,Nelson BR,McAnally J,Bezprozvannaya S,Liu Y,Lin W,Liu N,Bassel-Duby R,Olson EN

更新日期：2016-08-02 00:00:00

abstract：:Although much is known about the underlying mechanisms of p53 activity and regulation, the factors that influence the diversity and duration of p53 responses are not well understood. Here we describe a unique mode of p53 regulation involving alternative splicing of the TP53 gene. We found that the use of an alternativ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Senturk S,Yao Z,Camiolo M,Stiles B,Rathod T,Walsh AM,Nemajerova A,Lazzara MJ,Altorki NK,Krainer A,Moll UM,Lowe SW,Cartegni L,Sordella R

更新日期：2014-08-12 00:00:00

abstract：:We have developed an efficient, versatile, and user-friendly viral engineering and expression system that is based on in planta assembly of functional viral vectors from separate pro-vector modules. With this new system, instead of supplying a plant cell with a complete viral vector as a mature viral particle, an RNA ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Marillonnet S,Giritch A,Gils M,Kandzia R,Klimyuk V,Gleba Y

更新日期：2004-05-04 00:00:00

abstract：:This study challenges the paradigm that salt marsh plants prevent lateral wave-induced erosion along wetland edges by binding soil with live roots and clarifies the role of vegetation in protecting the coast. In both laboratory flume studies and controlled field experiments, we show that common salt marsh plants do no...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Feagin RA,Lozada-Bernard SM,Ravens TM,Möller I,Yeager KM,Baird AH

更新日期：2009-06-23 00:00:00

abstract：:Ferric uptake regulation protein (Fur) is a bacterial global regulator that uses iron as a cofactor to bind to specific DNA sequences. The function of Fur is not limited to iron homeostasis. A wide variety of genes involved in various mechanisms such as oxidative and acid stresses are under Fur control. Flavohemoglobi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： D'Autreaux B,Touati D,Bersch B,Latour JM,Michaud-Soret I

更新日期：2002-12-24 00:00:00

abstract：:We have detected a proteolytic mechanism in chloroplasts that selectively and rapidly degrades the imported small subunit of ribulose 1,5-bisphosphate carboxylase when pools of the chloroplast-synthesized large subunit are depleted. This degradation system is constitutively present and appears to be responsible for pr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schmidt GW,Mishkind ML

更新日期：1983-05-01 00:00:00

abstract：:The nuclear receptor corepressor, silencing mediator of retinoid and thyroid hormone receptors (SMRT), is recruited by a plethora of transcription factors to mediate lineage and signal-dependent transcriptional repression. We generated a knockin mutation in the receptor interaction domain (RID) of SMRT (SMRT(mRID)) th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nofsinger RR,Li P,Hong SH,Jonker JW,Barish GD,Ying H,Cheng SY,Leblanc M,Xu W,Pei L,Kang YJ,Nelson M,Downes M,Yu RT,Olefsky JM,Lee CH,Evans RM

更新日期：2008-12-16 00:00:00

abstract：:Allostery, the coupling between ligand binding and protein conformational change, is the heart of biological network and it has often been explained by two representative models, the induced-fit and the population-shift models. Here, we clarified for what systems one model fits better than the other by performing mole...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Okazaki K,Takada S

更新日期：2008-08-12 00:00:00

abstract：:Varicella-zoster virus (VZV) causes varicella and establishes latency in sensory ganglia. VZV reactivation results in herpes zoster. We developed a model using human dorsal root ganglion (DRG) xenografts in severe combined immunodeficient (SCID) mice to investigate VZV infection of differentiated neurons and satellite...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zerboni L,Ku CC,Jones CD,Zehnder JL,Arvin AM

更新日期：2005-05-03 00:00:00

abstract：:The genes encoding the variable (V) region of the B-cell antigen receptor (BCR) are assembled from V, D (diversity), and J (joining) elements through a RAG-mediated recombination process that relies on the recognition of recombination signal sequences (RSSs) flanking the individual elements. Secondary V(D)J rearrangem...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sun A,Novobrantseva TI,Coffre M,Hewitt SL,Jensen K,Skok JA,Rajewsky K,Koralov SB

更新日期：2015-02-03 00:00:00

abstract：:The relative importance of local ecological and larger-scale historical processes in causing differences in species richness across the globe remains keenly debated. To gain insight into these questions, we investigated the assembly of plant diversity in the Cerrado in South America, the world's most species-rich trop...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Simon MF,Grether R,de Queiroz LP,Skema C,Pennington RT,Hughes CE

更新日期：2009-12-01 00:00:00

abstract：:We have examined the kinetics of the interaction between endodeoxyribonuclease EcoRI (EC 3.1.23.13) and nine linear DNA fragments that range in size between 34 and 6,200 base pairs and contain the EcoRI site of plasmid pBR322 in a central location. The kinetic parameters governing both formation and decay of specific ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jack WE,Terry BJ,Modrich P

更新日期：1982-07-01 00:00:00

abstract：:We report light-induced electron paramagnetic resonance triplet spectra from samples of chloroplasts or digitonin photosystem I particles that depend upon the dark redox state of the bound acceptors of photosystem I. If the reaction centers are prepared in the redox state P-700 A X- FdB-FdA-, then upon illumination at...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Frank HA,McLean MB,Sauer K

更新日期：1979-10-01 00:00:00

abstract：:The integrase protein of human immunodeficiency virus type 1 is necessary for the stable integration of the viral genome into host DNA. Integrase catalyzes the 3' processing of the linear viral DNA and the subsequent DNA strand transfer reaction that inserts the viral DNA ends into host DNA. Although full-length integ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jenkins TM,Hickman AB,Dyda F,Ghirlando R,Davies DR,Craigie R

更新日期：1995-06-20 00:00:00

abstract：:Neuropathy target esterase (NTE) is a neuronal membrane protein originally identified for its property to be modified by organo-phosphates (OPs), which in humans cause neuropathy characterized by axonal degeneration. Drosophila mutants for the homolog gene of NTE, swisscheese (sws), indicated a possible involvement of...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Akassoglou K,Malester B,Xu J,Tessarollo L,Rosenbluth J,Chao MV

更新日期：2004-04-06 00:00:00

abstract：:The slow rolling motion of leukocytes along the walls of blood vessels mediated by specific receptor-ligand adhesion is important in inflammation and occurs in postcapillary venules over a wide range of wall shear stresses and vessel diameters. The ability of hydrodynamic collisions between cells to induce capture of ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： King MR,Hammer DA

更新日期：2001-12-18 00:00:00

abstract：:Factor XI (plasma thromboplastin antecedent) deficiency is a blood coagulation abnormality occurring in high frequency in Ashkenazi Jews. Three independent point mutations that result in a blood coagulation abnormality have been identified in the factor XI gene of six unrelated Ashkenazi patients. These mutations eith...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Asakai R,Chung DW,Ratnoff OD,Davie EW

更新日期：1989-10-01 00:00:00

abstract：:Kabuki syndrome is a Mendelian intellectual disability syndrome caused by mutations in either of two genes (KMT2D and KDM6A) involved in chromatin accessibility. We previously showed that an agent that promotes chromatin opening, the histone deacetylase inhibitor (HDACi) AR-42, ameliorates the deficiency of adult neur...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Benjamin JS,Pilarowski GO,Carosso GA,Zhang L,Huso DL,Goff LA,Vernon HJ,Hansen KD,Bjornsson HT

更新日期：2017-01-03 00:00:00

abstract：:Fragility is an empirical property that describes how abruptly a glass-forming material solidifies upon supercooling. The degree of fragility carries important implications for the functionality and processability of a material, as well as for our fundamental understanding of the glass transition. However, the microst...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ciarella S,Biezemans RA,Janssen LMC

更新日期：2019-12-10 00:00:00

abstract：:Infection of Swiss mouse 3T3FL cells with a clonal isolate of Moloney leukemia virus (MLV-IC) resulted in virus progeny composed of at least three different murine helper oncornaviruses. Each entity was purified in appropriate cells by several sequential terminal dilution isolations and was grouwn to high titers. Besi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fischinger PJ,Nomura S,Bolognesi DP

更新日期：1975-12-01 00:00:00

abstract：:Paracoccidioidomycosis, a disease caused by Paracoccidioides brasiliensis, which is endemic to Latin America, is much more common in men than women, suggesting a role for hormonal factors. We recently showed that two other yeasts possess steroid binding proteins and postulated that these receptor-like molecules repres...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Loose DS,Stover EP,Restrepo A,Stevens DA,Feldman D

更新日期：1983-12-01 00:00:00

abstract：:The basal ganglia are critical for selecting actions and evaluating their outcome. Although the circuitry for selection is well understood, how these nuclei evaluate the outcome of actions is unknown. Here, we show in lamprey that a separate evaluation circuit, which regulates the habenula-projecting globus pallidus (...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Stephenson-Jones M,Kardamakis AA,Robertson B,Grillner S

更新日期：2013-09-17 00:00:00

abstract：:Spectral methods are of fundamental importance in statistics and machine learning, because they underlie algorithms from classical principal components analysis to more recent approaches that exploit manifold structure. In most cases, the core technical problem can be reduced to computing a low-rank approximation to a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Belabbas MA,Wolfe PJ

更新日期：2009-01-13 00:00:00

abstract：:The relative stabilities and structural properties of a representative set of 20 ALS-mutant Cu,Zn-superoxide dismutase apoproteins were examined by using differential scanning calorimetry and hydrogen-deuterium (H/D) exchange followed by MS. Contrary to recent reports from other laboratories, we found that ALS-mutant ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rodriguez JA,Shaw BF,Durazo A,Sohn SH,Doucette PA,Nersissian AM,Faull KF,Eggers DK,Tiwari A,Hayward LJ,Valentine JS

更新日期：2005-07-26 00:00:00

abstract：:Two features make the tooth an excellent model in the study of evolutionary innovations: the relative simplicity of its structure and the fact that the major tooth-forming genes have been identified in eutherian mammals. To understand the nature of the innovation at the molecular level, it is necessary to identify the...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Toyosawa S,O'hUigin C,Figueroa F,Tichy H,Klein J

更新日期：1998-10-27 00:00:00