Direct inhibition by nitric oxide of the transcriptional ferric uptake regulation protein via nitrosylation of the iron.

abstract：:14-3-3 proteins are ubiquitously expressed regulators of various cellular functions, including proliferation, metabolism, and differentiation, and altered 14-3-3 expression is associated with development and progression of cancer. We report a transforming 14-3-3 oncoprotein, which we identified through conventional cy...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lee CH,Ou WB,Mariño-Enriquez A,Zhu M,Mayeda M,Wang Y,Guo X,Brunner AL,Amant F,French CA,West RB,McAlpine JN,Gilks CB,Yaffe MB,Prentice LM,McPherson A,Jones SJ,Marra MA,Shah SP,van de Rijn M,Huntsman DG,Dal Cin P

更新日期：2012-01-17 00:00:00

abstract：:Ubiquitin E3 ligases are crucial for eliminating misfolded proteins before they form cytotoxic aggregates that threaten cell fitness and survival. However, it remains unclear how emerging misfolded proteins in the cytoplasm can be selectively recognized and eliminated by E3 ligases in plants. We found that Misfolded P...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kim JH,Cho SK,Oh TR,Ryu MY,Yang SW,Kim WT

更新日期：2017-11-14 00:00:00

abstract：:A critical step in neuronal development is the formation of axon/dendrite polarity, a process involving symmetry breaking in the newborn neuron. Local self-amplifying processes could enhance and stabilize the initial asymmetry in the distribution of axon/dendrite determinants, but the identity of these processes remai...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cheng PL,Song AH,Wong YH,Wang S,Zhang X,Poo MM

更新日期：2011-11-08 00:00:00

abstract：:Insulin-like growth factors I and II (IGF-I and -II) are potent mitogens for various cancers, including carcinoma of the prostate. In several experimental cancers, treatment with antagonists of growth hormone-releasing hormone (GH-RH) produces a reduction in IGF-I and -II, concomitant to inhibition of tumor growth. To...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lamharzi N,Schally AV,Koppán M,Groot K

更新日期：1998-07-21 00:00:00

abstract：:A serumless, chemically defined medium has been developed for the culture of oligodendrocytes isolated from primary neonatal rat cerebral cultures. Combined together, insulin, transferrin, and fibroblast growth factor synergistically induced an essentially homogenous population (95-98%) of cells expressing glycerol-3-...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Saneto RP,de Vellis J

更新日期：1985-05-01 00:00:00

abstract：:Loss of the tumor suppressor, PTEN, is one of the most common findings in prostate cancer (PCa). This loss leads to overactive Akt signaling, which is correlated with increased metastasis and androgen independence. However, another tumor suppressor, inositol-polyphosphate 4-phosphatase type II (INPP4B), can partially ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chaurasiya S,Wu W,Strom AM,Warner M,Gustafsson JÅ

更新日期：2020-10-20 00:00:00

abstract：:Although aminoacyl-tRNA synthetases (ARSs) are essential for protein synthesis, they also function as regulators and signaling molecules in diverse biological processes. Here, we screened 11 different human ARSs to identify the enzyme that is secreted as a signaling molecule. Among them, we found that lysyl-tRNA synth...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Park SG,Kim HJ,Min YH,Choi EC,Shin YK,Park BJ,Lee SW,Kim S

更新日期：2005-05-03 00:00:00

abstract：:While South Americans are underrepresented in human genomic diversity studies, Brazil has been a classical model for population genetics studies on admixture. We present the results of the EPIGEN Brazil Initiative, the most comprehensive up-to-date genomic analysis of any Latin-American population. A population-based ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kehdy FS,Gouveia MH,Machado M,Magalhães WC,Horimoto AR,Horta BL,Moreira RG,Leal TP,Scliar MO,Soares-Souza GB,Rodrigues-Soares F,Araújo GS,Zamudio R,Sant Anna HP,Santos HC,Duarte NE,Fiaccone RL,Figueiredo CA,Silva TM,

更新日期：2015-07-14 00:00:00

abstract：:Dendritic cells (DCs) play a central role in determining the induction of T cell responses. IL-27 production by DCs favors induction of IL-10-producing regulatory T cells, whereas osteopontin (OPN) promotes pathogenic IL-17 T cell responses. The regulatory mechanisms in DCs that control these two cells types are not u...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Murugaiyan G,Mittal A,Weiner HL

更新日期：2010-06-22 00:00:00

abstract：:Extended defects are known to have critical influences in achieving desired material performance. However, the nature of extended defect generation is highly elusive due to the presence of multiple nucleation mechanisms with close energetics. A strategy to design extended defects in a simple and clean way is thus high...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang Z,Guo H,Shao S,Saghayezhian M,Li J,Fittipaldi R,Vecchione A,Siwakoti P,Zhu Y,Zhang J,Plummer EW

更新日期：2018-09-18 00:00:00

abstract：:Sulfur assimilation is an evolutionarily conserved pathway that plays an essential role in cellular and metabolic processes, including sulfation, amino acid biosynthesis, and organismal development. We report that loss of a key enzymatic component of the pathway, bisphosphate 3'-nucleotidase (Bpnt1), in mice, both who...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hudson BH,Hale AT,Irving RP,Li S,York JD

更新日期：2018-03-20 00:00:00

abstract：:Understanding the molecular determinants of specificity in protein-protein interaction is an outstanding challenge of postgenome biology. The availability of large protein databases generated from sequences of hundreds of bacterial genomes enables various statistical approaches to this problem. In this context covaria...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Weigt M,White RA,Szurmant H,Hoch JA,Hwa T

更新日期：2009-01-06 00:00:00

abstract：:Adverse social conditions have been linked to a conserved transcriptional response to adversity (CTRA) in circulating leukocytes that may contribute to social gradients in disease. However, the CNS mechanisms involved remain obscure, in part because CTRA gene-expression profiles often track external social-environment...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mehl MR,Raison CL,Pace TWW,Arevalo JMG,Cole SW

更新日期：2017-11-21 00:00:00

abstract：:The phosphatidylinositol 3-kinase subunit PIK3CA is frequently mutated in human cancers. Here we used gene targeting to "knock in" PIK3CA mutations into human breast epithelial cells to identify new therapeutic targets associated with oncogenic PIK3CA. Mutant PIK3CA knockin cells were capable of epidermal growth facto...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gustin JP,Karakas B,Weiss MB,Abukhdeir AM,Lauring J,Garay JP,Cosgrove D,Tamaki A,Konishi H,Konishi Y,Mohseni M,Wang G,Rosen DM,Denmeade SR,Higgins MJ,Vitolo MI,Bachman KE,Park BH

更新日期：2009-02-24 00:00:00

abstract：:Five protease inhibitors with different modes of action were found to reduce the growth of transformed mouse (Py3T3, SV3T3, and 3T12) and hamster (PyBHK) cells. Some of these inhibitors caused the transformed cells to cease growth at saturation densities characteristic for nontransformed cells. The protease inhibitors...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schnebli HP,Burger MM

更新日期：1972-12-01 00:00:00

abstract：:Polyadenylylated RNA synthesized after heat shock was isolated from polysomes of cultured cells of Drosophila melanogaster and used as template to prepare cDNA. An excess of poly(A)-RNA from heat-shocked cells hybridized to 80% of the cDNA, whereas cytoplasmic poly(A)-RNA from cells grown at 25 degrees could drive onl...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Biessmann H,Levy B,McCarthy BJ

更新日期：1978-02-01 00:00:00

abstract：:cDNAs representing the alpha subunit of polyomavirus enhancer binding protein 2 (PEBP2; also called PEA2) were isolated. The products of the cDNAs are highly homologous to that of Drosophila segmentation gene runt (run) for an N-proximal 128-amino acid region showing 66% identity. The run homology region encompasses t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ogawa E,Maruyama M,Kagoshima H,Inuzuka M,Lu J,Satake M,Shigesada K,Ito Y

更新日期：1993-07-15 00:00:00

abstract：:Communication about prescription drugs ought to be a paragon of public science communication. Unfortunately, it is not. Consumers see $4 billion of direct-to-consumer advertising annually, which typically fails to present data about how well drugs work. The professional label--the Food and Drug Administration's (FDA) ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schwartz LM,Woloshin S

更新日期：2013-08-20 00:00:00

abstract：:Using a high-resolution isoelectric focusing system, we have been able to separate the products of the individual "nonallelic+ mouse hemoglobin alpha-chain genes. The hemoglobins of mice of inbred strains that make two structurally different, but electrophoretically identical, alpha chains resolve into two bands on is...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Whitney JB 3rd,Copland GT,Skow LC,Russell ES

更新日期：1979-02-01 00:00:00

abstract：:A rapid method for quantitating products of the oligodeoxynucleotide processing reaction in vitro has been developed to facilitate enzymatic studies of the retroviral integrases. Unlike earlier procedures, this assay does not depend on polyacrylamide gel electrphoresis but separates products by batch adsorption to PEI...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Müller B,Jones KS,Merkel GW,Skalka AM

更新日期：1993-12-15 00:00:00

abstract：:A mitochondrial gene from Saccharomyces cerevisiae encoding a hydrophobic membrane protein, subunit 8 of the F0/F1-type mitochondrial ATPase complex, has been functionally replaced by an artificial nuclear gene specifying an imported version of this protein. The experiments reported here utilized a multicopy expressio...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nagley P,Farrell LB,Gearing DP,Nero D,Meltzer S,Devenish RJ

更新日期：1988-04-01 00:00:00

abstract：:Escherichia coli lipopolysaccharide (LPS)-induced nitrate biosynthesis was studied in LPS-sensitive C3H/He and LPS-resistant C3H/HeJ mice. Intraperitoneal injection of 15 micrograms of LPS led to a temporary 5- to 6-fold increase in blood nitrate concentration in the C3H/He strain. Levels of nitrate excreted in the ur...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Stuehr DJ,Marletta MA

更新日期：1985-11-01 00:00:00

abstract：:Mucopolysaccharidosis type VII is a lysosomal storage disorder resulting from inherited deficiency of beta-glucuronidase (GUS). Mucopolysaccharidosis type VII is characterized by glycosaminoglycan storage in most tissues, including brain. In these disorders, enzyme delivery across the blood-brain barrier (BBB) is the ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Urayama A,Grubb JH,Sly WS,Banks WA

更新日期：2004-08-24 00:00:00

abstract：:A serum-free culture of dissociated neurons from embryonic rat hippocampus has been established as a rapid and quantitative in vitro test system for neurotrophic signals in the mammalian brain. By means of this cell culture bioassay, a novel low molecular weight neurotrophic factor (NTF) could be identified. NTF is es...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Müller HW,Beckh S,Seifert W

更新日期：1984-02-01 00:00:00

abstract：:The amphipod crustacean Parhyale hawaiensis has been put forward as an attractive organism for evolutionary developmental comparisons, and considerable effort is being invested in isolating developmental genes and studying their expression patterns in this species. The scope of these studies could be significantly exp...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pavlopoulos A,Averof M

更新日期：2005-05-31 00:00:00

abstract：:Plants, although sessile, can reorient growth axes in response to changing environmental conditions. Phototropism and gravitropism represent adaptive growth responses induced by changes in light direction and growth axis orientation relative to gravitational direction, respectively. The nearly 80-year-old Cholodny-Wen...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Esmon CA,Tinsley AG,Ljung K,Sandberg G,Hearne LB,Liscum E

更新日期：2006-01-03 00:00:00

abstract：:The WWOX gene is a recently cloned tumor suppressor gene that spans the FRA16D fragile region. Wwox protein contains two WW domains that are generally known to mediate protein-protein interaction. Here we show that Wwox physically interacts via its first WW domain with the p53 homolog, p73. The tyrosine kinase, Src, p...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Aqeilan RI,Pekarsky Y,Herrero JJ,Palamarchuk A,Letofsky J,Druck T,Trapasso F,Han SY,Melino G,Huebner K,Croce CM

更新日期：2004-03-30 00:00:00

abstract：:The biological significance of DNA amplification in cancer is thought to be due to the selection of increased expression of a single or few important genes. However, systematic surveys of the copy number and expression of all genes within an amplified region of the genome have not been performed. Here we have used a c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Monni O,Barlund M,Mousses S,Kononen J,Sauter G,Heiskanen M,Paavola P,Avela K,Chen Y,Bittner ML,Kallioniemi A

更新日期：2001-05-08 00:00:00

abstract：:Cysteine-bound hemes are key components of many enzymes and biological sensors. Protonation (deprotonation) of the Cys ligand often accompanies redox transformations of these centers. To characterize these phenomena, we have engineered a series of Thr78Cys/Lys79Gly/Met80X mutants of yeast cytochrome c (cyt c) in which...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhong F,Lisi GP,Collins DP,Dawson JH,Pletneva EV

更新日期：2014-01-21 00:00:00

abstract：:The progesterone receptor (PGR) is a ligand-activated transcription factor with key roles in the regulation of female fertility. Much has been learned of the actions of PGR signaling through the use of pharmacologic inhibitors and genetic manipulation, using mouse mutagenesis. Characterization of rats with a null muta...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kubota K,Cui W,Dhakal P,Wolfe MW,Rumi MA,Vivian JL,Roby KF,Soares MJ

更新日期：2016-04-12 00:00:00